2,222
Views
37
CrossRef citations to date
0
Altmetric
Original Research

Intratumor heterogeneity of immune checkpoints in primary renal cell cancer: Focus on HLA-G/ILT2/ILT4

, , , , , , & show all
Article: e1342023 | Received 01 Feb 2017, Accepted 07 Jun 2017, Published online: 18 Jul 2017

References

  • Schreiber RD, Old LJ, Smyth MJ. Cancer immunoediting: integrating immunity's roles in cancer suppression and promotion. Science 2011; 331(6024):1565-70; PMID:21436444; https://doi.org/10.1126/science.1203486
  • Weber J. Immune checkpoint proteins: a new therapeutic paradigm for cancer–preclinical background: CTLA-4 and PD-1 blockade. Semin Oncol 2010; 37(5):430-9; PMID:21074057; https://doi.org/10.1053/j.seminoncol.2010.09.005
  • Kline J, Gajewski TF. Clinical development of mAbs to block the PD1 pathway as an immunotherapy for cancer. Curr Opin Investig Drugs 2010; 11(12):1354-9; PMID:21154117
  • Sharma P, Wagner K, Wolchok JD, Allison JP. Novel cancer immunotherapy agents with survival benefit: recent successes and next steps. Nat Rev Cancer 2011; 11(11):805-12; PMID:22020206; https://doi.org/10.1038/nrc3153
  • Wolchok JD, Chan TA. Cancer: Antitumour immunity gets a boost. Nature 2014; 515(7528):496-8; PMID:25428495; https://doi.org/10.1038/515496a
  • Carosella ED, Ploussard G, LeMaoult J, Desgrandchamps F. A Systematic Review of Immunotherapy in Urologic Cancer: Evolving Roles for Targeting of CTLA-4, PD-1/PD-L1, and HLA-G. Eur Urol 2015; 68(2):267-9; PMID:25824720; https://doi.org/10.1016/j.eururo.2015.02.032
  • Carosella ED, Rouas-Freiss N, Roux DT, Moreau P, LeMaoult J. HLA-G: An Immune Checkpoint Molecule. Adv Immunol 2015; 127:33-144; PMID: 26073983; https://doi.org/10.1016/bs.ai.2015.04.001
  • Agaugue S, Carosella ED, Rouas-Freiss N. Role of HLA-G in tumor escape through expansion of myeloid-derived suppressor cells and cytokinic balance in favor of Th2 versus Th1/Th17. Blood 2011; 117(26):7021-31; PMID:21482709; https://doi.org/10.1182/blood-2010-07-294389
  • Loumagne L, Baudhuin J, Favier B, Montespan F, Carosella ED, Rouas-Freiss N. In vivo evidence that secretion of HLA-G by immunogenic tumor cells allows their evasion from immunosurveillance. Int J Cancer 2014; 135(9):2107-17; PMID:24623585; https://doi.org/10.1002/ijc.28845
  • Colonna M, Navarro F, Bellon T, Llano M, Garcia P, Samaridis J, Angman L, Cella M, López-Botet M.. A common inhibitory receptor for major histocompatibility complex class I molecules on human lymphoid and myelomonocytic cells. J Exp Med 1997; 186(11):1809-1818; PMID:9382880; https://doi.org/10.1084/jem.186.11.1809
  • Colonna M, Samaridis J, Cella M, Angman L, Allen RL, O'Callaghan CA, Dunbar R, Ogg GS, Cerundolo V, Rolink A.. Human myelomonocytic cells express an inhibitory receptor for classical and nonclassical MHC class I molecules. J Immunol 1998; 160(7):3096-100; PMID:9531263
  • Liu J, Wang L, Gao W, Li L, Cui X, Yang H, Lin W, Dang Q, Zhang N, Sun Y. Inhibitory receptor immunoglobulin-like transcript 4 was highly expressed in primary ductal and lobular breast cancer and significantly correlated with IL-10. Diagnostic pathology 2014; 9:85; PMID:24762057; https://doi.org/10.1186/1746-1596-9-85
  • Sun Y, Liu J, Gao P, Wang Y, Liu C. Expression of Ig-like transcript 4 inhibitory receptor in human non-small cell lung cancer. Chest 2008; 134(4):783-8; PMID:18625675; https://doi.org/10.1378/chest.07-1100
  • Franklin C, Livingstone E, Roesch A, Schilling B, Schadendorf D. Immunotherapy in melanoma: Recent advances and future directions. Eur J Surg Oncol 2017; 43(3):604-11; PMID:27769635; https://doi.org/10.1016/j.ejso.2016.07.145
  • Borghaei H, Paz-Ares L, Horn L, Spigel DR, Steins M, Ready NE, Chow LQ, Vokes EE, Felip E, Holgado E, et al. Nivolumab versus Docetaxel in Advanced Nonsquamous Non-Small-Cell Lung Cancer. The New England journal of medicine 2015; 373(17):1627-39; PMID:26412456; https://doi.org/10.1056/NEJMoa1507643
  • Herbst RS, Soria JC, Kowanetz M, Fine GD, Hamid O, Gordon MS, Sosman JA, McDermott DF, Powderly JD, Gettinger SN, et al. Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients. Nature 2014; 515(7528):563-7; PMID:25428504; https://doi.org/10.1038/nature14011
  • Choueiri TK, Figueroa DJ, Fay AP, Signoretti S, Liu Y, Gagnon R, Deen K, Carpenter C, Benson P, Ho TH, et al. Correlation of PD-L1 tumor expression and treatment outcomes in patients with renal cell carcinoma receiving sunitinib or pazopanib: results from COMPARZ, a randomized controlled trial. Clin Cancer Res 2015; 21(5):1071-7; PMID:25538263; https://doi.org/10.1158/1078-0432.CCR-14-1993
  • Motzer RJ, Rini BI, McDermott DF, Redman BG, Kuzel TM, Harrison MR, Vaishampayan UN, Drabkin HA, George S, Logan TF, et al. Nivolumab for Metastatic Renal Cell Carcinoma: Results of a Randomized Phase II Trial. J Clin Oncol 2015; 33(13):1430-7; PMID:25452452; https://doi.org/10.1200/JCO.2014.59.0703
  • Motzer RJ, Escudier B, McDermott DF, George S, Hammers HJ, Srinivas S, Tykodi SS, Sosman JA, Procopio G, Plimack ER, et al. Nivolumab versus Everolimus in Advanced Renal-Cell Carcinoma. N Engl J Med 2015; 373(19):1803-13; PMID:26406148; https://doi.org/10.1056/NEJMoa1510665
  • Hassel JC. Ipilimumab plus nivolumab for advanced melanoma. Lancet Oncol 2016; 17(11):1471-2; PMID:27617662; https://doi.org/10.1016/S1470-2045(16)30409-0
  • Kourie HR, Klastersky JA. Side-effects of checkpoint inhibitor-based combination therapy. Curr Opin Oncol 2016; 28(4):306-13; PMID:27136134; https://doi.org/10.1097/CCO.0000000000000295
  • Rouas-Freiss N, Moreau P, Ferrone S, Carosella ED. HLA-G proteins in cancer: do they provide tumor cells with an escape mechanism? Cancer research 2005; 65(22):10139-10144; PMID:16287995; https://doi.org/10.1158/0008-5472.CAN-05-0097
  • Naji A, Le Rond S, Durrbach A, Krawice-Radanne I, Creput C, Daouya M, Caumartin J, LeMaoult J, Carosella ED, Rouas-Freiss N. CD3+CD4low and CD3+CD8low are induced by HLA-G: novel human peripheral blood suppressor T-cell subsets involved in transplant acceptance. Blood 2007; 110(12):3936-48; PMID:17804694; https://doi.org/10.1182/blood-2007-04-083139
  • LeMaoult J, Caumartin J, Daouya M, Favier B, Le Rond S, Gonzalez A, Carosella ED. Immune regulation by pretenders: cell-to-cell transfers of HLA-G make effector T cells act as regulatory cells. Blood 2007; 109(5):2040-48; PMID:17077329; https://doi.org/10.1182/blood-2006-05-024547
  • Djurisic S, Skibsted L, Hviid TV. A Phenotypic Analysis of Regulatory T Cells and Uterine NK Cells from First Trimester Pregnancies and Associations with HLA-G. Am J Reprod Immunol 2015; 74(5):427-44; PMID:26293482; https://doi.org/10.1111/aji.12421
  • Shiroishi M, Tsumoto K, Amano K, Shirakihara Y, Colonna M, Braud VM, Allan DS, Makadzange A, Rowland-Jones S, Willcox B, et al. Human inhibitory receptors Ig-like transcript 2 (ILT2) and ILT4 compete with CD8 for MHC class I binding and bind preferentially to HLA-G. Proc Natl Acad Sci U S A 2003; 100(15):8856-61; PMID:12853576; https://doi.org/10.1073/pnas.1431057100
  • Kang X, Kim J, Deng M, John S, Chen H, Wu G, Phan H, Zhang CC. Inhibitory leukocyte immunoglobulin-like receptors: Immune checkpoint proteins and tumor sustaining factors. Cell cycle 2016; 15(1):25-40; PMID:26636629; https://doi.org/10.1080/15384101.2015.1121324
  • Zhang P, Yu S, Li H, Liu C, Li J, Lin W, Gao A, Wang L, Gao W, Sun Y. ILT4 drives B7-H3 expression via PI3K/AKT/mTOR signalling and ILT4/B7-H3 co-expression correlates with poor prognosis in non-small cell lung cancer. FEBS Lett 2015; 589(17):2248-56; PMID:26149216; https://doi.org/10.1016/j.febslet.2015.06.037
  • Zhang P, Guo X, Li J, Yu S, Wang L, Jiang G, Yang D, Wei Z, Zhang N, Liu J, et al. Immunoglobulin-like transcript 4 promotes tumor progression and metastasis and up-regulates VEGF-C expression via ERK signaling pathway in non-small cell lung cancer. Oncotarget 2015; 6(15):13550-63; PMID:25948790; https://doi.org/10.18632/oncotarget.3624
  • Zhang Y, Zhao J, Qiu L, Zhang P, Li J, Yang D, Wei X, Han Y, Nie S, Sun Y. Co-expression of ILT4/HLA-G in human non-small cell lung cancer correlates with poor prognosis and ILT4-HLA-G interaction activates ERK signaling. Tumour Biol 2016; 37(8):11187-98; PMID:26939901; https://doi.org/10.1007/s13277-016-5002-5
  • Morandi F, Rizzo R, Fainardi E, Rouas-Freiss N, Pistoia V. Recent Advances in Our Understanding of HLA-G Biology: Lessons from a Wide Spectrum of Human Diseases. J Immunol Res 2016; 2016:4326495; PMID:27652273; https://doi.org/10.1155/2016/4326495
  • Hammers H. Immunotherapy in kidney cancer: the past, present, and future. Curr Opin Urol 2016; 26(6):543-7; PMID:27533501; https://doi.org/10.1097/MOU.0000000000000338
  • Escudier B, Kataja V, Group EGW. Renal cell carcinoma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Annals of oncology: official journal of the European Society for Medical Oncology / ESMO 2010; 21 Suppl 5:v137-139; PMID:20555064; https://doi.org/10.1093/annonc/mdq206

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.