Eosinophils: The unsung heroes in cancer?

References

• Kay AB. The early history of the eosinophil. Clin Exp Allergy. 2015;45(3):575–582. https://doi.org/10.1111/cea.12480. PMID:25544991
   PubMed Web of Science ®Google Scholar
• Johnston LK, Bryce PJ. Understanding Interleukin 33 and Its Roles in Eosinophil Development. Front Med (Lausanne). 2017;4(51); https://doi.org/10.3389/fmed.2017.00051.
   Google Scholar
• Varricchi G, Bagnasco D, Borriello F, Heffler E, Canonica GW. Interleukin-5 pathway inhibition in the treatment of eosinophilic respiratory disorders: evidence and unmet needs. Curr Opin Allergy Clin Immunol. 2016;16(2):186–200; https://doi.org/10.1097/aci.0000000000000251. PMID:26859368
   PubMed Web of Science ®Google Scholar
• Rosenberg HF, Dyer KD, Foster PS. Eosinophils: changing perspectives in health and disease. Nat Rev Immunol. 2013;13(1):9–22; https://doi.org/10.1038/nri3341. PMID:23154224
   PubMed Web of Science ®Google Scholar
• Furuta GT, Atkins FD, Lee NA, Lee JJ. Changing roles of eosinophils in health and disease. Ann Allergy Asthma Immunol. 2014;113(1):3–8; https://doi.org/10.1016/j.anai.2014.04.002. PMID:24795292
   PubMedGoogle Scholar
• Varricchi G, Senna G, Loffredo S, Bagnasco D, Ferrando M, Canonica GW. Reslizumab and Eosinophilic Asthma: One Step Closer to Precision Medicine? Front Immunol. 2017;8:242; https://doi.org/10.3389/fimmu.2017.00242. PMID:28344579
   PubMed Web of Science ®Google Scholar
• Huang L, Appleton JA. Eosinophils in Helminth Infection: Defenders and Dupes. Trends Parasitol. 2016;32(10):798–807; https://doi.org/10.1016/j.pt.2016.05.004. PMID:27262918
   PubMed Web of Science ®Google Scholar
• Wang Z, Lai Y, Bernard JJ, MacLeod DT, Cogen AL, Moss B, Di Nardo A. Skin Mast Cells Protect Mice against Vaccinia Virus by Triggering Mast Cell Receptor S1PR2 and Releasing Antimicrobial Peptides. J Immunol. 2012;188(1):345–357; https://doi.org/10.4049/jimmunol.1101703. PMID:22140255
   PubMed Web of Science ®Google Scholar
• Samarasinghe AE, Melo RC, Duan S, LeMessurier KS, Liedmann S, Surman SL, Lee JJ, Hurwitz JL, Thomas PG, McCullers JA. Eosinophils Promote Antiviral Immunity in Mice Infected with Influenza A Virus. J Immunol. 2017;198(8):3214–3226; https://doi.org/10.4049/jimmunol.1600787. PMID:28283567
   PubMed Web of Science ®Google Scholar
• Yousefi S, Gold JA, Andina N, Lee JJ, Kelly AM, Kozlowski E, Schmid I, Straumann A, Reichenbach J, Gleich GJ, et al. Catapult-like release of mitochondrial DNA by eosinophils contributes to antibacterial defense. Nat Med. 2008;14(9):949–953; https://doi.org/10.1038/nm.1855. PMID:18690244
   PubMed Web of Science ®Google Scholar
• Hogan SP, Rosenberg HF, Moqbel R, Phipps S, Foster PS, Lacy P, Kay AB, Rothenberg ME. Eosinophils: biological properties and role in health and disease. Clin Exp Allergy. 2008;38(5):709–750; https://doi.org/10.1111/j.1365-2222.2008.02958.x. PMID:18384431
   PubMed Web of Science ®Google Scholar
• Chan CY, St John AL, Abraham SN. Plasticity in mast cell responses during bacterial infections. Curr Opin Microbiol. 2012;15(1):78–84; https://doi.org/10.1016/j.mib.2011.10.007. PMID:22055570
   PubMedGoogle Scholar
• Josephs DH, Spicer JF, Corrigan CJ, Gould HJ, Karagiannis SN. Epidemiological associations of allergy, IgE and cancer. Clin Exp Allergy. 2013;43(10):1110–1123; https://doi.org/10.1111/cea.12178. PMID:24074329
   PubMed Web of Science ®Google Scholar
• Jensen-Jarolim E, Bax HJ, Bianchini R, Capron M, Corrigan C, Castells M, Dombrowicz D, Daniels-Wells TR, Fazekas J, Fiebiger E, et al. AllergoOncology – the impact of allergy in oncology: EAACI position paper. Allergy. 2017;72(6):866–887; https://doi.org/10.1111/all.13119. PMID:28032353
   PubMedGoogle Scholar
• Platzer B, Elpek KG, Cremasco V, Baker K, Stout MM, Schultz C, Dehlink E, Shade KT, Anthony RM, Blumberg RS, et al. IgE/FcepsilonRI-Mediated Antigen Cross-Presentation by Dendritic Cells Enhances Anti-Tumor Immune Responses. Cell Rep. 2015;10(9):1487–1495; https://doi.org/10.1016/j.celrep.2015.02.015. PMID:25753415
   PubMedGoogle Scholar
• Tomasetti C, Li L, Vogelstein B. Stem cell divisions, somatic mutations, cancer etiology, and cancer prevention. Science. 2017;355(6331):1330–1334; https://doi.org/10.1126/science.aaf9011. PMID:28336671
   PubMed Web of Science ®Google Scholar
• Dawson MA, Kouzarides T, Huntly BJ. Targeting epigenetic readers in cancer. N Engl J Med. 2012;367(7):647–657; https://doi.org/10.1056/NEJMra1112635. PMID:22894577
   PubMed Web of Science ®Google Scholar
• Dawson MA. The cancer epigenome: Concepts, challenges, and therapeutic opportunities. Science. 2017;355(6330):1147–1152; https://doi.org/10.1126/science.aam7304. PMID:28302822
   PubMed Web of Science ®Google Scholar
• Zitvogel L, Apetoh L, Ghiringhelli F, Andre F, Tesniere A, Kroemer G. The anticancer immune response: indispensable for therapeutic success? J Clin Invest. 2008;118(6):1991–2001; https://doi.org/10.1172/JCI35180. PMID:18523649
   PubMed Web of Science ®Google Scholar
• Zitvogel L, Galluzzi L, Smyth MJ, Kroemer G. Mechanism of action of conventional and targeted anticancer therapies: reinstating immunosurveillance. Immunity. 2013;39(1):74–88; https://doi.org/10.1016/j.immuni.2013.06.014. PMID:23890065
   PubMed Web of Science ®Google Scholar
• Bissell MJ, Hines WC. Why don't we get more cancer? A proposed role of the microenvironment in restraining cancer progression. Nat Med. 2011;17(3):320–329; https://doi.org/10.1038/nm.2328. PMID:21383745
   PubMed Web of Science ®Google Scholar
• Galdiero MR, Varricchi G, Marone G. The immune network in thyroid cancer. Oncoimmunology. 2016;5(6):e1168556; https://doi.org/10.1080/2162402X.2016.1168556. PMID:27471646
   PubMedGoogle Scholar
• Varricchi G, Galdiero MR, Loffredo S, Marone G, Iannone R, Granata F. Are Mast Cells MASTers in Cancer? Front Immunol. 2017;8:424; https://doi.org/10.3389/fimmu.2017.00424. PMID:28446910
   PubMed Web of Science ®Google Scholar
• Hanahan D, Coussens LM. Accessories to the crime: functions of cells recruited to the tumor microenvironment. Cancer Cell. 2012;21(3):309–322; https://doi.org/10.1016/j.ccr.2012.02.022. PMID:22439926
   PubMed Web of Science ®Google Scholar
• Mantovani A, Allavena P, Sica A, Balkwill F. Cancer-related inflammation. Nature. 2008;454(7203):436–444; https://doi.org/10.1038/nature07205. PMID:18650914
   PubMed Web of Science ®Google Scholar
• Galdiero MR, Garlanda C, Jaillon S, Marone G, Mantovani A. Tumor associated macrophages and neutrophils in tumor progression. J Cell Physiol. 2013;228(7):1404–1412; https://doi.org/10.1002/jcp.24260. PMID:23065796
   PubMed Web of Science ®Google Scholar
• Marone G, Varricchi G, Loffredo S, Granata F. Mast cells and basophils in inflammatory and tumor angiogenesis and lymphangiogenesis. Eur J Pharmacol. 2016;778:146–151; https://doi.org/10.1016/j.ejphar.2015.03.088. PMID:25941082
   PubMedGoogle Scholar
• Varricchi G, Galdiero MR, Marone G, Granata F, Borriello F. Controversial role of mast cells in skin cancers. Exp Dermatol. 2017;26(1):11–17; https://doi.org/10.1111/exd.13107. PMID:27305467
   PubMedGoogle Scholar
• Galdiero MR, Marone G, Mantovani A. Cancer Inflammation and Cytokines. Cold Spring Harb Perspect Biol. 2017;pii: a028662; in press. https://doi.org/10.1101/cshperspect.a028662. PMID:28778871
   PubMedGoogle Scholar
• Varricchi G, Granata F, Loffredo S, Genovese A, Marone G. Angiogenesis and lymphangiogenesis in inflammatory skin disorders. J Am Acad Dermatol. 2015;73(1):144–153; https://doi.org/10.1016/j.jaad.2015.03.041. PMID:25922287
   PubMedGoogle Scholar
• Nissim Ben Efraim AH, Levi-Schaffer F. Roles of eosinophils in the modulation of angiogenesis. Chem Immunol Allergy. 2014;99:138–154; https://doi.org/10.1159/000353251. PMID:24217607
   PubMedGoogle Scholar
• Jung Y, Wen T, Mingler MK, Caldwell JM, Wang YH, Chaplin DD, Lee EH, Jang MH, Woo SY, Seoh JY, et al. IL-1[beta] in eosinophil-mediated small intestinal homeostasis and IgA production. Mucosal Immunol. 2015;8(4):930–942; https://doi.org/10.1038/mi.2014.123. PMID:25563499
   PubMedGoogle Scholar
• Throsby M, Herbelin A, Pléau J-M, Dardenne M. CD11 c+Eosinophils in the Murine Thymus: Developmental Regulation and Recruitment upon MHC Class I-Restricted Thymocyte Deletion. J Immunol. 2000;165(4):1965–1975; https://doi.org/10.4049/jimmunol.165.4.1965. PMID:10925279
   PubMedGoogle Scholar
• Gouon-Evans Vr, Pollard JW. Eotaxin Is Required for Eosinophil Homing into the Stroma of the Pubertal and Cycling Uterus. Endocrinology. 2001;142(10):4515–4521; https://doi.org/10.1210/endo.142.10.8459. PMID:11564717
   PubMedGoogle Scholar
• Mesnil C, Raulier Sf, Paulissen Gv, Xiao X, Birrell MA, Pirottin D, Janss T, Starkl P, Ramery E, Henket M, et al. Lung-resident eosinophils represent a distinct regulatory eosinophil subset. J Clin Invest. 2016;126(9):3279–3295; https://doi.org/10.1172/jci85664. PMID:27548519
   PubMed Web of Science ®Google Scholar
• Wu D, Molofsky AB, Liang H-E, Ricardo-Gonzalez RR, Jouihan HA, Bando JK, Chawla A, Locksley RM. Eosinophils Sustain Adipose Alternatively Activated Macrophages Associated with Glucose Homeostasis. Science. 2011;332(6026):243–247; https://doi.org/10.1126/science.1201475. PMID:21436399
   PubMed Web of Science ®Google Scholar
• Rothenberg ME, Hogan SP. THE EOSINOPHIL. Ann Rev Immunol. 2006;24(1):147–174; https://doi.org/10.1146/annurev.immunol.24.021605.090720.
   PubMedGoogle Scholar
• Travers J, Rothenberg ME. Eosinophils in mucosal immune responses. Mucosal Immunol. 2015;8(3):464–475; https://doi.org/10.1038/mi.2015.2. PMID:25807184
   PubMed Web of Science ®Google Scholar
• Lee JJ, Jacobsen EA, McGarry MP, Schleimer RP, Lee NA. Eosinophils in health and disease: the LIAR hypothesis. Clin Exp Allergy. 2010;40(4):563–575; https://doi.org/10.1111/j.1365-2222.2010.03484.x. PMID:20447076
   PubMed Web of Science ®Google Scholar
• Long H, Liao W, Wang L, Lu Q. A Player and Coordinator: The Versatile Roles of Eosinophils in the Immune System. Transfus Med Hemother. 2016;43(2):96–108; https://doi.org/10.1159/000445215. PMID:27226792
   PubMed Web of Science ®Google Scholar
• Wen T, Rothenberg ME. The Regulatory Function of Eosinophils. Microbiol Spectr. 2016;4(5); https://doi.org/10.1128/microbiolspec.MCHD-0020-2015. PMID:27780017
   PubMedGoogle Scholar
• Galdiero MR, Varricchi G, Seaf M, Marone G, Levi-Schaffer F, Marone G. Bidirectional mast cell – eosinophil Interactions in inflammatory disorders and cancer Front Med (Lausanne). 2017;4:103; https://doi.org/10.3389/fmed.2017.00103.
   Google Scholar
• Broughton SE, Nero TL, Dhagat U, Kan WL, Hercus TR, Tvorogov D, Lopez AF, Parker MW. The betac receptor family – Structural insights and their functional implications. Cytokine. 2015;74(2):247–258; https://doi.org/10.1016/j.cyto.2015.02.005. PMID:25982846
   PubMedGoogle Scholar
• Nussbaum JC, Van Dyken SJ, von Moltke J, Cheng LE, Mohapatra A, Molofsky AB, Thornton EE, Krummel MF, Chawla A, Liang HE, et al. Type 2 innate lymphoid cells control eosinophil homeostasis. Nature. 2013;502(7470):245–248; https://doi.org/10.1038/nature12526. PMID:24037376
   PubMed Web of Science ®Google Scholar
• Dubucquoi S, Desreumaux P, Janin A, Klein O, Goldman M, Tavernier J, Capron A, Capron M. Interleukin 5 synthesis by eosinophils: association with granules and immunoglobulin-dependent secretion. J Exp Med 1994;179(2):703–708; https://doi.org/10.1084/jem.179.2.703. PMID:8294877
   PubMed Web of Science ®Google Scholar
• Drissen R, Buza-Vidas N, Woll P, Thongjuea S, Gambardella A, Giustacchini A, Mancini E, Zriwil A, Lutteropp M, Grover A, et al. Distinct myeloid progenitor-differentiation pathways identified through single-cell RNA sequencing. Nat Immunol. 2016;17(6):666–676; https://doi.org/10.1038/ni.3412. PMID:27043410
   PubMedGoogle Scholar
• Johnston LK, Hsu CL, Krier-Burris RA, Chhiba KD, Chien KB, McKenzie A, Berdnikovs S, Bryce PJ. IL-33 Precedes IL-5 in Regulating Eosinophil Commitment and Is Required for Eosinophil Homeostasis. J Immunol. 2016;197(9):3445–3453; https://doi.org/10.4049/jimmunol.1600611. PMID:27683753
   PubMed Web of Science ®Google Scholar
• Gabriele L, Schiavoni G, Mattei F, Sanchez M, Sestili P, Butteroni C, Businaro R, Mirchandani A, Niedbala W, Liew FY, et al. Novel allergic asthma model demonstrates ST2-dependent dendritic cell targeting by cypress pollen. J Allergy Clin Immunol. 2013;132(3):686–695; https://doi.org/10.1016/j.jaci.2013.02.037. PMID:23608732
   PubMedGoogle Scholar
• Anderson EL, Kobayashi T, Iijima K, Bartemes KR, Chen CC, Kita H. IL-33 Mediates reactive eosinophilopoiesis in response to airborne allergen exposure. Allergy. 2016;71(7):977−-988; https://doi.org/10.1111/all.12861. PMID:26864308
   PubMedGoogle Scholar
• Cherry WB, Yoon J, Bartemes KR, Iijima K, Kita H. A novel IL-1 family cytokine, IL-33, potently activates human eosinophils. J Allergy Clin Immunol. 2008;121(6):1484–1490; https://doi.org/10.1016/j.jaci.2008.04.005. PMID:18539196
   PubMed Web of Science ®Google Scholar
• Bouffi C, Rochman M, Zust CB, Stucke EM, Kartashov A, Fulkerson PC, Barski A, Rothenberg ME. IL-33 Markedly Activates Murine Eosinophils by an NF-κB-Dependent Mechanism Differentially Dependent upon an IL-4-Driven Autoinflammatory Loop. J Immunol. 2013;191(8):4317–4325; https://doi.org/10.4049/jimmunol.1301465. PMID:24043894
   PubMedGoogle Scholar
• Hashiguchi M, Kashiwakura Y, Kojima H, Kobayashi A, Kanno Y, Kobata T. IL-33 activates eosinophils of visceral adipose tissue both directly and via innate lymphoid cells. Eur J Immunol. 2015;45(3):876–885; https://doi.org/10.1002/eji.201444969. PMID:25504587
   PubMedGoogle Scholar
• Lucarini V, Ziccheddu G, Macchia I, La Sorsa V, Peschiaroli F, Buccione C, Sistigu A, Sanchez M, Andreone S, D'Urso MT, et al. IL-33 restricts tumor growth and inhibits pulmonary metastasis in melanoma-bearing mice through eosinophils. Oncoimmunology. 2017;6(6):e1317420; https://doi.org/10.1080/2162402x.2017.1317420. PMID:28680750
   PubMedGoogle Scholar
• Bochner BS. Novel Therapies for Eosinophilic Disorders. Immunol Allergy Clin North Am. 2015;35(3):577–598; https://doi.org/10.1016/j.iac.2015.05.007. PMID:26209901
   PubMedGoogle Scholar
• Ponath PD, Qin S, Post TW, Wang J, Wu L, Gerard NP, Newman W, Gerard C, Mackay CR. Molecular cloning and characterization of a human eotaxin receptor expressed selectively on eosinophils. J Exp Med 1996;183(6):2437–2448; https://doi.org/10.1084/jem.183.6.2437. PMID:8676064
   PubMed Web of Science ®Google Scholar
• Rot A, Krieger M, Brunner T, Bischoff SC, Schall TJ, Dahinden CA. RANTES and macrophage inflammatory protein 1 alpha induce the migration and activation of normal human eosinophil granulocytes. J Exp Med 1992;176(6):1489–1495; https://doi.org/10.1084/jem.176.6.1489 . PMID:1281207
   PubMed Web of Science ®Google Scholar
• Shinkai A, Yoshisue H, Koike M, Shoji E, Nakagawa S, Saito A, Takeda T, Imabeppu S, Kato Y, Hanai N, et al. A novel human CC chemokine, eotaxin-3, which is expressed in IL-4-stimulated vascular endothelial cells, exhibits potent activity toward eosinophils. J Immunol 1999;163(3):1602–1610. PMID:10415065
   PubMed Web of Science ®Google Scholar
• Looi LM. Tumor-associated tissue eosinophilia in nasopharyngeal carcinoma. A pathologic study of 422 primary and 138 metastatic tumors. Cancer 1987;59(3):466–470; https://doi.org/10.1002/1097-0142(19870201)59:3<466::AID-CNCR2820590319>3.0.CO;2-P.PMID:3791157
   PubMedGoogle Scholar
• Caruso RA, Parisi A, Quattrocchi E, Scardigno M, Branca G, Parisi C, Luciano R, Paparo D, Fedele F. Ultrastructural descriptions of heterotypic aggregation between eosinophils and tumor cells in human gastric carcinomas. Ultrastruct Pathol. 2011;35(4):145–149; https://doi.org/10.3109/01913123.2011.578233. PMID:21657821
   PubMed Web of Science ®Google Scholar
• Harbaum L, Pollheimer MJ, Kornprat P, Lindtner RA, Bokemeyer C, Langner C. Peritumoral eosinophils predict recurrence in colorectal cancer. Mod Pathol. 2015; 28(3):403–413; https://doi.org/10.1038/modpathol.2014.104. PMID:25216222
   PubMed Web of Science ®Google Scholar
• Xie F, Liu LB, Shang WQ, Chang KK, Meng YH, Mei J, Yu JJ, Li DJ, Li MQ. The infiltration and functional regulation of eosinophils induced by TSLP promote the proliferation of cervical cancer cell. Cancer Lett. 2015;364(2):106–117; https://doi.org/10.1016/j.canlet.2015.04.029. PMID:25979231
   PubMed Web of Science ®Google Scholar
• Prizment AE, Vierkant RA, Smyrk TC, Tillmans LS, Lee JJ, Sriramarao P, Nelson HH, Lynch CF, Thibodeau SN, Church TR, et al. Tumor eosinophil infiltration and improved survival of colorectal cancer patients: Iowa Women's Health Study. Mod Pathol. 2016;29(5):516–527; https://doi.org/10.1038/modpathol.2016.42. PMID:26916075
   PubMedGoogle Scholar
• Molin D, Glimelius B, Sundstrom C, Venge P, Enblad G. The serum levels of eosinophil cationic protein (ECP) are related to the infiltration of eosinophils in the tumours of patients with Hodgkin's disease. Leuk Lymphoma. 2001;42(3):457–465; https://doi.org/10.3109/10428190109064602. PMID:11699410
   PubMed Web of Science ®Google Scholar
• Cormier SA, Taranova AG, Bedient C, Nguyen T, Protheroe C, Pero R, Dimina D, Ochkur SI, O'Neill K, Colbert D, et al. Pivotal Advance: eosinophil infiltration of solid tumors is an early and persistent inflammatory host response. J Leukoc Biol. 2006;79(6):1131–1139; https://doi.org/10.1189/jlb.0106027. PMID:16617160
   PubMedGoogle Scholar
• Lorena SC, Oliveira DT, Dorta RG, Landman G, Kowalski LP. Eotaxin expression in oral squamous cell carcinomas with and without tumour associated tissue eosinophilia. Oral Dis. 2003;9(6):279–283; https://doi.org/10.1034/j.1601-0825.2003.00958.x. PMID:14629326
   PubMedGoogle Scholar
• Kay AB, McVie JM, Stuart AE, Krajewski A, Turnbull LW. Eosinophil chemotaxis of supernatants from cultured Hodgkin's lymph node cells. J Clin Pathol 1975;28(6):502–505; https://doi.org/10.1136/jcp.28.6.502. PMID:1141453
   PubMedGoogle Scholar
• Teruya-Feldstein J, Jaffe ES, Burd PR, Kingma DW, Setsuda JE, Tosato G. Differential chemokine expression in tissues involved by Hodgkin's disease: direct correlation of eotaxin expression and tissue eosinophilia. Blood 1999;93(8):2463–2470. PMID:10194423
   PubMed Web of Science ®Google Scholar
• Bertheloot D, Latz E. HMGB1, IL-1alpha, IL-33 and S100 proteins: dual-function alarmins. Cell Mol Immunol. 2017;14(1):43–64; https://doi.org/10.1038/cmi.2016.34. PMID:27569562
   PubMed Web of Science ®Google Scholar
• Nguyen AH, Detty SQ, Agrawal DK. Clinical Implications of High-mobility Group Box-1 (HMGB1) and the Receptor for Advanced Glycation End-products (RAGE) in Cutaneous Malignancy: A Systematic Review. Anticancer Res. 2017;37(1):1–7; https://doi.org/10.21873/anticanres.11282. PMID:28011467
   PubMedGoogle Scholar
• Abraham E, Arcaroli J, Carmody A, Wang H, Tracey KJ. HMG-1 as a mediator of acute lung inflammation. J Immunol. 2000;165(6):2950–2954; https://doi.org/10.4049/jimmunol.165.6.2950. PMID:10975801
   PubMed Web of Science ®Google Scholar
• Lotfi R, Herzog GI, DeMarco RA, Beer-Stolz D, Lee JJ, Rubartelli A, Schrezenmeier H, Lotze MT. Eosinophils Oxidize Damage-Associated Molecular Pattern Molecules Derived from Stressed Cells. J Immunol. 2009;183(8):5023–5031; https://doi.org/10.4049/jimmunol.0900504. PMID:19794066
   PubMedGoogle Scholar
• Cebrian MJ, Bauden M, Andersson R, Holdenrieder S, Ansari D. Paradoxical Role of HMGB1 in Pancreatic Cancer: Tumor Suppressor or Tumor Promoter? Anticancer Res. 2016;36(9):4381–4389; https://doi.org/10.21873/anticanres.10981. PMID:27630273
   PubMed Web of Science ®Google Scholar
• Martin NT, Martin MU. Interleukin 33 is a guardian of barriers and a local alarmin. Nat Immunol. 2016;17(2):122–131; https://doi.org/10.1038/ni.3370. PMID:26784265
   PubMed Web of Science ®Google Scholar
• Schmitz J, Owyang A, Oldham E, Song Y, Murphy E, McClanahan TK, Zurawski G, Moshrefi M, Qin J, Li X, et al. IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines. Immunity. 2005;23(5):479–490; https://doi.org/10.1016/j.immuni.2005.09.015. PMID:16286016
   PubMed Web of Science ®Google Scholar
• Drube S, Heink S, Walter S, Lohn T, Grusser M, Gerbaulet A, Berod L, Schons J, Dudeck A, Freitag J, et al. The receptor tyrosine kinase c-Kit controls IL-33 receptor signaling in mast cells. Blood. 2010;115(19):3899–3906; https://doi.org/10.1182/blood-2009-10-247411.. PMID:20200353
   PubMed Web of Science ®Google Scholar
• Griesenauer B, Paczesny S. The ST2/IL-33 Axis in Immune Cells during Inflammatory Diseases. Front Immunol. 2017;8:475; https://doi.org/10.3389/fimmu.2017.00475. PMID:28484466
   PubMed Web of Science ®Google Scholar
• Pecaric-Petkovic T, Didichenko SA, Kaempfer S, Spiegl N, Dahinden CA. Human basophils and eosinophils are the direct target leukocytes of the novel IL-1 family member IL-33. Blood. 2009;113(7):1526–1534; https://doi.org/10.1182/blood-2008-05-157818. PMID:18955562
   PubMed Web of Science ®Google Scholar
• Endo Y, Hirahara K, Iinuma T, Shinoda K, Tumes DJ, Asou HK, Matsugae N, Obata-Ninomiya K, Yamamoto H, Motohashi S, et al. The interleukin-33-p38 kinase axis confers memory T helper 2 cell pathogenicity in the airway. Immunity. 2015;42(2):294–308; https://doi.org/10.1016/j.immuni.2015.01.016. PMID:25692703
   PubMed Web of Science ®Google Scholar
• Taracanova A, Alevizos M, Karagkouni A, Weng Z, Norwitz E, Conti P, Leeman SE, Theoharides TC. SP and IL-33 together markedly enhance TNF synthesis and secretion from human mast cells mediated by the interaction of their receptors. Proc Natl Acad Sci U S A. 2017;114(20):E4002−E4009; https://doi.org/10.1073/pnas.1524845114. PMID:28461492
   PubMedGoogle Scholar
• Morita H, Arae K, Unno H, Miyauchi K, Toyama S, Nambu A, Oboki K, Ohno T, Motomura K, Matsuda A, et al. An Interleukin-33-Mast Cell-Interleukin-2 Axis Suppresses Papain-Induced Allergic Inflammation by Promoting Regulatory T Cell Numbers. Immunity. 2015;43(1):175–186; https://doi.org/10.1016/j.immuni.2015.06.021. PMID:26200013
   PubMed Web of Science ®Google Scholar
• Aymeric L, Apetoh L, Ghiringhelli Fo, Tesniere A, Martins I, Kroemer G, Smyth MJ, Zitvogel L. Tumor Cell Death and ATP Release Prime Dendritic Cells and Efficient Anticancer Immunity. Cancer Res. 2010;70(3):855–858; https://doi.org/10.1158/0008-5472.can-09-3566. PMID:20086177
   PubMed Web of Science ®Google Scholar
• Müller T, Robaye B, Vieira RP, Ferrari D, Grimm M, Jakob T, Martin SF, Di Virgilio F, Boeynaems JM, Virchow JC, et al. The purinergic receptor P2Y2 receptor mediates chemotaxis of dendritic cells and eosinophils in allergic lung inflammation. Allergy. 2010;65(12):1545–1553; https://doi.org/10.1111/j.1398-9995.2010.02426.x. PMID:20880147
   PubMedGoogle Scholar
• Kobayashi T, Soma T, Noguchi T, Nakagome K, Nakamoto H, Kita H, Nagata M. ATP drives eosinophil effector responses through P2 purinergic receptors. Allergol Int. 2015;64, Suppl S30–S36; https://doi.org/10.1016/j.alit.2015.04.009. .
   PubMedGoogle Scholar
• Slungaard A, Ascensao J, Zanjani E, Jacob HS. Pulmonary carcinoma with eosinophilia. Demonstration of a tumor-derived eosinophilopoietic factor. N Engl J Med 1983;309(13):778–781; https://doi.org/10.1056/NEJM198309293091307. PMID:6310397
   PubMed Web of Science ®Google Scholar
• Pandit R, Scholnik A, Wulfekuhler L, Dimitrov N. Non-small-cell lung cancer associated with excessive eosinophilia and secretion of interleukin-5 as a paraneoplastic syndrome. Am J Hematol. 2007;82(3):234–237; https://doi.org/10.1002/ajh.20789. PMID:17160990
   PubMed Web of Science ®Google Scholar
• Detoraki A, Staiano RI, Granata F, Giannattasio G, Prevete N, de Paulis A, Ribatti D, Genovese A, Triggiani M, Marone G. Vascular endothelial growth factors synthesized by human lung mast cells exert angiogenic effects. J Allergy Clin Immunol. 2009;123(5):1142–1149, 1149 e1141-1145; https://doi.org/10.1016/j.jaci.2009.01.044. PMID:19275959
   PubMed Web of Science ®Google Scholar
• Granata F, Frattini A, Loffredo S, Staiano RI, Petraroli A, Ribatti D, Oslund R, Gelb MH, Lambeau G, Marone G, et al. Production of vascular endothelial growth factors from human lung macrophages induced by group IIA and group X secreted phospholipases A2. J Immunol. 2010;184(9):5232–5241; https://doi.org/10.4049/jimmunol.0902501. PMID:20357262
   PubMed Web of Science ®Google Scholar
• Feistritzer C, Kaneider NC, Sturn DH, Mosheimer BA, Kahler CM, Wiedermann CJ. Expression and function of the vascular endothelial growth factor receptor FLT-1 in human eosinophils. Am J Respir Cell Mol Biol. 2004;30(5):729–735; https://doi.org/10.1165/rcmb.2003-0314OC. PMID:14607815
   PubMedGoogle Scholar
• Feistritzer C, Mosheimer BA, Sturn DH, Bijuklic K, Patsch JR, Wiedermann CJ. Expression and function of the angiopoietin receptor Tie-2 in human eosinophils. J Allergy Clin Immunol. 2004;114(5):1077–1084; https://doi.org/10.1016/j.jaci.2004.06.045. PMID:15536413
   PubMed Web of Science ®Google Scholar
• Gottfried E, Kreutz M, Mackensen A. Tumor metabolism as modulator of immune response and tumor progression. Semin Cancer Biol. 2012;22(4):335–341; https://doi.org/10.1016/j.semcancer.2012.02.009. PMID:22414910
   PubMed Web of Science ®Google Scholar
• Huang B, Lei Z, Zhang GM, Li D, Song C, Li B, Liu Y, Yuan Y, Unkeless J, Xiong H, et al. SCF-mediated mast cell infiltration and activation exacerbate the inflammation and immunosuppression in tumor microenvironment. Blood. 2008;112(4):1269–1279; https://doi.org/10.1182/blood-2008-03-147033. PMID:18524989
   PubMed Web of Science ®Google Scholar
• Visciano C, Liotti F, Prevete N, Cali G, Franco R, Collina F, de Paulis A, Marone G, Santoro M, Melillo RM. Mast cells induce epithelial-to-mesenchymal transition and stem cell features in human thyroid cancer cells through an IL-8-Akt-Slug pathway. Oncogene. 2015;34(40):5175–5186; https://doi.org/10.1038/onc.2014.441. PMID:25619830
   PubMed Web of Science ®Google Scholar
• Schratl P, Royer JF, Kostenis E, Ulven T, Sturm EM, Waldhoer M, Hoefler G, Schuligoi R, Lippe IT, Peskar BA, et al. The role of the prostaglandin D2 receptor, DP, in eosinophil trafficking. J Immunol. 2007;179(7):4792–4799; https://doi.org/10.4049/jimmunol.179.7.4792. PMID:17878378
   PubMedGoogle Scholar
• Capelo R, Lehmann C, Ahmad K, Snodgrass R, Diehl O, Ringleb J, Flamand N, Weigert A, Stark H, Steinhilber D, et al. Cellular analysis of the histamine H4 receptor in human myeloid cells. Biochem Pharmacol. 2016;103:74–84; https://doi.org/10.1016/j.bcp.2016.01.007. PMID:26774453
   PubMedGoogle Scholar
• Mattes J, Hulett M, Xie W, Hogan S, Rothenberg ME, Foster P, Parish C. Immunotherapy of cytotoxic T cell-resistant tumors by T helper 2 cells: an eotaxin and STAT6-dependent process. J Exp Med. 2003;197(3):387–393. PMID:12566422
   PubMed Web of Science ®Google Scholar
• Tepper RI, Coffman RL, Leder P. An eosinophil-dependent mechanism for the antitumor effect of interleukin-4. Science 1992;257(5069):548–551; https://doi.org/10.1126/science.1636093. PMID:1636093
   PubMed Web of Science ®Google Scholar
• Chevrier S, Levine JH, Zanotelli VRT, Silina K, Schulz D, Bacac M, Ries CH, Ailles L, Jewett MAS, Moch H, et al. An Immune Atlas of Clear Cell Renal Cell Carcinoma. Cell. 2017;169(4):736–749 e718; https://doi.org/10.1016/j.cell.2017.04.016.
   PubMed Web of Science ®Google Scholar
• Villani AC, Satija R, Reynolds G, Sarkizova S, Shekhar K, Fletcher J, Griesbeck M, Butler A, Zheng S, Lazo S, et al. Single-cell RNA-seq reveals new types of human blood dendritic cells, monocytes, and progenitors. Science. 2017;356(6335):pii: eaah4573; https://doi.org/10.1126/science.aah4573. PMID:28428369
   PubMedGoogle Scholar
• Allavena P, Sica A, Garlanda C, Mantovani A. The Yin-Yang of tumor-associated macrophages in neoplastic progression and immune surveillance. Immunol Rev. 2008;222:155–161; https://doi.org/10.1111/j.1600-065X.2008.00607.x. PMID:18364000
   PubMed Web of Science ®Google Scholar
• Fridlender ZG, Sun J, Kim S, Kapoor V, Cheng G, Ling L, Worthen GS, Albelda SM. Polarization of tumor-associated neutrophil phenotype by TGF-beta: “N1” versus “N2” TAN. Cancer Cell. 2009;16(3):183–194; https://doi.org/10.1016/j.ccr.2009.06.017. PMID:19732719
   PubMed Web of Science ®Google Scholar
• Sagiv JY, Michaeli J, Assi S, Mishalian I, Kisos H, Levy L, Damti P, Lumbroso D, Polyansky L, Sionov RV, et al. Phenotypic diversity and plasticity in circulating neutrophil subpopulations in cancer. Cell Rep. 2015;10(4):562–573; https://doi.org/10.1016/j.celrep.2014.12.039. doi:10.1016/j.celrep.2014.12.039. PMID:25620698
   PubMed Web of Science ®Google Scholar
• Abdala Valencia H, Loffredo LF, Misharin AV, Berdnikovs S. Phenotypic plasticity and targeting of Siglec-FhighCD11clow eosinophils to the airway in a murine model of asthma. Allergy. 2016;71(2):267–271; https://doi.org/10.1111/all.12776. PMID:26414117
   PubMed Web of Science ®Google Scholar
• Percopo CM, Brenner TA, Ma M, Kraemer LS, Hakeem RMA, Lee JJ, Rosenberg HF. SiglecF+Gr1hi eosinophils are a distinct subpopulation within the lungs of allergen-challenged mice. J Leukoc Biol. 2017;101(1):321–328; https://doi.org/10.1189/jlb.3A0416-166R. PMID:27531929
   PubMed Web of Science ®Google Scholar
• Reichman H, Karo-Atar D, Munitz A. Emerging Roles for Eosinophils in the Tumor Microenvironment. Trends Cancer. 2016;2(11):664–675; https://doi.org/10.1016/j.trecan.2016.10.002. PMID:28741505
   PubMed Web of Science ®Google Scholar
• Noffz G, Qin Z, Kopf M, Blankenstein T. Neutrophils but not eosinophils are involved in growth suppression of IL-4-secreting tumors. J Immunol. 1998;160(1):345–350. PMID:9551990
   PubMed Web of Science ®Google Scholar
• Ishibashi S, Ohashi Y, Suzuki T, Miyazaki S, Moriya T, Satomi S, Sasano H. Tumor-associated tissue eosinophilia in human esophageal squamous cell carcinoma. Anticancer Res. 2006;26(2B):1419–1424. PMID:16619553
   PubMed Web of Science ®Google Scholar
• Keresztes K, Szollosi Z, Simon Z, Tarkanyi I, Nemes Z, Illes A. Retrospective analysis of the prognostic role of tissue eosinophil and mast cells in Hodgkin's lymphoma. Pathol Oncol Res. 2007;13(3):237–242; https://doi.org/PAOR.2007.13.3.0237. PMID:17922053
   PubMed Web of Science ®Google Scholar
• Chua JC, Douglass JA, Gillman A, O'Hehir RE, Meeusen EN. Galectin-10, a Potential Biomarker of Eosinophilic Airway Inflammation. PLoS One. 2012;7(8):e42549. PMID:22880030
   PubMed Web of Science ®Google Scholar
• Sakkal S, Miller S, Apostolopoulos V, Nurgali K. Eosinophils in Cancer: Favourable or Unfavourable? Curr Med Chem. 2016;23(7):650–666; https://doi.org/10.2174/0929867323666160119094313. PMID:26785997
   PubMed Web of Science ®Google Scholar
• Tateno H, Crocker PR, Paulson JC. Mouse Siglec-F and human Siglec-8 are functionally convergent paralogs that are selectively expressed on eosinophils and recognize 6 ′-sulfo-sialyl Lewis X as a preferred glycan ligand. Glycobiology. 2005;15(11):1125–1135; https://doi.org/10.1093/glycob/cwi097. PMID:15972893
   PubMedGoogle Scholar
• Aguirre-Gamboa R, Gomez-Rueda H, Martinez-Ledesma E, Martinez-Torteya A, Chacolla-Huaringa R, Rodriguez-Barrientos A, Tamez-Peña José G TV. SurvExpress: An Online Biomarker Validation Tool and Database for Cancer Gene Expression Data Using Survival Analysis. PLoS One. 2013;8(9):e74250; https://doi.org/10.1371/journal.pone.0074250. PMID:24066126
   PubMed Web of Science ®Google Scholar
• Iwasaki K, Torisu M, Fujimura T. Malignant tumor and eosinophils. I. Prognostic significance in gastric cancer. Cancer 1986;58(6):1321–1327; https://doi.org/10.1002/1097-0142(19860915)58:6<1321::AID-CNCR2820580623>3.0.CO;2-O.
   Google Scholar
• Cuschieri A, Talbot IC, Weeden S. Influence of pathological tumour variables on long-term survival in resectable gastric cancer. Br J Cancer. 2002;86(5):674–679; https://doi.org/10.1038/sj.bjc.6600161. PMID:11875724
   PubMedGoogle Scholar
• Pretlow TP, Keith EF, Cryar AK, Bartolucci AA, Pitts AM, Pretlow TG, 2 nd, Kimball PM, Boohaker EA. Eosinophil infiltration of human colonic carcinomas as a prognostic indicator. Cancer Res 1983;43(6):2997–3000. PMID:6850611
   PubMed Web of Science ®Google Scholar
• Nielsen HJ, Hansen U, Christensen IJ, Reimert CM, Brunner N, Moesgaard F. Independent prognostic value of eosinophil and mast cell infiltration in colorectal cancer tissue. J Pathol 1999;189(4):487–495; https://doi.org/10.1002/(SICI)1096-9896(199912)189:4<487::AID-PATH484>3.0.CO;2-I. PMID:10629548
   PubMedGoogle Scholar
• Fernandez-Acenero MJ, Galindo-Gallego M, Sanz J, Aljama A. Prognostic influence of tumor-associated eosinophilic infiltrate in colorectal carcinoma. Cancer. 2000;88(7):1544–1548; https://doi.org/10.1002/(SICI)1097-0142(20000401)88:7<1544::AID-CNCR7>3.0.CO;2-S. PMID:10738211
   PubMedGoogle Scholar
• Fujii M, Yamashita T, Ishiguro R, Tashiro M, Kameyama K. Significance of epidermal growth factor receptor and tumor associated tissue eosinophilia in the prognosis of patients with nasopharyngeal carcinoma. Auris Nasus Larynx. 2002;29(2):175–181; https://doi.org/10.1016/S0385-8146(01)00135-3. PMID:11893453
   PubMedGoogle Scholar
• Dorta RG, Landman G, Kowalski LP, Lauris JR, Latorre MR, Oliveira DT. Tumour-associated tissue eosinophilia as a prognostic factor in oral squamous cell carcinomas. Histopathology. 2002;41(2):152–157; https://doi.org/10.1046/j.1365-2559.2002.01437.x. PMID:12147093
   PubMed Web of Science ®Google Scholar
• Jain M, Kasetty S, Sudheendra US, Tijare M, Khan S, Desai A. Assessment of tissue eosinophilia as a prognosticator in oral epithelial dysplasia and oral squamous cell carcinoma-an image analysis study. Patholog Res Int. 2014; 2014:507512; https://doi.org/10.1155/2014/507512. PMID:24693457
   PubMedGoogle Scholar
• Thompson AC, Bradley PJ, Griffin NR. Tumor-associated tissue eosinophilia and long-term prognosis for carcinoma of the larynx. Am J Surg 1994;168(5):469–471; https://doi.org/10.1016/S0002-9610(05)80102-3. PMID:7977976
   PubMedGoogle Scholar
• Ownby HE, Roi LD, Isenberg RR, Brennan MJ. Peripheral lymphocyte and eosinophil counts as indicators of prognosis in primary breast cancer. Cancer. 1983;52(1):126–130; https://doi.org/10.1002/1097-0142(19830701)52:1<126::aid-cncr2820520123>3.0.co;2-y. PMID:6850535
   PubMedGoogle Scholar
• von Wasielewski R, Seth S, Franklin J, Fischer R, Hubner K, Hansmann ML, Diehl V, Georgii A. Tissue eosinophilia correlates strongly with poor prognosis in nodular sclerosing Hodgkin's disease, allowing for known prognostic factors. Blood. 2000;95(4):1207–1213. PMID:10666192
   PubMed Web of Science ®Google Scholar
• Enblad G, Sundstrom C, Glimelius B. Infiltration of eosinophils in Hodgkin's disease involved lymph nodes predicts prognosis. Hematol Oncol 1993;11(4):187–193; https://doi.org/10.1002/hon.2900110404. PMID:8144133
   PubMedGoogle Scholar
• van Driel WJ, Hogendoorn PC, Jansen FW, Zwinderman AH, Trimbos JB, Fleuren GJ. Tumor-associated eosinophilic infiltrate of cervical cancer is indicative for a less effective immune response. Hum Pathol 1996;27(9):904–911; https://doi.org/10.1016/S0046-8177(96)90216-6. PMID:8816884
   PubMedGoogle Scholar
• Gebhardt C, Sevko A, Jiang H, Lichtenberger R, Reith M, Tarnanidis K, Holland-Letz T, Umansky L, Beckhove P, Sucker A, et al. Myeloid Cells and Related Chronic Inflammatory Factors as Novel Predictive Markers in Melanoma Treatment with Ipilimumab. Clin Cancer Res. 2015; 21(24):5453–5459; https://doi.org/10.1158/1078-0432.CCR-15-0676. PMID:26289067
   PubMed Web of Science ®Google Scholar
• Moreira A, Leisgang W, Schuler G, Heinzerling L. Eosinophilic count as a biomarker for prognosis of melanoma patients and its importance in the response to immunotherapy. Immunotherapy. 2017;9(2):115–121; https://doi.org/10.2217/imt-2016-0138. PMID:28128709
   PubMedGoogle Scholar
• Weide B, Martens A, Hassel JC, Berking C, Postow MA, Bisschop K, Simeone E, Mangana J, Schilling B, Di Giacomo AM, et al. Baseline Biomarkers for Outcome of Melanoma Patients Treated with Pembrolizumab. Clin Cancer Res. 2016;22(22):5487–5496; https://doi.org/10.1158/1078-0432.ccr-16-0127. PMID:27185375
   PubMed Web of Science ®Google Scholar
• Utsunomiya A, Ishida T, Inagaki A, Ishii T, Yano H, Komatsu H, Iida S, Yonekura K, Takeuchi S, Takatsuka Y, et al. Clinical significance of a blood eosinophilia in adult T-cell leukemia/lymphoma: a blood eosinophilia is a significant unfavorable prognostic factor. Leuk Res. 2007;31(7):915–920; https://doi.org/10.1016/j.leukres.2006.10.017. PMID:17123603
   PubMedGoogle Scholar
• Kruger-Krasagakes S, Li W, Richter G, Diamantstein T, Blankenstein T. Eosinophils infiltrating interleukin-5 gene-transfected tumors do not suppress tumor growth. Eur J Immunol 1993;23(4):992–995; https://doi.org/10.1002/eji.1830230438. PMID:8458388
   PubMedGoogle Scholar
• Gatault S, Delbeke M, Driss V, Sarazin A, Dendooven A, Kahn JE, Lefevre G, Capron M. IL-18 Is Involved in Eosinophil-Mediated Tumoricidal Activity against a Colon Carcinoma Cell Line by Upregulating LFA-1 and ICAM-1. J Immunol. 2015;195(5):2483–2492; https://doi.org/10.4049/jimmunol.1402914. . PMID:26216891
   PubMed Web of Science ®Google Scholar
• Legrand F, Driss V, Delbeke M, Loiseau S, Hermann E, Dombrowicz D, Capron M. Human eosinophils exert TNF-alpha and granzyme A-mediated tumoricidal activity toward colon carcinoma cells. J Immunol. 2010;185(12):7443–7451; https://doi.org/10.4049/jimmunol.1000446. PMID:21068403
   PubMedGoogle Scholar
• Carretero R, Sektioglu IM, Garbi N, Salgado OC, Beckhove P, Hammerling GJ. Eosinophils orchestrate cancer rejection by normalizing tumor vessels and enhancing infiltration of CD8(+) T cells. Nat Immunol. 2015;16(6):609–617; https://doi.org/10.1038/ni.3159. PMID:25915731
   PubMed Web of Science ®Google Scholar
• Ikutani M, Yanagibashi T, Ogasawara M, Tsuneyama K, Yamamoto S, Hattori Y, Kouro T, Itakura A, Nagai Y, Takaki S, et al. Identification of innate IL-5-producing cells and their role in lung eosinophil regulation and antitumor immunity. J Immunol. 2012;188(2):703–713; https://doi.org/10.4049/jimmunol.1101270. . PMID:22174445
   PubMed Web of Science ®Google Scholar
• Glimelius I, Rubin J, Fischer M, Molin D, Amini RM, Venge P, Enblad G. Effect of eosinophil cationic protein (ECP) on Hodgkin lymphoma cell lines. Exp Hematol. 2011;39(8):850–858; https://doi.org/10.1016/j.exphem.2011.05.006. PMID:21679745
   PubMedGoogle Scholar
• Kataoka S, Konishi Y, Nishio Y, Fujikawa-Adachi K, Tominaga A. Antitumor activity of eosinophils activated by IL-5 and eotaxin against hepatocellular carcinoma. DNA Cell Biol 2004;23(9):549–560; https://doi.org/10.1089/dna.2004.23.549. . PMID:15383175
   PubMedGoogle Scholar
• Furbert-Harris P, Parish-Gause D, Laniyan I, Hunter KA, Okomo-Awich J, Vaughn TR, Forrest KC, Howland C, Abdelnaby A, Oredipe OA. Inhibition of prostate cancer cell growth by activated eosinophils. Prostate. 2003;57(2):165–175; https://doi.org/10.1002/pros.10286. PMID:12949941
   PubMedGoogle Scholar
• Simson L, Ellyard JI, Dent LA, Matthaei KI, Rothenberg ME, Foster PS, Smyth MJ, Parish CR. Regulation of Carcinogenesis by IL-5 and CCL11: A Potential Role for Eosinophils in Tumor Immune Surveillance. J Immunol. 2007;178(7):4222–4229; https://doi.org/10.4049/jimmunol.178.7.4222. PMID:17371978
   PubMed Web of Science ®Google Scholar
• Lotfi R, Lee JJ, Lotze MT. Eosinophilic Granulocytes and Damage-associated Molecular Pattern Molecules (DAMPs): Role in the Inflammatory Response Within Tumors. J Immunother. 2007;30(1):16–28; https://doi.org/10.1097/01.cji.0000211324.53396.f6. PMID:17198080
   PubMedGoogle Scholar
• Davis BP, Rothenberg ME. Eosinophils and cancer. Cancer Immunol Res. 2014;2(1):1–8; https://doi.org/10.1158/2326-6066.CIR-13-0196. PMID:24778159
   PubMed Web of Science ®Google Scholar
• Gatault S, Legrand F, Delbeke M, Loiseau S, Capron M. Involvement of eosinophils in the anti-tumor response. Cancer Immunol Immunother. 2012;61(9):1527–1534; https://doi.org/10.1007/s00262-012-1288-3. PMID:22706380
   PubMed Web of Science ®Google Scholar
• Biswas SK, Mantovani A. Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm. Nat Immunol. 2010;11(10):889–896; https://doi.org/10.1038/ni.1937. PMID:20856220
   PubMed Web of Science ®Google Scholar
• Germain C, Gnjatic S, Tamzalit F, Knockaert S, Remark R, Goc J, Lepelley A, Becht E, Katsahian S, Bizouard G, et al. Presence of B cells in tertiary lymphoid structures is associated with a protective immunity in patients with lung cancer. Am J Respir Crit Care Med. 2014;189(7):832–844; https://doi.org/10.1164/rccm.201309-1611OC. PMID:24484236
   PubMedGoogle Scholar
• Eruslanov EB, Bhojnagarwala PS, Quatromoni JG, Stephen TL, Ranganathan A, Deshpande C, Akimova T, Vachani A, Litzky L, Hancock WW, et al. Tumor-associated neutrophils stimulate T cell responses in early-stage human lung cancer. J Clin Invest. 2014;124(12):5466–5480; https://doi.org/10.1172/JCI77053. . PMID:25384214
   PubMed Web of Science ®Google Scholar
• Zaretsky JM, Garcia-Diaz A, Shin DS, Escuin-Ordinas H, Hugo W, Hu-Lieskovan S, Torrejon DY, Abril-Rodriguez G, Sandoval S, Barthly L, et al. Mutations Associated with Acquired Resistance to PD-1 Blockade in Melanoma. N Engl J Med. 2016;375(9):819–829; https://doi.org/10.1056/NEJMoa1604958. PMID:27433843
   PubMed Web of Science ®Google Scholar
• Siiskonen H, Poukka M, Bykachev A, Tyynela-Korhonen K, Sironen R, Pasonen-Seppanen S, Harvima IT. Low numbers of tryptase+ and chymase+ mast cells associated with reduced survival and advanced tumor stage in melanoma. Melanoma Res. 2015;25(6):479–485; https://doi.org/10.1097/CMR.0000000000000192. PMID:26317168
   PubMed Web of Science ®Google Scholar
• Welsh TJ, Green RH, Richardson D, Waller DA, O'Byrne KJ, Bradding P. Macrophage and mast-cell invasion of tumor cell islets confers a marked survival advantage in non-small-cell lung cancer. J Clin Oncol. 2005;23(35):8959–8967; https://doi.org/10.1200/JCO.2005.01.4910. PMID:16219934
   PubMed Web of Science ®Google Scholar
• Shikotra A, Ohri CM, Green RH, Waller DA, Bradding P. Mast cell phenotype, TNFalpha expression and degranulation status in non-small cell lung cancer. Sci Rep. 2016;6:38352; https://doi.org/10.1038/srep38352. PMID:27922077
   PubMed Web of Science ®Google Scholar
• Carlini MJ, Dalurzo MC, Lastiri JM, Smith DE, Vasallo BC, Puricelli LI, Lauria de Cidre LS. Mast cell phenotypes and microvessels in non-small cell lung cancer and its prognostic significance. Hum Pathol. 2010;41(5):697–705; https://doi.org/10.1016/j.humpath.2009.04.029. PMID:20040391
   PubMedGoogle Scholar
• Cai SW, Yang SZ, Gao J, Pan K, Chen JY, Wang YL, Wei LX, Dong JH. Prognostic significance of mast cell count following curative resection for pancreatic ductal adenocarcinoma. Surgery. 2011;149(4):576–584; https://doi.org/10.1016/j.surg.2010.10.009. PMID:21167541
   PubMed Web of Science ®Google Scholar
• Rabenhorst A, Schlaak M, Heukamp LC, Forster A, Theurich S, von Bergwelt-Baildon M, Buttner R, Kurschat P, Mauch C, Roers A, et al. Mast cells play a protumorigenic role in primary cutaneous lymphoma. Blood. 2012;120(10):2042–2054; https://doi.org/10.1182/blood-2012-03-415638. PMID:22837530
   PubMedGoogle Scholar
• Lavin Y, Kobayashi S, Leader A, Amir ED, Elefant N, Bigenwald C, Remark R, Sweeney R, Becker CD, Levine JH, et al. Innate Immune Landscape in Early Lung Adenocarcinoma by Paired Single-Cell Analyses. Cell. 2017;169(4):750–765 e717; https://doi.org/10.1016/j.cell.2017.04.014.
   PubMed Web of Science ®Google Scholar
• Marone G, Granata F, eds. Angiogenesis, Lymphangiogenesis and Clinical Implications. Chem Immunol Allergy. Basel: Karger. 2014.
   Google Scholar
• Folkman J, Shing Y. Angiogenesis. J Biol Chem. 1992;267(16):10931–10934. PMID:1375931
   PubMed Web of Science ®Google Scholar
• Horiuchi T, Weller PF. Expression of vascular endothelial growth factor by human eosinophils: upregulation by granulocyte macrophage colony-stimulating factor and interleukin-5. Am J Respir Cell Mol Biol 1997;17(1):70–77; https://doi.org/10.1165/ajrcmb.17.1.2796. PMID:9224211
   PubMedGoogle Scholar
• Hoshino M, Takahashi M, Aoike N. Expression of vascular endothelial growth factor, basic fibroblast growth factor, and angiogenin immunoreactivity in asthmatic airways and its relationship to angiogenesis. J Allergy Clin Immunol. 2001;107(2):295–301; https://doi.org/10.1067/mai.2001.111928. PMID:11174196
   PubMed Web of Science ®Google Scholar
• Yousefi S, Hemmann S, Weber M, Holzer C, Hartung K, Blaser K, Simon HU. IL-8 is expressed by human peripheral blood eosinophils. Evidence for increased secretion in asthma. J Immunol 1995;154(10):5481–5490.
   Web of Science ®Google Scholar
• Puxeddu I, Berkman N, Ribatti D, Bader R, Haitchi HM, Davies DE, Howarth PH, Levi-Schaffer F. Osteopontin is expressed and functional in human eosinophils. Allergy. 2010;65(2):168–174; https://doi.org/10.1111/j.1398-9995.2009.02148.x. PMID:19804447
   PubMedGoogle Scholar
• Esposito I, Menicagli M, Funel N, Bergmann F, Boggi U, Mosca F, Bevilacqua G, Campani D. Inflammatory cells contribute to the generation of an angiogenic phenotype in pancreatic ductal adenocarcinoma. J Clin Pathol. 2004;57(6):630–636; https://doi.org/10.1136/jcp.2003.014498. PMID:15166270
   PubMed Web of Science ®Google Scholar
• Tataroglu C, Kargi A, Ozkal S, Esrefoglu N, Akkoclu A. Association of macrophages, mast cells and eosinophil leukocytes with angiogenesis and tumor stage in non-small cell lung carcinomas (NSCLC). Lung Cancer. 2004;43(1):47–54; https://doi.org/10.1016/j.lungcan.2003.08.013. PMID:14698536
   PubMed Web of Science ®Google Scholar
• Varey AH, Rennel ES, Qiu Y, Bevan HS, Perrin RM, Raffy S, Dixon AR, Paraskeva C, Zaccheo O, Hassan AB, et al. VEGF 165 b, an antiangiogenic VEGF-A isoform, binds and inhibits bevacizumab treatment in experimental colorectal carcinoma: balance of pro- and antiangiogenic VEGF-A isoforms has implications for therapy. Br J Cancer. 2008;98(8):1366–1379; https://doi.org/10.1038/sj.bjc.6604308. PMID:18349829
   PubMedGoogle Scholar
• Bates DO, Mavrou A, Qiu Y, Carter JG, Hamdollah-Zadeh M, Barratt S, Gammons MV, Millar AB, Salmon AH, Oltean S, et al. Detection of VEGF-A(xxx)b isoforms in human tissues. PLoS One. 2013;8(7):e68399; https://doi.org/10.1371/journal.pone.0068399. PMID:23935865
   PubMed Web of Science ®Google Scholar
• Loffredo S, Borriello F, Iannone R, Ferrara AL, Galdiero MR, Gigantino V, Esposito P, Varricchi G, Lambeau G, Cassatella MA, et al. Group V Secreted Phospholipase A2 Induces the Release of Proangiogenic and Antiangiogenic Factors by Human Neutrophils. Front Immunol. 2017;8:443; https://doi.org/10.3389/fimmu.2017.00443. PMID:28458672
   PubMed Web of Science ®Google Scholar
• Harper SJ, Bates DO. VEGF-A splicing: the key to anti-angiogenic therapeutics? Nat Rev Cancer. 2008;8(11):880–887; https://doi.org/10.1038/nrc2505.
   Google Scholar
• Stacker SA, Williams SP, Karnezis T, Shayan R, Fox SB, Achen MG. Lymphangiogenesis and lymphatic vessel remodelling in cancer. Nat Rev Cancer. 2014;14(3):159–172; https://doi.org/10.1038/nrc3677. PMID:24561443
   PubMed Web of Science ®Google Scholar
• Baram D, Vaday GG, Salamon P, Drucker I, Hershkoviz R, Mekori YA. Human mast cells release metalloproteinase-9 on contact with activated T cells: juxtacrine regulation by TNF-alpha. J Immunol. 2001;167(7):4008–4016; https://doi.org/10.4049/jimmunol.167.7.4008. PMID:11564820
   PubMed Web of Science ®Google Scholar
• Okada S, Kita H, George TJ, Gleich GJ, Leiferman KM. Migration of eosinophils through basement membrane components in vitro: role of matrix metalloproteinase-9. Am J Respir Cell Mol Biol 1997;17(4):519–528; https://doi.org/10.1165/ajrcmb.17.4.2877. PMID:9376127
   PubMed Web of Science ®Google Scholar
• Schwingshackl A, Duszyk M, Brown N, Moqbel R. Human eosinophils release matrix metalloproteinase-9 on stimulation with TNF-alpha. J Allergy Clin Immunol 1999;104(5):983–989; https://doi.org/10.1016/S0091-6749(99)70079-5. PMID:10550743
   PubMedGoogle Scholar
• Cools-Lartigue J, Spicer J, McDonald B, Gowing S, Chow S, Giannias B, Bourdeau F, Kubes P, Ferri L. Neutrophil extracellular traps sequester circulating tumor cells and promote metastasis. J Clin Invest. 2013;123(8):3446–3458; https://doi.org/10.1172/JCI67484. PMID:23863628
   PubMedGoogle Scholar
• Cedervall J, Zhang Y, Huang H, Zhang L, Femel J, Dimberg A, Olsson AK. Neutrophil Extracellular Traps Accumulate in Peripheral Blood Vessels and Compromise Organ Function in Tumor-Bearing Animals. Cancer Res. 2015;75(13):2653–2662; https://doi.org/10.1158/0008-5472.CAN-14-3299. PMID:26071254
   PubMed Web of Science ®Google Scholar
• Mollerherm H, von Kockritz-Blickwede M, Branitzki-Heinemann K. Antimicrobial Activity of Mast Cells: Role and Relevance of Extracellular DNA Traps. Front Immunol. 2016;7:265; https://doi.org/10.3389/fimmu.2016.00265. PMID:27486458
   PubMed Web of Science ®Google Scholar
• Ueki S, Konno Y, Takeda M, Moritoki Y, Hirokawa M, Matsuwaki Y, Honda K, Ohta N, Yamamoto S, Takagi Y, et al. Eosinophil extracellular trap cell death-derived DNA traps: Their presence in secretions and functional attributes. J Allergy Clin Immunol. 2016;137(1):258–267; https://doi.org/10.1016/j.jaci.2015.04.041. PMID:26070883
   PubMedGoogle Scholar
• Jorch SK, Kubes P. An emerging role for neutrophil extracellular traps in noninfectious disease. Nat Med. 2017;23(3):279–287; https://doi.org/10.1038/nm.4294. PMID:28267716
   PubMed Web of Science ®Google Scholar
• Huland E, Huland H. Tumor-associated eosinophilia in interleukin-2-treated patients: evidence of toxic eosinophil degranulation on bladder cancer cells. J Cancer Res Clin Oncol 1992;118(6):463–467; https://doi.org/10.1007/BF01629431. PMID:1618895
   PubMedGoogle Scholar
• Costain DJ, Guha AK, Liwski RS, Lee TDG. Murine hypodense eosinophils induce tumour cell apoptosis by a granzyme B-dependent mechanism. Cancer Immunol Immunother. 2001;50(6):293–299; https://doi.org/10.1007/pl00006690. PMID:11570582
   PubMedGoogle Scholar
• Ueki S, Tokunaga T, Fujieda S, Honda K, Hirokawa M, Spencer LA, Weller PF. Eosinophil ETosis and DNA Traps: a New Look at Eosinophilic Inflammation. Curr Allergy Asthma Rep. 2016;16(8):54; https://doi.org/10.1007/s11882-016-0634-5. PMID:27393701
   PubMed Web of Science ®Google Scholar
• O'Flaherty SM, Sutummaporn K, Häggtoft WL, Worrall AP, Rizzo M, Braniste V, Höglund P, Kadri N, Chambers BJ. TLR-Stimulated Eosinophils Mediate Recruitment and Activation of NK Cells In Vivo. Scand J Immunol. 2017;85(6):417–424; https://doi.org/10.1111/sji.12554. PMID:28426135
   PubMedGoogle Scholar
• Lotfi R, Lotze MT. Eosinophils induce DC maturation, regulating immunity. J Leukoc Biol. 2008;83(3):456–460; https://doi.org/10.1189/jlb.0607366. PMID:17991762
   PubMedGoogle Scholar
• Capobianco A, Manfredi AA, Monno A, Rovere-Querini P, Rugarli C. Melanoma and Lymphoma Rejection Associated With Eosinophil Infiltration Upon Intratumoral Injection of Dendritic and NK/LAK Cells. J Immunother. 2008;31(5):458–465; https://doi.org/10.1097/CJI.0b013e318174a512. PMID:18463539
   PubMedGoogle Scholar
• Shi H-Z. Eosinophils function as antigen-presenting cells. J Leukoc Biol. 2004;76(3):520–527; https://doi.org/10.1189/jlb.0404228. PMID:15218055
   PubMedGoogle Scholar
• Farhan RK, Vickers MA, Ghaemmaghami AM, Hall AM, Barker RN, Walsh GM. Effective antigen presentation to helper T cells by human eosinophils. Immunology. 2016;149(4):413–422; https://doi.org/10.1111/imm.12658. PMID:27502559
   PubMedGoogle Scholar
• Bagnasco D, Ferrando M, Caminati M, Bragantini A, Puggioni F, Varricchi G, Passalacqua G, Canonica GW. Targeting Interleukin-5 or Interleukin-5Ralpha: Safety Considerations. Drug Saf. 2017;40(7):559–570; https://doi.org/10.1007/s40264-017-0522-5. PMID:28321782
   PubMed Web of Science ®Google Scholar
• Schlehofer B, Siegmund B, Linseisen J, Schuz J, Rohrmann S, Becker S, Michaud D, Melin B, Bas Bueno-de-Mesquita H, Peeters PH, et al. Primary brain tumours and specific serum immunoglobulin E: a case-control study nested in the European Prospective Investigation into Cancer and Nutrition cohort. Allergy. 2011;66(11):1434–1441; https://doi.org/10.1111/j.1398-9995.2011.02670.x. PMID:21726235
   PubMedGoogle Scholar
• Vajdic CM, Falster MO, de Sanjose S, Martinez-Maza O, Becker N, Bracci PM, Melbye M, Smedby KE, Engels EA, Turner J, et al. Atopic disease and risk of non-Hodgkin lymphoma: an InterLymph pooled analysis. Cancer Res. 2009;69(16):6482–6489; https://doi.org/10.1158/0008-5472.CAN-08-4372. PMID:19654312
   PubMed Web of Science ®Google Scholar
• Nigro EA, Brini AT, Soprana E, Ambrosi A, Dombrowicz D, Siccardi AG, Vangelista L. Antitumor IgE adjuvanticity: key role of Fc epsilon RI. J Immunol. 2009;183(7):4530–4536; https://doi.org/10.4049/jimmunol.0900842. PMID:19748979
   PubMedGoogle Scholar
• Jensen-Jarolim E, Achatz G, Turner MC, Karagiannis S, Legrand F, Capron M, Penichet ML, Rodriguez JA, Siccardi AG, Vangelista L, et al. AllergoOncology: the role of IgE-mediated allergy in cancer. Allergy. 2008;63(10):1255–1266; https://doi.org/10.1111/j.1398-9995.2008.01768.x. PMID:18671772
   PubMed Web of Science ®Google Scholar
• West WH, Tauer KW, Yannelli JR, Marshall GD, Orr DW, Thurman GB, Oldham RK. Constant-infusion recombinant interleukin-2 in adoptive immunotherapy of advanced cancer. N Engl J Med 1987;316(15):898–905; https://doi.org/10.1056/NEJM198704093161502. PMID:3493433
   PubMed Web of Science ®Google Scholar
• Rivoltini L, Colombo MP, Parmiani G, Viggiano V, Spinazzè S, Santoro A, Takatsu K. In vitro anti-tumor activity of eosinophils from cancer patients treated with subcutaneous administration of interleukin 2. Role of interleukin 5. International Journal of Cancer 1993;54(1):8–15; https://doi.org/10.1002/ijc.2910540103. PMID:8386711
   PubMed Web of Science ®Google Scholar
• Hodi FS, O'Day SJ, McDermott DF, Weber RW, Sosman JA, Haanen JB, Gonzalez R, Robert C, Schadendorf D, Hassel JC, et al. Improved survival with ipilimumab in patients with metastatic melanoma. N Engl J Med. 2010;363(8):711–723; https://doi.org/10.1056/NEJMoa1003466. PMID:20525992
   PubMed Web of Science ®Google Scholar
• Brahmer JR, Tykodi SS, Chow LQ, Hwu WJ, Topalian SL, Hwu P, Drake CG, Camacho LH, Kauh J, Odunsi K, et al. Safety and activity of anti-PD-L1 antibody in patients with advanced cancer. N Engl J Med. 2012;366(26):2455–2465; https://doi.org/10.1056/NEJMoa1200694. PMID:22658128
   PubMed Web of Science ®Google Scholar
• Peters S, Gettinger S, Johnson ML, Janne PA, Garassino MC, Christoph D, Toh CK, Rizvi NA, Chaft JE, Carcereny Costa E, et al. Phase II Trial of Atezolizumab As First-Line or Subsequent Therapy for Patients With Programmed Death-Ligand 1-Selected Advanced Non-Small-Cell Lung Cancer (BIRCH). J Clin Oncol. 2017;35(24):2781–2789; https://doi.org/1410 JCO2016719476. PMID:28609226
   PubMed Web of Science ®Google Scholar
• Delyon J, Mateus C, Lefeuvre D, Lanoy E, Zitvogel L, Chaput N, Roy S, Eggermont AM, Routier E, Robert C. Experience in daily practice with ipilimumab for the treatment of patients with metastatic melanoma: an early increase in lymphocyte and eosinophil counts is associated with improved survival. Ann Oncol. 2013;24(6):1697–703; https://doi.org/10.1093/annonc/mdt027. PMID:23439861
   PubMedGoogle Scholar
• Umansky V, Utikal J, Gebhardt C. Predictive immune markers in advanced melanoma patients treated with ipilimumab. Oncoimmunology. 2016;5(6):e1158901; https://doi.org/10.1080/2162402X.2016.1158901. PMID:27471626
   PubMed Web of Science ®Google Scholar
• Martens A, Wistuba-Hamprecht K, Geukes Foppen MH, Yuan J, Postow MA, Wong P, Romano E, Khammari A, Dreno B, Capone M, et al. Baseline peripheral blood biomarkers associated with clinical outcome of advanced melanoma patients treated with ipilimumab. Clin Cancer Res. 2016; https://doi.org/10.1158/1078-0432.CCR-15-2412.
   Web of Science ®Google Scholar
• Movahedi K, Laoui D, Gysemans C, Baeten M, Stange G, Van den Bossche J, Mack M, Pipeleers D, In't Veld P, De Baetselier P, et al. Different tumor microenvironments contain functionally distinct subsets of macrophages derived from Ly6 C(high) monocytes. Cancer Res. 2010;70(14):5728–5739; https://doi.org/10.1158/0008-5472.CAN-09-4672. PMID:20570887
   PubMed Web of Science ®Google Scholar
• Wang HB, Ghiran I, Matthaei K, Weller PF. Airway eosinophils: allergic inflammation recruited professional antigen-presenting cells. J Immunol. 2007;179(11):7585–7592; https://doi.org/10.4049/jimmunol.179.11.7585. PMID:18025204
   PubMedGoogle Scholar
• Jacobsen EA, Zellner KR, Colbert D, Lee NA, Lee JJ. Eosinophils regulate dendritic cells and Th2 pulmonary immune responses following allergen provocation. J Immunol. 2011;187(11):6059–6068; https://doi.org/10.4049/jimmunol.1102299. PMID:22048766
   PubMed Web of Science ®Google Scholar
• De Monte L, Wormann S, Brunetto E, Heltai S, Magliacane G, Reni M, Paganoni AM, Recalde H, Mondino A, Falconi M, et al. Basophil Recruitment into Tumor-Draining Lymph Nodes Correlates with Th2 Inflammation and Reduced Survival in Pancreatic Cancer Patients. Cancer Res. 2016;76(7):1792–1803; https://doi.org/10.1158/0008-5472.CAN-15-1801-T. PMID:26873846
   PubMed Web of Science ®Google Scholar
• Lingblom C, Andersson J, Andersson K, Wenneras C. Regulatory Eosinophils Suppress T Cells Partly through Galectin-10. J Immunol. 2017;198(12):4672–4681; https://doi.org/10.4049/jimmunol.1601005. PMID:28515279
   PubMedGoogle Scholar
• Sotiriou C, Pusztai L. Gene-expression signatures in breast cancer. N Engl J Med. 2009;360(8):790–800; https://doi.org/10.1056/NEJMra0801289. PMID:19228622
   PubMed Web of Science ®Google Scholar
• Popper HH, Ryska A, Timar J, Olszewski W. Molecular testing in lung cancer in the era of precision medicine. Transl Lung Cancer Res. 2014;3(5):291–300; https://doi.org/10.3978/j.issn.2218-6751.2014.10.01. PMID:25806314
   PubMedGoogle Scholar
• Kim SY, Kim SN, Hahn HJ, Lee YW, Choe YB, Ahn KJ. Metaanalysis of BRAF mutations and clinicopathologic characteristics in primary melanoma. J Am Acad Dermatol. 2015;72(6):1036–1046 e1032; https://doi.org/10.1016/j.jaad.2015.02.1113.
   PubMed Web of Science ®Google Scholar
• Riquelme I, Saavedra K, Espinoza JA, Weber H, Garcia P, Nervi B, Garrido M, Corvalan AH, Roa JC, Bizama C. Molecular classification of gastric cancer: Towards a pathway-driven targeted therapy. Oncotarget. 2015;6(28):24750–24779; https://doi.org/10.18632/oncotarget.4990. PMID:26267324
   PubMedGoogle Scholar
• Holzel M, Landsberg J, Glodde N, Bald T, Rogava M, Riesenberg S, Becker A, Jonsson G, Tuting T. A Preclinical Model of Malignant Peripheral Nerve Sheath Tumor-like Melanoma Is Characterized by Infiltrating Mast Cells. Cancer Res. 2016;76(2):251–263; https://doi.org/10.1158/0008-5472.CAN-15-1090. PMID:26511633
   PubMedGoogle Scholar
• Coussens LM, Zitvogel L, Palucka AK. Neutralizing tumor-promoting chronic inflammation: a magic bullet? Science. 2013;339(6117):286–291; https://doi.org/10.1126/science.1232227.
   Google Scholar
• Bedard PL, Hansen AR, Ratain MJ, Siu LL. Tumour heterogeneity in the clinic. Nature. 2013;501(7467):355–364; https://doi.org/10.1038/nature12627. PMID:24048068
   PubMed Web of Science ®Google Scholar
• Sharma P, Allison JP. Immune checkpoint targeting in cancer therapy: toward combination strategies with curative potential. Cell. 2015;161(2):205–214; https://doi.org/10.1016/j.cell.2015.03.030. . PMID:25860605
   PubMed Web of Science ®Google Scholar
• Kleffel S, Posch C, Barthel SR, Mueller H, Schlapbach C, Guenova E, Elco CP, Lee N, Juneja VR, Zhan Q, et al. Melanoma Cell-Intrinsic PD-1 Receptor Functions Promote Tumor Growth. Cell. 2015;162(6):1242–1256; https://doi.org/10.1016/j.cell.2015.08.052. PMID:26359984
   PubMed Web of Science ®Google Scholar
• Pesce S, Thoren FB, Cantoni C, Prato C, Moretta L, Moretta A, Marcenaro E. The Innate Immune Cross Talk between NK Cells and Eosinophils Is Regulated by the Interaction of Natural Cytotoxicity Receptors with Eosinophil Surface Ligands. Front Immunol. 2017;8:510; https://doi.org/10.3389/fimmu.2017.00510.
   PubMed Web of Science ®Google Scholar