Melanoma induced immunosuppression is mediated by hematopoietic dysregulation

References

• He H, Zhang Z, Ge J, Zhou W. Leukemoid reaction associated with transitional cell carcinoma: a case report and literature review. Nigerian J Clin Practice. 2014;17:391–4. doi:10.4103/1119-3077.130256.
   PubMed Web of Science ®Google Scholar
• Kasuga I, Makino S, Kiyokawa H, Katoh H, Ebihara Y, Ohyashiki K. Tumor-related leukocytosis is linked with poor prognosis in patients with lung carcinoma. Cancer. 2001;92:2399–405. doi:10.1002/1097-0142(20011101)92:9%3c2399::AID-CNCR1588%3e3.0.CO;2-W. PMID:11745296.
   PubMed Web of Science ®Google Scholar
• Matsumoto M, Yazawa Y, Kanzaki M. An autopsy case of liposarcoma with granulocytic leukemoid reaction. Acta Pathologica Japonica. 1976;26:399–408. PMID:961420.
   PubMedGoogle Scholar
• Melhem MF, Meisler AI, Saito R, Finley GG, Hockman HR, Koski RA. Cytokines in inflammatory malignant fibrous histiocytoma presenting with leukemoid reaction. Blood. 1993;82:2038–44. PMID:7691245.
   PubMed Web of Science ®Google Scholar
• Nasser SM, Choudry UH, Nielsen GP, Ott MJ. A leukemoid reaction in a patient with a dedifferentiated liposarcoma. Surgery. 2001;129:765–7. doi:10.1067/msy.2001.109498. PMID:11391379.
   PubMed Web of Science ®Google Scholar
• Potasman I, Grupper M. Leukemoid reaction: spectrum and prognosis of 173 adult patients. Clin Infect Dis. 2013;57:e177–81. doi:10.1093/cid/cit562. PMID:23994818.
   PubMed Web of Science ®Google Scholar
• Wilcox RA. Cancer-associated myeloproliferation: old association, new therapeutic target. Mayo Clinic Proc. 2010;85:656–63. doi:10.4065/mcp.2010.0077.
   PubMed Web of Science ®Google Scholar
• Powell DR, Huttenlocher A. Neutrophils in the Tumor Microenvironment. Trends Immunol. 2016;37:41–52. doi:10.1016/j.it.2015.11.008. PMID:26700397.
   PubMed Web of Science ®Google Scholar
• Kim J, Bae JS. Tumor-Associated Macrophages and Neutrophils in Tumor Microenvironment. Mediators Inflammat. 2016;2016:6058147. doi:10.1155/2016/6058147.
   PubMed Web of Science ®Google Scholar
• Marvel D, Gabrilovich DI. Myeloid-derived suppressor cells in the tumor microenvironment: expect the unexpected. J Clin Invest. 2015;125:3356–64. doi:10.1172/JCI80005. PMID:26168215.
   PubMed Web of Science ®Google Scholar
• Kumar V, Patel S, Tcyganov E, Gabrilovich DI. The nature of myeloid-derived suppressor cells in the tumor microenvironment. Trends Immunol. 2016;37:208–20. doi:10.1016/j.it.2016.01.004. PMID:26858199.
   PubMed Web of Science ®Google Scholar
• Talmadge JE, Gabrilovich DI. History of myeloid-derived suppressor cells. Nat Rev Cancer. 2013;13:739–52. doi:10.1038/nrc3581. PMID:24060865.
   PubMed Web of Science ®Google Scholar
• Glatman Zaretsky A, Engiles JB, Hunter CA. Infection-induced changes in hematopoiesis. J Immunol. 2014;192:27–33. doi:10.4049/jimmunol.1302061. PMID:24363432.
   PubMed Web of Science ®Google Scholar
• King KY, Goodell MA. Inflammatory modulation of HSCs: viewing the HSC as a foundation for the immune response. Nat Rev Immunol. 2011;11:685–92. doi:10.1038/nri3062. PMID:21904387.
   PubMed Web of Science ®Google Scholar
• Takizawa H, Boettcher S, Manz MG. Demand-adapted regulation of early hematopoiesis in infection and inflammation. Blood. 2012;119:2991–3002. doi:10.1182/blood-2011-12-380113. PMID:22246037.
   PubMed Web of Science ®Google Scholar
• Spranger S, Sivan A, Corrales L, Gajewski TF. Tumor and host factors controlling antitumor immunity and efficacy of cancer immunotherapy. Adv Immunol. 2016;130:75–93. doi:10.1016/bs.ai.2015.12.003. PMID:26923000.
   PubMed Web of Science ®Google Scholar
• Kusmartsev S, Gabrilovich DI. Effect of tumor-derived cytokines and growth factors on differentiation and immune suppressive features of myeloid cells in cancer. Cancer Metastasis Rev. 2006;25:323–31. doi:10.1007/s10555-006-9002-6. PMID:16983515.
   PubMed Web of Science ®Google Scholar
• Prensner JR, Chinnaiyan AM. Metabolism unhinged: IDH mutations in cancer. Nat Med. 2011;17:291–3. doi:10.1038/nm0311-291. PMID:21383741.
   PubMed Web of Science ®Google Scholar
• Hirai H, Zhang P, Dayaram T, Hetherington CJ, Mizuno S, Imanishi J, Akashi K, Tenen DG. C/EBPbeta is required for ‘emergency’ granulopoiesis. Nat Immunol. 2006;7:732–9. doi:10.1038/ni1354. PMID:16751774.
   PubMed Web of Science ®Google Scholar
• Ueda Y, Cain DW, Kuraoka M, Kondo M, Kelsoe G. IL-1R type I-dependent hemopoietic stem cell proliferation is necessary for inflammatory granulopoiesis and reactive neutrophilia. J Immunol. 2009;182:6477–84. doi:10.4049/jimmunol.0803961. PMID:19414802.
   PubMed Web of Science ®Google Scholar
• Ergen AV, Boles NC, Goodell MA. Rantes/Ccl5 influences hematopoietic stem cell subtypes and causes myeloid skewing. Blood. 2012;119:2500–9. doi:10.1182/blood-2011-11-391730. PMID:22289892.
   PubMed Web of Science ®Google Scholar
• Boiko JR, Borghesi L. Hematopoiesis sculpted by pathogens: Toll-like receptors and inflammatory mediators directly activate stem cells. Cytokine. 2012;57:1–8. doi:10.1016/j.cyto.2011.10.005. PMID:22079335.
   PubMed Web of Science ®Google Scholar
• Cheshier SH, Prohaska SS, Weissman IL. The effect of bleeding on hematopoietic stem cell cycling and self-renewal. Stem Cells Dev. 2007;16:707–17. doi:10.1089/scd.2007.0017. PMID:17999593.
   PubMed Web of Science ®Google Scholar
• Cain DW, Snowden PB, Sempowski GD, Kelsoe G. Inflammation triggers emergency granulopoiesis through a density-dependent feedback mechanism. PloS One. 2011;6:e19957. doi:10.1371/journal.pone.0019957. PMID:21655273.
   PubMed Web of Science ®Google Scholar
• Dzierzak E, Philipsen S. Erythropoiesis: development and differentiation. Cold Spring Harbor Perspectives Med. 2013;3:a011601. doi:10.1101/cshperspect.a011601.
   PubMed Web of Science ®Google Scholar
• Dumitriu B, Patrick MR, Petschek JP, Cherukuri S, Klingmuller U, Fox PL, Lefebvre V. Sox6 cell-autonomously stimulates erythroid cell survival, proliferation, and terminal maturation and is thereby an important enhancer of definitive erythropoiesis during mouse development. Blood. 2006;108:1198–207. doi:10.1182/blood-2006-02-004184. PMID:16627753.
   PubMed Web of Science ®Google Scholar
• Kiel MJ, Yilmaz OH, Iwashita T, Yilmaz OH, Terhorst C, Morrison SJ. SLAM family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cells. Cell. 2005;121:1109–21. doi:10.1016/j.cell.2005.05.026. PMID:15989959.
   PubMed Web of Science ®Google Scholar
• O'Malley DP. Benign extramedullary myeloid proliferations. Modern Pathol. 2007;20:405–15. doi:10.1038/modpathol.3800768.
   PubMed Web of Science ®Google Scholar
• Basu S, Hodgson G, Zhang HH, Katz M, Quilici C, Dunn AR. “Emergency” granulopoiesis in G-CSF-deficient mice in response to Candida albicans infection. Blood. 2000;95:3725–33. PMID:10845903.
   PubMed Web of Science ®Google Scholar
• Bessman JD. Reticulocytes. In: Walker HK, Hall WD, Hurst JW, eds. Clinical methods: The history, physical, and laboratory examinations. Boston, 1990.
   Google Scholar
• Nagai Y, Garrett KP, Ohta S, Bahrun U, Kouro T, Akira S, Takatsu K, Kincade PW. Toll-like receptors on hematopoietic progenitor cells stimulate innate immune system replenishment. Immunity. 2006;24:801–12. doi:10.1016/j.immuni.2006.04.008. PMID:16782035.
   PubMed Web of Science ®Google Scholar
• Jones AT, Ziltener HJ. Enhancement of the biologic effects of interleukin-3 in vivo by anti-interleukin-3 antibodies. Blood. 1993;82:1133–41. PMID:8353280.
   PubMed Web of Science ®Google Scholar
• Ohmori K, Luo Y, Jia Y, Nishida J, Wang Z, Bunting KD, Wang D, Huang H. IL-3 induces basophil expansion in vivo by directing granulocyte-monocyte progenitors to differentiate into basophil lineage-restricted progenitors in the bone marrow and by increasing the number of basophil/mast cell progenitors in the spleen. J Immunol. 2009;182:2835–41. doi:10.4049/jimmunol.0802870. PMID:19234178.
   PubMed Web of Science ®Google Scholar
• Reed JA, McNutt NS, Bogdany JK, Albino AP. Expression of the mast cell growth factor interleukin-3 in melanocytic lesions correlates with an increased number of mast cells in the perilesional stroma: implications for melanoma progression. J Cutaneous Pathol. 1996;23:495–505. doi:10.1111/j.1600-0560.1996.tb01441.x.
   PubMed Web of Science ®Google Scholar
• Ito N, Matsuda T, Kakehi Y, Takeuchi E, Takahashi T, Yoshida O. Bladder cancer producing granulocyte colony-stimulating factor. N Eng J Med. 1990;323:1709–10. doi:10.1056/NEJM199012133232418.
   PubMed Web of Science ®Google Scholar
• Jardin F, Vasse M, Debled M, Dominique S, Courville P, Callonnec F, Buchonnet G, Thiberville L, Tilly H. Intense paraneoplastic neutrophilic leukemoid reaction related to a G-CSF-secreting lung sarcoma. Am J Hematol. 2005;80:243–5. doi:10.1002/ajh.20454. PMID:16247754.
   PubMed Web of Science ®Google Scholar
• Dukes JW, Tierney LM, Jr. Paraneoplastic leukemoid reaction as marker for transitional cell carcinoma recurrence. Urology. 2009;73:928. doi:10.1016/j.urology.2008.05.023. PMID:18718647.
   PubMed Web of Science ®Google Scholar
• Nimieri HS, Makoni SN, Madziwa FH, Nemiary DS. Leukemoid reaction response to chemotherapy and radiotherapy in a patient with cervical carcinoma. Annals Hematol. 2003;82:316–7.
   PubMed Web of Science ®Google Scholar
• Wu WC, Sun HW, Chen HT, Liang J, Yu XJ, Wu C, Wang Z, Zheng L. Circulating hematopoietic stem and progenitor cells are myeloid-biased in cancer patients. Proc Natl Acad Sci U S A. 2014;111:4221–6. doi:10.1073/pnas.1320753111. PMID:24591638.
   PubMed Web of Science ®Google Scholar
• Davis JL, Ripley RT, Frankel TL, Maric I, Lozier JN, Rosenberg SA. Paraneoplastic granulocytosis in metastatic melanoma. Melanoma Res. 2010;20:326–9. doi:10.1097/CMR.0b013e328339da1e. PMID:20440226.
   PubMed Web of Science ®Google Scholar
• Schniewind B, Christgen M, Hauschild A, Kurdow R, Kalthoff H, Klomp HJ. Paraneoplastic leukemoid reaction and rapid progression in a patient with malignant melanoma: establishment of KT293, a novel G-CSF-secreting melanoma cell line. Cancer Biol Therapy. 2005;4:23–7. doi:10.4161/cbt.4.1.1447.
   PubMed Web of Science ®Google Scholar
• Lilly MB, Devlin PE, Devlin JJ, Rado TA. Production of granulocyte colony-stimulating factor by a human melanoma cell line. Exp Hematol. 1987;15:966–71. PMID:3498641.
   PubMed Web of Science ®Google Scholar
• Gouveia E, Sousa M, Passos MJ, Moreira A. Paraneoplastic leukemoid reaction in a patient with BRAF V600E-mutated metastatic malignant melanoma. BMJ Case Reports. 2015;1–5. doi:10.1136/bcr-2014-208645.
   Google Scholar
• Sio A, Chehal MK, Tsai K, Fan X, Roberts ME, Nelson BH, Grembecka J, Cierpicki T, Krebs DL, Harder KW. Dysregulated hematopoiesis caused by mammary cancer is associated with epigenetic changes and hox gene expression in hematopoietic cells. Cancer Res. 2013;73:5892–904. doi:10.1158/0008-5472.CAN-13-0842. PMID:23913828.
   PubMed Web of Science ®Google Scholar
• Bouwhuis MG, ten Hagen TL, Eggermont AM. Immunologic functions as prognostic indicators in melanoma. Mol Oncol. 2011;5:183–9. doi:10.1016/j.molonc.2011.01.004. PMID:21367679.
   PubMed Web of Science ®Google Scholar
• Bernengo MG, Lisa F, Meregalli M, De Matteis A, Zina G. The prognostic value of T-lymphocyte levels in malignant melanoma. A five-year follow-up. Cancer. 1983;52:1841–8.
   Google Scholar