High β-1,4-Galactosyltransferase-I expression in peripheral T-lymphocytes is associated with a low risk of relapse in germ-cell cancer patients receiving high-dose chemotherapy with autologous stem cell reinfusion

References

• Lorch A, Neubauer A, Hackenthal M, Dieing A, Hartmann JT, Rick O, Bokemeyer C, Beyer J. High-dose chemotherapy (HDCT) as second-salvage treatment in patients with multiple relapsed or refractory germ-cell tumors. Ann Oncol. 2010;21(4):820–5. doi:10.1093/annonc/mdp366.
   PubMed Web of Science ®Google Scholar
• Hanna NH, Einhorn LH. Testicular cancer–discoveries and updates. N Engl J Med. 2014;371(21):2005–16. doi:10.1056/NEJMra1407550.
   PubMed Web of Science ®Google Scholar
• International Prognostic Factors Study G, Lorch A, Beyer J, Bascoul-Mollevi C, Kramar A, Einhorn LH, Necchi A, Massard C, De Giorgi U, Flechon A, et al. Prognostic factors in patients with metastatic germ cell tumors who experienced treatment failure with cisplatin-based first-line chemotherapy. J Clin Oncol. 2010;28(33):4906–11. doi:10.1200/JCO.2009.26.8128.
   PubMed Web of Science ®Google Scholar
• Perez EA, Thompson EA, Ballman KV, Anderson SK, Asmann YW, Kalari KR, Eckel-Passow JE, Dueck AC, Tenner KS, Jen J, et al. Genomic analysis reveals that immune function genes are strongly linked to clinical outcome in the North Central Cancer Treatment Group n9831 Adjuvant Trastuzumab Trial. J Clin Oncol. 2015;33(7):701–8. doi:10.1200/JCO.2014.57.6298.
   PubMed Web of Science ®Google Scholar
• Gu-Trantien C, Loi S, Garaud S, Equeter C, Libin M, de Wind A, Ravoet M, Le Buanec H, Sibille C, Manfouo-Foutsop G, et al. CD4(+) follicular helper T cell infiltration predicts breast cancer survival. J Clin Invest. 2013;123(7):2873–92. doi:10.1172/JCI67428.
   PubMed Web of Science ®Google Scholar
• Lu Y, Wang L, Liu P, Yang P, You M. Gene-expression signature predicts postoperative recurrence in stage I non-small cell lung cancer patients. PLoS One. 2012;7(1):e30880. doi:10.1371/journal.pone.0030880.
   PubMed Web of Science ®Google Scholar
• Cheng X, Wang X, Han Y, Wu Y. The expression and function of beta-1,4-galactosyltransferase-I in dendritic cells. Cell Immunol. 2010;266(1):32–9. doi:10.1016/j.cellimm.2010.08.008.
   PubMed Web of Science ®Google Scholar
• Han Y, Zhou X, Ji Y, Shen A, Sun X, Hu Y, Wu Q, Wang X. Expression of beta-1,4-galactosyltransferase-I affects cellular adhesion in human peripheral blood CD4+ T cells. Cell Immunol. 2010;262(1):11–7. doi:10.1016/j.cellimm.2009.08.004.
   PubMed Web of Science ®Google Scholar
• Furukawa K, Sato T. Beta-1,4-galactosylation of N-glycans is a complex process. Biochim Biophys Acta. 1999;1473(1):54–66. doi:10.1016/S0304-4165(99)00169-5.
   PubMed Web of Science ®Google Scholar
• Hill RL, Brew K, Vanaman TC, Trayer IP, Mattock P. The structure, function, and evolution of alpha-lactalbumin. Brookhaven Symp Biol. 1968;21(1):139–54.
   PubMedGoogle Scholar
• Russo RN, Shaper NL, Shaper JH. Bovine beta 1—-4-galactosyltransferase: two sets of mRNA transcripts encode two forms of the protein with different amino-terminal domains. In vitro translation experiments demonstrate that both the short and the long forms of the enzyme are type II membrane-bound glycoproteins. J Biol Chem. 1990;265(6):3324–31.
   PubMed Web of Science ®Google Scholar
• Zhao J, Gao Y, Cheng C, Yan M, Wang J. Upregulation of beta-1,4-galactosyltransferase I in rat spinal cord with experimental autoimmune encephalomyelitis. J Mol Neurosci. 2013;49(3):437–45. doi:10.1007/s12031-012-9824-3.
   PubMed Web of Science ®Google Scholar
• Mittermayr S, Le GN, Clarke C, Millan Martin S, Larkin AM, O'Gorman P, Bones J. Polyclonal Immunoglobulin G N-Glycosylation in the Pathogenesis of Plasma Cell Disorders. J Proteome Res. 2017;16(2):748–62. doi:10.1021/acs.jproteome.6b00768.
   PubMed Web of Science ®Google Scholar
• Poeta ML, Massi E, Parrella P, Pellegrini P, De Robertis M, Copetti M, Rabitti C, Perrone G, Muda AO, Molinari F, et al. Aberrant promoter methylation of beta-1,4 galactosyltransferase 1 as potential cancer-specific biomarker of colorectal tumors. Genes Chromosomes Cancer. 2012;51(12):1133–43. doi:10.1002/gcc.21998.
   PubMed Web of Science ®Google Scholar
• Xie H, Zhu Y, An H, Wang H, Zhu Y, Fu H, Wang Z, Fu Q, Xu J, Ye D. Increased B4GALT1 expression associates with adverse outcome in patients with non-metastatic clear cell renal cell carcinoma. Oncotarget. 2016;7(22):32723–30. doi:10.18632/oncotarget.8737.
   PubMed Web of Science ®Google Scholar
• Lorch A, Kollmannsberger C, Hartmann JT, Metzner B, Schmidt-Wolf IGH, Berdel WE, Weissinger F, Schleicher J, Egerer G, Haas A et al. Single versus sequential high-dose chemotherapyin patients with relapsed or refractory germ cell tumors: A prospective randomized multicenter trial of the German Testicular Cancer Study Group. J Clin Oncol. 2007;25(19):2778–2784. doi:10.1200/JCO.2006.09.2148.
   PubMed Web of Science ®Google Scholar
• Hartmann JT, Gauler T, Metzner B, Gerl A, Casper J, Rick O, Horger M, Schleicher J, Derigs G, Mayer-Steinacker R. Phase I/II study of sequential dose-intensified ifosfamide, cisplatin, and etoposideplus paclitaxel as induction chemotherapy for poor prognosis germ cell tumors by the German Testicular Cancer Study Group. J Clin Oncol. 2007;25(36):5742–5747. doi:10.1200/JCO.2007.11.9099.
   PubMed Web of Science ®Google Scholar
• Zschabitz S, Lasitschka F, Hadaschik B, Hofheinz RD, Jentsch-Ullrich K, Gruner M, Jager D, Grullich C. Response to anti-programmed cell death protein-1 antibodies in men treated for platinum refractory germ cell cancer relapsed after high-dose chemotherapy and stem cell transplantation. Eur J Cancer. 2017;76:1–7. doi:10.1016/j.ejca.2017.01.033.
   PubMed Web of Science ®Google Scholar
• Einhorn LH, Williams SD, Chamness A, Brames MJ, Perkins SM, Abonour R. High-dose chemotherapy and stem-cell rescue for metastatic germ-cell tumors. N Engl J Med. 2007;357(4):340–8. doi:10.1056/NEJMoa067749.
   PubMed Web of Science ®Google Scholar
• Lorch A, Kleinhans A, Kramar A, Kollmannsberger CK, Hartmann JT, Bokemeyer C, Rick O, Beyer J. Sequential versus single high-dose chemotherapy in patients with relapsed or refractory germ cell tumors: long-term results of a prospective randomized trial. J Clin Oncol. 2012;30(8):800–5. doi:10.1200/JCO.2011.38.6391.
   PubMed Web of Science ®Google Scholar
• Miyai K, Yamamoto S, Asano T, Tamai S, Matsubara O, Tsuda H. Protein overexpression and gene amplification of epidermal growth factor receptor in adult testicular germ cell tumors: potential role in tumor progression. Cancer Sci. 2010;101(9):1970–6. doi:10.1111/j.1349-7006.2010.01638.x.
   PubMed Web of Science ®Google Scholar
• Tang W, Weng S, Zhang S, Wu W, Dong L, Shen X, Zhang S, Gu J, Xue R. Direct interaction between surface beta1,4-galactosyltransferase 1 and epidermal growth factor receptor (EGFR) inhibits EGFR activation in hepatocellular carcinoma. Biochem Biophys Res Commun. 2013;434(3):449–54. doi:10.1016/j.bbrc.2013.03.094.
   PubMed Web of Science ®Google Scholar