Advanced search
Publication Cover
OncoImmunology Volume 8, 2019 - Issue 11
Submit an article Journal homepage
1,505
Views
8
CrossRef citations to date
0
Altmetric
Author's View

Extracellular vesicles released by ovarian carcinoma contain arginase 1 that mitigates antitumor immune response

Anna SosnowskaDepartment of Immunology, Medical University of Warsaw, Warsaw, Poland;Postgraduate School of Molecular Medicine, Medical University of Warsaw, Warsaw, PolandORCID Iconhttps://orcid.org/0000-0002-8939-6157
ORCID Icon,
Malgorzata Czystowska-KuzmiczDepartment of Immunology, Medical University of Warsaw, Warsaw, PolandORCID Iconhttps://orcid.org/0000-0001-9169-6194
ORCID Icon &
Jakub GolabDepartment of Immunology, Medical University of Warsaw, Warsaw, Poland;Centre for Preclinical Research and Technology, Medical University of Warsaw, Warsaw, PolandCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-2830-5100
ORCID Icon
Article: e1655370 | Received 02 Aug 2019, Accepted 09 Aug 2019, Published online: 20 Aug 2019

References

  • Alipour S, Zoghi S, Khalili N, Hirbod-Mobarakeh A, Emens LA, Rezaei N. Specific immunotherapy in ovarian cancer: a systematic review. Immunotherapy. 2016;8:1–3. doi:10.2217/imt-2016-0034.
  • Lemos H, Huang L, Prendergast GC, Mellor AL. Immune control by amino acid catabolism during tumorigenesis and therapy. Nature Rev Cancer. 2019;19:162–175. doi:10.1038/s41568-019-0106-z.
  • Miret JJ, Kirschmeier P, Koyama S, Zhu M, Li YY, Naito Y, Wu M, Malladi VS, Huang W, Walker W, et al. Suppression of myeloid cell arginase activity leads to therapeutic response in a NSCLC mouse model by activating anti-tumor immunity. J Immunother Cancer. 2019;7:32. doi:10.1186/s40425-019-0504-5.
  • Ma Z, Lian J, Yang M, Wuyang J, Zhao C, Chen W, Liu C, Zhao Q, Lou C, Han J, et al. Overexpression of Arginase-1 is an indicator of poor prognosis in patients with colorectal cancer. Pathol Res Pract. 2019;215:152383. doi:10.1016/j.prp.2019.03.012.
  • Steggerda SM, Bennett MK, Chen J, Emberley E, Huang T, Janes JR, Li W, MacKinnon AL, Makkouk A, Marguier G, et al. Inhibition of arginase by CB-1158 blocks myeloid cell-mediated immune suppression in the tumor microenvironment. J Immunother Cancer. 2017;5:101. doi:10.1186/s40425-017-0308-4.
  • Thery C, Ostrowski M, Segura E. Membrane vesicles as conveyors of immune responses. Nat Rev Immunol. 2009;9:581–593. doi:10.1038/nri2567.
  • Kosaka N, Kogure A, Yamamoto T, Urabe F, Usuba W, Prieto-Vila M, Ochiya T. Exploiting the message from cancer: the diagnostic value of extracellular vesicles for clinical applications. Exp Mol Med. 2019;51:31. doi:10.1038/s12276-019-0219-1.
  • Hoshino A, Costa-Silva B, Shen TL, Rodrigues G, Hashimoto A, Tesic Mark M, Molina H, Kohsaka S, Di Giannatale A, Ceder S, et al. Tumour exosome integrins determine organotropic metastasis. Nature. 2015;527:329–335. doi:10.1038/nature15756.
  • Dorayappan KDP, Wallbillich JJ, Cohn DE, Selvendiran K. The biological significance and clinical applications of exosomes in ovarian cancer. Gynecol Oncol. 2016;142:199–205. doi:10.1016/j.ygyno.2016.03.036.
  • Czystowska-Kuzmicz M, Sosnowska A, Nowis D, Ramji K, Szajnik M, Chlebowska-Tuz J, Wolinska E, Gaj P, Grazul M, Pilch Z, et al. Small extracellular vesicles containing arginase-1 suppress T-cell responses and promote tumor growth in ovarian carcinoma. Nat Commun. 2019;10:3000. doi:10.1038/s41467-019-10979-3.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.