1,655
Views
4
CrossRef citations to date
0
Altmetric
Review

IL15 synergizes with radiotherapy to reprogram the tumor immune contexture through a dendritic cell connection

ORCID Icon, ORCID Icon, & ORCID Icon
Article: 1790716 | Received 28 Jun 2020, Accepted 29 Jun 2020, Published online: 09 Jul 2020

References

  • Garcia-Martinez E, Smith M, Buque A, Aranda F, de la Pena FA, Ivars A, Canovas MS, Conesa MAV, Fucikova J, Spisek R, et al. Trial Watch: Immunostimulation with recombinant cytokines for cancer therapy. Oncoimmunology. 2018;7:e1433982. doi:10.1080/2162402X.2018.1433982.
  • Cheever MA. Twelve immunotherapy drugs that could cure cancers. Immunol Rev. 2008;222:357–2. doi:10.1111/j.1600-065X.2008.00604.x.
  • Miller JS, Morishima C, McNeel DG, Patel MR, Kohrt HEK, Thompson JA, Sondel PM, Wakelee HA, Disis ML, Kaiser JC, et al. A First-in-Human Phase I Study of Subcutaneous Outpatient Recombinant Human IL15 (rhIL15) in Adults with Advanced Solid Tumors. Clin Cancer Res. 2018;24:1525–1535. doi:10.1158/1078-0432.CCR-17-2451.
  • Steel JC, Waldmann TA, Morris JC. Interleukin-15 biology and its therapeutic implications in cancer. Trends Pharmacol Sci. 2012;33:35–41. doi:10.1016/j.tips.2011.09.004.
  • Bergamaschi C, Pandit H, Nagy BA, Stellas D, Jensen SM, Bear J, Cam M, Valentin A, Fox BA, Felber BK, et al. Heterodimeric IL-15 delays tumor growth and promotes intratumoral CTL and dendritic cell accumulation by a cytokine network involving XCL1, IFN-gamma, CXCL9 and CXCL10. J Immunother Cancer. 2020;8:e000599. doi:10.1136/jitc-2020-000599.
  • Bottcher JP, Reis ESC. The Role of Type 1 Conventional Dendritic Cells in Cancer Immunity. Trends Cancer. 2018;4:784–792. doi:10.1016/j.trecan.2018.09.001.
  • Pilones KA, Charpentier M, Garcia-Martinez E, Daviaud C, Kraynak J, Aryankalayil J, Formenti SC, Demaria S. Radiotherapy cooperates with IL15 to induce antitumor immune responses. Cancer Immunol Res OnlineFirst June. 2020;12:2020. doi:10.1158/2326-6066.CIR-1119-0338.
  • Margolin K, Morishima C, Velcheti V, Miller JS, Lee SM, Silk AW, Holtan SG, Lacroix AM, Fling SP, Kaiser JC, et al. Phase I Trial of ALT-803, A Novel Recombinant IL15 Complex, in Patients with Advanced Solid Tumors. Clin Cancer Res. 2018;24:5552–5561. doi:10.1158/1078-0432.CCR-18-0945.
  • Vanpouille-Box C, Alard A, Aryankalayil MJ, Sarfraz Y, Diamond JM, Schneider RJ, Inghirami G, Coleman CN, Formenti SC, Demaria S. DNA exonuclease Trex1 regulates radiotherapy-induced tumour immunogenicity. Nat Commun. 2017;8:15618. doi:10.1038/ncomms15618.
  • Chen DS, Mellman I. Oncology meets immunology: the cancer-immunity cycle. Immunity. 2013;39:1–10. doi:10.1016/j.immuni.2013.07.012.