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OncoImmunology Volume 10, 2021 - Issue 1
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Research Article

Cancer cells under immune attack acquire CD47-mediated adaptive immune resistance independent of the myeloid CD47-SIRPα axis

Mark A.J.M. Hendriksa Department of Surgery, Laboratory for Translational Surgical Oncology, University of Groningen, University Medical Center Groningen (UMCG), Groningen, The NetherlandsORCID Iconhttps://orcid.org/0000-0001-7276-4622View further author information
ORCID Icon,
Isabel Britscha Department of Surgery, Laboratory for Translational Surgical Oncology, University of Groningen, University Medical Center Groningen (UMCG), Groningen, The NetherlandsORCID Iconhttps://orcid.org/0000-0003-4772-9889View further author information
ORCID Icon,
Xiurong Kea Department of Surgery, Laboratory for Translational Surgical Oncology, University of Groningen, University Medical Center Groningen (UMCG), Groningen, The Netherlands;b Graduate School, Shantou University Medical College, Shantou, Guangdong, ChinaORCID Iconhttps://orcid.org/0000-0002-0640-4466View further author information
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Anne P. van Wijngardena Department of Surgery, Laboratory for Translational Surgical Oncology, University of Groningen, University Medical Center Groningen (UMCG), Groningen, The NetherlandsORCID Iconhttps://orcid.org/0000-0002-8221-1180View further author information
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Douwe F. Samploniusa Department of Surgery, Laboratory for Translational Surgical Oncology, University of Groningen, University Medical Center Groningen (UMCG), Groningen, The NetherlandsORCID Iconhttps://orcid.org/0000-0002-0613-7150View further author information
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Emily M. Ploega Department of Surgery, Laboratory for Translational Surgical Oncology, University of Groningen, University Medical Center Groningen (UMCG), Groningen, The NetherlandsORCID Iconhttps://orcid.org/0000-0002-0735-2020View further author information
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Wijnand Helfricha Department of Surgery, Laboratory for Translational Surgical Oncology, University of Groningen, University Medical Center Groningen (UMCG), Groningen, The NetherlandsCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0001-7004-3995View further author information
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Article: 2005344 | Received 26 Jul 2021, Accepted 03 Nov 2021, Published online: 20 Nov 2021

References

  • Jaiswal S, Jamieson CHM, Pang WW, Park CY, Chao MP, Majeti R, Traver D, van Rooijen N, Weissman IL. Cd47 is upregulated on circulating hematopoietic stem cells and leukemia cells to avoid phagocytosis. Cell. 2009;138(2):271–14. doi:10.1016/j.cell.2009.05.046.
  • Chao MP, Alizadeh AA, Tang C, Jan M, Weissman-Tsukamoto R, Zhao F, Park CY, Weissman IL, Majeti R. Therapeutic antibody targeting of cd47 eliminates human acute lymphoblastic leukemia. Cancer Res. 2011;71(4):1374–1384. doi:10.1158/0008-5472.CAN-10-2238.
  • Willingham SB, Volkmer JP, Gentles AJ, Sahoo D, Dalerba P, Mitra SS, Wang J, Contreras-Trujillo H, Martin R, Cohen JD. The CD47-signal regulatory protein alpha (Sirpa) interaction is a therapeutic target for human solid tumors. Proc Natl Acad Sci U.S.A. 2012;109(17):6662–6667. doi:10.1073/pnas.1121623109.
  • Tseng D, Volkmer JP, Willingham SB, Contreras-Trujillo , H, Fathman, JW, Fernhoff, NB, Seita, J, Inlay, MA, Weiskopf, K, Miyanishi, M, and Weissman, IL, et al. Anti-CD47 antibody–mediated phagocytosis of cancer by macrophages primes an effective antitumor T-cell response. PNAS. 2013;110(27):11103–11108. doi:10.1073/pnas.1305569110.
  • Liu X, Pu Y, Cron K, Deng, L, Kline, J, Frazier, WA, Xu, H, Peng, H, Fu, Y, and Xu, MM, et al. CD47 blockade triggers T cell–mediated destruction of immunogenic tumors. Nat Med. 2015;21(10):1209–1215. doi:10.1038/nm.3931.
  • Soto-Pantoja DR, Terabe M, Ghosh A, Ridnour LA, DeGraff WG, Wink DA, Berzofsky JA, Roberts DD. Cd47 in the tumor microenvironment limits cooperation between antitumor t-cell immunity and radiotherapy. Cancer Res. 2014;74(23):6771–6783. doi:10.1158/0008-5472.CAN-14-0037-T.
  • Logtenberg MEW, Scheeren FA, Schumacher TN. The cd47-sirpα immune checkpoint. Immunity. 2020;52(5):742–752. doi:10.1016/j.immuni.2020.04.011.
  • Hendriks MAJM, Ploeg EM, Koopmans I, Britsch I, Ke X, Samplonius DF, Helfrich W. Bispecific antibody approach for EGFR-directed blockade of the CD47-SIRPα “don’t eat me” immune checkpoint promotes neutrophil-mediated trogoptosis and enhances antigen cross-presentation. OncoImmunology. 2020;9(1):1824323. doi:10.1080/2162402X.2020.1824323.
  • Basile MS, Mazzon E, Russo A, Mammana, S, Longo, A, Bonfiglio, V, Fallico, M, Caltabiano, R, Fagone , P, Nicoletti, F, Avitabile, T, and Reibaldi, M, et al. Differential modulation and prognostic values of immune-escape genes in uveal melanoma. PLoS One. 2019;14:1.
  • Betancur PA, Abraham BJ, Yiu YY, Willingham SB, Khameneh F, Zarnegar M, Kuo AH, McKenna K, Kojima Y, Leeper NJ, et al. A CD47-associated super-enhancer links pro-inflammatory signalling to CD47 upregulation in breast cancer. Nat Commun. 2017;8(1):14802. doi:10.1038/ncomms14802.
  • Vafa O, Gilliland GL, Brezski RJ, Strake B, Wilkinson T, Lacy ER, Scallon B, Teplyakov A, Malia TJ, Strohl WR, et al. An engineered Fc variant of an IgG eliminates all immune effector functions via structural perturbations. Methods. 2014;65(1):114–126. doi:10.1016/j.ymeth.2013.06.035.
  • Al-Akhrass H, Naves T, Vincent F, Magnaudeix A, Durand K, Bertin F, Melloni B, Jauberteau M-O, Lalloué F. Sortilin limits EGFR signaling by promoting its internalization in lung cancer. Nat Commun. 2017;8(1):1182. doi:10.1038/s41467-017-01172-5.
  • Singh R, Letai A, Sarosiek K. Regulation of apoptosis in health and disease: the balancing act of BCL-2 family proteins. Nat Rev Mol Cell Biol. 2019;20(3):175–193. doi:10.1038/s41580-018-0089-8.
  • Leclair P, Liu -C-C, Monajemi M, Reid GS, Sly LM, Lim CJ. CD47-ligation induced cell death in T-acute lymphoblastic leukemia. Cell Death Dis. 2018;9(5):1–14. doi:10.1038/s41419-018-0601-2.
  • Uno S, Kinoshita Y, Azuma Y, Tsunenari T, Yoshimura Y, Iida S, Kikuchi Y, Yamada-Okabe H, Fukushima N. Antitumor activity of a monoclonal antibody against CD47 in xenograft models of human leukemia. Oncol Rep. 2007;17:1189–1194.
  • Sagawa M, Shimizu T, Fukushima N, Kinoshita Y, Ohizumi I, Uno S, Kikuchi Y, Ikeda Y, Yamada-Okabe H, Kizaki M, et al. A new disulfide-linked dimer of a single-chain antibody fragment against human CD47 induces apoptosis in lymphoid malignant cells via the hypoxia inducible factor-1α pathway. Cancer Sci. 2011;102(6):1208–1215. doi:10.1111/j.1349-7006.2011.01925.x.
  • Song KA, Hosono Y, Turner C, Jacob S, Lochmann TL, Murakami Y, Patel NU, Ham J, Hu B, Powell KM, et al. Increased synthesis of MCL-1 protein underlies initial survival of EGFR -mutant lung cancer to EGFR inhibitors and provides a novel drug target. Clin Cancer Res. 2018;24(22):5658–5672. doi:10.1158/1078-0432.CCR-18-0304.
  • Kroesen BJ, Ter Haar A, Spakman H, Willemse P, Sleijfer DT, De Vries EGE, Mulder NH, Berendsen HH, Limburg PC, The TH, et al. Local antitumour treatment in carcinoma patients with bispecific-monoclonal-antibody-redirected T cells. Cancer Immunol Immunother. 1993;37(6):400–407. doi:10.1007/BF01526797.
  • Sanjana NE, Shalem O, Zhang F. Improved vectors and genome-wide libraries for CRISPR screening. Nat Methods. 2014;11(8):783–784. doi:10.1038/nmeth.3047.
  • Kikuchi Y, Uno S, Yoshimura Y, Otabe K, Iida S-I, Oheda M, Fukushima N, Tsuchiya M. A bivalent single-chain Fv fragment against CD47 induces apoptosis for leukemic cells. Biochem Biophys Res Commun. 2004;315(4):912–918. doi:10.1016/j.bbrc.2004.01.128.
  • Wiersma VR, He Y, Samplonius DF, Van Ginkel RJ, Gerssen J, Eggleton P, Zhou J, Bremer E, Helfrich W. A CD47-blocking TRAIL fusion protein with dual pro-phagocytic and pro-apoptotic anticancer activity. Br J Haematol. 2014;164(2):304–307. doi:10.1111/bjh.12617.
  • Cerami E, Gao J, Dogrusoz U, Gross BE, Sumer SO, Aksoy BA, Jacobsen A, Byrne CJ, Heuer ML, Larsson E, et al. The cbio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data. Cancer Discov. 2012;2(5):401–404. doi:10.1158/2159-8290.CD-12-0095.

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