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Brief Report

Reprogramming monocyte-derived macrophages through caspase inhibition

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Article: 2015859 | Received 24 Sep 2021, Accepted 03 Dec 2021, Published online: 30 Dec 2021

References

  • Shapouri-Moghaddam A, Mohammadian S, Vazini H, Taghadosi M, Esmaeili SA, Mardani F, Seifi B, Mohammadi A, Afshari JT, Sahebkar A, et al. Macrophage plasticity, polarization, and function in health and disease. J Cell Physiol. 2018 Sep;233(9):6425–7. doi:10.1002/jcp.26429.
  • Bleriot C, Chakarov S, Ginhoux F. Determinants of resident tissue macrophage identity and function. Immunity. 2020 Jun 16;52(6):957–970. doi:10.1016/j.immuni.2020.05.014.
  • Zhang C, Yang M, Ericsson AC. Function of macrophages in disease: current understanding on molecular mechanisms. Front Immunol. 2021;12:620510. doi:10.3389/fimmu.2021.620510.
  • Ricketts TD, Prieto-Dominguez N, Gowda PS, Ubil E. Mechanisms of macrophage plasticity in the tumor environment: manipulating activation state to improve outcomes. Front Immunol. 2021;12:642285. doi:10.3389/fimmu.2021.642285.
  • Rebe C, Cathelin S, Launay S, Filomenko R, Prevotat L, L’Ollivier C, Gyan E, Micheau O, Grant S, Dubart-Kupperschmitt A, et al. Caspase-8 prevents sustained activation of NF-kappaB in monocytes undergoing macrophagic differentiation. Blood. 2007 Feb 15, 109(4):1442–1450. doi:10.1182/blood-2006-03-011585.
  • Jacquel A, Benikhlef N, Paggetti J, Lalaoui N, Guery L, Dufour EK, Ciudad M, Racoeur C, Micheau O, Delva L, et al. Colony-stimulating factor-1-induced oscillations in phosphatidylinositol-3 kinase/AKT are required for caspase activation in monocytes undergoing differentiation into macrophages. Blood. 2009 Oct 22, 114(17):3633–3641. doi:10.1182/blood-2009-03-208843.
  • Guery L, Benikhlef N, Gautier T, Paul C, Jego G, Dufour E, Jacquel A, Cally R, Manoury B, Vanden Berghe T, et al. Fine-tuning nucleophosmin in macrophage differentiation and activation. Blood. 2011 Oct 27, 118(17):4694–4704. doi:10.1182/blood-2011-03-341255.
  • Cathelin S, Rebe C, Haddaoui L, Simioni N, Verdier F, Fontenay M, Launay S, Mayeux P, Solary E. Identification of proteins cleaved downstream of caspase activation in monocytes undergoing macrophage differentiation. J Biol Chem. 2006 Jun 30;281(26):17779–17788. doi:10.1074/jbc.M600537200.
  • Jacquel A, Obba S, Boyer L, Dufies M, Robert G, Gounon P, Lemichez E, Luciano F, Solary E, Auberger P, et al. Autophagy is required for CSF-1-induced macrophagic differentiation and acquisition of phagocytic functions. Blood. 2012 May 10, 119(19):4527–4531. doi:10.1182/blood-2011-11-392167.
  • Obba S, Hizir Z, Boyer L, Selimoglu-Buet D, Pfeifer A, Michel G, Hamouda M-A, Gonçalvès D, Cerezo M, Marchetti S, et al. The PRKAA1/AMPKalpha1 pathway triggers autophagy during CSF1-induced human monocyte differentiation and is a potential target in CMML. Autophagy. 2015;11(7):1114–1129. doi:10.1080/15548627.2015.1034406.
  • Lee H, Shin EA, Lee JH, Ahn D, Kim CG, Kim JH, et al. Caspase inhibitors: a review of recently patented compounds (2013-2015). Expert Opin Ther Pat. 2018 Jan;28(1):47–59. doi:10.1080/13543776.2017.1378426.
  • Baskin-Bey ES, Washburn K, Feng S, Oltersdorf T, Shapiro D, Huyghe M, Burgart L, Garrity-Park M, van Vilsteren FGI, Oliver LK, et al. Clinical Trial of the Pan-Caspase Inhibitor, IDN-6556, in human liver preservation injury. Am J Transplant. 2007 Jan;7(1):218–225. doi:10.1111/j.1600-6143.2006.01595.x.
  • Chen Y, Jin H, Song Y, Huang T, Cao J, Tang Q, et al. Targeting tumor-associated macrophages: a potential treatment for solid tumors. J Cell Physiol. 2021 May;236(5):3445–3465. doi:10.1002/jcp.30139.
  • Poltavets AS, Vishnyakova PA, Elchaninov AV, Sukhikh GT, Fatkhudinov TK. Macrophage modification strategies for efficient cell therapy. Cells. 2020 Jun 24;9(6):1535. doi:10.3390/cells9061535.