Immunization against TGF-β1 reduces collagen deposition but increases sustained inflammation in a murine asthma model

References

• Yang YC, Zhang N, Van Crombruggen K, Hu GH, Hong SL, Bachert C. Transforming growth factor-beta1 in inflammatory airway disease: a key for understanding inflammation and remodeling. Allergy 2012; 67:1193-202; PMID:22913656; http://dx.doi.org/10.1111/j.1398-9995.2012.02880.x
   PubMed Web of Science ®Google Scholar
• Yoshimura A, Wakabayashi Y, Mori T. Cellular and molecular basis for the regulation of inflammation by TGF-beta. J Biochem 2010; 147:781-92; PMID:20410014; http://dx.doi.org/10.1093/jb/mvq043
   PubMed Web of Science ®Google Scholar
• Li MO, Wan YY, Flavell RA. T cell-produced transforming growth factor-beta1 controls T cell tolerance and regulates Th1- and Th17-cell differentiation. Immunity 2007; 26:579-91; PMID:17481928; http://dx.doi.org/10.1016/j.immuni.2007.03.014
   PubMed Web of Science ®Google Scholar
• Wahl SM. Transforming growth factor-beta: innately bipolar. Curr Opin Immunol 2007; 19:55-62; PMID:17137775; http://dx.doi.org/10.1016/j.coi.2006.11.008
   PubMed Web of Science ®Google Scholar
• Letterio JJ, Roberts AB. Regulation of immune responses by TGF-beta. Annu Rev Immunol 1998; 16:137-61; PMID:9597127; http://dx.doi.org/10.1146/annurev.immunol.16.1.137
   PubMed Web of Science ®Google Scholar
• Tran DQ. TGF-beta: the sword, the wand, and the shield of FOXP3(+) regulatory T cells. J Mol Cell Biol 2012; 4:29-37; PMID:22158907; http://dx.doi.org/10.1093/jmcb/mjr033
   PubMed Web of Science ®Google Scholar
• Shevach EM, Tran DQ, Davidson TS, Andersson J. The critical contribution of TGF-beta to the induction of Foxp3 expression and regulatory T cell function. Eur J Immunol 2008; 38:915-7; PMID:18395859; http://dx.doi.org/10.1002/eji.200738111
   PubMed Web of Science ®Google Scholar
• Halwani R, Al-Muhsen S, Al-Jahdali H, Hamid Q. Role of transforming growth factor-beta in airway remodeling in asthma. Am J Respir Cell Mol Biol 2011; 44:127-33; PMID:20525803; http://dx.doi.org/10.1165/rcmb.2010-0027TR
   PubMed Web of Science ®Google Scholar
• Fattouh R, Jordana M. TGF-beta, eosinophils and IL-13 in allergic airway remodeling: a critical appraisal with therapeutic considerations. Inflamm Allergy Drug Targets 2008; 7:224-36; PMID:19075788; http://dx.doi.org/10.2174/187152808786848388
   PubMedGoogle Scholar
• Crosby LM, Waters CM. Epithelial repair mechanisms in the lung. Am J Physiol Lung Cell Mol Physiol 2010; 298:L715-31; PMID:20363851; http://dx.doi.org/10.1152/ajplung.00361.2009
   PubMed Web of Science ®Google Scholar
• Ohbayashi H, Shimokata K. Matrix metalloproteinase-9 and airway remodeling in asthma. Curr Drug Targets Inflamm Allergy 2005; 4:177-81; PMID:15853739; http://dx.doi.org/10.2174/1568010053586246
   PubMedGoogle Scholar
• Watelet JB, Bachert C, Claeys C, Van Cauwenberge P. Matrix metalloproteinases MMP-7, MMP-9 and their tissue inhibitor TIMP-1: expression in chronic sinusitis vs nasal polyposis. Allergy 2004; 59:54-60; PMID:14674934; http://dx.doi.org/10.1046/j.1398-9995.2003.00364.x
   PubMed Web of Science ®Google Scholar
• Broide DH. Immunologic and inflammatory mechanisms that drive asthma progression to remodeling. J Allergy Clin Immunol 2008; 121:560-70; quiz 71–2; PMID:18328887; http://dx.doi.org/10.1016/j.jaci.2008.01.031
   PubMed Web of Science ®Google Scholar
• Ierodiakonou D, Postma DS, Koppelman GH, Gerritsen J, ten Hacken NH, Timens W, Boezen HM, Vonk JM. TGF-beta1 polymorphisms and asthma severity, airway inflammation, and remodeling. J Allergy Clin Immunol 2013; 131:582-5; PMID:23111237; http://dx.doi.org/10.1016/j.jaci.2012.08.013
   PubMed Web of Science ®Google Scholar
• Zhang Y, Zhang J, Huang J, Li X, He C, Tian C, Peng C, Guo L, Xiao Y, Fan H. Polymorphisms in the transforming growth factor-beta1 gene and the risk of asthma: A meta-analysis. Respirology 2010; 15:643-50; PMID:20409029; http://dx.doi.org/10.1111/j.1440-1843.2010.01748.x
   PubMed Web of Science ®Google Scholar
• Camara J, Jarai G. Epithelial-mesenchymal transition in primary human bronchial epithelial cells is Smad-dependent and enhanced by fibronectin and TNF-alpha. Fibrogenesis Tissue Repair 2010; 3:2; PMID:20051102; http://dx.doi.org/10.1186/1755-1536-3-2
   PubMedGoogle Scholar
• Brown SD, Baxter KM, Stephenson ST, Esper AM, Brown LA, Fitzpatrick AM. Airway TGF-beta1 and oxidant stress in children with severe asthma: association with airflow limitation. J Allergy Clin Immunol 2012; 129:388-96, 96 e1–8; PMID:22206775; http://dx.doi.org/10.1016/j.jaci.2011.11.037
   PubMed Web of Science ®Google Scholar
• Hoshino M, Nakamura Y, Sim JJ. Expression of growth factors and remodelling of the airway wall in bronchial asthma. Thorax 1998; 53:21-7; PMID:9577517; http://dx.doi.org/10.1136/thx.53.1.21
   PubMed Web of Science ®Google Scholar
• Lee CG, Cho SJ, Kang MJ, Chapoval SP, Lee PJ, Noble PW, Yehualaeshet T, Lu B, Flavell RA, Milbrandt J. Early growth response gene 1-mediated apoptosis is essential for transforming growth factor beta1-induced pulmonary fibrosis. J Exp Med 2004; 200:377-89; PMID:15289506; http://dx.doi.org/10.1084/jem.20040104
   PubMed Web of Science ®Google Scholar
• Le AV, Cho JY, Miller M, McElwain S, Golgotiu K, Broide DH. Inhibition of allergen-induced airway remodeling in Smad 3-deficient mice. J Immunol 2007; 178:7310-6; PMID:17513781; http://dx.doi.org/10.4049/jimmunol.178.11.7310
   PubMed Web of Science ®Google Scholar
• Leung SY, Niimi A, Noble A, Oates T, Williams AS, Medicherla S, Protter AA, Chung KF. Effect of transforming growth factor-beta receptor I kinase inhibitor 2,4-disubstituted pteridine (SD-208) in chronic allergic airway inflammation and remodeling. J Pharmacol Exp Ther 2006; 319:586-94; PMID:16888081; http://dx.doi.org/10.1124/jpet.106.109314
   PubMed Web of Science ®Google Scholar
• Bottoms SE, Howell JE, Reinhardt AK, Evans IC, McAnulty RJ. Tgf-Beta isoform specific regulation of airway inflammation and remodelling in a murine model of asthma. PLoS One 2010; 5:e9674; PMID:20300191; http://dx.doi.org/10.1371/journal.pone.0009674
   PubMed Web of Science ®Google Scholar
• Alcorn JF, Rinaldi LM, Jaffe EF, van Loon M, Bates JH, Janssen-Heininger YM, Irvin CG. Transforming growth factor-beta1 suppresses airway hyperresponsiveness in allergic airway disease. Am J Respir Crit Care Med 2007; 176:974-82; PMID:17761617; http://dx.doi.org/10.1164/rccm.200702-334OC
   PubMed Web of Science ®Google Scholar
• McMillan SJ, Xanthou G, Lloyd CM. Manipulation of allergen-induced airway remodeling by treatment with anti-TGF-beta antibody: effect on the Smad signaling pathway. J Immunol 2005; 174:5774-80; PMID:15843580; http://dx.doi.org/10.4049/jimmunol.174.9.5774
   PubMed Web of Science ®Google Scholar
• Nakao A, Miike S, Hatano M, Okumura K, Tokuhisa T, Ra C, Iwamoto I. Blockade of transforming growth factor beta/Smad signaling in T cells by overexpression of Smad7 enhances antigen-induced airway inflammation and airway reactivity. J Exp Med 2000; 192:151-8; PMID:10899902; http://dx.doi.org/10.1084/jem.192.2.151
   PubMed Web of Science ®Google Scholar
• Scherf W, Burdach S, Hansen G. Reduced expression of transforming growth factor beta 1 exacerbates pathology in an experimental asthma model. Eur J Immunol 2005; 35:198-206; PMID:15593298; http://dx.doi.org/10.1002/eji.200425209
   PubMed Web of Science ®Google Scholar
• Fattouh R, Midence NG, Arias K, Johnson JR, Walker TD, Goncharova S, Souza KP, Gregory RC Jr, Lonning S, Gauldie J, et al. Transforming growth factor-beta regulates house dust mite-induced allergic airway inflammation but not airway remodeling. Am J Respir Crit Care Med 2008; 177:593-603; PMID:18174546; http://dx.doi.org/10.1164/rccm.200706-958OC
   PubMed Web of Science ®Google Scholar
• Al-Alawi M, Hassan T, Chotirmall SH. Transforming growth factor beta and severe asthma: a perfect storm. Respir Med 2014; 108:1409-23; PMID:25240764; http://dx.doi.org/10.1016/j.rmed.2014.08.008
   PubMed Web of Science ®Google Scholar
• Ma Y, Guan Q, Bai A, Weiss CR, Hillman CL, Ma A, Zhou G, Qing G, Peng Z. Targeting TGF-beta1 by employing a vaccine ameliorates fibrosis in a mouse model of chronic colitis. Inflamm Bowel Dis 2010; 16:1040-50; PMID:19924805; http://dx.doi.org/10.1002/ibd.21167
   PubMed Web of Science ®Google Scholar
• Ma Y, Halayko AJ, Basu S, Guan Q, Weiss CR, Ma AG, HayGlass KT, Becker AB, Warrington RJ, Peng Z. Sustained suppression of IL-13 by a vaccine attenuates airway inflammation and remodeling in mice. Am J Respir Cell Mol Biol 2013; 48:540-9; PMID:23470628; http://dx.doi.org/10.1165/rcmb.2012-0060OC
   PubMed Web of Science ®Google Scholar
• Lloyd CM, Hawrylowicz CM. Regulatory T cells in asthma. Immunity 2009; 31:438-49; PMID:19766086; http://dx.doi.org/10.1016/j.immuni.2009.08.007
   PubMed Web of Science ®Google Scholar
• Royce SG, Cheng V, Samuel CS, Tang ML. The regulation of fibrosis in airway remodeling in asthma. Mol Cell Endocrinol 2012; 351:167-75; PMID:22266540; http://dx.doi.org/10.1016/j.mce.2012.01.007
   PubMed Web of Science ®Google Scholar
• McParland BE, Macklem PT, Pare PD. Airway wall remodeling: friend or foe? J Appl Physiol (1985) 2003; 95:426-34; PMID:NOT_FOUND; http://dx.doi.org/10.1152/japplphysiol.00159.2003
   PubMed Web of Science ®Google Scholar
• Long Q, Huang W, Yao Y, Yang X, Sun W, Jin X, Li Y, Chu X, Liu C, Peng Z, et al. Virus-like particles presenting interleukin-33 molecules: immunization characteristics and potentials of blockingIL-33/ST2 pathway in allergic airway inflammation. Hum Vaccin Immunother 2014; 10:2303-11; PMID:25424936; http://dx.doi.org/10.4161/hv.29425
   PubMed Web of Science ®Google Scholar