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Review

Intradermal vaccination for infants and children

&
Pages 2447-2455 | Received 22 Jan 2016, Accepted 06 Apr 2016, Published online: 19 Jul 2016

References

  • Kupper TS, Fuhlbrigge RC. Immune surveillance in the skin: mechanisms and clinical consequences. Nat Rev Immunol 2004; 4:211-22; PMID:15039758; http://dx.doi.org/10.1038/nri1310
  • Nestle FO, Di Meglio P, Qin JZ, Nickoloff BJ. Skin immune sentinels in health and disease. Nat Rev Immunol 2009; 9:679-91; PMID:19763149
  • Zehrung D, Jarrahian C, Wales A. Intradermal delivery for vaccine dose sparing: overview of current issues. Vaccine 2013; 31:3392-5; PMID:23176978; http://dx.doi.org/10.1016/j.vaccine.2012.11.021
  • Weniger BG, Glenn GM. Cutaneous vaccination: antigen delivery into or onto the skin. Vaccine 2013; 31:3389-91; PMID:23684830; http://dx.doi.org/10.1016/j.vaccine.2013.05.048
  • Hickling J, Jones R. Intradermal delivery of vaccines: a review of the literature and the potential for development for use in low-and middle-income countries. Program for Appropriate Technology in Health (PATH). Ferney Voltaire 2009; 5–7.
  • Levine MM. Can needle-free administration of vaccines become the norm in global immunization? Nat Med 2003; 9:99-103; PMID:12514720; http://dx.doi.org/10.1038/nm0103-99
  • World Health Organization. Vaccine-preventable diseases. Available at: http://apps.who.int/immunization_monitoring/diseases/en/ (accessed 29 December 2015)
  • Bruce GW, Mark JP. Cutaneous vaccination. In: Plotkin SA, Orenstein WA, Offit PA. Vaccines. 6th ed. Philadelphia: Saunders Elsevier; 2012. p. 1200-1212
  • Kis EE, Winter G, Myschik J. Devices for intradermal vaccination. Vaccine 2012; 30:523-38; PMID:22100637; http://dx.doi.org/10.1016/j.vaccine.2011.11.020
  • Laurent A, Mistretta F, Bottigioli D, Dahel K, Goujon C, Nicolas JF, Hennino A, Laurent PE. Echographic measurement of skin thickness in adults by high frequency ultrasound to assess the appropriate microneedle length for intradermal delivery of vaccines. Vaccine 2007; 25:6423-30; PMID:17640778; http://dx.doi.org/10.1016/j.vaccine.2007.05.046
  • Ploin D, Schwarzenbach F, Dubray C, Nicolas JF, Goujon C, Trong MD, Laurent PE. Echographic measurement of skin thickness in sites suitable for intradermal vaccine injection in infants and children. Vaccine 2011; 29:8438-42; PMID:21821081; http://dx.doi.org/10.1016/j.vaccine.2011.07.111
  • Saitoh A, Aizawa Y, Sato I, Hirano H, Sakai T, Mori M. Skin thickness in young infants and adolescents: Applications for intradermal vaccination. Vaccine 2015; 33:3384-91; PMID:25944297; http://dx.doi.org/10.1016/j.vaccine.2015.04.081
  • Kenney RT, Frech SA, Muenz LR, Villar CP, Glenn GM. Dose sparing with intradermal injection of influenza vaccine. N Engl J Med 2004; 351:2295-301; PMID:15525714; http://dx.doi.org/10.1056/NEJMoa043540
  • Leroux-Roels I, Weber F. Intanza ((R)) 9 microg intradermal seasonal influenza vaccine for adults 18 to 59 years of age. Hum Vaccin Immunother 2013; 9:115-21; PMID:23442585; http://dx.doi.org/10.4161/hv.22342
  • Icardi G, Orsi A, Ceravolo A, Ansaldi F. Current evidence on intradermal influenza vaccines administered by Soluvia licensed micro injection system. Hum Vaccin Immunother 2012; 8:67-75; PMID:22293531; http://dx.doi.org/10.4161/hv.8.1.18419
  • Young F, Marra F. A systematic review of intradermal influenza vaccines. Vaccine 2011; 29:8788-801; PMID:21968444; http://dx.doi.org/10.1016/j.vaccine.2011.09.077
  • Gorse GJ, Falsey AR, Fling JA, Poling TL, Strout CB, Tsang PH. Intradermally-administered influenza virus vaccine is safe and immunogenic in healthy adults 18–64 years of age. Vaccine 2013; 31:2358-65; PMID:23499604; http://dx.doi.org/10.1016/j.vaccine.2013.03.008
  • Frenck RW, Jr, Belshe R, Brady RC, Winokur PL, Campbell JD, Treanor J, Hay CM, Dekker CL, Walter EB, Jr, Cate TR, et al. Comparison of the immunogenicity and safety of a split-virion, inactivated, trivalent influenza vaccine (Fluzone(R)) administered by intradermal and intramuscular route in healthy adults. Vaccine 2011; 29:5666-74; PMID:21699951; http://dx.doi.org/10.1016/j.vaccine.2011.06.010
  • Belshe RB, Newman FK, Cannon J, Duane C, Treanor J, Van Hoecke C, Howe BJ, Dubin G. Serum antibody responses after intradermal vaccination against influenza. N Engl J Med 2004; 351:2286-94; PMID:15525713; http://dx.doi.org/10.1056/NEJMoa043555
  • Troy SB, Kouiavskaia D, Siik J, Kochba E, Beydoun H, Mirochnitchenko O, Levin Y, Khardori N, Chumakov K, Maldonado Y. Comparison of the Immunogenicity of Various Booster Doses of Inactivated Polio Vaccine Delivered Intradermally Versus Intramuscularly to HIV-Infected Adults. J Infect Dis 2015; 211:1969-76; PMID:25567841; http://dx.doi.org/10.1093/infdis/jiu841
  • Nelson KS, Janssen JM, Troy SB, Maldonado Y. Intradermal fractional dose inactivated polio vaccine: a review of the literature. Vaccine 2012; 30:121-5; PMID:22100886; http://dx.doi.org/10.1016/j.vaccine.2011.11.018
  • Wieten RW, Leenstra T, van Thiel PP, van Vugt M, Stijnis C, Goorhuis A, Grobusch MP. Rabies vaccinations: are abbreviated intradermal schedules the future? Clin Infect Dis 2013; 56:414-9; PMID:23042968; http://dx.doi.org/10.1093/cid/cis853
  • Wongsaroj P, Udomchaisakul P, Tepsumethanon S, Khawplod P, Tantawichien T. Rabies neutralizing antibody after 2 intradermal doses on days 0 and 21 for pre-exposure prophylaxis. Vaccine 2013; 31:1748-51; PMID:23370149; http://dx.doi.org/10.1016/j.vaccine.2013.01.035
  • Rabies vaccines. WHO position paper–recommendations. Vaccine 2010; 28:7140-2; PMID:20831913; http://dx.doi.org/10.1016/j.vaccine.2010.08.082
  • Quiambao BP, Dimaano EM, Ambas C, Davis R, Banzhoff A, Malerczyk C. Reducing the cost of post-exposure rabies prophylaxis: efficacy of 0.1 ml PCEC rabies vaccine administered intradermally using the Thai Red Cross post-exposure regimen in patients severely exposed to laboratory-confirmed rabid animals. Vaccine 2005; 23:1709-14; PMID:15705476; http://dx.doi.org/10.1016/j.vaccine.2004.09.027
  • Laurent PE, Bourhy H, Fantino M, Alchas P, Mikszta JA. Safety and efficacy of novel dermal and epidermal microneedle delivery systems for rabies vaccination in healthy adults. Vaccine 2010; 28:5850-6; PMID:20600481; http://dx.doi.org/10.1016/j.vaccine.2010.06.062
  • Roukens AH, Vossen AC, Bredenbeek PJ, van Dissel JT, Visser LG. Intradermally administered yellow fever vaccine at reduced dose induces a protective immune response: a randomized controlled non-inferiority trial. PLoS One 2008; 3:e1993; PMID:18431480; http://dx.doi.org/10.1371/journal.pone.0001993
  • Wilck MB, Seaman MS, Baden LR, Walsh SR, Grandpre LE, Devoy C, Giri A, Kleinjan JA, Noble LC, Stevenson KE, et al. Safety and immunogenicity of modified vaccinia Ankara (ACAM3000): effect of dose and route of administration. J Infect Dis 2010; 201:1361-70; PMID:20350191; http://dx.doi.org/10.1086/651561
  • Atmar RL, Patel SM, Keitel WA. Intanza((R)): a new intradermal vaccine for seasonal influenza. Expert Rev Vaccines 2010; 9:1399-409; PMID:21105776; http://dx.doi.org/10.1586/erv.10.134
  • Gorse GJ, Falsey AR, Ozol-Godfrey A, Landolfi V, Tsang PH. Safety and immunogenicity of a quadrivalent intradermal influenza vaccine in adults. Vaccine 2015; 33:1151-9; PMID:25613721; http://dx.doi.org/10.1016/j.vaccine.2015.01.025
  • Laurent PE, Bonnet S, Alchas P, Regolini P, Mikszta JA, Pettis R, Harvey NG. Evaluation of the clinical performance of a new intradermal vaccine administration technique and associated delivery system. Vaccine 2007; 25:8833-42; PMID:18023942; http://dx.doi.org/10.1016/j.vaccine.2007.10.020
  • Arakane R, Annaka R, Takahama A, Ishida K, Yoshiike M, Nakayama T, Takeshita F. Superior immunogenicity profile of the new intradermal influenza vaccine compared to the standard subcutaneous vaccine in subjects 65 years and older: A randomized controlled phase III study. Vaccine 2015; 33:6650-8; PMID:26519549; http://dx.doi.org/10.1016/j.vaccine.2015.10.088
  • Pileggi C, Lotito F, Bianco A, Nobile CG, Pavia M. Immunogenicity and safety of intradermal influenza vaccine in immunocompromized patients: a meta-analysis of randomized controlled trials. BMC Infect Dis 2015; 15:427; PMID:26466898; http://dx.doi.org/10.1186/s12879-015-1161-z
  • Chiu SS, Peiris JS, Chan KH, Wong WH, Lau YL. Immunogenicity and safety of intradermal influenza immunization at a reduced dose in healthy children. Pediatrics 2007; 119:1076-82; PMID:17545373; http://dx.doi.org/10.1542/peds.2006-3176
  • Chiu SS, Chan KH, Tu W, Lau YL, Peiris JS. Immunogenicity and safety of intradermal versus intramuscular route of influenza immunization in infants less than 6 months of age: a randomized controlled trial. Vaccine 2009; 27:4834-9; PMID:19523908; http://dx.doi.org/10.1016/j.vaccine.2009.05.066
  • Esposito S, Daleno C, Picciolli I, Tagliaferri L, Scala A, Prunotto G, Montinaro V, Galeone C, Principi N. Immunogenicity and safety of intradermal influenza vaccine in children. Vaccine 2011; 29:7606-10; PMID:21855592; http://dx.doi.org/10.1016/j.vaccine.2011.08.021
  • Sugimura T, Ito Y, Tananari Y, Ozaki Y, Maeno Y, Yamaoka T, Kudo Y. Improved antibody responses in infants less than 1 year old using intradermal influenza vaccination. Vaccine 2008; 26:2700-5; PMID:18436353; http://dx.doi.org/10.1016/j.vaccine.2008.03.016
  • Kumagai T, Nagai K, Okui T, Tsutsumi H, Nagata N, Yano S, Nakayama T, Okuno Y, Kamiya H. Poor immune responses to influenza vaccination in infants. Vaccine 2004; 22:3404-10; PMID:15308365; http://dx.doi.org/10.1016/j.vaccine.2004.02.030
  • Adams A, Salisbury DM. Eradicating polio. Science 2015; 350:609; PMID:26542542; http://dx.doi.org/10.1126/science.aad7294
  • Jenkins HE, Aylward RB, Gasasira A, Donnelly CA, Mwanza M, Corander J, Garnier S, Chauvin C, Abanida E, Pate MA, et al. Implications of a circulating vaccine-derived poliovirus in Nigeria. N Engl J Med 2010; 362:2360-9; PMID:20573924; http://dx.doi.org/10.1056/NEJMoa0910074
  • Mohammed AJ, AlAwaidy S, Bawikar S, Kurup PJ, Elamir E, Shaban MM, Sharif SM, van der Avoort HG, Pallansch MA, Malankar P, et al. Fractional doses of inactivated poliovirus vaccine in Oman. N Engl J Med 2010; 362:2351-9; PMID:20573923; http://dx.doi.org/10.1056/NEJMoa0909383
  • Conclusions and recommendations of the Advisory Committee on Poliomyelitis Eradication, Geneva, 27–28 November 2007. Wkly Epidemiol Rec 2008; 83:25-35
  • Salk JE. Recent studies on immunization against poliomyelitis. Pediatrics 1953; 12:471-82; PMID:13111847
  • Salk JE. Studies in human subjects on active immunization against poliomyelitis. I. A preliminary report of experiments in progress. J Am Med Assoc 1953; 151:1081-98; PMID:13034436; http://dx.doi.org/10.1001/jama.1953.02940140013005
  • Hickling J, Jones R, Nundy N. Improving the affordability of inactivated poliovirus vaccines (IPV) for use in low-and middle-income countries. An economic analysis of strategies to reduce the cost of routine IPV immunization. Program for Appropriate Technology in Health (PATH), Seattle 2010.
  • Cadorna-Carlos J, Vidor E, Bonnet MC. Randomized controlled study of fractional doses of inactivated poliovirus vaccine administered intradermally with a needle in the Philippines. Int J Infect Dis 2012; 16:e110-6; PMID:22153001; http://dx.doi.org/10.1016/j.ijid.2011.10.002
  • Resik S, Tejeda A, Lago PM, Diaz M, Carmenates A, Sarmiento L, Alemañi N, Galindo B, Burton A, Friede M, et al. Randomized controlled clinical trial of fractional doses of inactivated poliovirus vaccine administered intradermally by needle-free device in Cuba. J Infect Dis 2010; 201:1344-52; PMID:20350164; http://dx.doi.org/10.1086/651611
  • Estivariz CF, Jafari H, Sutter RW, John TJ, Jain V, Agarwal A, Verma H, Pallansch MA, Singh AP, Guirguis S, et al. Immunogenicity of supplemental doses of poliovirus vaccine for children aged 6–9 months in Moradabad, India: a community-based, randomised controlled trial. Lancet Infect Dis 2012; 12:128-35; PMID:22071249; http://dx.doi.org/10.1016/S1473-3099(11)70190-6
  • Resik S, Tejeda A, Mach O, Fonseca M, Diaz M, Alemany N, Garcia G, Hung LH, Martinez Y, Sutter R. Immune responses after fractional doses of inactivated poliovirus vaccine using newly developed intradermal jet injectors: a randomized controlled trial in Cuba. Vaccine 2015; 33:307-13; PMID:25448109; http://dx.doi.org/10.1016/j.vaccine.2014.11.025
  • Anand A, Zaman K, Estivariz CF, Yunus M, Gary HE, Weldon WC, Bari TI, Steven Oberste M, Wassilak SG, Luby SP, et al. Early priming with inactivated poliovirus vaccine (IPV) and intradermal fractional dose IPV administered by a microneedle device: A randomized controlled trial. Vaccine 2015; 33:6816-22; PMID:26476367; http://dx.doi.org/10.1016/j.vaccine.2015.09.039
  • Resik S, Tejeda A, Sutter RW, Diaz M, Sarmiento L, Alemani N, Garcia G, Fonseca M, Hung LH, Kahn AL, et al. Priming after a fractional dose of inactivated poliovirus vaccine. N Engl J Med 2013; 368:416-24; PMID:23363495; http://dx.doi.org/10.1056/NEJMoa1202541
  • Minor PD. Antigenic structure of picornaviruses. Curr Top Microbiol Immunol 1990; 161:121-54; PMID:2169382
  • Chulasugandha P, Khawplod P, Havanond P, Wilde H. Cost comparison of rabies pre-exposure vaccination with post-exposure treatment in Thai children. Vaccine 2006; 24:1478-82; PMID:16221511; http://dx.doi.org/10.1016/j.vaccine.2005.03.059
  • Chutivongse S, Wilde H, Supich C, Baer GM, Fishbein DB. Postexposure prophylaxis for rabies with antiserum and intradermal vaccination. Lancet 1990; 335:896-8; PMID:1969993; http://dx.doi.org/10.1016/0140-6736(90)90488-Q
  • Briggs DJ, Banzhoff A, Nicolay U, Sirikwin S, Dumavibhat B, Tongswas S, Wasi C. Antibody response of patients after postexposure rabies vaccination with small intradermal doses of purified chick embryo cell vaccine or purified Vero cell rabies vaccine. Bull World Health Organ 2000; 78:693-8; PMID:10859864
  • Wilde H, Khawplod P, Khamoltham T, Hemachudha T, Tepsumethanon V, Lumlerdacha B, Mitmoonpitak C, Sitprija V. Rabies control in South and Southeast Asia. Vaccine 2005; 23:2284-9; PMID:15755612; http://dx.doi.org/10.1016/j.vaccine.2005.01.030
  • Yang Y, Zhang J. An experimental study on the endurance of immunologic memory of intradermal micro-injection with rabies vaccine and boosting immune effect. J Epidemiol 1999; 9:209-15; PMID:10510577; http://dx.doi.org/10.2188/jea.9.209
  • Kamoltham T, Thinyounyong W, Phongchamnaphai P, Phraisuwan P, Khawplod P, Banzhoff A, Malerczyk C. Pre-exposure rabies vaccination using purified chick embryo cell rabies vaccine intradermally is immunogenic and safe. J Pediatr 2007; 151:173-7; PMID:17643772; http://dx.doi.org/10.1016/j.jpeds.2007.02.044
  • Kamoltham T, Thinyounyong W, Khawplod P, Phraisuwan P, Phongchamnaphai P, Anders G, Malerczyk C. Immunogenicity of Simulated PCECV Postexposure Booster Doses 1, 3, and 5 Years after 2-Dose and 3-Dose Primary Rabies Vaccination in Schoolchildren. Adv Prev Med 2011; 2011:403201; PMID:21991438; http://dx.doi.org/10.4061/2011/403201
  • Sabchareon A, Chantavanich P, Pasuralertsakul S, Pojjaroen-Anant C, Prarinyanupharb V, Attanath P, Singhasivanon V, Buppodom W, Lang J. Persistence of antibodies in children after intradermal or intramuscular administration of preexposure primary and booster immunizations with purified Vero cell rabies vaccine. Pediatr Infect Dis J 1998; 17:1001-7; PMID:9849982; http://dx.doi.org/10.1097/00006454-199811000-00007
  • Pengsaa K, Limkittikul K, Sabchareon A, Ariyasriwatana C, Chanthavanich P, Attanath P, Malerczyk C. A three-year clinical study on immunogenicity, safety, and booster response of purified chick embryo cell rabies vaccine administered intramuscularly or intradermally to 12- to 18-month-old Thai children, concomitantly with Japanese encephalitis vaccine. Pediatr Infect Dis J 2009; 28:335-7; PMID:19333080; http://dx.doi.org/10.1097/INF.0b013e3181906351
  • Bryan JP, Sjogren MH, Perine PL, Legters LJ. Low-dose intradermal and intramuscular vaccination against hepatitis B. Clin Infect Dis 1992; 14:697-707; PMID:1532914; http://dx.doi.org/10.1093/clinids/14.3.697
  • Bryan JP, Sjogren MH, Macarthy P, Cox E, Legters LJ, Perine PL. Persistence of antibody to hepatitis B surface antigen after low-dose, intradermal hepatitis B immunization and response to a booster dose. Vaccine 1992; 10:33-8; PMID:1531719; http://dx.doi.org/10.1016/0264-410X(92)90416-H
  • Sangare L, Manhart L, Zehrung D, Wang CC. Intradermal hepatitis B vaccination: a systematic review and meta-analysis. Vaccine 2009; 27:1777-86; PMID:19200451; http://dx.doi.org/10.1016/j.vaccine.2009.01.043
  • Coberly JS, Townsend T, Repke J, Fields H, Margolis H, Halsey NA. Suboptimal response following intradermal hepatitis B vaccine in infants. Vaccine 1994; 12:984-7; PMID:7975851; http://dx.doi.org/10.1016/0264-410X(94)90332-8
  • Egemen A, Aksit S, Kurugol Z, Erensoy S, Bilgic A, Akilli M. Low-dose intradermal versus intramuscular administration of recombinant hepatitis B vaccine: a comparison of immunogenicity in infants and preschool children. Vaccine 1998; 16:1511-5; PMID:9711797; http://dx.doi.org/10.1016/S0264-410X(98)80006-6
  • Bunupuradah T, Ananworanich J, Pancharoen C, Petoumenos K, Prasitsuebsai W, Wongngam W, Wongngam W, Ubolyam S, Sriheara C, Lange J, et al. Randomized study of intradermal compared to intramuscular hepatitis B vaccination in HIV-infected children without severe immunosuppression. Vaccine 2011; 29:2962-7; PMID:21329776; http://dx.doi.org/10.1016/j.vaccine.2011.01.114
  • Leonardi S, Pratico AD, Lionetti E, Spina M, Vitaliti G, La Rosa M. Intramuscular vs intradermal route for hepatitis B booster vaccine in celiac children. World J Gastroenterol 2012; 18:5729-33; PMID:23155313; http://dx.doi.org/10.3748/wjg.v18.i40.5729
  • Pancharoen C, Mekmullica J, Thisyakorn U, Kasempimolporn S, Wilde H, Herzog C. Reduced-dose intradermal vaccination against hepatitis A with an aluminum-free vaccine is immunogenic and can lower costs. Clin Infect Dis 2005; 41:1537-40; PMID:16231271; http://dx.doi.org/10.1086/497266
  • Cutts FT, Clements CJ, Bennett JV. Alternative routes of measles immunization: a review. Biologicals 1997; 25:323-38; PMID:9325001; http://dx.doi.org/10.1006/biol.1997.0103
  • Dhont PA, Albert A, Brenders P, Podwapinska A, Pollet A, Scheveneels D, Tihon F, Verheyden I, Victor J, Samson SI. Acceptability of Intanza(R) 15 mug intradermal influenza vaccine in Belgium during the 2010–2011 influenza season. Adv Ther 2012; 29:562-77; PMID:22678831; http://dx.doi.org/10.1007/s12325-012-0025-9
  • Foy JE, Hendriksz T, Malouf P, Tobin A. Acceptability of fluzone intradermal vaccine to patients and vaccine administrators. J Am Osteopath Assoc 2013; 113:134-43; PMID:23412675
  • Eizenberg P, Booy R, Naser N, Mason G, Stamboulian D, Weber F. Acceptance of Intanza(R) 9 mug intradermal influenza vaccine in routine clinical practice in Australia and Argentina. Adv Ther 2011; 28:640-9; PMID:21751080; http://dx.doi.org/10.1007/s12325-011-0042-0
  • Prymula R, Usluer G, Altinel S, Sichova R, Weber F. Acceptance and opinions of Intanza/IDflu intradermal influenza vaccine in the Czech Republic and Turkey. Adv Ther 2012; 29:41-52; PMID:22228256; http://dx.doi.org/10.1007/s12325-011-0090-5
  • Durando P, Alicino C, Alberti M, Sticchi L, Turello V, Marensi L, Caiazzo AL, Panico MG, Giugliano F, Parlato A, et al. Acceptance and safety of the intradermal influenza vaccine among the elderly in Italy: an on-field national study. Adv Ther 2012; 29:312-26; PMID:22529024; http://dx.doi.org/10.1007/s12325-012-0012-1
  • Hung IF, Levin Y, To KK, Chan KH, Zhang AJ, Li P, Li C, Xu T, Wong TY, Yuen KY. Dose sparing intradermal trivalent influenza (2010/2011) vaccination overcomes reduced immunogenicity of the 2009 H1N1 strain. Vaccine 2012; 30:6427-35; PMID:22910287; http://dx.doi.org/10.1016/j.vaccine.2012.08.014
  • Seidenari S, Giusti G, Bertoni L, Magnoni C, Pellacani G. Thickness and echogenicity of the skin in children as assessed by 20-MHz ultrasound. Dermatology 2000; 201:218-22; PMID:11096192; http://dx.doi.org/10.1159/000018491

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