Adjuvants for allergy immunotherapeutics

References

• Mukherjee M , Stoddart A , Gupta RP , Nwaru BI , Farr A , Heaven M , Fitzsimmons D , Bandyopadhyay A , Aftab C , Simpson CR , et al. The epidemiology, healthcare and societal burden and costs of asthma in the UK and its member nations: analyses of standalone and linked national databases. BMC Med 2016; 14(113):13; PMID:26817443
   PubMed Web of Science ®Google Scholar
• Nwaru BI , Hickstein L , Panesar SS , Muraro A , Werfel T , Cardona V , Dubois AE , Halken S , Hoffmann-Sommergruber K , Poulsen LK , et al. The epidemiology of food allergy in Europe: a systematic review and meta-analysis. Allergy 2014; 69(1):62-75; PMID:24205824; https://doi.org/10.1111/all.12305
   PubMed Web of Science ®Google Scholar
• Turner PJ , Gowland MH , Sharma V , Ierodiakonou D , Harper N , Garcez T , Pumphrey R , Boyle RJ. Increase in anaphylaxis-related hospitalizations but no increase in fatalities: an analysis of United Kingdom national anaphylaxis data, 1992–2012. J Allergy Clin Immunol 2015; 135(4):956-63; PMID:25468198; https://doi.org/10.1016/j.jaci.2014.10.021
   PubMed Web of Science ®Google Scholar
• Grabenhenrich LB , Dolle S , Moneret-Vautrin A , Kohli A , Lange L , Spindler T , Ruëff F , Nemat K , Maris I , Roumpedaki E , et al. Anaphylaxis in children and adolescents: The European Anaphylaxis Registry. J Allergy Clin Immunol 2016; 137(4):1128-37; PMID:26806049; https://doi.org/10.1016/j.jaci.2015.11.015
   PubMed Web of Science ®Google Scholar
• Tejedor-Alonso MA , Moro-Moro M , Mosquera Gonzalez M , Rodriguez-Alvarez M , Perez Fernandez E , Latasa Zamalloa P , Farias Aquino E , Gil Prieto R , Gil de Miguel A . Increased incidence of admissions for anaphylaxis in Spain 1998–2011. Allergy 2015; 70(7):880-3; PMID:25808198; https://doi.org/10.1111/all.12613
   PubMed Web of Science ®Google Scholar
• Nunes C , Pereira AM , Morais-Almeida M . Asthma costs and social impact. Asthma Res Pract 2017; 3:1; PMID:28078100; https://doi.org/10.1186/s40733-016-0029-3
   PubMedGoogle Scholar
• Linneberg AA-O , Dam Petersen K , Hahn-Pedersen J , Hammerby E , Serup-Hansen N , Boxall N . Burden of allergic respiratory disease: a systematic review. Clinical and molecular allergy: CMA 2016; 14:12; PMID:27708552; https://doi.org/10.1186/s12948-016-0049-9
   PubMedGoogle Scholar
• Tavakoli H , FitzGerald JM , Chen W , Lynd L , Kendzerska T , Aaron S , Gershon A , Marra C , Sadatsafavi, M , Canadian Respiratory Research Network . Ten-year trends in direct costs of asthma: a population-based study. Allergy 2017; 72(2):291-9; PMID:27455382; https://doi.org/10.1111/all.12993
   PubMed Web of Science ®Google Scholar
• Caulley L , Thavorn K , Rudmik L , Cameron C , Kilty SJ . Direct costs of adult chronic rhinosinusitis by using 4 methods of estimation: Results of the US Medical Expenditure Panel Survey. J Allergy Clin Immunol 2015; 136(6):1517-22; PMID:26483176; https://doi.org/10.1016/j.jaci.2015.08.037
   PubMed Web of Science ®Google Scholar
• Martino DJ , Prescott SL . Silent mysteries: epigenetic paradigms could hold the key to conquering the epidemic of allergy and immune disease. Allergy 2010; 65(1):7-15; PMID:19796189; https://doi.org/10.1111/j.1398-9995.2009.02186.x
   PubMed Web of Science ®Google Scholar
• Gause WC , Wynn TA , Allen JE . Type 2 immunity and wound healing: evolutionary refinement of adaptive immunity by helminths. Nat Rev Immunol 2013; 13(8):607-614; PMID:23827958; https://doi.org/10.1038/nri3476
   PubMed Web of Science ®Google Scholar
• Palm NW , Rosenstein RK , Medzhitov R . Allergic host defences. Nature 2012; 484(7395):465-472; PMID:22538607; https://doi.org/10.1038/nature11047
   PubMed Web of Science ®Google Scholar
• Finkelman J. Anaphylaxis . Lessons from mouse models allergy. Clin Immunol; 115: 449-57 (2005).
   Google Scholar
• Peck A , Mellins ED . Plasticity of T‐cell phenotype and function: the T helper type 17 example. Immunology 2010; 129(2):147-153; PMID:19922424; https://doi.org/10.1111/j.1365-2567.2009.03189.x
   PubMed Web of Science ®Google Scholar
• Akdis CA , and Akdis M . Mechanisms and treatment of allergic disease in the big picture of regulatory T cells. J Allergy Clin Immunol 2009; 123 4:735-746; https://doi.org/10.1016/j.jaci.2009.02.030
   PubMed Web of Science ®Google Scholar
• Noon L . Prophylactic inoculations against hay fever. Lancet; 1911 1:1572-1573; https://doi.org/10.1016/S0140-6736(00)78276-6
   Google Scholar
• Ragusa, VF and Massolo A . Non-fatal systemic reactions to subcutaneous immunotherapy: a 20-year experience comparison of two 10-year periods. Eur Ann Allergy Clin Immunol 2004; 36(2):52-55; PMID:15061395
   PubMedGoogle Scholar
• Amin, HS , Liss, GM , and Bernstein, DI . Evaluation of near-fatal reactions to allergen immunotherapy injections. J Allergy Clini Immunol 2006; 117(1):169-175; PMID:16387602; https://doi.org/10.1016/j.jaci.2005.10.010
   PubMed Web of Science ®Google Scholar
• National Center for Immunization and Respiratory Diseases . General recommendations on immunization. Recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Recomm Rep 2011; 60:1-64.
   PubMedGoogle Scholar
• Jutel M . International consensus on allergy immunotherapy. J Allergy Clin Immunol 2015;136: 556-568; PMID:26162571; https://doi.org/10.1016/j.jaci.2015.04.047
   PubMed Web of Science ®Google Scholar
• Klimek L , Uhlig J , Mösges R , Rettig K . O Pfaar A high polymerized grass pollen extract is efficacious and safe in randomized double-blind, placebo-controlled study using a novel up-dosing cluster-protocol. Allergy 2014; 69(12): 1629-38. Published online 2014 Oct 6. https://doi.org/10.1111/all.12513
   PubMed Web of Science ®Google Scholar
• Passalacqua G , Canonica GW . Allergen Immunotherapy: History and Future Developments. Immunol Allergy Clin North Am 2016; 36:1-12; PMID:26617223; https://doi.org/10.1016/j.iac.2015.08.001
   PubMed Web of Science ®Google Scholar
• Di Bona D , Plaia A , Leto-Barone MS , La Piana S , Di Lorenzo G . Efficacy of subcutaneous and sublingual immunotherapy with grass allergens for seasonal allergic rhinitis: a meta-analysis-based comparison. J Allergy Clin Immunol 2012; 130:1097-107; PMID:23021885; https://doi.org/10.1016/j.jaci.2012.08.012
   PubMed Web of Science ®Google Scholar
• Nelson HS , Makatsori M , Calderon MA . Subcutaneous Immunotherapy and Sublingual Immunotherapy: Comparative Efficacy, Current and Potential Indications, and Warnings–United States Versus Europe. Immunol Allergy Clin North Am 2016; 36:13-24; PMID:26617224; https://doi.org/10.1016/j.iac.2015.08.005
   PubMed Web of Science ®Google Scholar
• Kiel M , Röder E , Gerth van Wijk R , Al M , Hop W , Rutten-van Mölken M . Real-life compliance and persistence among users of subcutaneous and sublingual allergen immunotherapy. J Allergy Clin Immunol 2013; 132:353-60; PMID:23651609; https://doi.org/10.1016/j.jaci.2013.03.013
   PubMed Web of Science ®Google Scholar
• Dahl R , Kapp A , Colombo G , de Monchy JG , Rak S , Emminger W , Rivas MF , Ribel M , Durham SR . Efficacy and safety of sublingual immunotherapy with grass allergen tablets for seasonal allergic rhinoconjunctivitis. J Allergy Clin Immunol 2006; 118:434-40; PMID:16890769; https://doi.org/10.1016/j.jaci.2006.05.003
   PubMed Web of Science ®Google Scholar
• Didier A , Malling HJ , Worm M , Horak F , Jäger S , Montagut A , André C , de Beaumont O , Melac M . Optimal dose, efficacy, and safety of once-daily sublingual immunotherapy with a 5 grass pollen tablet for seasonal allergic rhinitis. J Allergy Clin Immunol 2007; 120:1338-45; PMID:17935764; https://doi.org/10.1016/j.jaci.2007.07.046
   PubMed Web of Science ®Google Scholar
• Durham SR , Penagos M . Sublingual or subcutaneous immunotherapy for allergic rhinitis?. J Allergy Clin Immunol 2016; 137:339-349; PMID:26853126; https://doi.org/10.1016/j.jaci.2015.12.1298
   PubMed Web of Science ®Google Scholar
• Nurmatov U , Dhami S, Arasi S, Pajno GB, Fernandez-Rivas M, Muraro A, Roberts G, Akdis C, Alvaro-Lozano M, Beyer K, et al. Allergen immunotherapy for IgE-mediated food allergy: A systematic review and meta-analysis. Allergy 72(8):1133-1147; https://doi.org/10.1111/all.13124.
   Google Scholar
• Jones SM , Sicherer SH , Burks AW , Leung DY , Lindblad RW , Dawson P , Henning AK , Berin MC , Chiang D , Vickery BP , et al. Epicutaneous immunotherapy for the treatment of peanut allergy in children and young adults. J Allergy Clin Immunol 2017; 139(4): 1242-1252.e9. https://doi.org/10.1016/j.jaci.2016.08.017
   Web of Science ®Google Scholar
• Hylander T , Larsson O , Petersson-Westin U , Eriksson M , Kumlien Georén S , Winqvist O , Cardell LO . Intralymphatic immunotherapy of pollen-induced rhinoconjunctivitis: a double-blind placebo-controlled trial. Respir Res 2016; 17:10; https://doi.org/10.1186/s12931-016-0324-9
   PubMed Web of Science ®Google Scholar
• Niederberger V , Horak F , Vrtala S , Spitzauer S , Krauth MT , Valent P , Valenta R . Vaccination with genetically engineered allergens prevents progression of allergic disease. Proc Natl Acad Sci 2004; 101:14677-14682; https://doi.org/10.1073/pnas.0404735101
   PubMed Web of Science ®Google Scholar
• Weiss R , Scheiblhofer S , Machado Y , Thalhamer J . New approaches to transcutaneous immunotherapy: targeting dendritic cells with novel allergen conjugates. Curr Opin Allergy Clin Immunol 2013; 13(6):669-76; PMID:24169433; https://doi.org/10.1097/ACI.0b013e328364f4df
   PubMed Web of Science ®Google Scholar
• Weinberger EE , Himly M , Myschik J , Hauser M , Altmann F , Isakovic A , Weiss R . Generation of hypoallergenic neoglycoconjugates for dendritic cell targeted vaccination: A novel tool for specific immunotherapy. J Control Release 2013; 165(2):101-109; PMID:23147517; https://doi.org/10.1016/j.jconrel.2012.11.002
   PubMed Web of Science ®Google Scholar
• King TP , Jim SY , Monsalve RI , Kagey-Sobotka A , Lichtenstein LM , Spangfort MD . Recombinant allergens with reduced allergenicity but retaining immunogenicity of the natural allergens: hybrids of yellow jacket and paper wasp venom allergen antigen 5s. J Immunol 2001; 166:6057-65; PMID:11342623; https://doi.org/10.4049/jimmunol.166.10.6057
   PubMed Web of Science ®Google Scholar
• Valenta R , Campana R , Focke-Tejkl M , Niederberger V . Vaccine development for allergen-specific immunotherapy based on recombinant allergens and synthetic allergen peptides: Lessons from the past and novel mechanisms of action for the future. J Allergy Clin Immunol 2016; 137:351-7; PMID:26853127; https://doi.org/10.1016/j.jaci.2015.12.1299
   PubMed Web of Science ®Google Scholar
• Cornelius C , Schöneweis K , Georgi F , Weber M , Niederberger V , Zieglmayer P , Niespodziana K , Trauner M , Hofer H , Urban S , Valenta R . Immunotherapy with the PreS-based Grass Pollen Allergy Vaccine BM32 Induces Antibody Responses Protecting Against Hepatitis B Infection. EBioMedicine 2016; 11:58-67; PMID:27568223; https://doi.org/10.1016/j.ebiom.2016.07.023
   PubMed Web of Science ®Google Scholar
• Meyer W , Narkus A , Salapatek AM , Häfner D . Double-blind, placebo-controlled, dose-ranging study of new recombinant hypoallergenic Bet v 1 in an environmental exposure chamber. Allergy 2013; 68:724-31; PMID:23621350; https://doi.org/10.1111/all.12148
   PubMed Web of Science ®Google Scholar
• Moingeon P . Adjuvants for allergy vaccines. Hum Vaccin Immunother 2012; 8(10):1492-8; PMID:23095872; https://doi.org/10.4161/hv.21688
   PubMed Web of Science ®Google Scholar
• Chesné J , S.-Schmidt-Weber CB , Esse von-Bieren J . The use of adjuvants for enhancing allergen immunotherapy efficacy. Immunol Allergy Clin North Am 2016; 36:125-45.
   PubMed Web of Science ®Google Scholar
• Brehler R . [Adjuvants]. Der Hautarzt. 2017; 68(4):292-296.
   Google Scholar
• Klimek L , Schmidt-Weber CB , Kramer MF , Skinner MA , Heath MD . Clinical use of adjuvants in allergen-immunotherapy. Expert Rev Clin Immunol 2017; 13(6):599-610; PMID:28162007; https://doi.org/10.1080/1744666X.2017.1292133
   PubMed Web of Science ®Google Scholar
• Leynadier F , Banoun L , Dollois B , Terrier P , Epstein M , Guinnepain MT , Firon D , Traube C , Fadel R , André C . Immunotherapy with a calcium phosphate-adsorbed five-grass-pollen extract in seasonal rhinoconjunctivitis: a double-blind, placebo-controlled study. Clin Exp Allergy 2001; 31(7):988-96; PMID:11467988; https://doi.org/10.1046/j.1365-2222.2001.01145.x
   PubMed Web of Science ®Google Scholar
• Wilcock, LK , Francis JN , and Durham SR . Aluminium hydroxide down-regulates T helper 2 responses by allergen-stimulated human peripheral blood mononuclear cells. Clin Exp Allergy 2004; 34(9):1373-8; PMID:15347369; https://doi.org/10.1111/j.1365-2222.2004.02052.x
   PubMed Web of Science ®Google Scholar
• Kramer MF , Heath, MD . Aluminium in allergen-specific subcutaneous immunotherapy - a german perspective. Vaccine 2014; 32:4140-8; PMID:24892252; https://doi.org/10.1016/j.vaccine.2014.05.063
   PubMed Web of Science ®Google Scholar
• Jensen-Jarolim E . Aluminium in Allergies and Allergen immunotherapy. World Allergy Organ J 2015; 8(1):7; PMID:25780491; https://doi.org/10.1186/s40413-015-0060-5
   PubMed Web of Science ®Google Scholar
• Lauren CTBD , Morel KD , LaRussa P . Case Report of Subcutaneous Nodules and Sterile Abscesses Due to Delayed Type Hypersensitivity to Aluminum-Containing Vaccines. Pediatrics 2016; 138: pii: e20141690.
   Web of Science ®Google Scholar
• Perricone C , Colafrancesco S , Mazor RD , Soriano A , Agmon-Levin N , Shoenfeld Y . Corrigendum to “Autoimmune/inflammatory syndrome induced by adjuvants (ASIA) 2013: Unveiling the pathogenic, clinical and diagnostic aspects” [J. Autoimmun. 47C (2013) 1–16]. J Autoimmun 2016; 72:126; PMID:27269045
   PubMed Web of Science ®Google Scholar
• Soriano A , Nesher G , Shoenfeld Y . Predicting post-vaccination autoimmunity: who might be at risk? Pharmacol Res 2015; 92:18-22.
   PubMed Web of Science ®Google Scholar
• Baldrick P , Richardson D , Wheeler AW . Review of L -Tyrosine Confirming its Safe Human Use as an Adjuvant. Journal of Applied Toxicology 2002; 22:333-44; PMID:12355563; https://doi.org/10.1002/jat.869
   PubMed Web of Science ®Google Scholar
• Wheeler AW , Moran DM , Robins BE , Driscoll A . L-Tyrosine as an immunological adjuvant. Int Arch Allergy Appl Immun 1982; 69:113-9; https://doi.org/10.1159/000233157
   PubMedGoogle Scholar
• Wheeler AW , Woroniecki SR . Immunological adjuvants in allergy vaccines: past, present and future. Allergol Int 2001; 50(4):295-301; https://doi.org/10.1046/j.1440-1592.2001.00230.x
   Google Scholar
• Baldrick P , Richardson, D , Wheeler AW . Review of l-tyrosine confirming its safe human use as an adjuvant. J Appl Toxicol 2002; 22:333-44.
   PubMed Web of Science ®Google Scholar
• DuBuske LM , Frew, AJ , Horak, F , Keith PK , Corrigan CJ , Aberer W , Holdich T , von Weikersthal-Drachenberg KJ . Ultrashort-specific immunotherapy successfully treats seasonal allergic rhinoconjunctivitis to grass pollen. Allergy Asthma Proc 2011; 32:239-47; PMID:21535913; https://doi.org/10.2500/aap.2011.32.3453
   PubMed Web of Science ®Google Scholar
• Irache JM , Esparza I , Gamazo C , Agüeros M , Espuelas, S . Nanomedicine: novel approaches in human and veterinary therapeutics. Vet Parasitol 2011;180(1–2):47-71; PMID:21680101; https://doi.org/10.1016/j.vetpar.2011.05.028
   PubMed Web of Science ®Google Scholar
• O'Neill LAJ , Golenbock D and Bowie AG . The history of Toll-like receptors, redefining innate immunity. Nature Reviews Immunology 2013; 13:453-60; PMID:23681101; https://doi.org/10.1038/nri3446
   PubMed Web of Science ®Google Scholar
• Elinav E , Strowig T , Henao-Mejia J , Flavell RA . Regulation of the antimicrobial response by NLR proteins. Immunity 2011; 34:665-79; PMID:21616436; https://doi.org/10.1016/j.immuni.2011.05.007
   PubMed Web of Science ®Google Scholar
• Loo Y-M , Gale M . Immune signaling by RIG-I-like receptors. Immunity 2011;34:680-92; PMID:21616437; https://doi.org/10.1016/j.immuni.2011.05.003
   PubMed Web of Science ®Google Scholar
• Taro K and Akira S . The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors. Nature Immunology 2010; 11,373-84; PMID:20404851; https://doi.org/10.1038/ni.1863
   PubMed Web of Science ®Google Scholar
• O'Hagan DT. , De Gregorio E . The path to a successful vaccine adjuvant. The long and winding road. Drug Discovery Today 2009; 14:541-51; https://doi.org/10.1016/j.drudis.2009.02.009
   PubMed Web of Science ®Google Scholar
• Rosewich MGK , Zielen S , Schubert R , Schulze J . Induction of Bronchial Tolerance After 1 Cycle of Monophosphoryl-A-Adjuvanted SpecificImmunotherapy in Children With Grass Pollen Allergies. Allergy Asthma Immunol Res 2016; 8:253-67.
   Web of Science ®Google Scholar
• Mothes N1HM , Drachenberg KJ , Sperr WR , Krauth MT , Majlesi Y , Semper H , Valent P , Niederberger V , Kraft D , Valenta R . Allergen-specific immunotherapy with a monophosphoryl lipid A-adjuvanted vaccine: reduced seasonally boosted immunoglobulin E production and inhibition of basophil histamine release by therapy-induced blocking antibodies. Clin Exp Allergy 2003; 33:1198-208… PMID:12956739
   PubMed Web of Science ®Google Scholar
• Gómez S , Gamazo C , San Román B , Ferrer M , Sanz ML , Espuelas S , Irache JM . Allergen immunotherapy with nanoparticles containing lipopolysaccharide from Brucella ovis. Eur. J. Pharm. Biopharm 2008; 70:711-717; PMID:18582571; https://doi.org/10.1016/j.ejpb.2008.05.016
   PubMed Web of Science ®Google Scholar
• Burdette DL , and Vance RE . STING and the innate immune response to nucleic acids in the cytosol. Nat Immunol 2013; 14: 19-26; PMID:23238760; https://doi.org/10.1038/ni.2491
   PubMed Web of Science ®Google Scholar
• Creticos PS , Schroeder, JT , Hamilton RG , Balcer-Whaley SL , Khattignavong AP , Lindblad R , Li H , Coffman R , Seyfert V , Eiden JJ , et al. Immunotherapy with a ragweed–toll-like receptor 9 agonist vaccine for allergic rhinitis. N Engl J Med 2006; 355:1445-55.
   PubMed Web of Science ®Google Scholar
• Klimek L , Bachmann MF , Senti G , Kündig TM . Immunotherapy of type-1 allergies with virus-like particles and CpG-motifs. Expert Rev Clin Immunol 2014;. 10(8):1059-67.
   PubMed Web of Science ®Google Scholar
• Tang ML , Ponsonby, AL , Orsini F , Tey D , Robinson M , Su EL , Licciardi P , Burks W , Donath S . Administration of a probiotic with peanut oral immunotherapy: a randomized trial. J Allergy Clin Immunol 2015; 135:737–44…; PMID:25592987; https://doi.org/10.1016/j.jaci.2014.11.034
   PubMed Web of Science ®Google Scholar
• Ghadimi DF-HR , de Vrese M , Winkler P , Heller KJ , Schrezenmeir J . Effects of probiotic bacteria and their genomic DNA on Th1/Th2-cytokine production by peripheral blood mononuclear cells (PBMCs) of healthy and allergic subjects. Immunobiology 2008; 213:677-92; PMID:18950596; https://doi.org/10.1016/j.imbio.2008.02.001
   PubMed Web of Science ®Google Scholar
• Zahra Aryan, EC , Giorgio Walter Canonica , Nima Rezaei . Allergen-specific immunotherapy in asthmatic children: from the basis to clinical applications. Clin Exp Vaccines 2013; 12:639-59; https://doi.org/10.1586/erv.13.45
   PubMed Web of Science ®Google Scholar
• Petrarca C , Clemente E , Amato V , Gatta A , Cortese S , Lamolinara A , Rossi C , Zanotta S , Mistrello G , Paganelli R , et al. Vitamin D3 improves the effects of low dose Der p 2 allergoid treatment in Der p 2 sensitized BALB/c mice. Clin Mol Allergy 2016; 14:7.
   PubMedGoogle Scholar
• Baris S. , Kiykim A. , Ozen A. , Tulunay A. , Karakoc-Aydiner E. , Barlan, IB . -Vitamin D as an adjunct to subcutaneous allergen immunotherapy in asthmatic children sensitized to house dust mite. Allergy 2014; 69(2):246-53; PMID:24180595; https://doi.org/10.1111/all.12278
   PubMed Web of Science ®Google Scholar
• Jerzynsak J , Stelmach W , Rychlik B , Lechańska J , Podlecka D , Stelmach I . The clinical effect of vitamin D Supplementation combined with grass-specific sublingual immunotherapy in children with allergic rhinitis. Allergy Asthma Proc 2016; 37:105-14; PMID:26932169; https://doi.org/10.2500/aap.2016.37.3921
   PubMed Web of Science ®Google Scholar
• Penna G , Adorini L . 1 Alpha, 25-di-hydroxyvitamin D3 inhibits differentiation,maturation, activation, and survival of den-dritic cells leading to impaired alloreactive Tcell activation. J Immunol 2000; 164:2405-11; PMID:10679076; https://doi.org/10.4049/jimmunol.164.5.2405
   PubMed Web of Science ®Google Scholar
• Cantorna MT , Snyder L , Lin YD , Yang L . Vitamin D and 1,25(OH)2D regulation of T cells. Nutrients 2015; 7(4):3011-21; https://doi.org/10.3390/nu7043011
   PubMed Web of Science ®Google Scholar
• van Hemelen D . Adjuvants for immunotherapy: lost in translation? Clin Exp Allergy 2009; 39(12):1783-5; https://doi.org/10.1111/j.1365-2222.2009.03396.x
   PubMed Web of Science ®Google Scholar
• Schöll I , Weissenböck, A , Förster-Waldl, E , Untersmayr E , Walter F , Willheim M , Boltz-Nitulescu G , Scheiner O , Gabor F , Jensen-Jarolim E . Allergen-loaded biodegradable poly(D,L-lactic-coglycolic) acid nanoparticles down-regulate an ongoing Th2 response in the BALB/c mouse model. Clin Exp Allergy 2004; 34:315-21; PMID:14987314; https://doi.org/10.1111/j.1365-2222.2004.01884.x
   PubMed Web of Science ®Google Scholar
• Sanders MT , Brown, LE , Deliyannis, G , Pearse MJ . ISCOM-based vaccines: the second decade. Immunol Cell Biol 2005; 83:119-28; PMID:15748208; https://doi.org/10.1111/j.1440-1711.2005.01319.x
   PubMed Web of Science ®Google Scholar
• Yoksan R , Chirachanchai S . Amphiphilic chitosan nanosphere: studies on formation, toxicity, and guest molecule incorporation. Bioorg Med Chem 2008; 16(5):2687-96; PMID:18061462; https://doi.org/10.1016/j.bmc.2007.11.037
   PubMed Web of Science ®Google Scholar
• Ojer P , de Cerain AL , Areses P , Peñuelas I , Irache JM . Toxicity studies of poly(anhydride) nanoparticles as carriers for oral drug delivery. Pharm Res 2012; 29(9):2615-27; PMID:22638871; https://doi.org/10.1007/s11095-012-0791-8
   PubMed Web of Science ®Google Scholar
• Schöll I , Kopp T , Bohle B , Jensen-Jarolim E . Biodegradable PLGA particles for improved systemic and mucosal treatment of Type I allergy. Immunol Allergy Clin N Am 2006; 26:349-64; https://doi.org/10.1016/j.iac.2006.02.007
   PubMed Web of Science ®Google Scholar
• Pandey RS , Sahu S , Sudheesh MS , Madan J , Kumar M , Dixit VK . Carbohydrate modified ultrafine ceramic nanoparticles for allergen immunotherapy. Int Immunopharmacol 2011; 11:925-31; PMID:21333772; https://doi.org/10.1016/j.intimp.2011.02.004
   PubMed Web of Science ®Google Scholar
• Wang CQ , Wu JL , Zhuo RX , Cheng SX . Protamine sulfate-calcium carbonate-plasmid DNA ternary nanoparticles for efficient gene delivery. Mol Biosyst 2014; 10(3):672-8; PMID:24442276; https://doi.org/10.1039/c3mb70502a
   PubMed Web of Science ®Google Scholar
• Nouri HR , Varasteh A , Jaafari MR , Davies JM , Sankian M . Induction of a Th1 immune response and suppression of IgE via immunotherapy with a recombinant hybrid molecule encapsulated in liposome-protamine-DNA nanoparticles in a model of experimental allergy. Immunol Res 2015; 62(3):280-91; https://doi.org/10.1007/s12026-015-8659-8
   PubMed Web of Science ®Google Scholar
• Pali-Schöll I , Szöllösi H , Starkl P , Scheicher B , Stremnitzer C , Hofmeister A , Roth-Walter F , Lukschal A , Diesner SC , Zimmer A , Jensen-Jarolim E . Protamine nanoparticles with CpG-oligodeoxynucleotide prevent an allergen-induced Th2-response in BALB/c mice. Eur J Pharm Biopharm 2013; 85 656-64; PMID:23523543; https://doi.org/10.1016/j.ejpb.2013.03.003
   PubMed Web of Science ®Google Scholar
• Beilvert F , Tissot A , Langelot M , Mevel M , Chatin B , Lair D , Magnan A , Pitard B . DNA/amphiphilic block copolymer nanospheres reduce asthmatic response in a mouse model of allergic asthma. Hum Gene Ther 2012; 23:597-608; PMID:22429072; https://doi.org/10.1089/hum.2012.024
   PubMed Web of Science ®Google Scholar
• Gamazo CGG , Ferrer M , Sanz ML , Irache JM . Nanoparticle based-immunotherapy against allergy. Immunotherapy 2014(6):885-97; PMID:25290419; https://doi.org/10.2217/imt.14.63
   PubMed Web of Science ®Google Scholar
• Pecquet S , Leo E , Fritsche R , Pfeifer A , Couvreur P , Fattal E . Oral tolerance elicited in mice by β-lactoglobulin entrapped in biodegradable microspheres. Vaccine 2000; 18:1196-202; PMID:10649620; https://doi.org/10.1016/S0264-410X(99)00384-9
   PubMed Web of Science ®Google Scholar
• Srivastava KD , Siefert A , Fahmy TM , Caplan MJ , Li XM , Sampson HA . Investigation of peanut oral immunotherapy with CpG/peanut nanoparticles in a murine model of peanut allergy. J Allergy Clin Immunol 2016; https://doi.org/10.1016/j.jaci.2016.01.047
   Web of Science ®Google Scholar
• Bohle B , Jahn-Schmid B , Maurer D , Kraft D , Ebner C . Oligodeoxynucleotides containing CpG motifs induce IL-12, IL-18 and IFN-g production in cells from allergic individuals and inhibit IgE synthesis in vitro. Eur J Immunol 1999; 29:2344-53; PMID:10427997; https://doi.org/10.1002/(SICI)1521-4141(199907)29:07%3c2344::AID-IMMU2344%3e3.0.CO;2-R
   PubMed Web of Science ®Google Scholar
• Ochoa J , Irache JM , Tamayo I , Walz A , DelVecchio VG , Gamazo C . Protective immunity of biodegradable nanoparticle-based vaccine against an experimental challenge with Salmonella Enteritidis in mice. Vaccine 2007; 25:4410-19; PMID:17434651; https://doi.org/10.1016/j.vaccine.2007.03.025
   PubMed Web of Science ®Google Scholar
• Gómez S , Gamazo C , San Roman B , Vauthier C , Ferrer M , Irache JM . Development of a novel vaccine delivery system based on Gantrez nanoparticles. J Nanosci Nanotechnol 2006; 6:3283-3289; https://doi.org/10.1166/jnn.2006.471
   PubMed Web of Science ®Google Scholar
• Camacho AI , Da Costa Martins R , Tamayo I , de Souza J , Lasarte JJ , Mansilla C , Esparza I , Irache JM , Gamazo C . Poly(methyl vinyl ether-co-maleic anhydride) nanoparticles as innate immune system activators. Vaccine 2011; 29:7130-5; PMID:21651945; https://doi.org/10.1016/j.vaccine.2011.05.072
   PubMed Web of Science ®Google Scholar
• Denzel A , Maus UA , Rodriguez Gomez M , Moll C , Niedermeier M , Winter C , Maus R , Hollingshead S , Briles DE , Kunz-Schughart LA , et al. Basophils enhance immunological memory responses. Nat Immunol 2008; 9:733-42; PMID:18516038; https://doi.org/10.1038/ni.1621
   PubMed Web of Science ®Google Scholar
• Gomez S , Gamazo C , San Roman B , Ferrer M , Sanz ML , Irache JM . Gantrez AN nanoparticles as an adjuvant for oral immunotherapy with allergens. Vaccine 2007; 25:5263-71; PMID:17576025; https://doi.org/10.1016/j.vaccine.2007.05.020
   PubMed Web of Science ®Google Scholar
• De Souza Reboucas J , Irache JM , Camacho AI , Gastaminza G , Sanz ML , Ferrer M , Gamazo C . Immunogenicity of peanut proteins containing poly(anhydride) nanoparticles. Clin Vaccine Immunol 2014; 21:1106-12; PMID:24899075; https://doi.org/10.1128/CVI.00359-14
   PubMed Web of Science ®Google Scholar
• Carroll EC , Jin L , Mori A , Munoz-Wolf N , Oleszycka E , Moran HB , Mansouri S , McEntee CP , Lambe E , Agger EM , et al. The vaccine adjuvant chitosan promotes cellular immunity via DNA sensor cGAS-STING-dependent induction of type I interferons. Immunity 2016; 44:597-608; PMID:26944200; https://doi.org/10.1016/j.immuni.2016.02.004
   PubMed Web of Science ®Google Scholar
• Sogias IA , Williams AC , Khutoryanskiy VV . Why is chitosan mucoadhesive? Biomacromolecules 2008; 9(7):1837-42.
   PubMed Web of Science ®Google Scholar
• Roy K , Mao HQ , Huang SK , Leong KW . Oral gene delivery with chitosan–DNA nanoparticles generates immunologic protection in a murine model of peanut allergy. Nat Med 1999; 5:387-91; PMID:10202926; https://doi.org/10.1038/7385
   PubMed Web of Science ®Google Scholar
• Chew JL , Wolfowicz CB , Mao HQ , Leong KW , Chua KY . Chitosan nanoparticles containing plasmid DNA encoding house dust mite allergen, Der p 1 for oral vaccination in mice. Vaccine 2003; 21:2720-29; PMID:12798609; https://doi.org/10.1016/S0264-410X(03)00228-7
   PubMed Web of Science ®Google Scholar
• Li GP , Liu ZG , Liao B , Zhong NS . Induction of Th1-type immune response by chitosan nanoparticles containing plasmid DNA encoding house dust mite allergen Der p 2 for oral vaccination in mice. Cell Mol. Immunol 2009; 6:45-50; PMID:19254479; https://doi.org/10.1038/cmi.2009.6
   PubMed Web of Science ®Google Scholar
• Chesné J , Schmidt-Weber CB , Esser von-Bieren J . The use of adjuvants for enhancing allergen immunotherapy efficacy. Immunol Allergy Clin North Am 2016; 36(1):125-45; PMID:26617231; https://doi.org/10.1016/j.iac.2015.08.009
   PubMed Web of Science ®Google Scholar
• Mold M , Shardlow E , Exley C . Insight into the cellular fate and toxicity of aluminium adjuvants used in clinically approved human vaccinations. Sci Rep 2016; 6:31578; PMID:27515230; https://doi.org/10.1038/srep31578
   PubMed Web of Science ®Google Scholar
• Committee World Health Organization Vaccine Safety Advisory . Macrophagic myofasciitis and aluminum-containing vaccines. Wkly Epidemiol Rec 1999; 74:338-40.
   Google Scholar
• Gherardi RK , Aouizerate J , Cadusseau J , Yara S , Authier FJ . Morphologie. Aluminum adjuvants of vaccines injected into the muscle: Normal fate, pathology and associated disease. Morphologie 2016; 100(329):85-94; https://doi.org/10.1016/j.morpho.2016.01.002
   PubMedGoogle Scholar
• De Souza Rebouças J , Esparza I , Ferrer M , Sanz ML , Irache JM , Gamazo C . Nanoparticulate adjuvants and delivery systems for allergen immunotherapy. J Biomed Biotechnol 2012; 2012:474605; PMID:22496608; https://doi.org/10.1155/2012/474605
   PubMed Web of Science ®Google Scholar
• Anderson RC , Fox CB , Dutill TS , Shaverdian N , Evers TL , Poshusta GR , Chesko J , Coler RN , Friede M , Reed SG , et al. Physicochemical characterization and biological activity of synthetic TLR4 agonist formulations. Colloids and Surfaces B: Biointerfaces 2010; 75:123-32; https://doi.org/10.1016/j.colsurfb.2009.08.022
   PubMed Web of Science ®Google Scholar
• Schülke S , Vogel L , Junker AC , Hanschmann KM , Flaczyk A , Vieths S , Scheurer S . A fusion protein consisting of the vaccine adjuvant monophosphoryl lipid A and the allergen ovalbumin boosts allergen-specific Th1, Th2, and Th17 responses in vitro. J Immunol Res 2016; 2016:415-426.
   Web of Science ®Google Scholar
• Johansen P , von Moos S , Mohanan D , Kündig TM , Senti G . New routes for allergen immunotherapy. Hum Vaccin Immunother 2012; 8(10):1525-33; PMID:23095873; https://doi.org/10.4161/hv.21948
   PubMed Web of Science ®Google Scholar
• Irache JM , Salman HH , Gomez S , Espuelas S , Gamazo C . Poly(anhydride) nanoparticles as adjuvants for mucosal vaccination. Frontiers in Bioscience 2010; 2:876-90; https://doi.org/10.2741/s108
   Google Scholar
• Petrovsky, N and Aguilar JC . Vaccine adjuvants: Current state and future trends. Immunology and Cell Biology 2004; 82:488-96; PMID:15479434; https://doi.org/10.1111/j.0818-9641.2004.01272.x
   PubMed Web of Science ®Google Scholar
• Moller C , Dreborg S , Ferdousi HA , Halken S , Høst A , Jacobsen L , Koivikko A , Koller DY , Niggemann B , Norberg LA , et al. Pollen immunotherapy reduces thedevelopment of asthma in children with seasonal rhinoconjunctivitis (the PATstudy). J Allergy Clin Immunol 2002; 109:251-6.
   PubMed Web of Science ®Google Scholar
• Marogna M , Tomassetti D , Bernasconi A , Colombo F , Massolo A , Businco AD , Canonica GW , Passalacqua G , Tripodi S . Preventive effects of sublingual immunotherapy in childhood: an open randomized controlled study. Ann Allergy Asthma Immunol 2008; 101:206-11; PMID:18727478; https://doi.org/10.1016/S1081-1206(10)60211-6
   PubMed Web of Science ®Google Scholar
• Durham SR , Yang WH , Pedersen MR , Johansen N , Rak S . Sublingual immunotherapy with once daily grass-allergen tablets: a randomised controlled trial in seasonal allergic rhinoconjunctivitis. J Allergy Clin Immunol 2006; 117:802; PMID:16630937; https://doi.org/10.1016/j.jaci.2005.12.1358
   PubMed Web of Science ®Google Scholar
• Creticos PS , Maloney J , Bernstein DI , Casale T , Kaur A , Fisher R , Liu N , Murphy K , Nékám K , Nolte H . Randomized controlled trial of a ragweed allergy immunotherapy tablet in North American and European adults. J Allergy Clin Immunol 2013; 131:1342-9; PMID:23622121; https://doi.org/10.1016/j.jaci.2013.03.019
   PubMed Web of Science ®Google Scholar
• Fiocchi A , Burks, W , Bahna, SL , Bielory L , Boyle RJ , Cocco R , Dreborg S , Goodman R , Kuitunen M , Haahtela T , et al. Clinical use of probiotics in pediatric allergy (CUPPA): a World Allergy Organization position paper. World Allergy Organ J 2012; 5:148-67.
   PubMedGoogle Scholar