Interleukin-22, a potent target for treatment of non-autoimmune diseases

References

• Brockmann L, Giannou AD, Gagliani N, Huber S. Regulation of th17 cells and associated cytokines in wound healing, tissue regeneration, and carcinogenesis [J]. Int J Mol Sci. 2017;18(5):1033. doi:10.3390/ijms18051033.
   Web of Science ®Google Scholar
• Kumar P, Thakar MS, Ouyang W, Malarkannan S. Il-22 from conventional nk cells is epithelial regenerative and inflammation protective during influenza infection [J]. Mucosal Immunol. 2013;6(1):69–82. doi:10.1038/mi.2012.49.
   PubMed Web of Science ®Google Scholar
• Sedda S, Marafini I, Figliuzzi MM, Pallone F, Monteleone G. An overview of the role of innate lymphoid cells in gut infections and inflammation [J]. Mediators Inflamm. 2014;2014:235460. doi:10.1155/2014/235460.
   PubMedGoogle Scholar
• Gong F, Wu J, Zhou P, Zhang M, Liu J, Liu Y, Lu X, Liu Z. Interleukin-22 might act as a double-edged sword in type 2 diabetes and coronary artery disease [J]. Mediators Inflamm. 2016;2016:8254797. doi:10.1155/2016/8254797.
   PubMedGoogle Scholar
• Zenewicz LA, Yancopoulos GD, Valenzuela DM, Murphy AJ, Karow M, Flavell RA. Il-22 but not il-17 provides protection to hepatocytes during acute liver inflammation [J]. Immunity. 2007. doi:10.1016/j.immuni.2007.07.023.
   PubMed Web of Science ®Google Scholar
• Graham AC, Carr KD, Sieve AN, Indramohan M, Break TJ, Berg RE. Il-22 production is regulated by il-23 during listeria monocytogenes infection but is not required for bacterial clearance or tissue protection [J]. PLoS One. 2011;6(2):e17171. doi:10.1371/journal.pone.0017171.
   PubMed Web of Science ®Google Scholar
• Fumagalli S, Torri A, Papagna A, Citterio S, Mainoldi F, Foti M. Il-22 is rapidly induced by pathogen recognition receptors stimulation in bone-marrow-derived dendritic cells in the absence of il-23 [J]. Sci Rep. 2016;6:33900. doi:10.1038/srep33900.
   PubMed Web of Science ®Google Scholar
• Chellan B, Yan L, Sontag TJ, Reardon CA, Hofmann Bowman MA. Il-22 is induced by s100/calgranulin and impairs cholesterol efflux in macrophages by downregulating abcg1 [J]. J Lipid Res. 2014;55(3):443–454. doi:10.1194/jlr.M044305.
   PubMed Web of Science ®Google Scholar
• Qin S, Wen J, Bai XC, Chen TY, Zheng RC, Zhou GB, Ma J, Feng JY, Zhong BL, Li YM. Endogenous n-3 polyunsaturated fatty acids protect against imiquimod-induced psoriasis-like inflammation via the il-17/il-23 axis [J]. Mol Med Rep. 2014;9(6):2097–2104. doi:10.3892/mmr.2014.2136.
   PubMed Web of Science ®Google Scholar
• Peterson RA. Regulatory t-cells: diverse phenotypes integral to immune homeostasis and suppression [J]. Toxicol Pathol. 2012;40(2):186–204. doi:10.1177/0192623311430693.
   PubMed Web of Science ®Google Scholar
• Pan HF, Li XP, Zheng SG, Ye DQ. Emerging role of interleukin-22 in autoimmune diseases [J]. Cytokine Growth Factor Rev. 2013;24(1):51–57. doi:10.1016/j.cytogfr.2012.07.002.
   PubMed Web of Science ®Google Scholar
• Li LJ, Gong C, Zhao MH, Feng BS. Role of interleukin-22 in inflammatory bowel disease [J]. World J Gastroenterol. 2014;20(48):18177–18188. doi:10.3748/wjg.v20.i48.18177.
   PubMed Web of Science ®Google Scholar
• Perriard G, Mathias A, Enz L, Canales M, Schluep M, Gentner M, Schaeren-Wiemers N, Du Pasquier RA. Interleukin-22 is increased in multiple sclerosis patients and targets astrocytes [J]. J Neuroinflammation. 2015;12:119. doi:10.1186/s12974-015-0335-3.
   PubMed Web of Science ®Google Scholar
• Alunno A, Carubbi F, Bistoni O, Caterbi S, Bartoloni E, Mirabelli G, Cannarile F, Cipriani P, Giacomelli R, Gerli R. T regulatory and t helper 17 cells in primary sjogren’s syndrome: facts and perspectives [J]. Mediators Inflamm. 2015;2015:243723. doi:10.1155/2015/125380.
   PubMed Web of Science ®Google Scholar
• Yang X, Zheng SG. Interleukin-22: A likely target for treatment of autoimmune diseases [J]. Autoimmun Rev. 2014;13(6):615–620. doi:10.1016/j.autrev.2013.11.008.
   PubMed Web of Science ®Google Scholar
• Kebir H, Kreymborg K, Ifergan I, Dodelet-Devillers A, Cayrol R, Bernard M, Giuliani F, Arbour N, Becher B, Prat A. Human th17 lymphocytes promote blood-brain barrier disruption and central nervous system inflammation [J]. Nat Med. 2007;13(10):1173–1175. doi:10.1038/nm1651.
   PubMed Web of Science ®Google Scholar
• Weng CH, Gupta S, Geraghty P, Foronjy R, Pernis AB. Cigarette smoke inhibits rock2 activation in t cells and modulates il-22 production [J]. Mol Immunol. 2016;71:115–122. doi:10.1016/j.molimm.2016.01.013.
   PubMed Web of Science ®Google Scholar
• Gorzelak-Pabis P, Chalubinski M, Wojdan K, Luczak E, Borowiec M, Broncel M. Il-22 modulates inflammatory properties of human primary aortic smooth muscle cells [J]. Adv Clin Exp Med. 2017;26(3):461–466.
   PubMed Web of Science ®Google Scholar
• Herder C, Kannenberg JM, Carstensen-Kirberg M, Huth C, Meisinger C, Koenig W, Peters A, Rathmann W, Roden M, Thorand B. Serum levels of interleukin-22, cardiometabolic risk factors and incident type 2 diabetes: Kora f4/ff4 study [J]. Cardiovasc Diabetol. 2017;16(1):17. doi:10.1186/s12933-017-0624-5.
   PubMedGoogle Scholar
• Muhl H, Scheiermann P, Bachmann M, Hardle L, Heinrichs A, Pfeilschifter J. Il-22 in tissue-protective therapy [J]. Br J Pharmacol. 2013;169(4):761–771. doi:10.1111/bph.12196.
   PubMed Web of Science ®Google Scholar
• Akiyama T, Tateishi R, Akiyama N, Yoshinaga R, Kobayashi TJ. Positive and negative regulatory mechanisms for fine-tuning cellularity and functions of medullary thymic epithelial cells [J]. Front Immunol. 2015;6:461. doi:10.3389/fimmu.2015.00461.
   PubMed Web of Science ®Google Scholar
• Lindemans CA, Calafiore M, Mertelsmann AM, O’Connor MH, Dudakov JA, Jenq RR, Velardi E, Young LF, Smith OM, Lawrence G, et al. Interleukin-22 promotes intestinal-stem-cell-mediated epithelial regeneration [J]. Nature. 2015;528(7583):560–564. doi:10.1038/nature16460.
   PubMed Web of Science ®Google Scholar
• Sanos SL, Vonarbourg C, Mortha A, Diefenbach A. Control of epithelial cell function by interleukin-22-producing rorgammat+ innate lymphoid cells [J]. Immunology. 2011;132(4):453–465. doi:10.1111/j.1365-2567.2011.03410.x.
   PubMed Web of Science ®Google Scholar
• Dudakov JA, Hanash AM, van den Brink MR. Interleukin-22: immunobiology and pathology [J]. Annu Rev Immunol. 2015;33:747–785. doi:10.1146/annurev-immunol-032414-112123.
   PubMed Web of Science ®Google Scholar
• Dumoutier L, van Roost E, Ameye G, Michaux L, Renauld JC. Il-tif/il-22: genomic organization and mapping of the human and mouse genes [J]. Genes Immun. 2000;1:488–494. doi:10.1038/sj.gene.6363716.
   PubMed Web of Science ®Google Scholar
• Harrington LE, Hatton RD, Mangan PR, Turner H, Murphy TL, Murphy KM, Weaver CT. Interleukin 17-producing cd4+ effector t cells develop via a lineage distinct from the t helper type 1 and 2 lineages [J]. Nat Immunol. 2005;6(11):1123–1132. doi:10.1038/ni1254.
   PubMed Web of Science ®Google Scholar
• Awasthi A, Kuchroo VK. Th17 cells: from precursors to players in inflammation and infection [J]. Int Immunol. 2009;21(5):489–498. doi:10.1093/intimm/dxp021.
   PubMed Web of Science ®Google Scholar
• Pickert G, Neufert C, Leppkes M, Zheng Y, Wittkopf N, Warntjen M, Lehr HA, Hirth S, Weigmann B, Wirtz S, et al. Stat3 links il-22 signaling in intestinal epithelial cells to mucosal wound healing [J]. J Exp Med. 2009;206(7):1465–1472. doi:10.1084/jem.20082683.
   PubMed Web of Science ®Google Scholar
• van Maele L. Tlr5 signaling stimulates the innate production of il-17 and il-22 by cd3(neg)cd127(+) immune cells in spleen and mucosa [J]. 2010;185(2):1177–1185. doi:10.4049/jimmunol.1000115.
   Google Scholar
• Abt MC, Buffie CG, Susac B, Becattini S, Carter RA, Leiner I, Keith JW, Artis D, Osborne LC, Pamer EG. Tlr-7 activation enhances il-22-mediated colonization resistance against vancomycin-resistant enterococcus [J]. Sci Transl Med. 2016;8(327):327ra25. doi:10.1126/scitranslmed.aaf0746.
   PubMed Web of Science ®Google Scholar
• Hardle L, Bachmann M, Bollmann F, Pautz A, Schmid T, Eberhardt W, Kleinert H, Pfeilschifter J, Muhl H. Tristetraprolin regulation of interleukin-22 production [J]. Sci Rep. 2015;5:15112. doi:10.1038/srep15112.
   PubMed Web of Science ®Google Scholar
• Wolk K, Sabat R. Interleukin-22: A novel t- and nk-cell derived cytokine that regulates the biology of tissue cells [J]. Cytokine Growth Factor Rev. 2006;17(5):367–380. doi:10.1016/j.cytogfr.2006.09.001.
   PubMed Web of Science ®Google Scholar
• Wolk K, Kunz S, Witte E, Friedrich M, Asadullah K, Sabat R. Il-22 increases the innate immunity of tissues [J]. Immunity. 2004;21(2):241–254. doi:10.1016/j.immuni.2004.07.007.
   PubMed Web of Science ®Google Scholar
• Wolk K, Haugen HS, Xu W, Witte E, Waggie K, Anderson M, Vom Baur E, Witte K, Warszawska K, Philipp S, et al. Il-22 and il-20 are key mediators of the epidermal alterations in psoriasis while il-17 and ifn-gamma are not [J]. J Mol Med (Berl). 2009;87(5):523–536. doi:10.1007/s00109-009-0457-0.
   PubMed Web of Science ®Google Scholar
• van de Veerdonk FL, Stoeckman AK, Wu G, Boeckermann AN, Azam T, Netea MG, Joosten LA, van der Meer JW, Hao R, Kalabokis V, et al. Il-38 binds to the il-36 receptor and has biological effects on immune cells similar to il-36 receptor antagonist [J]. Proc Natl Acad Sci USA. 2012;109(8):3001–3005. doi:10.1073/pnas.1121534109.
   PubMed Web of Science ®Google Scholar
• Martin JC, Beriou G, Heslan M, Chauvin C, Utriainen L, Aumeunier A, Scott CL, Mowat A, Cerovic V, Houston SA, et al. Interleukin-22 binding protein (il-22bp) is constitutively expressed by a subset of conventional dendritic cells and is strongly induced by retinoic acid [J]. Mucosal Immunol. 2014;7(1):101–113. doi:10.1038/mi.2013.28.
   PubMed Web of Science ®Google Scholar
• Wei CC, Ho TW, Liang WG, Chen GY, Chang MS. Cloning and characterization of mouse il-22 binding protein [J]. Genes Immun. 2003;4(3):204–211. doi:10.1038/sj.gene.6363947.
   PubMed Web of Science ®Google Scholar
• Xu W, Presnell SR, Parrish-Novak J, Kindsvogel W, Jaspers S, Chen Z, Dillon SR, Gao Z, Gilbert T, Madden K, et al. A soluble class ii cytokine receptor, il-22ra2, is a naturally occurring il-22 antagonist [J]. Proc Natl Acad Sci USA. 2001;98(17):9511–9516. doi:10.1073/pnas.171303198.
   PubMed Web of Science ®Google Scholar
• Kotenko SV, Izotova LS, Mirochnitchenko OV, Esterova E, Dickensheets H, Donnelly RP, Pestka S. Identification, cloning, and characterization of a novel soluble receptor that binds il-22 and neutralizes its activity [J]. J Immunol. 2001;166(12):7096–7103.
   PubMed Web of Science ®Google Scholar
• Huber S, Gagliani N, Zenewicz LA, Huber FJ, Bosurgi L, Hu B, Hedl M, Zhang W, O’Connor W Jr., Murphy AJ, et al. Il-22bp is regulated by the inflammasome and modulates tumorigenesis in the intestine [J]. Nature. 2012;491(7423):259–263. doi:10.1038/nature11535.
   PubMed Web of Science ®Google Scholar
• Xie MH, Aggarwal S, Ho WH, Foster J, Zhang Z, Stinson J, Wood WI, Goddard AD, Gurney AL. Interleukin (il)-22, a novel human cytokine that signals through the interferon receptor-related proteins crf2-4 and il-22r [J]. J Biol Chem. 2000;275(40):31335–31339. doi:10.1074/jbc.M005304200.
   PubMed Web of Science ®Google Scholar
• Dube S, Matam T, Yen J, Mang HE, Dagher PC, Hato T, Sutton TA. Endothelial stat3 modulates protective mechanisms in a mouse ischemia-reperfusion model of acute kidney injury [J]. J Immunol Res. 2017;2017:4609502. doi:10.1155/2017/5974574.
   PubMedGoogle Scholar
• Lejeune D, Dumoutier L, Constantinescu S, Kruijer W, Schuringa JJ, Renauld JC. Interleukin-22 (il-22) activates the jak/stat, erk, jnk, and p38 map kinase pathways in a rat hepatoma cell line. Pathways that are shared with and distinct from il-10 [J]. J Biol Chem. 2002;277(37):33676–33682. doi:10.1074/jbc.M204204200.
   PubMed Web of Science ®Google Scholar
• Dumoutier L, de Meester C, Tavernier J, Renauld JC. New activation modus of stat3: A tyrosine-less region of the interleukin-22 receptor recruits stat3 by interacting with its coiled-coil domain [J]. J Biol Chem. 2009;284(39):26377–26384. doi:10.1074/jbc.M109.007955.
   PubMed Web of Science ®Google Scholar
• Ren W, Wang Z, Wu Z, Hu Z, Dai F, Chang J, Li B, Liu H, Ruan Y. Jak2/stat3 pathway was associated with the protective effects of il-22 on aortic dissection with acute lung injury [J]. Dis Markers. 2017;2017:1917804. doi:10.1155/2017/1917804.
   PubMedGoogle Scholar
• Moriwaki Y, Takada K, Nagasaki T, Kubo N, Ishii T, Kose K, Kageyama T, Tsuji S, Kawashima K, Misawa H. Il-22/stat3-induced increases in slurp1 expression within psoriatic lesions exerts antimicrobial effects against staphylococcus aureus [J]. PLoS One. 2015;10(10):e0140750. doi:10.1371/journal.pone.0140750.
   PubMed Web of Science ®Google Scholar
• Liang M, Wang J, Chu H, Zhu X, He H, Liu Q, Qiu J, Zhou X, Guan M, Xue Y, et al. Interleukin-22 inhibits bleomycin-induced pulmonary fibrosis [J]. Mediators Inflamm. 2013;2013:209179. doi:10.1155/2013/209179.
   PubMed Web of Science ®Google Scholar
• Simonian PL, Wehrmann F, Roark CL, Born WK, O’Brien RL, Fontenot AP. Gammadelta t cells protect against lung fibrosis via il-22 [J]. J Exp Med. 2010;207(10):2239–2253. doi:10.1084/jem.20100061.
   PubMed Web of Science ®Google Scholar
• Johnson JR, Nishioka M, Chakir J, Risse P-A, Almaghlouth I, Bazarbashi AN, Plante S, Martin JG, Eidelman D, Hamid Q. Il-22 contributes to tgf-β1-mediated epithelial-mesenchymal transition in asthmatic bronchial epithelial cells [J]. Respir Res. 2013. doi:10.1186/1465-9921-14-118.
   Web of Science ®Google Scholar
• McGee HM, Schmidt BA, Booth CJ, Yancopoulos GD, Valenzuela DM, Murphy AJ, Stevens S, Flavell RA, Horsley V. Il-22 promotes fibroblast-mediated wound repair in the skin [J]. J Invest Dermatol. 2013;133(5):1321–1329. doi:10.1038/jid.2012.463.
   PubMed Web of Science ®Google Scholar
• Guo Y, Wu W, Cen Z, Li X, Kong Q, Zhou Q. Il-22-producing th22 cells play a protective role in cvb3-induced chronic myocarditis and dilated cardiomyopathy by inhibiting myocardial fibrosis [J]. Virol J. 2014;11:230. doi:10.1186/s12985-014-0230-z.
   PubMed Web of Science ®Google Scholar
• Radaeva S, Sun R, Pan HN, Hong F, Gao B. Interleukin 22 (il-22) plays a protective role in t cell-mediated murine hepatitis: il-22 is a survival factor for hepatocytes via stat3 activation [J]. Hepatology. 2004;39(5):1332–1342. doi:10.1002/hep.20184.
   PubMed Web of Science ®Google Scholar
• Park O, Wang H, Weng H, Feigenbaum L, Li H, Yin S, Ki SH, Yoo SH, Dooley S, Wang FS, et al. In vivo consequences of liver-specific interleukin-22 expression in mice: implications for human liver disease progression [J]. Hepatology. 2011;54(1):252–261. doi:10.1002/hep.24339.
   PubMed Web of Science ®Google Scholar
• Zenewicz LA, Yancopoulos GD, Valenzuela DM, Murphy AJ, Karow M, Flavell RA. Interleukin-22 but not interleukin-17 provides protection to hepatocytes during acute liver inflammation [J]. Immunity. 2007;27(4):647–659. doi:10.1016/j.immuni.2007.07.023.
   PubMed Web of Science ®Google Scholar
• Paget C, Ivanov S, Fontaine J, Renneson J, Blanc F, Pichavant M, Dumoutier L, Ryffel B, Renauld JC, Gosset P, et al. Interleukin-22 is produced by invariant natural killer t lymphocytes during influenza a virus infection: potential role in protection against lung epithelial damages [J]. J Biol Chem. 2012;287(12):8816–8829. doi:10.1074/jbc.M111.304758.
   PubMed Web of Science ®Google Scholar
• Kong Q, Wu W, Yang F, Liu Y, Xue Y, Gao M, Lai W, Pan X, Yan Y, Pang Y, et al. Increased expressions of il-22 and th22 cells in the coxsackievirus b3-induced mice acute viral myocarditis [J]. Virol J. 2012;9:232. doi:10.1186/1743-422X-9-232.
   PubMed Web of Science ®Google Scholar
• Andrea Sommer MF. Vitamin d regulates cytokine pattern secreted by dendritic cells to promote differentiation of il-22-producing t cells [J]. PLoS One. 2015; 10(6): e0130395.
   PubMedGoogle Scholar
• Ji YW, Mittal SK, Hwang HS, Chang EJ, Lee JH, Seo Y, Yeo A, Noh H, Lee HS, Chauhan SK, et al. Lacrimal gland-derived il-22 regulates il-17-mediated ocular mucosal inflammation [J]. Mucosal Immunol. 2017;10(5):1202–1210. doi:10.1038/mi.2016.119.
   PubMed Web of Science ®Google Scholar
• Hu M, Yang S, Yang L, Cheng Y, Zhang H. Interleukin-22 alleviated palmitate-induced endoplasmic reticulum stress in ins-1 cells through activation of autophagy [J]. PLoS One. 2016;11(1):e0146818. doi:10.1371/journal.pone.0146818.
   PubMed Web of Science ®Google Scholar
• Sziksz E, Pap D, Lippai R, Beres NJ, Fekete A, Szabo AJ, Vannay A. Fibrosis related inflammatory mediators: role of the il-10 cytokine family [J]. Mediators Inflamm. 2015;2015:764641. doi:10.1155/2015/125380.
   PubMed Web of Science ®Google Scholar
• Chan YR, Chen K, Duncan SR, Lathrop KL, Latoche JD, Logar AJ, Pociask DA, Wahlberg BJ, Ray P, Ray A, et al. Patients with cystic fibrosis have inducible il-17+il-22+ memory cells in lung draining lymph nodes [J]. J Allergy Clin Immunol. 2013;131(4):1117–29, 1129 e1-5. doi:10.1016/j.jaci.2012.05.036.
   Web of Science ®Google Scholar
• Ngo VL, Abo H, Maxim E, Harusato A, Geem D, Medina-Contreras O, Merlin D, Gewirtz AT, Nusrat A, Denning TL. A cytokine network involving il-36γ, il-23, and il-22 promotes antimicrobial defense and recovery from intestinal barrier damage [J]. Proc Natl Acad Sci. 2018. doi:10.1073/pnas.1718902115.
   Web of Science ®Google Scholar
• Butcher MJ, Waseem TC, Galkina EV. Smooth muscle cell-derived interleukin-17c plays an atherogenic role via the recruitment of proinflammatory interleukin-17a+ t cells to the aorta [J]. Arterioscler Thromb Vasc Biol. 2016;36(8):1496–1506. doi:10.1161/ATVBAHA.116.307892.
   PubMed Web of Science ®Google Scholar
• Takata K, Imaizumi S, Zhang B, Miura S, Saku K. Stabilization of high-risk plaques [J]. Cardiovasc Diagn Ther. 2016;6(4):304–321. doi:10.21037/cdt.2015.10.03.
   PubMed Web of Science ®Google Scholar
• Tiniakou I, Drakos E, Sinatkas V, van Eck M, Zannis VI, Boumpas D, Verginis P, Kardassis D. High-density lipoprotein attenuates th1 and th17 autoimmune responses by modulating dendritic cell maturation and function [J]. J Immunol. 2015;194(10):4676–4687. doi:10.4049/jimmunol.1402870.
   PubMed Web of Science ®Google Scholar
• Shimada K, Park JK, Daida H. T helper 1/t helper 2 balance and hmg-coa reductase inhibitors in acute coronary syndrome: statins as immunomodulatory agents? [J]. Eur Heart J. 2006;27(24):2916–2918. doi:10.1093/eurheartj/ehl376.
   PubMed Web of Science ®Google Scholar
• Methe H, Brunner S, Wiegand D, Nabauer M, Koglin J, Edelman ER. Enhanced t-helper-1 lymphocyte activation patterns in acute coronary syndromes [J]. J Am Coll Cardiol. 2005;45(12):1939–1945. doi:10.1016/j.jacc.2005.03.040.
   PubMed Web of Science ®Google Scholar
• Cavusoglu E, Marmur JD, Hojjati MR, Chopra V, Butala M, Subnani R, Huda MS, Yanamadala S, Ruwende C, Eng C, et al. Plasma interleukin-10 levels and adverse outcomes in acute coronary syndrome [J]. Am J Med. 2011;124(8):724–730. doi:10.1016/j.amjmed.2011.02.040.
   PubMed Web of Science ®Google Scholar
• Liuzzo G, Kopecky SL, Frye RL, O’Fallon WM, Maseri A, Goronzy JJ, Weyand CM. Perturbation of the t-cell repertoire in patients with unstable angina [J]. Circulation. 1999;100(21):2135–2139.
   PubMed Web of Science ®Google Scholar
• Yamashita H, Shimada K, Seki E, Mokuno H, Daida H. Concentrations of interleukins, interferon, and c-reactive protein in stable and unstable angina pectoris [J]. Am J Cardiol. 2003;91(2):133–136.
   PubMed Web of Science ®Google Scholar
• Cheng X, Yu X, Ding YJ, Fu QQ, Xie JJ, Tang TT, Yao R, Chen Y, Liao YH. The th17/treg imbalance in patients with acute coronary syndrome [J]. Clin immunol. 2008;127(1):89–97.
   PubMed Web of Science ®Google Scholar
• Potekhina AV, Pylaeva E, Provatorov S, Ruleva N, Masenko V, Noeva E, Krasnikova T, Arefieva T. Treg/th17 balance in stable cad patients with different stages of coronary atherosclerosis [J]. Atherosclerosis. 2015;238(1):17–21. doi:10.1016/j.atherosclerosis.2014.10.088.
   PubMed Web of Science ®Google Scholar
• Zhang L, Wang T, Wang XQ, Du RZ, Zhang KN, Liu XG, Ma DX, Yu S, Su GH, Li ZH, et al. Elevated frequencies of circulating th22 cell in addition to th17 cell and th17/th1 cell in patients with acute coronary syndrome [J]. PLoS One. 2013;8(12):e71466. doi:10.1371/journal.pone.0071466.
   PubMed Web of Science ®Google Scholar
• Lin YZ, Wu BW, Lu ZD, Huang Y, Shi Y, Liu H, Liu L, Zeng QT, Wang X, Ji QW. Circulating th22 and th9 levels in patients with acute coronary syndrome [J]. Mediators Inflamm. 2013;2013:635672. doi:10.1155/2013/635672.
   PubMedGoogle Scholar
• Krishnamurthy P, Thal M, Verma S, Hoxha E, Lambers E, Ramirez V, Qin G, Losordo D, Kishore R. Interleukin-10 deficiency impairs bone marrow-derived endothelial progenitor cell survival and function in ischemic myocardium [J]. Circ Res. 2011;109(11):1280–1289. doi:10.1161/CIRCRESAHA.111.248369.
   PubMed Web of Science ®Google Scholar
• Gao B. Hepatoprotective and anti-inflammatory cytokines in alcoholic liver disease [J]. J Gastroenterol Hepatol. 2012;27(Suppl 2):89–93. doi:10.1111/j.1440-1746.2011.07003.x.
   PubMedGoogle Scholar
• Wolk K, Witte E, Witte K, Warszawska K, Sabat R. Biology of interleukin-22 [J]. Semin Immunopathol. 2010;32(1):17–31. doi:10.1007/s00281-009-0188-x.
   PubMed Web of Science ®Google Scholar
• Juno JA, Keynan Y, Fowke KR. Invariant nkt cells: regulation and function during viral infection [J]. PLoS Pathog. 2012;8:e1002838. doi:10.1371/journal.ppat.1002838.
   PubMed Web of Science ®Google Scholar
• Yang J, Yang M, Htut TM, Ouyang X, Hanidu A, Li X, Sellati R, Jiang H, Zhang S, Li H, et al. Epstein-barr virus-induced gene 3 negatively regulates il-17, il-22 and rorgamma t [J]. Eur J Immunol. 2008;38(5):1204–1214. doi:10.1002/eji.200838145.
   PubMed Web of Science ®Google Scholar
• Barros KV, Flor Silveira VL, Laranjeira MS, Wandalsen NF, Passeti S, de Oliveira R, Munekata RV, Noakes PS, Miles EA, Calder PC. Evidence for involvement of il-9 and il-22 in cows’ milk allergy in infants [J]. Nutrients. 2017;9(10):1048. doi:10.3390/nu9101048.
   Web of Science ®Google Scholar
• Wu H, Ballantyne CM. Inflammation versus host defense in obesity [J]. Cell Metab. 2014;20(5):708–709. doi:10.1016/j.cmet.2014.10.013.
   PubMed Web of Science ®Google Scholar