1,260
Views
0
CrossRef citations to date
0
Altmetric
Immunotherapy - Cancer

AIM2 fosters lung adenocarcinoma immune escape by modulating PD-L1 expression in tumor-associated macrophages via JAK/STAT3

, , , , , , , , & show all
Article: 2269790 | Received 12 May 2023, Accepted 08 Oct 2023, Published online: 25 Oct 2023

References

  • Wang J, Zhao X, Wang Y, Ren F, Sun D, Yan Y, Kong X, Bu J, Liu M, Xu S. circRNA-002178 act as a ceRNA to promote PDL1/PD1 expression in lung adenocarcinoma. Cell Death Disease. 2020;11(1):32. doi:10.1038/s41419-020-2230-9.
  • Chen Z, Huang Y, Hu Z, Zhao M, Li M, Bi G, Zheng Y, Liang J, Lu T, Jiang W, et al. Landscape and dynamics of single tumor and immune cells in early and advanced-stage lung adenocarcinoma. Clin Transl Med. 2021;11(3):e350. doi:10.1002/ctm2.350.
  • Hao J, Wang H, Song L, Li S, Che N, Zhang S, Zhang H, Wang J. Infiltration of CD8(+) FOXP3(+) T cells, CD8(+) T cells, and FOXP3(+) T cells in non-small cell lung cancer microenvironment. Int J Clin Exp Pathol. 2020;13:880–10.
  • Fang W, Zhou T, Shi H, Yao M, Zhang D, Qian H, Zeng Q, Wang Y, Jin F, Chai C, et al. Progranulin induces immune escape in breast cancer via up-regulating PD-L1 expression on tumor-associated macrophages (TAMs) and promoting CD8(+) T cell exclusion. J Exp Clin Cancer Res. 2021;40(1):4. doi:10.1186/s13046-020-01786-6.
  • Essandoh K, Li Y, Huo J, Fan GC. MiRNA-Mediated macrophage polarization and its potential role in the regulation of inflammatory response. Shock. 2016;46(2):122–31. doi:10.1097/SHK.0000000000000604.
  • Rhee I. Diverse macrophages polarization in tumor microenvironment. Arch Pharm Res. 2016;39(11):1588–96. doi:10.1007/s12272-016-0820-y.
  • Pello OM, De Pizzol M, Mirolo M, Soucek L, Zammataro L, Amabile A, Doni A, Nebuloni M, Swigart LB, Evan GI, et al. Role of c-MYC in alternative activation of human macrophages and tumor-associated macrophage biology. Blood. 2012;119(2):411–21. doi:10.1182/blood-2011-02-339911.
  • Li S, Ding J, Wang Y, Wang X, Lv L. CD155/TIGIT signaling regulates the effector function of tumor-infiltrating CD8+ T cell by NF-kappaB pathway in colorectal cancer. J Gastroenterol Hepatol. 2022;37(1):154–63. doi:10.1111/jgh.15730.
  • Yan K, Fu Y, Zhu N, Wang Z, Hong JL, Li Y, Li WJ, Zhang HB, Song JH. Repression of lncRNA NEAT1 enhances the antitumor activity of CD8(+)T cells against hepatocellular carcinoma via regulating miR-155/Tim-3. Int J Biochem Cell Biol. 2019;110:1–8. doi:10.1016/j.biocel.2019.01.019.
  • Li H, Li Y, Song C, Hu Y, Dai M, Liu B, Pan P. Neutrophil extracellular traps augmented alveolar macrophage pyroptosis via AIM2 inflammasome activation in LPS-Induced ALI/ARDS. J Inflamm Res. 2021;14:4839–58. doi:10.2147/JIR.S321513.
  • Yang M, Long D, Hu L, Zhao Z, Li Q, Guo Y, He Z, Zhao M, Lu L, Li F, et al. AIM2 deficiency in B cells ameliorates systemic lupus erythematosus by regulating Blimp-1–Bcl-6 axis-mediated B-cell differentiation. Signal Transduct Target Ther. 2021;6(1):341. doi:10.1038/s41392-021-00725-x.
  • Lozano-Ruiz B, Gonzalez-Navajas JM. The emerging relevance of AIM2 in liver disease. Int J Mol Sci. 2020;21(18):6535. doi:10.3390/ijms21186535.
  • He B, Zhao Z, Cai Q, Zhang Y, Zhang P, Shi S, Xie H, Peng X, Yin W, Tao Y, et al. miRNA-based biomarkers, therapies, and resistance in cancer. Int J Biol Sci. 2020;16(14):2628–47. doi:10.7150/ijbs.47203.
  • Choubey D. Absent in melanoma 2 proteins in the development of cancer. Cell Mol Life Sci. 2016;73(23):4383–95. doi:10.1007/s00018-016-2296-9.
  • Xu M, Wang J, Li H, Zhang Z, Cheng Z. AIM2 inhibits colorectal cancer cell proliferation and migration through suppression of Gli1. Aging (Albany NY). 2020;13(1):1017–31. doi:10.18632/aging.202226.
  • Li Y, Wang W, Li A, Huang W, Chen S, Han F, Wang L. Dihydroartemisinin induces pyroptosis by promoting the AIM2/caspase-3/DFNA5 axis in breast cancer cells. Chem Biol Interact. 2021;340:109434. doi:10.1016/j.cbi.2021.109434.
  • Fukuda K, Okamura K, Riding RL, Fan X, Afshari K, Haddadi NS, McCauley SM, Guney MH, Luban J, Funakoshi T, et al. AIM2 regulates anti-tumor immunity and is a viable therapeutic target for melanoma. J Exp Med. 2021;218(9). doi:10.1084/jem.20200962.
  • Su S, Zhao J, Xing Y, Zhang X, Liu J, Ouyang Q, Chen J, Su F, Liu Q, Song E. Immune checkpoint inhibition overcomes ADCP-Induced immunosuppression by macrophages. Cell. 2018;175(2):442–57 e23. doi:10.1016/j.cell.2018.09.007.
  • Shi S, Ma B, Sun F, Qu C, Li G, Shi D, Liu W, Zhang H, An H. Zafirlukast inhibits the growth of lung adenocarcinoma via inhibiting TMEM16A channel activity. J Biol Chem. 2022;298(3):101731. doi:10.1016/j.jbc.2022.101731.
  • Hou Y, Zhu L, Tian H, Sun HX, Wang R, Zhang L, Zhao Y. IL-23-induced macrophage polarization and its pathological roles in mice with imiquimod-induced psoriasis. Protein Cell. 2018;9(12):1027–38. doi:10.1007/s13238-018-0505-z.
  • Dai X, Lu L, Deng S, Meng J, Wan C, Huang J, Sun Y, Hu Y, Wu B, Wu G, et al. USP7 targeting modulates anti-tumor immune response by reprogramming tumor-associated macrophages in lung cancer. Theranostics. 2020;10(20):9332–47. doi:10.7150/thno.47137.
  • Oliveira LJ, McClellan S, Hansen PJ, Kaul R. Differentiation of the endometrial macrophage during pregnancy in the cow. PloS One. 2010;5(10):e13213. doi:10.1371/journal.pone.0013213.
  • Wang T, Fahrmann JF, Lee H, Li YJ, Tripathi SC, Yue C, Zhang C, Lifshitz V, Song J, Yuan Y, et al. JAK/STAT3-regulated fatty acid β-oxidation is Critical for breast cancer stem cell self-renewal and Chemoresistance. Cell Metabolism. 2018;27(1):136–50 e5. doi:10.1016/j.cmet.2017.11.001.
  • Sun C, Mezzadra R, Schumacher TN. Regulation and function of the PD-L1 checkpoint. Immunity. 2018;48(3):434–52. doi:10.1016/j.immuni.2018.03.014.
  • Francisco LM, Sage PT, Sharpe AH. The PD-1 pathway in tolerance and autoimmunity. Immunol Rev. 2010;236(1):219–42. doi:10.1111/j.1600-065X.2010.00923.x.
  • Wang Y. Circ-ANXA7 facilitates lung adenocarcinoma progression via miR-331/LAD1 axis. Cancer Cell Int. 2021;21(1):85. doi:10.1186/s12935-021-01791-5.
  • Feng M, Jiang W, Kim BYS, Zhang CC, Fu YX, Weissman IL. Phagocytosis checkpoints as new targets for cancer immunotherapy. Nat Rev Cancer. 2019;19(10):568–86. doi:10.1038/s41568-019-0183-z.
  • Pasaoglu A, Patiroglu TE, Orhon C, Yildizhan A. Cervical spinal intramedullary myxoma in childhood: case report. J Neurosurg. 1988;69(5):772–4. doi:10.3171/jns.1988.69.5.0772.
  • Tu D, Dou J, Wang M, Zhuang H, Zhang X. M2 macrophages contribute to cell proliferation and migration of breast cancer. Cell Biol Int. 2021;45(4):831–8. doi:10.1002/cbin.11528.
  • Ye Y, Xu Y, Lai Y, He W, Li Y, Wang R, Luo X, Chen R, Chen T. Long non-coding RNA cox-2 prevents immune evasion and metastasis of hepatocellular carcinoma by altering M1/M2 macrophage polarization. J Cell Biochem. 2018;119(3):2951–63. doi:10.1002/jcb.26509.
  • Yang Y, Ren G, Wang Z, Wang B. Human cytomegalovirus IE2 protein regulates macrophage-mediated immune escape by upregulating GRB2 expression in UL122 genetically modified mice. Biosci Trends. 2020;13(6):502–9. doi:10.5582/bst.2019.01197.
  • Dawson RE, Deswaerte V, West AC, Tang K, West AJ, Balic JJ, Gearing LJ, Saad MI, Yu L, Wu Y, et al. STAT3-mediated upregulation of the AIM2 DNA sensor links innate immunity with cell migration to promote epithelial tumourigenesis. Gut. 2022;71(8):1515–31. doi:10.1136/gutjnl-2020-323916.
  • Ratsimandresy RA, Indramohan M, Dorfleutner A, Stehlik C. The AIM2 inflammasome is a central regulator of intestinal homeostasis through the IL-18/IL-22/STAT3 pathway. Cell Mol Immunol. 2017;14(1):127–42. doi:10.1038/cmi.2016.35.
  • Zhang X, Zeng Y, Qu Q, Zhu J, Liu Z, Ning W, Zeng H, Zhang N, Du W, Chen C, et al. PD-L1 induced by IFN-γ from tumor-associated macrophages via the JAK/STAT3 and PI3K/AKT signaling pathways promoted progression of lung cancer. Int J Clin Oncol. 2017;22(6):1026–33. doi:10.1007/s10147-017-1161-7.
  • Qiu XY, Hu DX, Chen WQ, Chen RQ, Qian SR, Li CY, Li YJ, Xiong XX, Liu D, Pan F, et al. PD-L1 confers glioblastoma multiforme malignancy via Ras binding and Ras/Erk/EMT activation. Biochim Biophys Acta Mol Basis Dis. 2018;1864(5):1754–69. doi:10.1016/j.bbadis.2018.03.002.
  • Li P, Huang T, Zou Q, Liu D, Wang Y, Tan X, Wei Y, Qiu H. FGFR2 promotes expression of PD-L1 in colorectal cancer via the JAK/STAT3 signaling pathway. J Immunol. 2019;202(10):3065–75. doi:10.4049/jimmunol.1801199.
  • Liu D, Xu X, Dai Y, Zhao X, Bao S, Ma W, Zha L, Liu S, Liu Y, Zheng J, et al. Blockade of AIM2 inflammasome or α1-AR ameliorates IL-1β release and macrophage-mediated immunosuppression induced by CAR-T treatment. J Immunother Cancer. 2021;9(1):e001466. doi:10.1136/jitc-2020-001466.