Understanding the impact of adult pertussis and current approaches to vaccination: A narrative review and expert panel recommendations

References

• CDC. The Pink Book: Pertussis. Atlanta, GA: Centres for Disease Control and Prevention; 2021.
   Google Scholar
• Diavatopoulos DA, Cummings CA, Schouls LM, Brinig MM, Relman DA, Mooi FR, Hultgren S. Bordetella pertussis, the causative agent of whooping cough, evolved from a distinct, human-associated lineage of B. bronchiseptica. PLoS Pathog. 2005;1(4):e45. doi:10.1371/journal.ppat.0010045.
   PubMed Web of Science ®Google Scholar
• WHO. Pertussis vaccines: WHO position paper – August 2015. World Health Organization; 2015 [accessed 2023 Sep 7]. https://apps.who.int/iris/rest/bitstreams/959578/retrieve.
   Google Scholar
• WHO. WHO SAGE pertussis working group. Background Paper; 2014 [accessed 2023 Sep 29]. https://terrance.who.int/mediacentre/data/sage/SAGE_Docs_Ppt_Apr2014/8_session_pertussis/Apr2014_session8_pertussis.pdf.
   Google Scholar
• ECDC. Surveillance atlas of infectious diseases for infectious diseases: pertussis. European Centre For Disease Prevention and Control; 2021 [accessed 2023 Aug 18]. https://atlas.ecdc.europa.eu/public/index.aspx?Dataset=27&HealthTopic=38.
   Google Scholar
• Jenkins VA, Savic M, Kandeil W. Pertussis in high risk groups: an overview of the past quarter century. Hum Vaccines Immunother. 2020;16(11):2609–11. doi:10.1080/21645515.2020.1738168.
   PubMed Web of Science ®Google Scholar
• Kandeil W, Atanasov P, Avramioti D, Fu J, Demarteau N, Li X. The burden of pertussis in older adults: what is the role of vaccination? A systematic literature review. Expert Rev Vaccines. 2019;18(5):439–455. doi:10.1080/14760584.2019.1588727.
   PubMed Web of Science ®Google Scholar
• De Serres G, Shadmani R, Duval B, Boulianne N, Déry P, Douville Fradet M, Rochette L, Halperin SA. Morbidity of pertussis in adolescents and adults. J Infect Dis. 2000;182(1):174–179. doi:10.1086/315648.
   PubMed Web of Science ®Google Scholar
• McGuiness CB, Hill J, Fonseca E, Hess G, Hitchcock W, Krishnarajah G. The disease burden of pertussis in adults 50 years old and older in the United States: a retrospective study. BMC Infect Dis. 2013;13(1):32. doi:10.1186/1471-2334-13-32.
   PubMed Web of Science ®Google Scholar
• van Hoek AJ, Campbell H, Andrews N, Vasconcelos M, Amirthalingam G, Miller E. The burden of disease and health care use among pertussis cases in school aged children and adults in England and Wales; a patient survey. PLoS One. 2014;9(11):e111807. doi:10.1371/journal.pone.0111807.
   PubMed Web of Science ®Google Scholar
• Aris E, Harrington L, Bhavsar A, Simeone JC, Ramond A, Papi A, Vogelmeier CF, Meszaros K, Lambrelli D, Mukherjee P. Burden of pertussis in COPD: a retrospective database study in England. COPD. 2021;18(2):157–169. doi:10.1080/15412555.2021.1899155.
   PubMedGoogle Scholar
• Hewlett EL, Edwards KM. Pertussis — not just for kids. N Engl J Med. 2005;352(12):1215–1222. doi:10.1056/NEJMcp041025.
   PubMed Web of Science ®Google Scholar
• Walker JL, Rentsch CT, McDonald HI, Bak J, Minassian C, Amirthalingam G, Edelstein M, Thomas S. Social determinants of pertussis and influenza vaccine uptake in pregnancy: a national cohort study in England using electronic health records. BMJ Open. 2021;11(6):e046545. doi:10.1136/bmjopen-2020-046545.
   PubMed Web of Science ®Google Scholar
• Pelullo CP, Della Polla G, Napolitano F, Di Giuseppe G, Angelillo IF. Healthcare workers’ knowledge, attitudes, and practices about vaccinations: a cross-sectional study in Italy. Nato Adv Sci Inst Se. 2020;8(2):148. doi:10.3390/vaccines8020148.
   Google Scholar
• Kolobova I, Nyaku MK, Karakusevic A, Bridge D, Fotheringham I, O’Brien M. Vaccine uptake and barriers to vaccination among at-risk adult populations in the US. Hum Vaccin Immunother. 2022;18(5):2055422. doi:10.1080/21645515.2022.2055422.
   PubMed Web of Science ®Google Scholar
• Rieck T, Steffen A, Feig MAS. Impfquoten bei Erwachsenen in Deutschland – Aktuelles aus der KV-Impfsurveillance. Das Robert Koch-Institut; 2022 [accessed 2023 Sep 7]. https://www.rki.de/DE/Content/Infekt/EpidBull/Archiv/2022/Ausgaben/49_22.pdf?__blob=publicationFile.
   Google Scholar
• Choi JH, Correia de Sousa J, Fletcher M, Gabutti G, Harrington L, Holden M, Kim H, Michel JP, Mukherjee P, Nolan T, et al. Improving vaccination rates in older adults and at-risk groups: focus on pertussis. Aging Clin Exp Res. 2022;34(1):1–8. doi:10.1007/s40520-021-02018-3.
   PubMed Web of Science ®Google Scholar
• Guiso N, König C. Surveillance of pertussis: methods and implementation. Expert Rev Anti-infect Ther. 2016;14:657–667. doi:10.1080/14787210.2016.1190272.
   PubMed Web of Science ®Google Scholar
• van der Zee A, Schellekens JFP, Mooi FR. Laboratory diagnosis of pertussis. Clin Microbiol Rev. 2015;28(4):1005–1026. doi:10.1128/cmr.00031-15.
   PubMed Web of Science ®Google Scholar
• Lutwick L, Preis J. Chapter 27 - Pertussis. In: Ergönül Ö, Can F, Madoff L, Akova M, editors. Emerging infectious diseases. Amsterdam: Academic Press; 2014. p. 359–371.
   Google Scholar
• WHO. Pertussis vaccines: WHO position paper – January 2010. World Health Organization; 2010 [accessed 2023 Sep 7]. https://www.who.int/publications/i/item/WER8540.
   Google Scholar
• Kilgore PE, Salim AM, Zervos MJ, Schmitt H-J. Pertussis: microbiology, disease, treatment, and prevention. Clin Microbiol Rev. 2016;29(3):449–486. doi:10.1128/cmr.00083-15.
   PubMed Web of Science ®Google Scholar
• Mattoo S, Cherry JD. Molecular pathogenesis, epidemiology, and clinical manifestations of respiratory infections due to bordetella pertussis and other bordetella subspecies. Clin Microbiol Rev. 2005;18(2):326–382. doi:10.1128/cmr.18.2.326-382.2005.
   PubMed Web of Science ®Google Scholar
• WHO. World health statistics 2022: monitoring health for the SDGs, sustainable development goals. World Health Organization; 2022 [accessed 2023 Sep 7]. https://cdn.who.int/media/docs/default-source/immunization/vpd_surveillance/vpd-surveillance-standards-publication/who-surveillancevaccinepreventable-16-pertussis-r2.pdf.
   Google Scholar
• Bhatti MM, Rucinski SL, Schwab JJ, Cole NC, Gebrehiwot SA, Patel R. Eight-year review of bordetella pertussis testing reveals seasonal pattern in the United States. J Pediatric Infect Dis Soc. 2015;6(1):91–93. doi:10.1093/jpids/piv079.
   Web of Science ®Google Scholar
• ECDC. Pertussis - annual epidemiological report for 2018. European Centre for Disease Prevention and Control; 2020 [accessed 2023 Sep 7]. https://www.ecdc.europa.eu/en/publications-data/pertussis-annual-epidemiological-report-2018.
   Google Scholar
• Addiss DG, Davis JP, Meade BD, Burstyn DG, Meissner M, Zastrow JA, Berg JL, Drinka P, Phillips R. A pertussis outbreak in a Wisconsin nursing home. J Infect Dis. 1991;164(4):704–710. doi:10.1093/infdis/164.4.704.
   PubMed Web of Science ®Google Scholar
• Schellekens J, von König CH, Gardner P. Pertussis sources of infection and routes of transmission in the vaccination era. Pediatr Infect Dis J. 2005;24(5 Suppl):S19–S24. doi:10.1097/01.inf.0000160909.24879.e6.
   PubMedGoogle Scholar
• Stone H, Moa A, MacIntyre CR, Chughtai AA. Using open source data to estimate the global epidemiology of pertussis. Global Biosecur. 2020;1(4). doi:10.31646/gbio.65.
   Google Scholar
• Deville JG, Cherry JD, Christenson PD, Pineda E, Leach CT, Kuhls TL, Viker S. Frequency of unrecognized Bordetella pertussis infections in adults. Clin Infect Dis. 1995;21(3):639–642. doi:10.1093/clinids/21.3.639.
   PubMed Web of Science ®Google Scholar
• CDC. Pertussis treatment recommendations. Centers for Disease Control and Prevention; 2023 [accessed 2023 Sep 22]. https://www.cdc.gov/pertussis/clinical/treatment.html.
   Google Scholar
• Mooi FR, van Loo IH, van Gent M, He Q, Bart MJ, Heuvelman KJ, de Greeff SC, Diavatopoulos D, Teunis P, Nagelkerke N, et al. Bordetella pertussis strains with increased toxin production associated with pertussis resurgence. Emerg Infect Dis. 2009;15(8):1206–1213. doi:10.3201/eid1508.081511.
   PubMed Web of Science ®Google Scholar
• Macina D, Evans KE. Bordetella pertussis in school-age children, adolescents, and adults: a systematic review of epidemiology, burden, and mortality in Asia. Infect Dis Ther. 2021;10(3):1115–1140. doi:10.1007/s40121-021-00439-1.
   PubMed Web of Science ®Google Scholar
• Macina D, Evans KE. Bordetella pertussis in school-age children, adolescents and adults: a systematic review of epidemiology and mortality in Europe. Infect Dis Ther. 2021;10(4):2071–2118. doi:10.1007/s40121-021-00520-9.
   PubMed Web of Science ®Google Scholar
• CDC. Pertussis 2020 case definition. Centers for Disease Control and Prevention; 2023 [accessed 2023 Sep 25]. https://ndc.services.cdc.gov/case-definitions/pertussis-2020.
   Google Scholar
• Seppälä E, Kristoffersen A, Bøås H, Vestrheim D, Greve-Isdahl M, De Blasio B, Steens A. Pertussis epidemiology including direct and indirect effects of the childhood pertussis booster vaccinations, Norway, 1998–2019. Vaccine. 2022;40:3142–3149. doi:10.1016/j.vaccine.2022.04.038.
   PubMed Web of Science ®Google Scholar
• Bagordo F, Grassi T, Savio M, Rota MC, Baldovin T, Vicentini C, Napolitano F, Trombetta CM, Gabutti G. Assessment of pertussis underreporting in Italy. J Clin Med. 2023;12(5):1732. doi:10.3390/jcm12051732.
   PubMed Web of Science ®Google Scholar
• WHO. Laboratory manual for the diagnosis of whooping cough caused by bordetella pertussis/bordetella parapertussis: update 2014. World Health Organization; 2014 [accessed 2023 Sep 7]. https://apps.who.int/iris/handle/10665/127891.
   Google Scholar
• Clarke MF, Rasiah K, Copland J, Watson M, Koehler AP, Dowling K, Marshall HS. The pertussis epidemic: informing strategies for prevention of severe disease. Epidemiol Infect. 2013;141(3):463–471. doi:10.1017/s095026881200091x.
   PubMed Web of Science ®Google Scholar
• Skoff TH, Faulkner AE, Liang JL, Barnes M, Kudish K, Thomas E, Kenyon C, Hoffman M, Pradhan E, Liko J, et al. Pertussis infections among pregnant women in the United States, 2012-2017. Clin Infect Dis. 2021;73(11):3836–3841. doi:10.1093/cid/ciaa1112.
   Web of Science ®Google Scholar
• Gilberg S, Njamkepo E, Du Châtelet IP, Partouche H, Gueirard P, Ghasarossian C, Schlumberger M, Guiso N. Evidence of bordetella pertussis infection in adults presenting with persistent cough in a French area with very high whole-cell vaccine coverage. J Infect Dis. 2002;186(3):415–418. doi:10.1086/341511.
   PubMed Web of Science ®Google Scholar
• Bhavsar A, Aris E, Harrington L, Simeone JC, Ramond A, Lambrelli D, Papi A, Boulet LP, Meszaros K, Jamet N, et al. Burden of pertussis in individuals with a diagnosis of asthma: a retrospective database study in England. J Asthma Allergy. 2022;15:35–51. doi:10.2147/jaa.S335960.
   PubMed Web of Science ®Google Scholar
• Wilkinson TMA, Van den Steen P, Cheuvart B, Baudson N, Dodet M, Turriani E, Harrington L, Meyer N, Rondini S, Taddei L, et al. Seroprevalence of bordetella pertussis infection in patients with chronic obstructive pulmonary disease in England: analysis of the AERIS cohort. COPD. 2021;18(3):341–348. doi:10.1080/15412555.2021.1920904.
   PubMedGoogle Scholar
• Buck PO, Meyers JL, Gordon LD, Parikh R, Kurosky SK, Davis KL. Economic burden of diagnosed pertussis among individuals with asthma or chronic obstructive pulmonary disease in the USA: an analysis of administrative claims. Epidemiol Infect. 2017;145(10):2109–2121. doi:10.1017/s0950268817000887.
   PubMed Web of Science ®Google Scholar
• Kwon JH, Wi CI, Seol HY, Park M, King K, Ryu E, Sohn S, Liu H, Juhn YJ. Risk, mechanisms and implications of asthma-associated infectious and inflammatory multimorbidities (AIMs) among individuals with asthma: a systematic review and a case study. Allergy Asthma Immunol Res. 2021;13(5):697–718. doi:10.4168/aair.2021.13.5.697.
   PubMed Web of Science ®Google Scholar
• Liu BC, McIntyre P, Kaldor JM, Quinn HE, Ridda I, Banks E. Pertussis in older adults: prospective study of risk factors and morbidity. Clin Infect Dis. 2012;55(11):1450–1456. doi:10.1093/cid/cis627.
   PubMed Web of Science ®Google Scholar
• Teepe J, Broekhuizen BD, Ieven M, Loens K, Huygen K, Kretzschmar M, de Melker H, Butler CC, Little P, Stuart B, et al. Prevalence, diagnosis, and disease course of pertussis in adults with acute cough: a prospective, observational study in primary care. Br J Gen Pract. 2015;65(639):e662–e667. doi:10.3399/bjgp15X686917.
   PubMed Web of Science ®Google Scholar
• Postels-Multani S, Schmitt HJ, Wirsing von König CH, Bock HL, Bogaerts H. Symptoms and complications of pertussis in adults. Infection. 1995;23(3):139–142. doi:10.1007/bf01793853.
   PubMed Web of Science ®Google Scholar
• de Greeff SC, de Melker HE, van Gageldonk PG, Schellekens JF, van der Klis FR, Mollema L, Mooi FR, Berbers GA. Seroprevalence of pertussis in the Netherlands: evidence for increased circulation of bordetella pertussis. PLoS One. 2010;5(12):e14183. doi:10.1371/journal.pone.0014183.
   PubMed Web of Science ®Google Scholar
• Bolotin S, Deeks SL, Marchand-Austin A, Rilkoff H, Dang V, Walton R, Hashim A, Farrell D, Crowcroft NS, Hozbor DF. Correlation of real time PCR cycle threshold cut-off with bordetella pertussis clinical severity. PLoS One. 2015;10(7):e0133209. doi:10.1371/journal.pone.0133209.
   PubMed Web of Science ®Google Scholar
• Bocka JJ. Pertussis clinical presentation. Medscape; 2023 [accessed 2023 Sep 26]. https://emedicine.medscape.com/article/967268-clinical.
   Google Scholar
• Jones TC, Gasser M, Erb P, Oechslin H. Cough and fear of sleep: early clinical signs of bordetella pertussis in an adult. Braz J Infect Dis. 2004;8(4):324–327. doi:10.1590/s1413-86702004000400009.
   PubMedGoogle Scholar
• Lee LH, Pichichero ME. Costs of illness due to Bordetella pertussis in families. Arch Fam Med. 2000;9(10):989–96. doi:10.1001/archfami.9.10.989.
   PubMedGoogle Scholar
• Danuta MS, Buxton JA, Hestrin M, Keyes RD, Lynch K, Halperin SA. Carotid artery dissection as a possible severe complication of pertussis in an adult: clinical case report and review. Clin Infect Dis. 2003;36(1):1–4. doi:10.1086/344776.
   PubMed Web of Science ®Google Scholar
• Leong RNF, Wood JG, Liu B, McIntyre PB, Newall AT. High healthcare resource utilisation due to pertussis in Australian adults aged 65 years and over. Vaccine. 2020;38(19):3553–3559. doi:10.1016/j.vaccine.2020.03.021.
   PubMed Web of Science ®Google Scholar
• Koh MT, Liu CS, Chiu CH, Boonsawat W, Watanaveeradej V, Abdullah N, Zhang X, Devadiga R, Chen J. Under-recognized pertussis in adults from Asian countries: a cross-sectional seroprevalence study in Malaysia, Taiwan and Thailand. Epidemiol Infect. 2016;144(6):1192–200. doi:10.1017/s0950268815002393.
   PubMed Web of Science ®Google Scholar
• van Hoek AJ, Underwood A, Jit M, Miller E, Edmunds WJ. The impact of pandemic influenza H1N1 on health-related quality of life: a prospective population-based study. PLoS One. 2011;6(3):e17030. doi:10.1371/journal.pone.0017030.
   PubMed Web of Science ®Google Scholar
• Fernández-Cano MI, Armadans Gil L, Martínez Gómez X, Campins Martí M. Incidence of whooping cough in Spain (1997–2010): an underreported disease. Eur J Pediatr. 2014;173(6):721–726. doi:10.1007/s00431-013-2228-8.
   PubMed Web of Science ®Google Scholar
• Juhn YJ, Wi CI, Takahashi PY, Ryu E, King KS, Hickman JA, Yao JD, Binnicker MJ, Natoli TL, Evans TK, et al. Incidence of respiratory syncytial virus infection in older adults before and during the COVID-19 pandemic. JAMA Netw Open. 2023;6(1):e2250634. doi:10.1001/jamanetworkopen.2022.50634.
   PubMed Web of Science ®Google Scholar
• McCarthy A, Galvin R, Dockery F, McLoughlin K, O’Connor M, Corey G, Whiston A, Carey L, Steed F, Tierney A, et al. Multidisciplinary inpatient rehabilitation for older adults with COVID-19: a systematic review and meta-analysis of clinical and process outcomes. BMC Geriatr. 2023;23(1):391. doi:10.1186/s12877-023-04098-4.
   PubMed Web of Science ®Google Scholar
• Covino M, Russo A, Salini S, De Matteis G, Simeoni B, Pirone F, Massaro C, Recupero C, Landi F, Gasbarrini A, et al. Long-term effects of hospitalization for COVID-19 on frailty and quality of life in older adults ≥80 years. J Clin Med. 2022;11(19):5787. doi:10.3390/jcm11195787.
   PubMed Web of Science ®Google Scholar
• da Silva Antunes R, Garrigan E, Quiambao LG, Dhanda SK, Marrama D, Westernberg L, Wang E, Abawi A, Sutherland A, Armstrong SK, et al. T cell reactivity to bordetella pertussis is highly diverse regardless of childhood vaccination. Cell Host Microbe. 2023;31(8):1404–16.e4. doi:10.1016/j.chom.2023.06.015.
   PubMed Web of Science ®Google Scholar
• Cattelan N, Dubey P, Arnal L, Yantorno OM, Deora R, Carbonetti N. Bordetella biofilms: a lifestyle leading to persistent infections. Pathog Dis. 2016;74(1):ftv108. doi:10.1093/femspd/ftv108.
   PubMed Web of Science ®Google Scholar
• Moore A, Harnden A, Grant CC, Patel S, Irwin RS, Altman KW, Azoulay E, Barker AF, Bolser DC, Birring SS, et al. Clinically diagnosing pertussis-associated cough in adults and children: CHEST guideline and expert panel report. CHEST. 2019;155(1):147–154. doi:10.1016/j.chest.2018.09.027.
   PubMed Web of Science ®Google Scholar
• Wright SW, Edwards KM, Decker MD, Zeldin MH. Pertussis infection in adults with persistent cough. JAMA. 1995;273(13):1044–1046. doi:10.1001/jama.1995.03520370086042.
   PubMed Web of Science ®Google Scholar
• Huang QS, Baker M, McArthur C, Roberts S, Williamson D, Grant C, Trenholme A, Wong C, Taylor S, LeComte L, et al. Implementing hospital-based surveillance for severe acute respiratory infections caused by influenza and other respiratory pathogens in New Zealand. Western Pac Surveill Response J. 2014;5(2):23–30. doi:10.5365/wpsar.2014.5.1.004.
   PubMedGoogle Scholar
• Rigoine de Fougerolles T, Puig-Barbera J, Kassianos G, Vanhems P, Schelling J, Crepey P, de Lejarazu RO, Ansaldi F, Fruhwein M, Galli C, et al. A comparison of coronavirus disease 2019 and seasonal influenza surveillance in five European countries: France, Germany, Italy, Spain and the United Kingdom. Influenza Other Respir Viruses. 2022;16(3):417–428. doi:10.1111/irv.12941.
   PubMed Web of Science ®Google Scholar
• Vega T, Lozano JE, Meerhoff T, Snacken R, Beauté J, Jorgensen P, Ortiz de Lejarazu R, Domegan L, Mossong J, Nielsen J, et al. Influenza surveillance in Europe: comparing intensity levels calculated using the moving epidemic method. Influenza Other Respir Viruses. 2015;9(5):234–246. doi:10.1111/irv.12330.
   PubMed Web of Science ®Google Scholar
• Slifka AM, Park B, Gao L, Slifka MK. Incidence of tetanus and diphtheria in relation to adult vaccination schedules. Clin Infect Dis. 2021;72(2):285–292. doi:10.1093/cid/ciaa017.
   PubMed Web of Science ®Google Scholar
• Heininger U. Diphtheria, tetanus, and pertussis: unequal vaccine siblings with distinct characteristics. Clin Infect Dis. 2020;74(3):562–563. doi:10.1093/cid/ciaa643.
   Web of Science ®Google Scholar
• Rohani P, Zhong X, King A. Contact network structure explains the changing epidemiology of pertussis. Science (New York, NY). 2010;330:982–985. doi:10.1126/science.1194134.
   Google Scholar
• Saeidpour A, Bansal S, Rohani P, Perkins A. Dissecting recurrent waves of pertussis across the boroughs of London. PLoS Comput Biol. 2022;18(4):e1009898. doi:10.1371/journal.pcbi.1009898.
   PubMed Web of Science ®Google Scholar
• Holubová J, Staněk O, Brázdilová L, Mašín J, Bumba L, Gorringe AR, Alexander F, Šebo P. Acellular pertussis vaccine inhibits Bordetella pertussis clearance from the nasal mucosa of mice. Vaccines (Basel). 2020;8(4):695. doi:10.3390/vaccines8040695.
   PubMed Web of Science ®Google Scholar
• Barkoff AM, Mertsola J, Pierard D, Dalby T, Hoegh SV, Guillot S, Stefanelli P, van Gent M, Berbers G, Vestrheim D, et al. Pertactin-deficient bordetella pertussis isolates: evidence of increased circulation in Europe, 1998 to 2015. Euro Surveill. 2019;24(7). doi:10.2807/1560-7917.Es.2019.24.7.1700832.
   PubMedGoogle Scholar
• Bart MJ, Harris SR, Advani A, Arakawa Y, Bottero D, Bouchez V, Cassiday PK, Chiang CS, Dalby T, Fry NK, et al. Global population structure and evolution of bordetella pertussis and their relationship with vaccination. mBio. 2014;5(2):e01074. doi:10.1128/mBio.01074-14.
   PubMed Web of Science ®Google Scholar
• Heininger U, André P, Chlibek R, Kristufkova Z, Kutsar K, Mangarov A, Mészner Z, Nitsch-Osuch A, Petrović V, Prymula R, et al. Comparative epidemiologic characteristics of pertussis in 10 Central and Eastern European countries, 2000–2013. PLoS One. 2016;11(6):e0155949. doi:10.1371/journal.pone.0155949.
   PubMed Web of Science ®Google Scholar
• Szwejser-Zawislak E, Wilk MM, Piszczek P, Krawczyk J, Wilczyńska D, Hozbor D. Evaluation of whole-cell and acellular pertussis vaccines in the context of long-term herd immunity. Vaccines (Basel). 2022;11(1):1. doi:10.3390/vaccines11010001.
   PubMed Web of Science ®Google Scholar
• Warfel JM, Zimmerman LI, Merkel TJ. Acellular pertussis vaccines protect against disease but fail to prevent infection and transmission in a nonhuman primate model. Proc Natl Acad Sci USA. 2014;111(2):787–792. doi:10.1073/pnas.1314688110.
   PubMed Web of Science ®Google Scholar
• Chasaide CN, Mills KHG. Next-generation pertussis vaccines based on the induction of protective T cells in the respiratory tract. Vaccines (Basel). 2020;8(4):621. doi:10.3390/vaccines8040621.
   PubMed Web of Science ®Google Scholar
• Wilk MM, Borkner L, Misiak A, Curham L, Allen AC, Mills KHG. Immunization with whole cell but not acellular pertussis vaccines primes CD4 T(RM) cells that sustain protective immunity against nasal colonization with Bordetella pertussis. Emerg Microbes Infect. 2019;8(1):169–185. doi:10.1080/22221751.2018.1564630.
   PubMed Web of Science ®Google Scholar
• Kapil P, Wang Y, Zimmerman L, Gaykema M, Merkel TJ. Repeated bordetella pertussis infections are required to reprogram acellular pertussis vaccine–primed host responses in the baboon model. J Infect Dis. 2023;229:376–383. doi:10.1093/infdis/jiad332.
   Web of Science ®Google Scholar
• Diavatopoulos DA, Mills KHG, Kester KE, Kampmann B, Silerova M, Heininger U, van Dongen JJM, van der Most RG, Huijnen MA, Siena E, et al. PERISCOPE: road towards effective control of pertussis. Lancet Infect Dis. 2019;19(5):179–186. doi:10.1016/S1473-3099(18)30646-7.
   PubMed Web of Science ®Google Scholar
• de Graaf H, Ibrahim M, Hill AR, Gbesemete D, Vaughan AT, Gorringe A, Preston A, Buisman AM, Faust SN, Kester KE, et al. Controlled human infection with Bordetella pertussis induces asymptomatic, immunizing colonization. Clin Infect Dis. 2020;71(2):403–411. doi:10.1093/cid/ciz840.
   PubMed Web of Science ®Google Scholar
• Conway MA, Madrigal-Estebas L, McClean S, Brayden DJ, Mills KH. Protection against bordetella pertussis infection following parenteral or oral immunization with antigens entrapped in biodegradable particles: effect of formulation and route of immunization on induction of Th1 and Th2 cells. Vaccine. 2001;19(15–16):1940–1950. doi:10.1016/s0264-410x(00)00433-3.
   PubMed Web of Science ®Google Scholar
• Yount KS, Hall JM, Caution K, Shamseldin MM, Guo M, Marion K, Fullen AR, Huang Y, Maynard JA, Quataert SA, et al. Systemic priming and intranasal booster with a BcfA-adjuvanted acellular pertussis vaccine generates CD4+ IL-17+ nasal tissue resident T cells and reduces B. pertussis nasal colonization. Front Immunol. 2023:14. doi:10.3389/fimmu.2023.1181876.
   Web of Science ®Google Scholar
• Carriquiriborde F, Martin Aispuro P, Ambrosis N, Zurita E, Bottero D, Gaillard ME, Castuma C, Rudi E, Lodeiro A, Hozbor DF. Pertussis vaccine candidate based on outer membrane vesicles derived from biofilm culture. Front Immunol. 2021;12:730434. doi:10.3389/fimmu.2021.730434.
   PubMed Web of Science ®Google Scholar
• Solans L, Debrie AS, Borkner L, Aguiló N, Thiriard A, Coutte L, Uranga S, Trottein F, Martín C, Mills KHG, et al. IL-17-dependent SIgA-mediated protection against nasal bordetella pertussis infection by live attenuated BPZE1 vaccine. Mucosal Immunol. 2018;11(6):1753–1762. doi:10.1038/s41385-018-0073-9.
   PubMed Web of Science ®Google Scholar
• Keech C, Miller VE, Rizzardi B, Hoyle C, Pryor MJ, Ferrand J, Solovay K, Thalen M, Noviello S, Goldstein P, et al. Immunogenicity and safety of BPZE1, an intranasal live attenuated pertussis vaccine, versus tetanus-diphtheria-acellular pertussis vaccine: a randomised, double-blind, phase 2b trial. Lancet. 2023;401(10379):843–855. doi:10.1016/S0140-6736(22)02644-7.
   PubMed Web of Science ®Google Scholar