References
- Fleischmann-Struzek C, Goldfarb DM, Schlattmann P, et al. Kissoon N: the global burden of paediatric and neonatal sepsis: a systematic review. Lancet Respir Med. 2018;6(3):223–230.
- Weiss SL, Peters MJ, Alhazzani W, et al. Surviving sepsis campaign international guidelines for the management of septic shock and sepsis-associated organ dysfunction in children. Pediatr Crit Care Med. 2020;21(2):e52–e106.
- Spaeder MC, Moorman JR, Tran CA, et al. Clark MT: predictive analytics in the pediatric intensive care unit for early identification of sepsis: capturing the context of age. Pediatr Res. 2019;82(11):655–661.
- Nagano T. Fraser P: no-nonsense functions for long noncoding RNAs. Cell. 2011;145(2):178–181.
- Khorkova O, Hsiao J. Wahlestedt C: basic biology and therapeutic implications of lncRNA. Adv Drug Deliv Rev. 2015;87:15–24.
- Zhang TN, Li D, Xia J, et al. Liu CF: non-coding RNA: a potential biomarker and therapeutic target for sepsis. Oncotarget. 2017;8(53):91765–91778.
- Dai Y, Liang Z, Li Y, et al. Chen L: circulating long noncoding RNAs as potential biomarkers of sepsis: a preliminary study. Genet Test Mol Biomarkers. 2017;21(11):649–657.
- Li Y, Li Y, Bai Z, et al. Fang F: identification of potential transcriptomic markers in developing pediatric sepsis: a weighted gene co-expression network analysis and a case-control validation study. J Transl Med. 2017;15(1):254.
- Mohammed A, Cui Y, Mas VR. Kamaleswaran R: differential gene expression analysis reveals novel genes and pathways in pediatric septic shock patients. Sci Rep. 2019;9(1):11270.
- Manatakis DV, VanDevender A. Manolakos ES: an information-theoretic approach for measuring the distance of organ tissue samples using their transcriptomic signatures. Bioinformatics. 2020;36(21):5194–5204.
- Banerjee S, Mohammed A, Wong HR, et al. Kamaleswaran R: machine learning identifies complicated sepsis course and subsequent mortality based on 20 genes in peripheral blood immune cells at 24 H post-ICU admission. Front Immunol. 2021;12:592303.
- Langfelder P. Horvath S: WGCNA: an R package for weighted correlation network analysis. BMC Bioinformatics. 2008;9(1):559.
- Zhang B, Horvath S. A general framework for weighted gene co-expression network analysis. Stat Appl Genet Mol Biol. 2005;4(1):17. Article.
- Carlson MR, Zhang B, Fang Z, et al. Nelson SF: gene connectivity, function, and sequence conservation: predictions from modular yeast co-expression networks. BMC Genomics. 2006;7(1):40.
- Vachharajani V. McCall CE: epigenetic and metabolic programming of innate immunity in sepsis. Innate Immun. 2019;25(5):267–279.
- Hassan FI, Didari T, Khan F, et al. Abdollahi M: the role of epigenetic alterations involved in sepsis: an overview. Curr Pharm Des. 2018;24(24):2862–2869.
- David VL, Ercisli MF. Rogobete AF: early prediction of sepsis incidence in critically Ill patients using specific genetic polymorphisms. Biochem Genet. 2017;55(3):193–203.
- Fan R, Cao C, Zhao X, et al. Xu S: downregulated long noncoding RNA ALDBGALG0000005049 induces inflammation in chicken muscle suffered from selenium deficiency by regulating stearoyl-CoA desaturase. Oncotarget. 2017;8(32):52761–52774.
- Hu G, Dong B, Zhang J, et al. The long noncoding RNA HOTAIR activates the Hippo pathway by directly binding to SAV1 in renal cell carcinoma. Oncotarget. 2017;8(35):58654–58667.
- Pan W, Wei N, Xu W, et al. Li N: microRNA-124 alleviates the lung injury in mice with septic shock through inhibiting the activation of the MAPK signaling pathway by downregulating MAPK14. Int Immunopharmacol. 2019;76:105835.
- Sheneef A, Mohamed T, Boraey NF. Mohammed MA: neutrophil CD11b, CD64 and Lipocalin-2: early diagnostic markers of neonatal sepsis. Egypt J Immunol. 2017;24(1):29–36.
- Jamsa J, Huotari V, Savolainen ER, et al. Ala-Kokko T: kinetics of leukocyte CD11b and CD64 expression in severe sepsis and non-infectious critical care patients. Acta Anaesthesiol Scand. 2015;59(7):881–891.
- Zhou H, Li Y, Gui H, et al. Antagonism of integrin CD11b affords protection against endotoxin shock and polymicrobial sepsis via attenuation of hmgb1 nucleocytoplasmic translocation and extracellular release. J Immunol. 2018;200(5):1771–1780.
- Hoshi M, Osawa Y, Ito H, et al. Seishima M: blockade of indoleamine 2,3-dioxygenase reduces mortality from peritonitis and sepsis in mice by regulating functions of CD11b+ peritoneal cells. Infect Immun. 2014;82(11):4487–4495.
- Smith JA, Stallons LJ. Schnellmann RG: renal cortical hexokinase and pentose phosphate pathway activation through the EGFR/Akt signaling pathway in endotoxin-induced acute kidney injury. Am J Physiol Renal Physiol. 2014;307(4):F435–444.
- Monteiro AP, Soledade E, Pinheiro CS, et al. Canetti C: pivotal role of the 5-lipoxygenase pathway in lung injury after experimental sepsis. Am J Respir Cell Mol Biol. 2014;50(1):87–95.
- Awwad K, Steinbrink SD, Fromel T, et al. Electrophilic fatty acid species inhibit 5-lipoxygenase and attenuate sepsis-induced pulmonary inflammation. Antioxid Redox Signal. 2014;20(17):2667–2680.
- Brekke OL, Hellerud BC, Christiansen D, et al. Neisseria meningitidis and Escherichia coli are protected from leukocyte phagocytosis by binding to erythrocyte complement receptor 1 in human blood. Mol Immunol. 2011;48(15–16):2159–2169.
- Sakiniene E, Heyman B. Tarkowski A: interaction with complement receptor 1 (CD35) leads to amelioration of sepsis-triggered mortality but aggravation of arthritis during Staphylococcus aureus infection. Scand J Immunol. 1999;50(3):250–255.
- Lowell CA. Berton G: resistance to endotoxic shock and reduced neutrophil migration in mice deficient for the Src-family kinases Hck and Fgr. Proc Natl Acad Sci U S A. 1998;50(1):7580–7584.
- Leu TH, Charoenfuprasert S, Yen CK, et al. Maa MC: lipopolysaccharide-induced c-Src expression plays a role in nitric oxide and TNFalpha secretion in macrophages. Mol Immunol. 2006;50(1):308–316.
- Zhu G, Chen J, Tian J, et al. Tang G: expression of NLRC4 in children with septicaemia and mechanisms of NLRC4 in in vitro cytokine secretion. Mol Med Rep. 2016;14(1):509–514.
- Touyama K, Khan M, Aoki K, et al. Bif-1/Endophilin B1/SH3GLB1 regulates bone homeostasis. J Cell Biochem. 2019;120(11):18793–18804.
- Xiao Y, Gu Y, Purwaha P, et al. Qian SY: characterization of free radicals formed from COX-catalyzed DGLA peroxidation. Free Radic Biol Med. 2011;50(9):1163–1170.
- Winter S, Hultqvist Hopkins M, Laulund F. Holmdahl R: a reduction in intracellular reactive oxygen species due to a mutation in NCF4 promotes autoimmune arthritis in mice. Antioxid Redox Signal. 2016;95(13):983–996.
- Kim YM. Cho M: activation of NADPH oxidase subunit NCF4 induces ROS-mediated EMT signaling in HeLa cells. Cell Signal. 2014;26(4):784–796.
- Schmidt F, Thywißen A, Goldmann M, et al. Flotillin-dependent membrane microdomains are required for functional phagolysosomes against fungal infections. Cell Rep. 2020;25(18):108017.
- Wilson GA, Butcher LM, Foster HR, et al. Bell CG: human-specific epigenetic variation in the immunological leukotriene B4 receptor (LTB4R/BLT1) implicated in common inflammatory diseases. Genome Med. 2014;6(3):19.
- Akinosoglou K. Alexopoulos D: use of antiplatelet agents in sepsis: a glimpse into the future. Thromb Res. 2014;32(7):131–138.