2,735
Views
22
CrossRef citations to date
0
Altmetric
Research Paper

Inhibition of micro RNA miR-122-5p prevents lipopolysaccharide-induced myocardial injury by inhibiting oxidative stress, inflammation and apoptosis via targeting GIT1

, , , , & ORCID Icon
Pages 1902-1915 | Received 25 Feb 2021, Accepted 01 May 2021, Published online: 18 May 2021

References

  • Singer M, Deutschman CS, Seymour CW, et al. The third international consensus definitions for Sepsis and septic shock (Sepsis-3). Jama. 2016;315(8):801–810.
  • Weber GF, Chousterman BG, He S, et al. Interleukin-3 amplifies acute inflammation and is a potential therapeutic target in sepsis. Science (New York, NY). 2015;347(6227):1260–1265.
  • Cohen J, Vincent JL, Adhikari NK, et al. Sepsis: a roadmap for future research. Lancet Infect Dis. 2015;15:581–614.
  • Bickler SW, De Maio A. Dysfunction of the innate immune system during sepsis: a call for research. Crit Care Med. 2013;41(1):364–365.
  • Cawcutt KA, Peters SG. Severe sepsis and septic shock: clinical overview and update on management. Mayo Clin Proc. 2014;89(11):1572–1578.
  • Kotecha A, Vallabhajosyula S, Coville HH, et al. Cardiorenal syndrome in sepsis: a narrative review. J Crit Care. 2018;43:122–127.
  • Annane D, Bellissant E, Cavaillon JM. Septic shock. Lancet. 2005;365(9453):63–78.
  • Court O, Kumar A, Parrillo JE, et al. Clinical review: myocardial depression in sepsis and septic shock. Crit Care. 2002;6(6):500–508.
  • Ambros V. The functions of animal microRNAs. Nature. 2004;431(7006):350–355.
  • Maute RL, Schneider C, Sumazin P, et al. tRNA-derived microRNA modulates proliferation and the DNA damage response and is down-regulated in B cell lymphoma. Proceedings of the National Academy of Sciences of the United States of America. 2013; 110(4):1404–1409.
  • Ambros V. microRNAs: tiny regulators with great potential. Cell. 2001;107(7):823–826.
  • Bartel DP. MicroRNAs: genomics, biogenesis, mechanism, and function. Cell. 2004;116(2):281–297.
  • Wang H, Bei Y, Shen S, et al. miR-21-3p controls sepsis-associated cardiac dysfunction via regulating SORBS2. J Mol Cell Cardiol. 2016;94:43–53.
  • An R, Feng J, Xi C, et al. miR-146a attenuates Sepsis-induced myocardial dysfunction by suppressing IRAK1 and TRAF6 via targeting ErbB4 expression. Oxid Med Cell Longev. 2018;2018:7163057.
  • Zhu XG, Zhang TN, Wen R, et al. Overexpression of miR-150-5p alleviates apoptosis in Sepsis-induced myocardial depression. Biomed Res Int. 2020;2020:3023186.
  • Xu J, Feng Y, Jeyaram A, et al. Circulating plasma extracellular vesicles from septic mice induce inflammation via MicroRNA- and TLR7-dependent mechanisms. J Immunol. 2018;201(11):3392–3400.
  • Zhang TN, Yang N, Goodwin JE, et al. Characterization of circular RNA and microRNA profiles in septic myocardial depression: a Lipopolysaccharide-induced rat septic shock model. Inflammation. 2019;42(6):1990–2002.
  • Zhao Z, Zhong L, Li P, et al. Cholesterol impairs hepatocyte lysosomal function causing M1 polarization of macrophages via exosomal miR-122-5p. Exp Cell Res. 2020;387(1):111738.
  • Aslan JE. Platelet Rho GTPase regulation in physiology and disease. Platelets. 2019;30(1):17–22.
  • Zhang LQ, Zhao GZ, Xu XY, et al. Integrin-β1 regulates chondrocyte proliferation and apoptosis through the upregulation of GIT1 expression. Int J Mol Med. 2015;35(4):1074–1080.
  • Zhao SJ, Liu H, Chen J, et al. Macrophage GIT1 contributes to bone regeneration by regulating inflammatory responses in an ERK/NRF2-dependent way. J Bone Miner Res: the official journal of the American Society for Bone and Mineral Research. 2020;35(10):2015–2031.
  • Pang J, Xu X, Getman MR, et al. G protein coupled receptor kinase 2 interacting protein 1 (GIT1) is a novel regulator of mitochondrial biogenesis in heart. J Mol Cell Cardiol. 2011;51(5):769–776.
  • Yang N, Shi XL, Zhang BL, et al. The trend of β3-adrenergic receptor in the development of septic myocardial depression: a Lipopolysaccharide-induced rat septic shock model. Cardiology. 2018;139(4):234–244.
  • Li P, Shen M, Gao F, et al. An antagomir to MicroRNA-106b-5p Ameliorates cerebral ischemia and reperfusion injury in rats via inhibiting apoptosis and oxidative stress. Mol Neurobiol. 2017;54(4):2901–2921.
  • Liu X, Xiao J, Zhu H, et al. miR-222 is necessary for exercise-induced cardiac growth and protects against pathological cardiac remodeling. Cell Metab. 2015;21(4):584–595.
  • Kang W, Cheng Y, Zhou F, et al. Neuregulin‑1 protects cardiac function in septic rats through multiple targets based on endothelial cells. Int J Mol Med. 2019;44(4):1255–1266.
  • Huang M, Cai S, Su J. The pathogenesis of Sepsis and potential therapeutic targets. Int J Mol Sci. 2019;20(21):5376.
  • Mirna M, Paar V, Rezar R, et al. MicroRNAs in inflammatory heart diseases and Sepsis-induced cardiac dysfunction: a potential scope for the future? Cells. 2019;8(11):1352.
  • Cortez-Dias N, Costa MC, Carrilho-Ferreira P, et al. Circulating miR-122-5p/miR-133b ratio is a specific early prognostic biomarker in acute myocardial infarction. Circ J: official journal of the Japanese Circulation Society. 2016;80(10):2183–2191.
  • Liu Y, Song JW, Lin JY, et al. Roles of MicroRNA-122 in cardiovascular fibrosis and related diseases. Cardiovasc Toxicol. 2020;20(5):463–473.
  • Lang MB, Segersvärd R, Grundsten M, et al. Management of alcohol use disorders in patients with chronic pancreatitis. JOP. 2012;13(6):654–659.
  • Lu Z, Feng H, Shen X, et al. MiR-122-5p protects against acute lung injury via regulation of DUSP4/ERK signaling in pulmonary microvascular endothelial cells. Life Sci. 2020;256:117851.
  • Song JJ, Yang M, Liu Y, et al. MicroRNA-122 aggravates angiotensin II-mediated apoptosis and autophagy imbalance in rat aortic adventitial fibroblasts via the modulation of SIRT6-elabela-ACE2 signaling. Eur J Pharmacol. 2020;883:173374.
  • Li N, Zhou H, Wu H, et al. STING-IRF3 contributes to lipopolysaccharide-induced cardiac dysfunction, inflammation, apoptosis and pyroptosis by activating NLRP3. Redox Biol. 2019;24:101215.
  • Peng H, Luo Y, Ying Y. lncRNA XIST attenuates hypoxia-induced H9c2 cardiomyocyte injury by targeting the miR-122-5p/FOXP2 axis. Mol Cell Probes. 2020;50:101500.
  • Lin J, Zheng X. Salvianolate blocks apoptosis during myocardial infarction by down regulating miR-122-5p. Curr Neurovasc Res. 2017;14:323–329.
  • Rahim I, Sayed RK, Fernández-Ortiz M, et al. Melatonin alleviates sepsis-induced heart injury through activating the Nrf2 pathway and inhibiting the NLRP3 inflammasome. Naunyn-Schmiedeberg’s Archives of Pharmacology. 2021;394(2):261–277.
  • Meng M, Zhang R, Han R, et al. The polysaccharides from the Grifola frondosa fruiting body prevent lipopolysaccharide/D-galactosamine-induced acute liver injury via the miR-122-Nrf2/ARE pathways. Food Funct. 2021;12(5):1973–1982.
  • Qiu L, Fan H, Jin W, et al. miR-122-induced down-regulation of HO-1 negatively affects miR-122-mediated suppression of HBV. Biochem Biophys Res Commun. 2010;398(4):771–777.