Omarigliptin ameliorated high glucose-induced nucleotide oligomerization domain-like receptor protein 3 (NLRP3) inflammasome activation through activating adenosine monophosphate-activated protein kinase α (AMPKα) in renal glomerular endothelial cells

References

• Jung SW, Moon JY. The role of inflammation in diabetic kidney disease. Korean J Intern Med. 2021;36(4):753–766.
   PubMed Web of Science ®Google Scholar
• Lim AK. Diabetic nephropathy–complications and treatment. Int J Nephrol Renovascular Dis. 2014;7:361. .
   PubMedGoogle Scholar
• Bhattacharjee N, Barma S, Konwar N, et al. Mechanistic insight of diabetic nephropathy and its pharmacotherapeutic targets: an update. Eur J Pharmacol. 2016;791:8–24.
   PubMed Web of Science ®Google Scholar
• Mauer M, Doria A. Uric acid and diabetic nephropathy risk. Contrib Nephrol. 2018;192:103–109.
   PubMed Web of Science ®Google Scholar
• Zeng O, Li F, Li Y, et al. Effect of Novel Gasotransmitter hydrogen sulfide on renal fibrosis and connexins expression in diabetic rats. Bioengineered. 2016;7(5):314–320. .
   PubMed Web of Science ®Google Scholar
• Haraldsson B, Nystrom J, Deen WM. Properties of the glomerular barrier and mechanisms of proteinuria. Physiol Rev. 2008;88(2):451–487.
   PubMed Web of Science ®Google Scholar
• Kelley N, Jeltema D, Duan Y, et al. The NLRP3 inflammasome: an overview of mechanisms of activation and regulation. Int J Mol Sci. 2019;20(13):3328. .
   PubMed Web of Science ®Google Scholar
• Yu ZW, Zhang J, Li X, et al. A new research hot spot: the role of NLRP3 inflammasome activation, a key step in pyroptosis, in diabetes and diabetic complications. Life Sci. 2019;240:117138.
   PubMed Web of Science ®Google Scholar
• Gao C, Chen J, Fan F, et al. RIPK2-mediated autophagy and negatively regulated ROS-NLRP3 inflammasome signaling in GMCs stimulated with high glucose. Mediators Inflamm. 2019;2019:6207563. doi: 10.1155/2019/6207563.
   Web of Science ®Google Scholar
• Wang Q, Wei S, Zhou S, et al. Hyperglycemia aggravates acute liver injury by promoting liver-resident macrophage NLRP3 inflammasome activation via the inhibition of AMPK/mTOR-mediated autophagy induction. Immunol Cell Biol. 2020;98(1):54–66. .
   PubMed Web of Science ®Google Scholar
• Yang F, Qin Y, Wang Y, et al. Metformin Inhibits the NLRP3 Inflammasome via AMPK/mTOR-dependent Effects in Diabetic Cardiomyopathy. Int J Biol Sci. 2019;15(5):1010–1019. .
   PubMed Web of Science ®Google Scholar
• Yazbeck R, Jaenisch SE, Abbott CA. Dipeptidyl peptidase 4 inhibitors: applications in innate immunity. Biochem Pharmacol. 2021;188:114517.
   PubMed Web of Science ®Google Scholar
• Krishna R, Addy C, Tatosian D, et al. Pharmacokinetics and pharmacodynamics of omarigliptin, a once-weekly dipeptidyl peptidase-4 (DPP-4) inhibitor, after single and multiple doses in healthy subjects. J Clin Pharmacol. 2016;56(12):1528–1537. .
   PubMed Web of Science ®Google Scholar
• Ndibalema AR, Kabuye D, Wen S, et al. Empagliflozin protects against proximal renal tubular cell injury induced by high glucose via regulation of hypoxia-inducible factor 1-alpha. Diabetes Metab Syndr Obes. 2020;13:1953–1967.
   PubMed Web of Science ®Google Scholar
• Zhu DZ, Shi CF, Jiang YN, et al. Cisatracurium inhibits the growth and induces apoptosis of ovarian cancer cells by promoting lincRNA-p21. Bioengineered. 2021;12(1):1505–1516. .
   PubMed Web of Science ®Google Scholar
• Wang JP, Lv P. Chrysophanol inhibits the osteoglycin/mTOR and activats NF2 signaling pathways to reduce viability and proliferation of malignant meningioma cells. Bioengineered. 2021;12(1):755–762.
   PubMed Web of Science ®Google Scholar
• Lu Q, Wang WW, Zhang MZ, et al. ROS induces epithelial-mesenchymal transition via the TGF-beta1/PI3K/Akt/mTOR pathway in diabetic nephropathy. Exp Ther Med. 2019;17(1):835–846.
   PubMed Web of Science ®Google Scholar
• Alicic RZ, Rooney MT, Tuttle KR. Diabetic Kidney Disease: challenges, Progress, and Possibilities. Clin J Am Soc Nephrol. 2017;12(12):2032–2045.
   PubMed Web of Science ®Google Scholar
• Dai H, Liu Q, Liu B. Research progress on mechanism of podocyte depletion in diabetic nephropathy. J Diabetes Res. 2017;2017:2615286. doi: 10.1155/2017/2615286.
   Google Scholar
• Adamiak M, Lenkiewicz AM, Cymer M, et al. Novel evidence that an alternative complement cascade pathway is involved in optimal mobilization of hematopoietic stem/progenitor cells in Nlrp3 inflammasome-dependent manner. Leukemia. 2019;33(12):2967–2970. .
   PubMed Web of Science ®Google Scholar
• Du L, Dong F, Guo L, et al. Interleukin-1beta increases permeability and upregulates the expression of vascular endothelial-cadherin in human renal glomerular endothelial cells. Mol Med Rep. 2015;11(5):3708–3714. .
   PubMed Web of Science ®Google Scholar
• Wu M, Han W, Song S, et al. NLRP3 deficiency ameliorates renal inflammation and fibrosis in diabetic mice. Mol Cell Endocrinol. 2018;478:115–125.
   PubMed Web of Science ®Google Scholar
• Carling D. AMPK signaling in health and disease. Curr Opin Cell Biol. 2017;45:31–37.
   PubMed Web of Science ®Google Scholar
• Wang Q, Liu S, Zhai A, et al. AMPK-mediated regulation of lipid metabolism by phosphorylation. Biol Pharm Bull. 2018;41(7):985–993. .
   PubMed Web of Science ®Google Scholar
• Alers S, Loffler AS, Wesselborg S, et al. Role of AMPK-mTOR-Ulk1/2 in the regulation of autophagy: cross talk, shortcuts, and feedbacks. Mol Cell Biol. 2012;32(1):2–11. .
   PubMed Web of Science ®Google Scholar
• Wang H, Zhong P, Sun L. Exogenous hydrogen sulfide mitigates NLRP3 inflammasome-mediated inflammation through promoting autophagy via the AMPK-mTOR pathway. Biol Open. 2019;8(7):bio043653. doi: 10.1242/bio.043653.
   Web of Science ®Google Scholar
• Legrand-Poels S, Esser N, L’homme L, et al. Free fatty acids as modulators of the NLRP3 inflammasome in obesity/type 2 diabetes. Biochem Pharmacol. 2014;92(1):131–141. .
   PubMed Web of Science ®Google Scholar
• Chang YW, Hung LC, Chen YC, et al. Insulin reduces inflammation by regulating the activation of the NLRP3 inflammasome. Front Immunol. 2021;11:587229.
   PubMed Web of Science ®Google Scholar