References
- Jemal A, Bray F, Center MM, et al. Global cancer statistics. CA Cancer J Clin. 2011;61:69–90.
- Shibahara T. [Oral cancer -diagnosis and therapy-.]. Clin Calcium. 2017;27:1427–1433.
- Kumar M, Nanavati R, Modi TG, et al. Oral cancer: etiology and risk factors: a review. J Cancer Res Ther. 2016;12:458–463.
- Valdez JA, Brennan MT. Impact of Oral Cancer on Quality of Life. Dent Clin North Am. 2018;62:143–154.
- Yang R, Yuan BC, Ma YS, et al. The anti-inflammatory activity of licorice, a widely used Chinese herb. Pharm Biol. 2017;55:5–18.
- Deutch MR, Grimm D, Wehland M, et al. Bioactive Candy: Effects of Licorice on the Cardiovascular System. 2019;8(10):495.
- Jiang M, Zhu M, Wang L, et al. Anti-tumor effects and associated molecular mechanisms of myricetin. Biomed Pharmacothe. 2019;120:109506.
- Huynh DL, Sharma N, Kumar Singh A, et al. Anti-tumor activity of wogonin, an extract from Scutellaria baicalensis, through regulating different signaling pathways. Chin J Nat Med. 2017;15:15–40.
- Wang D, Wong HK, Feng YB, et al. Liquiritigenin exhibits antitumour action in pituitary adenoma cells via Ras/ERKs and ROS-dependent mitochondrial signalling pathways. J Pharm Pharmacol. 2014;66:408–417.
- Meng FC, Lin JK. Liquiritigenin Inhibits Colorectal Cancer Proliferation, Invasion, and Epithelial-to-Mesenchymal Transition by Decreasing Expression of Runt-Related Transcription Factor 2. Oncol Res. 2019;27:139–146.
- Onorati AV, Dyczynski M, Ojha R, et al. Targeting autophagy in cancer. Cancer. 2018;124:3307–3318.
- Zhang B, Liu L. Autophagy is a double-edged sword in the therapy of colorectal cancer. Oncol Lett. 2021;21:378.
- Chu CW, Ko HJ, Chou CH, et al. Thioridazine Enhances P62-Mediated Autophagy and Apoptosis Through Wnt/β-Catenin Signaling Pathway in Glioma Cells. Int J Mol Sci. 2019;20(3):473.
- Amaravadi R, Kimmelman AC, White E. Recent insights into the function of autophagy in cancer. Genes Dev. 2016;30:1913–1930.
- Gao X, Wang Y, Li Y, et al. Huganpian, a traditional chinese medicine, inhibits liver cancer growth in vitro and in vivo by inducing autophagy and cell cycle arrest. Biomed Pharmacothe. 2019;120:109469.
- Jia L, Huang S, Yin X, et al. Quercetin suppresses the mobility of breast cancer by suppressing glycolysis through Akt-mTOR pathway mediated autophagy induction. Life Sci. 2018;208:123–130.
- Shen TS, Hsu YK, Huang YF, et al. Licochalcone A Suppresses the Proliferation of Osteosarcoma Cells through Autophagy and ATM-Chk2 Activation. 2019;24(13):2435.
- Lv H, Yang H, Wang Z, et al. Nrf2 signaling and autophagy are complementary in protecting lipopolysaccharide/d-galactosamine-induced acute liver injury by licochalcone A. Cell Death Dis. 2019;10:313.
- Liang F, Zhang H, Gao H, et al. Liquiritigenin decreases tumorigenesis by inhibiting DNMT activity and increasing BRCA1 transcriptional activity in triple-negative breast cancer. Exp Biol Med. 2021;246:459–466.
- Kim C, Park S. IGF-1 protects SH-SY5Y cells against MPP(+)-induced apoptosis via PI3K/PDK-1/Akt pathway. Endocr Connect. 2018;7:443–455.
- Liang Z, Chi YJ, Lin GQ, et al. MiRNA-26a promotes angiogenesis in a rat model of cerebral infarction via PI3K/AKT and MAPK/ERK pathway. Eur Rev Med Pharmacol Sci. 2018;22:3485–3492.
- Chen JY, Xu LF, Hu HL, et al. MiRNA-215-5p alleviates the metastasis of prostate cancer by targeting PGK1. Eur Rev Med Pharmacol Sci. 2020;24:639–646.
- Wang R, Bao H, Zhang S, et al. miR-186-5p Promotes Apoptosis by Targeting IGF-1 in SH-SY5Y OGD/R Model. Int J Biol Sci. 2018;14:1791–1799.
- Zhang B, Shetti D, Fan C, et al. miR-29b-3p promotes progression of MDA-MB-231 triple-negative breast cancer cells through downregulating TRAF3. 52(38):2019;52(1):38.
- Liu W, Wang X, Liu Z, et al. SGK1 inhibition induces autophagy-dependent apoptosis via the mTOR-Foxo3a pathway. Br J Cancer. 2017;117:1139–1153.
- Liu XH, Sun M, Nie FQ, et al. Lnc RNA HOTAIR functions as a competing endogenous RNA to regulate HER2 expression by sponging miR-331-3p in gastric cancer. Mol Cancer. 2014;13:92.
- D’Arcy MS. Cell death: a review of the major forms of apoptosis, necrosis and autophagy. Cell Biol Int. 2019;43:582–592.
- Carneiro BA, El-Deiry WS. Targeting apoptosis in cancer therapy. Nat Rev Clin Oncol. 2020;17:395–417.
- Xiang Y, Guo Z, Zhu P, et al. Traditional Chinese medicine as a cancer treatment: modern perspectives of ancient but advanced science. Cancer Med. 2019(8):1958-75.
- Huang CH, Chan WH. Protective Effects of Liquiritigenin against Citrinin-Triggered, Oxidative-Stress-Mediated Apoptosis and Disruption of Embryonic Development in Mouse Blastocysts. Int J Mol Sci. 2017;;18(12):2538.
- Zhang SP, Zhou YJ, Liu Y, et al. Effect of liquiritigenin, a flavanone existed from Radix glycyrrhizae on pro-apoptotic in SMMC-7721 cells. Food and chemical toxicology: an international journal published for the British Industrial Biological Research Association. 2009;47:693–701.
- Dikic I, Elazar Z. Mechanism and medical implications of mammalian autophagy. Nat Rev Mol Cell Biol. 2018;19:349–364.
- Ravanan P, Srikumar IF, Talwar P. Autophagy: the spotlight for cellular stress responses. Life Sci. 2017;188:53–67.
- Kocaturk NM, Akkoc Y, Kig C, et al. Autophagy as a molecular target for cancer treatment. Eur J Pharm Sci. 2019;134:116–137.
- White E. The role for autophagy in cancer. J Clin Invest. 2015;125:42–46.
- Patra S, Panigrahi DP, Praharaj PP, et al. Dysregulation of histone deacetylases in carcinogenesis and tumor progression: a possible link to apoptosis and autophagy. Cell Mol Life Sci. 2019;76:3263–3282.
- Levy JMM, Towers CG, Thorburn A. Targeting autophagy in cancer. Nat Rev Cancer. 2017;17:528–542.
- Wei F, Jiang X, Gao HY, et al. Liquiritin induces apoptosis and autophagy in cisplatin (DDP)-resistant gastric cancer cells in vitro and xenograft nude mice in vivo. Int J Oncol. 2017;51:1383–1394.
- Mizushima N. The ATG conjugation systems in autophagy. Curr Opin Cell Biol. 2020;63:1–10.
- Chen ST, Lee TY, Tsai TH, et al. Traditional Chinese medicine Danggui Buxue Tang inhibits colorectal cancer growth through induction of autophagic cell death. Oncotarget. 2017;8:88563–88574.
- Zhu ML, Lu JX, Pan GP, Ping S, Zhao FR, Qi HT, et al. Traditional Chinese medicine Ka-Sai-Ping suppresses the growths of gastric cancers via induction of autophagy. Oncotarget. 2017;8:95075–95082.
- Liu W, Li S, Qu Z, et al. Betulinic acid induces autophagy-mediated apoptosis through suppression of the PI3K/AKT/mTOR signaling pathway and inhibits hepatocellular carcinoma. Am J Transl Res. 2019;11:6952–6964.
- Shariati M, Targeting M-BF. AKT for cancer therapy. Expert Opin Investig Drugs. 2019;28:977–988.
- Yan D, Yan X, Dai X, et al. Activation of AKT/AP1/FoxM1 signaling confers sorafenib resistance to liver cancer cells. Oncol Rep. 2019;42:785–796.
- Man J, Chen L, Zhai XW, et al. [Expression of p-AKT and p-mTOR in pediatric Burkitt lymphoma and their correlation with prognosis]. Zhonghua Bing Li Xue Za Zhi. 2020;49:156–161.
- Zhu Q, Enkhjargal B, Huang L, et al. Aggf1 attenuates neuroinflammation and BBB disruption via PI3K/Akt/NF-κB pathway after subarachnoid hemorrhage in rats. J Neuroinflammation. 2018;15:178.
- Zuo E, Zhang C, Mao J, et al. 2,5-Hexanedione mediates neuronal apoptosis through suppression of NGF via PI3K/Akt signaling in the rat sciatic nerve. Biosci Rep. 2019;39.
- Liu Y, Xie S, Wang Y, et al. Liquiritigenin inhibits tumor growth and vascularization in a mouse model of HeLa cells. Molecules. 2012;17:7206–7216.