Four specific biomarkers associated with the progression of glioblastoma multiforme in older adults identified using weighted gene co-expression network analysis

References

• Lah TT, Novak M, Breznik B. Brain malignancies: glioblastoma and brain metastases. Semin Cancer Biol. 2020;60:262–273.
   PubMed Web of Science ®Google Scholar
• Tewarie IA, Senders JT, Kremer S, et al. Survival prediction of glioblastoma patients-are we there yet? A systematic review of prognostic modeling for glioblastoma and its clinical potential. Neurosurg Rev. 2021;44(4):2047–2057.
   PubMed Web of Science ®Google Scholar
• Laigle-Donadey F. [Glioblastoma in the elderly]. Geriatr Psychol Neuropsychiatr Vieil. 2019;17:173–178.
   PubMed Web of Science ®Google Scholar
• Iskandar AS, Kerr WT, Hwang A, et al. Impact of therapeutic modalities on disease-specific survival in older adults with glioblastoma: a single-institution retrospective cohort study. J Oncol Pharm Pract. 2019;25(8):1999–2003.
   PubMed Web of Science ®Google Scholar
• Silantyev AS, Falzone L, Libra M, et al. Current and future trends on diagnosis and prognosis of glioblastoma: from molecular biology to proteomics. Cells. 2019;8(8):863.
   PubMed Web of Science ®Google Scholar
• Jovčevska I. Sequencing the next generation of glioblastomas. Crit Rev Clin Lab Sci. 2018;55(4):264–282.
   PubMed Web of Science ®Google Scholar
• Zhao C, Gao Y, Guo R, et al. Microarray expression profiles and bioinformatics analysis of mRNAs, lncRNAs, and circRNAs in the secondary temozolomide-resistant glioblastoma. Invest New Drugs. 2020;38(5):1227–1235.
   PubMed Web of Science ®Google Scholar
• Candido S, Lupo G, Pennisi M, et al. The analysis of miRNA expression profiling datasets reveals inverse microRNA patterns in glioblastoma and Alzheimer’s disease. Oncol Rep. 2019;42:911–922.
   PubMed Web of Science ®Google Scholar
• Stella M, Falzone L, Caponnetto A, et al. Serum extracellular vesicle-derived circHIPK3 and circSMARCA5 are two novel diagnostic biomarkers for glioblastoma multiforme. Pharmaceuticals (Basel). 2021;14(7):618.
   PubMedGoogle Scholar
• Zhou L, Tang H, Wang F, et al. Bioinformatics analyses of significant genes, related pathways and candidate prognostic biomarkers in glioblastoma. Mol Med Rep. 2018;18:4185–4196.
   PubMed Web of Science ®Google Scholar
• Langfelder P, Wgcna: HS. An R package for weighted correlation network analysis. BMC Bioinformatics. 2008;9(1):559.
   PubMed Web of Science ®Google Scholar
• Kakati T, Bhattacharyya DK, Barah P, et al. Comparison of methods for differential co-expression analysis for disease biomarker prediction. Comput Biol Med. 2019;113:103380.
   PubMed Web of Science ®Google Scholar
• Liu W, Li L, Ye H, et al. [Weighted gene co-expression network analysis in biomedicine research]. Sheng Wu Gong Cheng Xue Bao. 2017;33:1791–1801.
   PubMedGoogle Scholar
• Yang Q, Wang R, Wei B, et al. Candidate biomarkers and molecular mechanism investigation for glioblastoma multiforme utilizing WGCNA. BioMed Res Int. 2018; 2018: 4246703.
   PubMed Web of Science ®Google Scholar
• Lin S, Xu H, Zhang A, et al. Prognosis analysis and validation of m6A signature and tumor immune microenvironment in glioma. Front Oncol. 2020;10:541401.
   PubMed Web of Science ®Google Scholar
• Blum A, Wang P, Zenklusen JC. SnapShot: TCGA-analyzed tumors. Cell. 2018;173(2):530.
   PubMed Web of Science ®Google Scholar
• Sepulveda JL. Using R and bioconductor in clinical genomics and transcriptomics. J Mol Diagn. 2020;22(1):3–20.
   PubMed Web of Science ®Google Scholar
• Huang DW, Sherman BT, Lempicki RA. Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc. 2009;4(1):44–57.
   PubMed Web of Science ®Google Scholar
• Crosara KTB, Moffa EB, Xiao Y, et al. Merging in-silico and in vitro salivary protein complex partners using the STRING database: a tutorial. J Proteomics. 2018;171:87–94.
   PubMed Web of Science ®Google Scholar
• Bell GW, Lewitter F. Visualizing networks. Methods Enzymol. 2006;411:408–421.
   PubMed Web of Science ®Google Scholar
• Wu J, Lv Q, Huang H, et al. Screening and identification of key biomarkers in inflammatory breast cancer through integrated bioinformatic analyses. Genet Test Mol Biomarkers. 2020;24(8):484–491.
   PubMed Web of Science ®Google Scholar
• Chambless LB, Kistka HM, Parker SL, et al. The relative value of postoperative versus preoperative Karnofsky Performance Scale scores as a predictor of survival after surgical resection of glioblastoma multiforme. J Neurooncol. 2015;121(2):359–364.
   PubMed Web of Science ®Google Scholar
• Sacko A, Hou MM, Temgoua M, et al. Evolution of the Karnosky Performance Status throughout life in glioblastoma patients. J Neurooncol. 2015;122(3):567–573.
   PubMed Web of Science ®Google Scholar
• Wang S, Wang T, Liu T, et al. Ermin is a p116RIP-interacting protein promoting oligodendroglial differentiation and myelin maintenance. Glia. 2020;68:2264–2276.
   PubMed Web of Science ®Google Scholar
• Salek Esfahani B, Gharesouran J, Ghafouri-Fard S, et al. Down-regulation of ERMN expression in relapsing remitting multiple sclerosis. Metab Brain Dis. 2019;34(5):1261–1266.
   PubMed Web of Science ®Google Scholar
• Novarino G, Fenstermaker AG, Zaki MS, et al. Exome sequencing links corticospinal motor neuron disease to common neurodegenerative disorders. Science. 2014;343(6170):506–511.
   PubMed Web of Science ®Google Scholar
• Sun X, Wang L, Li H, et al. Identification of microenvironment related potential biomarkers of biochemical recurrence at 3 years after prostatectomy in prostate adenocarcinoma. Aging (Albany NY). 2021;13(12):16024–16042.
   PubMedGoogle Scholar
• Loers G, Aboul-Enein F, Bartsch U, et al. Comparison of myelin, axon, lipid, and immunopathology in the central nervous system of differentially myelin-compromised mutant mice: a morphological and biochemical study. Mol Cell Neurosci. 2004;27(2):175–189.
   PubMed Web of Science ®Google Scholar
• Kaye JF, Kerlero DR, Mendel N, et al. A. The central nervous system-specific myelin oligodendrocytic basic protein (MOBP) is encephalitogenic and a potential target antigen in multiple sclerosis (MS). J Neuroimmunol. 2000;102(2):189–198.
   PubMed Web of Science ®Google Scholar
• Davuluri S, Bajpai AK, Thirumurugan K, et al. The molecular basis of gender disparities in smoking lung cancer patients. Life Sci. 2021;267:118927.
   PubMed Web of Science ®Google Scholar
• Wang E, Dimova N, Sperle K, et al. Deletion of a splicing enhancer disrupts PLP1/DM20 ratio and myelin stability. Exp Neurol. 2008;214(2):322–330.
   PubMed Web of Science ®Google Scholar
• Numasawa-Kuroiwa Y, Okada Y, Shibata S, et al. Involvement of ER stress in dysmyelination of Pelizaeus–Merzbacher disease with PLP1 missense mutations shown by iPSC-derived oligodendrocytes. Stem Cell Rep. 2014;2(5):648–661.
   PubMed Web of Science ®Google Scholar
• Morimura T, Numata Y, Nakamura S, et al. Attenuation of endoplasmic reticulum stress in Pelizaeus–Merzbacher disease by an anti-malaria drug, chloroquine. Exp Biol Med. 2014;239(4):489–501.
   Web of Science ®Google Scholar
• Kouga T, Koizume S, Aoki S, et al. Drug screening for Pelizaeus–Merzbacher disease by quantifying the total levels and membrane localization of PLP1. Mol Genet Metab Rep. 2019;20:100474.
   PubMed Web of Science ®Google Scholar
• He Y, Su J, Lan B, et al. Targeting off-target effects: endoplasmic reticulum stress and autophagy as effective strategies to enhance temozolomide treatment. Onco Targets Ther. 2019;12:1857–1865.
   PubMed Web of Science ®Google Scholar
• Yoshikawa F, Sato Y, Tohyama K, et al. Opalin, a transmembrane sialylglycoprotein located in the central nervous system myelin paranodal loop membrane. J Biol Chem. 2008;283(30):20830–20840.
   PubMed Web of Science ®Google Scholar
• de Faria OJ, Dhaunchak AS, Kamen Y, et al. TMEM10 promotes oligodendrocyte differentiation and is expressed by oligodendrocytes in human remyelinating multiple sclerosis plaques. Sci Rep. 2019;9(1):3606.
   PubMedGoogle Scholar
• Hardt R, Jordans S, Winter D, et al. Decreased turnover of the CNS myelin protein opalin in a mouse model of hereditary spastic paraplegia 35. Hum Mol Genet. 2021;29(22):3616–36130.
   PubMed Web of Science ®Google Scholar
• El-Derany MO, Noureldein MH. Bone marrow mesenchymal stem cells and their derived exosomes resolve doxorubicin-induced chemobrain: critical role of their miRNA cargo. Stem Cell Res Ther. 2021;12(1):322.
   PubMed Web of Science ®Google Scholar