References
- Mattiuzzi C, Lippi G. Cancer statistics: a comparison between World Health Organization (WHO) and Global Burden of Disease (GBD). Eur J Public Health. 2020;30(5):1026–1027.
- Clarke MF. Clinical and therapeutic implications of cancer stem cells. N Engl J Med. 2019;380(23):2237–2245.
- Eide CA, Druker BJ. Understanding cancer from the stem cells up. Nat Med. 2017;23(6):656–657.
- Rigaud VOC, Hoy R, Mohsin S, et al. Stem cell metabolism: powering cell-based therapeutics. Cells. 2020;9(11):2490.
- Di W, Lv J, Jiang S, et al. PGC-1: the energetic regulator in cardiac metabolism. Curr Issues Mol Biol. 2018;28:29–46.
- Son MJ, Oh KJ, Park A, et al. GATA3 induces the upregulation of UCP-1 by directly binding to PGC-1α during adipose tissue browning. Metabolism. 2020;109:154280.
- Soyal S, Krempler F, Oberkofler H, et al. PGC-1α: a potent transcriptional cofactor involved in the pathogenesis of type 2 diabetes. Diabetologia. 2006;49(7):1477–1488.
- Dumauthioz N, Tschumi B, Wenes M, et al. Enforced PGC-1α expression promotes CD8 T cell fitness, memory formation and antitumor immunity. Cell Mol Immunol. 2021;18(7):1761–1771.
- Cantó C, Auwerx J.PGC-1α, SIRT1 and AMPK, an energy sensing network that controls energy expenditure. Curr Opin Lipidol. 2009;20(2):98–105.
- Chambers JM, Wingert RA. PGC-1α in Disease: recent Renal Insights into a Versatile Metabolic Regulator. Cells. 2020;9(10):2234.
- Lee JE, Jeon IS, Han NE, et al. Ubiquilin 1 interacts with Orai1 to regulate calcium mobilization. Mol Cells. 2013;35(1):41–46.
- Li X, Zhou J, Chen H, et al. The association between the UBQLN1 polymorphism and Alzheimer’s disease risk: a systematic review. Cell Mol Biol (Noisy-le-grand). 2017;63(5):94–96.
- Gadhave K, Kumar P, Kapuganti SK, et al. Unstructured biology of proteins from ubiquitin-proteasome system: roles in cancer and neurodegenerative diseases. Biomolecules. 2020;10(5):797.
- Beverly LJ, Lockwood WW, Shah PP, et al. Ubiquitination, localization, and stability of an anti-apoptotic BCL2-like protein, BCL2L10/BCLb, are regulated by Ubiquilin1. Proc Natl Acad Sci U S A. 2012;109(3):E119–126.
- Tanaka K, Funakoshi M, Kobayashi H. A Cdc2-sensitive interaction of the UbL domain of XDRP1S with cyclin B mediates the degradation of cyclin B in Xenopus egg extracts. Biochem Biophys Res Commun. 2006;350(3):774–782.
- Chen G, Wang X, Yu J, et al. Autoantibody profiles reveal ubiquilin 1 as a humoral immune response target in lung adenocarcinoma. Cancer Res. 2007;67(7):3461–3467.
- Zhang J, Zhang Q. Using seahorse machine to measure OCR and ECAR in Cancer Cells. Methods Mol Biol. 2019;1928:353–363.
- Nagy Á, Munkácsy G, Győrffy B. Pancancer survival analysis of cancer hallmark genes. Sci Rep. 2021;11(1):6047.
- Duma N, Santana-Davila R, Molina JR. Non–small cell lung cancer: epidemiology, screening, diagnosis, and treatment. Mayo Clin Proc. 2019;94(8):1623–1640.
- Yang Y, Li X, Wang T, et al. Emerging agents that target signaling pathways in cancer stem cells. J Hematol Oncol. 2020;13(1):60.
- Lee DS, Oh K. Cancer stem cells in the immune microenvironment. Adv Exp Med Biol. 2021;1187:245–266.
- Srinivas US, Tan BWQ, Vellayappan BA, et al. ROS and the DNA damage response in cancer. Redox Biol. 2019;25:101084.
- Fuhrmann DC, Brüne B. Mitochondrial composition and function under the control of hypoxia. Redox Biol. 2017;12:208–215.
- Wei L, Lee D, Law CT, et al. Genome-wide CRISPR/Cas9 library screening identified PHGDH as a critical driver for Sorafenib resistance in HCC. Nat Commun. 2019;10(1):4681.
- Dou Z, Berger SL. Senescence elicits stemness: a surprising mechanism for cancer relapse. Cell Metab. 2018;27(4):710–711.
- Tang M, Yang M, Wu G, et al. Epigenetic induction of mitochondrial fission is required for maintenance of liver cancer–initiating cells. Cancer Res. 2021;81(14):3835–3848.
- Cherng YG, Chu YC, Yadav VK, et al. Induced mitochondrial alteration and DNA Damage via IFNGR-JAK2-STAT1-PARP1 pathway facilitates viral hepatitis associated hepatocellular carcinoma aggressiveness and stemness. Cancers (Basel). 2021;13(11):2755.
- Ristow M, Zarse K, Oberbach A, et al. Antioxidants prevent health-promoting effects of physical exercise in humans. Proc Natl Acad Sci U S A. 2009;106(21):8665–8670.
- Bost F, Kaminski L. The metabolic modulator PGC-1α in cancer. Am J Cancer Res. 2019;9(2):198–211.
- Luo C, Lim JH, Lee Y, et al. A PGC1α-mediated transcriptional axis suppresses melanoma metastasis. Nature. 2016;537(7620):422–426.
- Nimmakayala RK, Rauth S, Chirravuri Venkata R, et al. PGC1α-mediated metabolic reprogramming drives the stemness of pancreatic precursor lesions. Clin Cancer Res off J Am Assoc Cancer Res. 2021. DOI:10.1158/1078-0432.CCR-20-5020.
- Xu J, Ji L, Ruan Y, et al. UBQLN1 mediates sorafenib resistance through regulating mitochondrial biogenesis and ROS homeostasis by targeting PGC1β in hepatocellular carcinoma. Signal Transduct Target Ther. 2021;6(1). DOI:10.1038/s41392-021-00594-4.