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Research Paper

Zhike Pingchuan Granule suppresses interleukin (IL)-6 or the medium of M2 macrophages induced apoptosis in human bronchial epithelial cells

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Pages 7694-7703 | Received 23 Jul 2021, Accepted 11 Sep 2021, Published online: 05 Oct 2021

References

  • Ren Y, Liu Y, Wang S, et al. Zhike pingchuan granules improve bronchial asthma by regulating the IL-6/JAK2/STAT3 pathway. Exp Ther Med. 2021;22(2):899.
  • Li X, Feng Z, Huo W, et al. [Study on dissolution in vitro of Zhike Pingchuan sustained-release tablets]. Zhongguo Zhong Yao Za Zhi. 2009;34:1216–1219.
  • Yokoyama A. Circulating interleukin-6 levels in patients with bronchial asthma. Am J Respir Crit Care Med. 1995;151(5):1354-1358.
  • Neveu WA, Allard JL, Raymond DM, et al. Elevation of IL-6 in the allergic asthmatic airway is independent of inflammation but associates with loss of central airway function. Respir Res. 2010;11(1):28.
  • Zhang JG, Chen XJ, Tao L, et al. FOXP3+ associated with the pro-inflammatory regulatory?T and T helper?17 effector cells in asthma patients. Exp Ther Med. 2016;12(4):2753.
  • Wang W-C, Kuo C-Y, Tzang B-S, et al. IL-6 augmented motility of airway epithelial cell BEAS-2B via Akt/GSK-3β signaling pathway. J Cell Biochem. 2012;113(11):3567–3575.
  • Gubernatorova EO, Gorshkova EA, Namakanova OA, et al. Non-redundant functions of IL-6 produced by macrophages and dendritic cells in allergic airway inflammation. Front Immunol. 2018;9:2718.
  • Jevnikar Z, Östling J, Ax E, et al. Epithelial IL-6 trans-signaling defines a new asthma phenotype with increased airway inflammation. J Allergy Clin Immunol. 2019;143(2):577–590.
  • Yap HM, Israf DA, Harith HH, et al. Crosstalk between signaling pathways involved in the regulation of airway smooth muscle cell hyperplasia. Front Pharmacol. 2019;10:1148.
  • Fang Z, Yang H, Chen D, et al. YY1 promotes colorectal cancer proliferation through the miR-526b-3p/E2F1 axis. Am J Cancer Res. 2019;9:2679–2692.
  • Hao W, Wang J, Zhang Y, et al. Leptin positively regulates MUC5AC production and secretion induced by interleukin-13 in human bronchial epithelial cells. Biochem Biophys Res Commun. 2017;493(2):979–984.
  • Yao Y, Wang ZC, Liu JX, et al. Increased expression of TIPE2 in alternatively activated macrophages is associated with eosinophilic inflammation and disease severity in chronic rhinosinusitis with nasal polyps. Int Forum Allergy Rhinol. 2017;7(10):963–972.
  • Houghton AM, Hartzell WO, Robbins CS, et al. Macrophage elastase kills bacteria within murine macrophages. Nature. 2009;460(7255):637–641.
  • Draijer C, Boorsma CE, Robbe P, et al. Human asthma is characterized by more IRF5+ M1 and CD206+ M2 macrophages and less IL-10+ M2-like macrophages around airways compared with healthy airways. J Allergy Clin Immunol. 2017;140(1):280–283.e283.
  • Tan HY, Wang N, Li S, et al. The reactive oxygen species in macrophage polarization: reflecting its dual role in progression and treatment of human diseases. Oxid Med Cell Longev. 2016;2016:2795090.
  • Becerra-Díaz M, Strickland AB, Keselman A, et al. Androgen and androgen receptor as enhancers of M2 macrophage polarization in allergic lung inflammation. J Immunol. 2018;201(10):2923–2933.
  • Shapouri‐Moghaddam A, Mohammadian S, Vazini H, et al. Macrophage plasticity, polarization, and function in health and disease. J Cell Physiol. 2018;233(9):6425–6440.
  • Li R, Shang Y, Hu X, et al. ATP/P2X7r axis mediates the pathological process of allergic asthma by inducing M2 polarization of alveolar macrophages. Exp Cell Res. 2020;386(1):111708.
  • Girodet P-O, Nguyen D, Mancini JD, et al. Alternative macrophage activation is increased in asthma. Am J Respir Cell Mol Biol. 2016;55(4):467–475.
  • Huang Y, Du KL, Guo PY, et al. IL-16 regulates macrophage polarization as a target gene of mir-145-3p. Mol Immunol. 2019;107:1–9.
  • Bazan-Socha S, Mastalerz L, Cybulska A, et al. Prothrombotic state in asthma is related to increased levels of inflammatory cytokines, IL-6 and TNFα, in peripheral blood. Inflammation. 2017;40(4):1225–1235.
  • Peters MC, Mauger D, Ross KR, et al. Evidence for exacerbation-prone asthma and predictive biomarkers of exacerbation frequency. Am J Respir Crit Care Med. 2020;202(7):973–982.
  • Peters MC, McGrath KW, Hawkins GA, et al. Plasma interleukin-6 concentrations, metabolic dysfunction, and asthma severity: a cross-sectional analysis of two cohorts. Lancet Respir Med. 2016;4(7):574–584.
  • Esty B, Harb H, Bartnikas LM, et al. Treatment of severe persistent asthma with IL-6 receptor blockade. J Allergy Clin Immunol Pract. 2019;7(5):1639–1642.e1634.
  • Mitzel DN, Jaramillo RJ, Stout-Delgado H, et al. Human metapneumovirus inhibits the IL-6-induced JAK/STAT3 signalling cascade in airway epithelium. J Gen Virol. 2014;95(1):26–37.
  • Xu Z, Wu H, Zhang H, et al. Interleukins 6/8 and cyclooxygenase-2 release and expressions are regulated by oxidative stress-JAK2/STAT3 signaling pathway in human bronchial epithelial cells exposed to particulate matter ≤2.5 μm. J Appl Toxicol. 2020;40(9):1210–1218.
  • Tsai YG, Wen YS, Wang JY, et al. Complement regulatory protein CD46 induces autophagy against oxidative stress-mediated apoptosis in normal and asthmatic airway epithelium. Sci Rep. 2018;8(1):12973.
  • Fitzpatrick AM, Park Y, Brown LAS, et al. Children with severe asthma have unique oxidative stress–associated metabolomic profiles. J Allergy Clin Immunol. 2014;133(1): 258-258.
  • Brown SD, Baxter KM, Stephenson ST, et al. Airway TGF-β1 and oxidant stress in children with severe asthma: association with airflow limitation. J Allergy Clin Immunol. 2012;129(2):388–396, 396.e381-388.
  • Auerbach A, Hernandez ML. The effect of environmental oxidative stress on airway inflammation. Curr Opin Allergy Clin Immunol. 2012;12(2):133–139.
  • Lin YC, Lin CH, Yao HT, et al. Platycodon grandiflorum (PG) reverses angiotensin II-induced apoptosis by repressing IGF-IIR expression. J Ethnopharmacol. 2017;205:41–50.
  • Zhang W, Hou J, Yan X, et al. Platycodon grandiflorum saponins ameliorate cisplatin-induced acute nephrotoxicity through the NF-κB-mediated inflammation and PI3K/Akt/apoptosis signaling pathways. Nutrients. 2018;10(9):1328.
  • Melgert BN, ten Hacken NH, Rutgers B, et al. More alternative activation of macrophages in lungs of asthmatic patients. J Allergy Clin Immunol. 2011;127(3):831–833.
  • Draijer C, Robbe P, Boorsma CE, et al. Characterization of macrophage phenotypes in three murine models of house-dust-mite-induced asthma. Mediators Inflamm. 2013;2013:632049.
  • Lee HS, Park DE, Bae B, et al. Transglutaminase 2 contributes to the asthmatic inflammation by modulating activation of alveolar macrophages. Immun Inflamm Dis. 2021;9(3):871–882.
  • Bonner K, Pease JE, Corrigan CJ, et al. CCL17/thymus and activation-regulated chemokine induces calcitonin gene–related peptide in human airway epithelial cells through CCR4. J Allergy Clin Immunol. 2013;132(4):942–943.
  • Oyamada H, Kamada Y, Kuwasaki T, et al. CCR3 mRNA expression in bronchial epithelial cells and various cells in allergic inflammation. Int Arch Allergy Immunol. 1999;120(Suppl 1):45–47.