1,158
Views
3
CrossRef citations to date
0
Altmetric
Research paper

Pseudogene fms-related tyrosine kinase 1 pseudogene 1 (FLT1P1) cooperates with RNA binding protein dyskeratosis congenita 1 (DKC1) to restrain trophoblast cell proliferation and angiogenesis by targeting fms-related tyrosine kinase 1 (FLT1) in preeclampsia

, , , , & ORCID Icon
Pages 8885-8897 | Received 26 Jul 2021, Accepted 29 Sep 2021, Published online: 26 Oct 2021

References

  • Ramos JGL, Sass N, Costa SHM. Preeclampsia. Rev Bras Ginecol Obstet. 2017 Sep;39(9):496–512.
  • Murthi P, Pinar AA, Dimitriadis E, et al.Inflammasomes-A Molecular Link for Altered Immunoregulation and Inflammation Mediated Vascular Dysfunction in Preeclampsia. Int J Mol Sci. 2020 Feb 19;Vol. 21:4.
  • Sánchez-Aranguren LC, Prada CE, Riaño-Medina CE, et al. Endothelial dysfunction and preeclampsia: role of oxidative stress. Front Physiol. 2014;5:372.
  • Phipps EA, Thadhani R, Benzing T, et al. Pre-eclampsia: pathogenesis, novel diagnostics and therapies. Nat Rev Nephrol. 2019 May;15(5):275–289.
  • Rana S, Lemoine E, Granger JP, et al. Preeclampsia: pathophysiology, challenges, and perspectives. Circ Res. 2019 Mar 29;124(7):1094–1112.
  • Shen Y, Liu S, Fan J, et al. Nuclear retention of the lncRNA SNHG1 by doxorubicin attenuates hnRNPC-p53 protein interactions. EMBO Rep. 2017 Apr;18(4):536–548.
  • Chen X, Yan CC, Zhang X, et al. Long non-coding RNAs and complex diseases: from experimental results to computational models. Brief Bioinform. 2017 Jul 1;18(4):558–576.
  • Xu Y, Ge Z, Zhang E, et al. The lncRNA TUG1 modulates proliferation in trophoblast cells via epigenetic suppression of RND3. Cell Death Dis. 2017 Oct 12;8(10):e3104.
  • Cao C, Li J, Li J, et al. Long non-coding RNA Uc.187 Is upregulated in preeclampsia and modulates proliferation, apoptosis, and invasion of HTR-8/SVneo trophoblast cells. J Cell Biochem. 2017 Jun;118(6):1462–1470.
  • Zhang Y, Zou Y, Wang W, et al. Down-regulated long non-coding RNA MEG3 and its effect on promoting apoptosis and suppressing migration of trophoblast cells. J Cell Biochem. 2015 Apr;116(4):542–550.
  • Chen H, Meng T, Liu X, et al. Long non-coding RNA MALAT-1 is downregulated in preeclampsia and regulates proliferation, apoptosis, migration and invasion of JEG-3 trophoblast cells. Int J Clin Exp Pathol. 2015;8(10):12718–12727.
  • Karreth FA, Reschke M, Ruocco A, et al. The BRAF pseudogene functions as a competitive endogenous RNA and induces lymphoma in vivo. Cell. 2015 Apr 9;161(2):319–332.
  • Lai Y, Li J, Zhong L, et al. The pseudogene PTENP1 regulates smooth muscle cells as a competing endogenous RNA. Clin Sci (Lond). 2019 Jul 15;133(13):1439–1455.
  • Zhou LY, Zhai LL, Yin JY, et al. Pseudogene BMI1P1 expression as a novel predictor for acute myeloid leukemia development and prognosis. Oncotarget. 2016 Jul 26;7(30):47376–47386.
  • Gupta A, Brown CT, Zheng YH, et al. Differentially-Expressed pseudogenes in HIV-1 infection. Viruses. 2015 Sep 29;7(10):5191–5205.
  • Yu L, Kuang LY, He F, et al. The role and molecular mechanism of long noncoding RNA-MEG3 in the pathogenesis of preeclampsia. Reprod Sci. 2018 Dec;25(12):1619–1628.
  • Tong J, Yang J, Lv H, et al. Dysfunction of pseudogene PGK1P2 is involved in preeclampsia by acting as a competing endogenous RNA of PGK1. Pregnancy Hypertens. 2018 Jul;13:37–45.
  • D’Angelo D, Arra C, Fusco A. RPSAP52 lncRNA inhibits p21Waf1/CIP expression by interacting with the RNA binding protein HuR. Oncol Res. 2020 Mar 27;28(2):191–201.
  • Oliveira-Mateos C, Sánchez-Castillo A, Soler M, et al. The transcribed pseudogene RPSAP52 enhances the oncofetal HMGA2-IGF2BP2-RAS axis through LIN28B-dependent and independent let-7 inhibition. Nat Commun. 2019 Sep 4;10(1):3979.
  • Heiss NS, Knight SW, Vulliamy TJ, et al. X-linked dyskeratosis congenita is caused by mutations in a highly conserved gene with putative nucleolar functions. Nat Genet. 1998 May;19(1):32–38.
  • Mitchell JR, Wood E, Collins K. A telomerase component is defective in the human disease dyskeratosis congenita. Nature. 1999 Dec 2;402(6761):551–555.
  • Yang Z, Wang Z, LncRNA DY. MEG3 inhibits non-small cell lung cancer via interaction with DKC1 protein. Oncol Lett. 2020 Sep;20(3):2183–2190.
  • Wang R, Zou L. Downregulation of LncRNA-MEG3 promotes HTR8/SVneo cells apoptosis and attenuates its migration by repressing Notch1 signal in preeclampsia. Reproduction. 2020 Jul;160(1):21–29.
  • Zhang J, Liu X, Gao Y. The long noncoding RNA MEG3 regulates Ras-MAPK pathway through RASA1 in trophoblast and is associated with unexplained recurrent spontaneous abortion. Mol Med. 2021 Jul 8;27(1):70.
  • Ye X, Fan F, Bhattacharya R, et al. VEGFR-1 Pseudogene expression and regulatory function in human colorectal cancer cells. Mol Cancer Res. 2015 Sep;13(9):1274–1282.
  • Song X, Luo X, Gao Q, et al. Dysregulation of LncRNAs in placenta and pathogenesis of preeclampsia. Curr Drug Targets. 2017;18(10):1165–1170.
  • Sagrillo-Fagundes L, Clabault H, Laurent L, et al. Human primary trophoblast cell culture model to study the protective effects of melatonin against hypoxia/reoxygenation-induced disruption. J Vis Exp. 2016;30:113.
  • Zou Z, Ma T, He X, et al. Long intergenic non-coding RNA 00324 promotes gastric cancer cell proliferation via binding with HuR and stabilizing FAM83B expression. Cell Death Dis. 2018 Jun 18;9(7):717.
  • Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods. 2001 Dec;25(4):402–408.
  • Li P, Gu L, Bian Q, et al. Long non-coding RNA MALAT1 enhances the protective effect of dexmedetomidine on acute lung injury by sponging miR-135a-5p to downregulate the ratio of X-box binding proteins XBP-1S/XBP-1U. Bioengineered. 2021 Dec;12(1):6377–6389.
  • Ritter A, Roth S, Kreis NN, et al. Primary cilia in trophoblastic cells: potential involvement in preeclampsia. Hypertension. 2020 Nov;76(5):1491–1505.
  • Chen L, Fang Z, Wang X, et al. G protein-coupled receptor 39 activation alleviates oxidized low-density lipoprotein-induced macrophage inflammatory response, lipid accumulation and apoptosis by inducing A20 expression. Bioengineered. 2021;Dec;12(1):4070–4080.
  • Yuan S, Si W, Zhuang K, et al. LncRNA UCID Promotes hepatocellular carcinoma metastasis via stabilization of snail. Onco Targets Ther. 2021;14:725–736.
  • Barros-Silva D, Lobo J, Guimarães-Teixeira C, et al. VIRMA-Dependent N6-methyladenosine modifications regulate the expression of long non-coding RNAs CCAT1 and CCAT2 in prostate cancer. Cancers (Basel). 2020 Mar 25;12(4):4.
  • Palazzo AF, Lee ES. Non-coding RNA: what is functional and what is junk? Front Genet. 2015;6:2.
  • Milligan MJ, Lipovich L. Pseudogene-derived lncRNAs: emerging regulators of gene expression. Front Genet. 2014;5:476.
  • Tong J, Zhao W, Lv H, et al. Transcriptomic profiling in human decidua of severe preeclampsia detected by RNA sequencing. J Cell Biochem. 2018 Jan;119(1):607–615.
  • Lv H, Tong J, Yang J, et al. Dysregulated pseudogene HK2P1 may contribute to preeclampsia as a competing endogenous RNA for hexokinase 2 by impairing decidualization. Hypertension. 2018 Apr;71(4):648–658.
  • Cha J, Sun X, Dey SK. Mechanisms of implantation: strategies for successful pregnancy. Nat Med. 2012 Dec;18(12):1754–1767.
  • Zhang D, Chang X, Bai J, et al. The study of cyclooxygenase 2 in human decidua of preeclampsia. Biol Reprod. 2016 Sep;95(3):56.
  • Masoura S, Kalogiannidis I, Makedou K, et al. Biomarkers of endothelial dysfunction in preeclampsia and neonatal morbidity: a case–control study. Eur J Obstet Gynecol Reprod Biol. 2014 Apr;175:119–123.
  • Amosco MD, Villar VA, Naniong JM, et al. VEGF-A and VEGFR1 SNPs associate with preeclampsia in a Philippine population. Clin Exp Hypertens. 2016;38(7):578–585.
  • Levine RJ, Maynard SE, Qian C, et al. Circulating angiogenic factors and the risk of preeclampsia. N Engl J Med. 2004 Feb 12;350(7):672–683.
  • Chiefari E, Arcidiacono B, Mirabelli M, et al. Methods to study protein-binding to pseudogene transcripts. Methods Mol Biol. 2021;2324:187–202.
  • Donaires FS, Alves-Paiva RM, Gutierrez-Rodrigues F, et al. Telomere dynamics and hematopoietic differentiation of human DKC1-mutant induced pluripotent stem cells. Stem Cell Res. 2019 Oct;40:101540.