Analysis of immune-related key genes in Alzheimer’s disease

References

• Cipriani G, Dolciotti C, Picchi L, et al. Alzheimer and his disease: a brief history. Neurol Sci 2011; 32(2):275–279.
   PubMed Web of Science ®Google Scholar
• Selkoe DJ. Translating cell biology into therapeutic advances in Alzheimer’s disease. Nature. 1999;399(6738):A23–31.
   PubMed Web of Science ®Google Scholar
• Perl DP. Neuropathology of Alzheimer’s disease. Mt Sinai J Med. 2010;77(1):32–42.
   PubMedGoogle Scholar
• Alzheimer A, Stelzmann RA, Schnitzlein HN, et al. An English translation of Alzheimer’s 1907 paper, “Uber eine eigenartige Erkankung der Hirnrinde”. Clin Anat. 1995;8(6):429–431.
   PubMedGoogle Scholar
• Glabe C. Intracellular mechanisms of amyloid accumulation and pathogenesis in Alzheimer’s disease. J Mol Neurosci. 2001;17(2):137–145.
   PubMed Web of Science ®Google Scholar
• Jack CR Jr., Knopman DS, Jagust WJ, et al. Hypothetical model of dynamic biomarkers of the Alzheimer’s pathological cascade. Lancet Neurol. 2010;9(1):119–128.
   PubMed Web of Science ®Google Scholar
• Hardy J, Allsop D. Amyloid deposition as the central event in the aetiology of Alzheimer’s disease. Trends Pharmacol Sci. 1991;12:383–388.
   PubMed Web of Science ®Google Scholar
• Monsonego A, Zota V, Karni A, et al. Increased T cell reactivity to amyloid beta protein in older humans and patients with Alzheimer disease. J Clin Invest. 2003;112:415–422.
   PubMed Web of Science ®Google Scholar
• Shi Y, Holtzman DM. Interplay between innate immunity and Alzheimer disease: APOE and TREM2 in the spotlight. Nat Rev Immunol. 2018;18(12):759–772.
   PubMed Web of Science ®Google Scholar
• Lombardi VR, Garcia M, Rey L, et al. Characterization of cytokine production, screening of lymphocyte subset patterns and in vitro apoptosis in healthy and Alzheimer’s Disease (AD) individuals. J Neuroimmunol. 1999;97(1–2):163–171.
   PubMed Web of Science ®Google Scholar
• Speciale L, Calabrese E, Saresella M, et al. Lymphocyte subset patterns and cytokine production in Alzheimer’s disease patients. Neurobiol Aging. 2007;28(8):1163–1169.
   PubMed Web of Science ®Google Scholar
• Saresella M, Calabrese E, Marventano I, et al. Increased activity of Th-17 and Th-9 lymphocytes and a skewing of the post-thymic differentiation pathway are seen in Alzheimer’s disease. Brain Behav Immun. 2011;25(3):539–547.
   PubMed Web of Science ®Google Scholar
• Togo T, Akiyama H, Iseki E, et al. Occurrence of T cells in the brain of Alzheimer’s disease and other neurological diseases. J Neuroimmunol. 2002;124(1–2):83–92.
   PubMed Web of Science ®Google Scholar
• Song J, Lee JE. miR-155 is involved in Alzheimer’s disease by regulating T lymphocyte function. Front Aging Neurosci. 2015;7:61.
   PubMed Web of Science ®Google Scholar
• Schindowski K, Eckert A, Peters J, et al. Increased T-cell reactivity and elevated levels of CD8+ memory T-cells in Alzheimer’s disease-patients and T-cell hyporeactivity in an Alzheimer’s disease-mouse model: implications for immunotherapy. Neuromolecular Med. 2007;9(4):340–354.
   PubMed Web of Science ®Google Scholar
• Browne TC, McQuillan K, McManus RM, et al. IFN-gamma production by amyloid beta-specific Th1 cells promotes microglial activation and increases plaque burden in a mouse model of Alzheimer’s disease. J Immunol. 2013;190(5):2241–2251.
   PubMed Web of Science ®Google Scholar
• Stopa EG, Tanis KQ, Miller MC, et al. Comparative transcriptomics of choroid plexus in Alzheimer’s disease, frontotemporal dementia and Huntington’s disease: implications for CSF homeostasis. Fluids Barriers CNS. 2018;15(1):18.
   PubMed Web of Science ®Google Scholar
• McKay EC, Beck JS, Khoo SK, et al. Peri-infarct upregulation of the oxytocin receptor in vascular dementia. J Neuropathol Exp Neurol. 2019;78(5):436–452.
   PubMed Web of Science ®Google Scholar
• Ritchie ME, Phipson B, Wu D, et al. limma powers differential expression analyses for RNA-sequencing and microarray studies. Nucleic Acids Res. 2015;43(7):e47.
   PubMed Web of Science ®Google Scholar
• Langfelder P, Horvath S. WGCNA: an R package for weighted correlation network analysis. BMC Bioinformatics. 2008;9(1):559.
   PubMed Web of Science ®Google Scholar
• Newman AM, Liu CL, Green MR, et al. Robust enumeration of cell subsets from tissue expression profiles. Nat Methods. 2015;12(5):453–457.
   PubMed Web of Science ®Google Scholar
• Yu G, Wang LG, Han Y, et al. clusterProfiler: an R package for comparing biological themes among gene clusters. OMICS. 2012;16(5):284–287.
   PubMed Web of Science ®Google Scholar
• Pathan M, Keerthikumar S, Ang CS, et al. FunRich: An open access standalone functional enrichment and interaction network analysis tool. Proteomics. 2015;15(15):2597–2601.
   PubMed Web of Science ®Google Scholar
• Szklarczyk D, Gable AL, Lyon D, et al. STRING v11: protein-protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets. Nucleic Acids Res. 2019;47(D1):D607–D13.
   PubMed Web of Science ®Google Scholar
• Robin X, Turck N, Hainard A, et al. pROC: an open-source package for R and S+ to analyze and compare ROC curves. BMC Bioinformatics. 2011;12(1):77.
   PubMed Web of Science ®Google Scholar
• Du Q, Zhu X, Si J. Angelica polysaccharide ameliorates memory impairment in Alzheimer’s disease rat through activating BDNF/TrkB/CREB pathway. Exp Biol Med (Maywood). 2020;245(1):1–10.
   PubMed Web of Science ®Google Scholar
• Soria Lopez JA, Gonzalez HM, Leger GC. Alzheimer’s disease. Handb Clin Neurol. 2019;167:231–255.
   PubMedGoogle Scholar
• St George-Hyslop PH, Westaway DA. Alzheimer’s disease. Antibody clears senile plaques. Nature. 1999;400(6740):116–117.
   PubMed Web of Science ®Google Scholar
• Noguchi A, Matsumura S, Dezawa M, et al. Isolation and characterization of patient-derived, toxic, high mass amyloid beta-protein (Abeta) assembly from Alzheimer disease brains. J Biol Chem. 2009;284(47):32895–32905.
   PubMed Web of Science ®Google Scholar
• Sardi F, Fassina L, Venturini L, et al. Alzheimer’s disease, autoimmunity and inflammation. The good, the bad and the ugly. Autoimmun Rev. 2011;11(2):149–153.
   PubMed Web of Science ®Google Scholar
• Larbi A, Pawelec G, Witkowski JM, et al. Dramatic shifts in circulating CD4 but not CD8 T cell subsets in mild Alzheimer’s disease. J Alzheimers Dis. 2009;17(1):91–103.
   PubMed Web of Science ®Google Scholar
• Pellicano M, Larbi A, Goldeck D, et al. Immune profiling of Alzheimer patients. J Neuroimmunol. 2012;242(1–2):52–59.
   PubMed Web of Science ®Google Scholar
• Kutz SM, Higgins CE, Higgins PJ. Novel combinatorial therapeutic targeting of PAI-1 (SERPINE1) gene expression in alzheimer’s disease. Mol Med Ther. 2012;1(2):106.
   PubMedGoogle Scholar
• Ibrahim KS, McLaren CJ, Abd-Elrahman KS, et al. Optineurin deletion disrupts metabotropic glutamate receptor 5-mediated regulation of ERK1/2, GSK3beta/ZBTB16, mTOR/ULK1 signaling in autophagy. Biochem Pharmacol. 2021;185:114427.
   PubMed Web of Science ®Google Scholar
• Cao L, Wang Z, Wan W. Suppressor of cytokine signaling 3: Emerging role linking central insulin resistance and Alzheimer’s disease. Front Neurosci. 2018;12:417.
   PubMed Web of Science ®Google Scholar
• Marsh SE, Abud EM, Lakatos A, et al. The adaptive immune system restrains Alzheimer’s disease pathogenesis by modulating microglial function. Proc Natl Acad Sci U S A. 2016;113(9):E1316–25.
   PubMed Web of Science ®Google Scholar