Transcription factor paired related homeobox 1 (PRRX1) activates matrix metalloproteinases (MMP)13, which promotes the dextran sulfate sodium-induced inflammation and barrier dysfunction of NCM460 cells

References

• Cader M, Kaser A. Recent advances in inflammatory bowel disease: mucosal immune cells in intestinal inflammation. Gut. 2013;62(11): 1653–1664.
   PubMed Web of Science ®Google Scholar
• Aleksandrova K, Romero-Mosquera B, Hernandez V. Diet, gut microbiome and epigenetics: emerging links with inflammatory bowel diseases and prospects for management and prevention. Nutrients. 2017;9 :962.
   PubMed Web of Science ®Google Scholar
• Agilli M, Aydin F, Cayci T, et al. Assessment of active mucosal inflammation in IBD patients in clinical remission. J Gastrointestin Liver Dis. 2014;23(4): 462–463.
   PubMed Web of Science ®Google Scholar
• Hildner K, Punkenburg E, Abendroth B, et al. Immunopathogenesis of IBD: batf as a key driver of disease activity. Dig Dis. 2016;34(Suppl. 1): 40–47.
   PubMedGoogle Scholar
• Ng S, Shi H, Hamidi N, et al. Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century: a systematic review of population-based studies. Lancet. 2017;390(10114): 2769–2778.
   PubMed Web of Science ®Google Scholar
• Høivik M, Moum B, Solberg I, et al. Work disability in inflammatory bowel disease patients 10 years after disease onset: results from the IBSEN study. Gut. 2013;62(3): 368–375.
   PubMed Web of Science ®Google Scholar
• Ishiguro Y. Mucosal proinflammatory cytokine production correlates with endoscopic activity of ulcerative colitis. J Gastroenterol. 1999;34(1): 66–74.
   PubMed Web of Science ®Google Scholar
• Wu X, Huang X, Chen R, et al. Paeoniflorin prevents intestinal barrier disruption and inhibits Lipopolysaccharide (LPS)-Induced inflammation in Caco-2 cell monolayers. Inflammation. 2019;42(6): 2215–2225.
   PubMed Web of Science ®Google Scholar
• Ailenberg M, Sefton M. Effect of a matrix metalloproteinase sequestering biomaterial on Caco-2 epithelial cell barrier integrity in vitro. Acta Biomater. 2009;5(6): 1898–1904.
   PubMed Web of Science ®Google Scholar
• Nagase H, Jf W Jr. Matrix metalloproteinases. J Biol Chem. 1999;274(31): 21491–21494.
   PubMed Web of Science ®Google Scholar
• Vizoso F, González L, Corte M, et al. Collagenase-3 (MMP-13) expression by inflamed mucosa in inflammatory bowel disease. Scand J Gastroenterol. 2006;41(9): 1050–1055.
   PubMed Web of Science ®Google Scholar
• Kern M, Argao E, Birkenmeier E, et al. Genomic organization and chromosome localization of the murine homeobox gene Pmx. Genomics. 1994;19(2): 334–340.
   PubMed Web of Science ®Google Scholar
• Yang R, Liu Y, Wang Y, et al. Low PRRX1 expression and high ZEB1 expression are significantly correlated with epithelial-mesenchymal transition and tumor angiogenesis in non-small cell lung cancer. Medicine (Baltimore). 2021;100(4): e24472.
   PubMed Web of Science ®Google Scholar
• Dankel S, Grytten E, Bjune J, et al. COL6A3 expression in adipose tissue cells is associated with levels of the homeobox transcription factor PRRX1. Sci Rep. 2020;10(1): 20164.
   PubMedGoogle Scholar
• Bartha Á, Győrffy B. TNMplot.com: a web tool for the comparison of gene expression in normal, tumor and metastatic tissues. Int J Mol Sci 2021 22 . 2622 .
   PubMed Web of Science ®Google Scholar
• Ding A, Wen X. Dandelion root extract protects NCM460 colonic cells and relieves experimental mouse colitis. J Nat Med. 2018;72(4): 857–866.
   PubMed Web of Science ®Google Scholar
• Wang Y, Chen H, Chen Q, et al. The protective mechanism of CAY10683 on intestinal mucosal barrier in acute liver failure through LPS/TLR4/MyD88 pathway. Mediators Inflamm. 2018;2018: 7859601.
   PubMed Web of Science ®Google Scholar
• Wang J, Fan Z, Li J, et al. Transcription factor specificity protein 1-mediated Serine/threonine kinase 39 upregulation promotes the proliferation, migration, invasion and epithelial-mesenchymal transition of hepatocellular carcinoma cells by activating the transforming growth factor-beta1 /Smad2/3 pathway. Bioengineered. 2021;12(1): 3566–3577.
   PubMed Web of Science ®Google Scholar
• Xing J, Jia Z, Xu Y, et al. KLF9 (Kruppel Like Factor 9) induced PFKFB3 (6-Phosphofructo-2-Kinase/Fructose-2, 6-Biphosphatase 3) downregulation inhibits the proliferation, metastasis and aerobic glycolysis of cutaneous squamous cell carcinoma cells. Bioengineered. 2021;12(1): 7563–7576.
   PubMed Web of Science ®Google Scholar
• Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods. 2001;25(4): 402–408.
   PubMed Web of Science ®Google Scholar
• Ramos GP, Papadakis KA. Mechanisms of disease: inflammatory bowel diseases. Mayo Clin Proc. 2019;94(1): 155–165.
   PubMed Web of Science ®Google Scholar
• Lu M, Ji J, Jiang Y, et al. An inhibitor of the Keap1-Nrf2 protein-protein interaction protects NCM460 colonic cells and alleviates experimental colitis. Sci Rep. 2016;6(1): 26585.
   PubMedGoogle Scholar
• Gamah M, Alahdal M, Zhang Y, et al. High-altitude hypoxia exacerbates dextran sulfate sodium (DSS)-induced colitis by upregulating Th1 and Th17 lymphocytes. Bioengineered. 2021;12(1): 7985–7994.
   PubMed Web of Science ®Google Scholar
• Reinecker H, Steffen M, Witthoeft T, et al. Enhanced secretion of tumour necrosis factor-alpha, IL-6, and IL-1 beta by isolated lamina propria mononuclear cells from patients with ulcerative colitis and Crohn’s disease. Clin Exp Immunol. 1993;94: 174–181.
   PubMed Web of Science ®Google Scholar
• Gadaleta R, van Erpecum K, Oldenburg B, et al. Farnesoid X receptor activation inhibits inflammation and preserves the intestinal barrier in inflammatory bowel disease. Gut. 2011;60(4): 463–472.
   PubMed Web of Science ®Google Scholar
• Hooper L, Bry L, Falk P, et al. Host-microbial symbiosis in the mammalian intestine: exploring an internal ecosystem. BioEssays. 1998;20(4): 336–343.
   PubMed Web of Science ®Google Scholar
• Citalán-Madrid A, Vargas-Robles H, García-Ponce A, et al. Cortactin deficiency causes increased RhoA/ROCK1-dependent actomyosin contractility, intestinal epithelial barrier dysfunction, and disproportionately severe DSS-induced colitis. Mucosal Immunol. 2017;10(5): 1237–1247.
   PubMed Web of Science ®Google Scholar
• Giuffrida P, Biancheri P, MacDonald TT. Proteases and small intestinal barrier function in health and disease. Curr Opin Gastroenterol. 2014;30(2): 147–153.
   PubMed Web of Science ®Google Scholar
• Medina C, Radomski M. Role of matrix metalloproteinases in intestinal inflammation. J Pharmacol Exp Ther. 2006;318(3): 933–938.
   PubMed Web of Science ®Google Scholar
• Vaalamo M, Karjalainen-Lindsberg M, Puolakkainen P, et al. Distinct expression profiles of stromelysin-2 (MMP-10), collagenase-3 (MMP-13), macrophage metalloelastase (MMP-12), and tissue inhibitor of metalloproteinases-3 (TIMP-3) in intestinal ulcerations. Am J Pathol. 1998;152(4): 1005–1014.
   PubMed Web of Science ®Google Scholar
• Rath T, Roderfeld M, Graf J, et al. Enhanced expression of MMP-7 and MMP-13 in inflammatory bowel disease: a precancerous potential? Inflamm Bowel Dis. 2006;12(11): 1025–1035.
   PubMed Web of Science ®Google Scholar
• Vandenbroucke R, Dejonckheere E, Van Hauwermeiren F, et al. Matrix metalloproteinase 13 modulates intestinal epithelial barrier integrity in inflammatory diseases by activating TNF. EMBO Mol Med. 2013;5(7): 1000–1016.
   PubMed Web of Science ®Google Scholar