A transcriptomic analysis of neuropathic pain in the anterior cingulate cortex after nerve injury

References

• Scholz J, Finnerup NB, Attal N, et al. The IASP classification of chronic pain for ICD-11: chronic neuropathic pain. Pain. 2019;160:53–59.
   PubMed Web of Science ®Google Scholar
• Taylor AM, Harris AD, Varnava A, et al. Neural responses to a modified Stroop paradigm in patients with complex chronic musculoskeletal pain compared to matched controls: an experimental functional magnetic resonance imaging study. BMC Psychol. 2016;4:5.
   PubMedGoogle Scholar
• Buffington AL, Hanlon CA, McKeown MJ. Acute and persistent pain modulation of attention-related anterior cingulate fMRI activations. Pain. 2005;113:172–184.
   PubMed Web of Science ®Google Scholar
• Fomberstein K, Qadri S, Ramani R. Functional MRI and pain. Curr Opin Anaesthesiol. 2013;26:588–593.
   PubMed Web of Science ®Google Scholar
• Zhuo M. Cortical excitation and chronic pain. Trends Neurosci. 2008;31:199–207.
   PubMed Web of Science ®Google Scholar
• Luo C, Kuner T, Kuner R. Synaptic plasticity in pathological pain. Trends Neurosci. 2014;37:343–355.
   PubMed Web of Science ®Google Scholar
• Zhao MG, Ko SW, Wu LJ, et al. Enhanced presynaptic neurotransmitter release in the anterior cingulate cortex of mice with chronic pain. J Neurosci. 2006;26:8923–8930.
   PubMed Web of Science ®Google Scholar
• Xu H, Wu LJ, Wang H, et al. Presynaptic and postsynaptic amplifications of neuropathic pain in the anterior cingulate cortex. J Neurosci. 2008;28:7445–7453.
   PubMed Web of Science ®Google Scholar
• Ko HG, Choi JH, Park DI, et al. Rapid turnover of cortical NCAM1 regulates synaptic reorganization after peripheral nerve injury. Cell Rep. 2018;22:748–759.
   PubMed Web of Science ®Google Scholar
• Li XY, Ko HG, Chen T, et al. Alleviating neuropathic pain hypersensitivity by inhibiting PKMzeta in the anterior cingulate cortex. Science. 2010;330:1400–1404.
   PubMed Web of Science ®Google Scholar
• Wang H, Xu H, Wu LJ, et al. Identification of an adenylyl cyclase inhibitor for treating neuropathic and inflammatory pain. Sci Transl Med. 2011;3:65ra3.
   PubMed Web of Science ®Google Scholar
• Zhou Y, Lutz PE, Wang YC, et al. Global long non-coding RNA expression in the rostral anterior cingulate cortex of depressed suicides. Transl Psychiatry. 2018;8:224.
   PubMed Web of Science ®Google Scholar
• Akula N, Marenco S, Johnson K, et al. Deep transcriptome sequencing of subgenual anterior cingulate cortex reveals cross-diagnostic and diagnosis-specific RNA expression changes in major psychiatric disorders. Neuropsychopharmacol. 2021;46:1364–1372.
   PubMed Web of Science ®Google Scholar
• Kao CY, He Z, Zannas AS, et al. Fluoxetine treatment prevents the inflammatory response in a mouse model of posttraumatic stress disorder. J Psychiatr Res. 2016;76:74–83.
   PubMed Web of Science ®Google Scholar
• Logan RW, Xue X, Ketchesin KD, et al. Sex differences in molecular rhythms in the human cortex. Biol Psychiatry. 2022;91(1): 152–162.
   PubMed Web of Science ®Google Scholar
• Li M, Su S, Cai W, et al. Differentially expressed genes in the brain of aging mice with cognitive alteration and depression- and anxiety-like behaviors. Front Cell Dev Biol. 2020;8:814.
   PubMed Web of Science ®Google Scholar
• Su S, Li M, Wu D, et al. Gene transcript alterations in the spinal cord, anterior cingulate cortex, and amygdala in mice following peripheral nerve injury. Front Cell Dev Biol. 2021;9:634810.
   PubMed Web of Science ®Google Scholar
• Bennett GJ, Xie YK. A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man. Pain. 1988;33:87–107.
   PubMed Web of Science ®Google Scholar
• Shen Y, Ding Z, Ma S, et al. SETD7 mediates spinal microgliosis and neuropathic pain in a rat model of peripheral nerve injury. Brain Behav Immun. 2019;82:382–395.
   PubMed Web of Science ®Google Scholar
• Shen Y, Ding Z, Ma S, et al. Targeting Aurora kinase B alleviates spinal microgliosis and neuropathic pain in a rat model of peripheral nerve injury. J Neurochem. 2020;152:72–91.
   PubMed Web of Science ®Google Scholar
• Wang D, An SC, Zhang X. Prevention of chronic stress-induced depression-like behavior by inducible nitric oxide inhibitor. Neurosci Lett. 2008;433:59–64.
   PubMed Web of Science ®Google Scholar
• Han M, Xiao X, Yang Y, et al. SIP30 is required for neuropathic pain-evoked aversion in rats. J Neurosci. 2014;34:346–355.
   PubMed Web of Science ®Google Scholar
• Pertea M, Kim D, Pertea GM, et al. Transcript-level expression analysis of RNA-seq experiments with HISAT, StringTie and Ballgown. Nat Protoc. 2016;11:1650–1667.
   PubMed Web of Science ®Google Scholar
• Mortazavi A, Williams BA, McCue K, et al. Mapping and quantifying mammalian transcriptomes by RNA-Seq. Nat Methods. 2008;5:621–628.
   PubMed Web of Science ®Google Scholar
• Liu P, Yang S, Wang Z, et al. Feasibility and mechanism analysis of shenfu injection in the treatment of idiopathic pulmonary fibrosis. Front Pharmacol. 2021;12:670146.
   PubMed Web of Science ®Google Scholar
• Huang J, Ma J, Wang J, et al. Whole-transcriptome analysis of rat cavernosum and identification of circRNA-miRNA-mRNA networks to investigate nerve injury erectile dysfunction pathogenesis. Bioengineered. 2021;12:6516–6528.
   PubMed Web of Science ®Google Scholar
• Ernst J, Bar-Joseph Z. STEM: a tool for the analysis of short time series gene expression data. BMC Bioinformatics. 2006;7:191.
   PubMed Web of Science ®Google Scholar
• Szklarczyk D, Morris JH, Cook H, et al. The STRING database in 2017: quality-controlled protein-protein association networks, made broadly accessible. Nucleic Acids Res. 2017;45:D362–d8.
   PubMed Web of Science ®Google Scholar
• Liu K, Fu Q, Liu Y, et al. An integrative bioinformatics analysis of microarray data for identifying hub genes as diagnostic biomarkers of preeclampsia. Biosci Rep. 2019;39. DOI:10.1042/BSR20190187
   Web of Science ®Google Scholar
• Wu XB, He LN, Jiang BC, et al. Increased CXCL13 and CXCR5 in anterior cingulate cortex contributes to neuropathic pain-related conditioned place aversion. Neurosci Bull. 2019;35:613–623.
   PubMed Web of Science ®Google Scholar
• Harrison NA, Brydon L, Walker C, et al. Neural origins of human sickness in interoceptive responses to inflammation. Biol Psychiatry. 2009;66:415–422.
   PubMed Web of Science ®Google Scholar
• Slavich GM, Way BM, Eisenberger NI, et al. Neural sensitivity to social rejection is associated with inflammatory responses to social stress. Proc Natl Acad Sci U S A. 2010;107:14817–14822.
   PubMed Web of Science ®Google Scholar
• Holmes SE, Hinz R, Conen S, et al. Elevated translocator protein in anterior cingulate in major depression and a role for inflammation in suicidal thinking: a positron emission tomography study. Biol Psychiatry. 2018;83:61–69.
   PubMed Web of Science ®Google Scholar
• Wang Z, Song K, Zhao W, et al. Dendritic cells in tumor microenvironment promoted the neuropathic pain via paracrine inflammatory and growth factors. Bioengineered. 2020;11:661–678.
   PubMed Web of Science ®Google Scholar
• Miu J, Mitchell AJ, Müller M, et al. Chemokine gene expression during fatal murine cerebral malaria and protection due to CXCR3 deficiency. J Immunol. 2008;180:1217–1230.
   PubMed Web of Science ®Google Scholar
• Kwiatkowski K, Piotrowska A, Rojewska E, et al. Beneficial properties of maraviroc on neuropathic pain development and opioid effectiveness in rats. Prog Neuropsychopharmacol Biol Psychiatry. 2016;64:68–78.
   PubMed Web of Science ®Google Scholar
• Liou JT, Yuan HB, Mao CC, et al. Absence of C-C motif chemokine ligand 5 in mice leads to decreased local macrophage recruitment and behavioral hypersensitivity in a murine neuropathic pain model. Pain. 2012;153:1283–1291.
   PubMed Web of Science ®Google Scholar
• Liou JT, Mao CC, Ching-Wah Sum D, et al. Peritoneal administration of Met-RANTES attenuates inflammatory and nociceptive responses in a murine neuropathic pain model. J Pain. 2013;14:24–35.
   PubMed Web of Science ®Google Scholar
• Wu XB, He LN, Jiang BC, et al. Spinal CXCL9 and CXCL11 are not involved in neuropathic pain despite an upregulation in the spinal cord following spinal nerve injury. Mol Pain. 2018;14:1744806918777401.
   Web of Science ®Google Scholar
• Raghu H, Lepus CM, Wang Q, et al. CCL2/CCR2, but not CCL5/CCR5, mediates monocyte recruitment, inflammation and cartilage destruction in osteoarthritis. Ann Rheum Dis. 2017;76:914–922.
   PubMed Web of Science ®Google Scholar
• Tacke F, Alvarez D, Kaplan TJ, et al. Monocyte subsets differentially employ CCR2, CCR5, and CX3CR1 to accumulate within atherosclerotic plaques. J Clin Invest. 2007;117:185–194.
   PubMed Web of Science ®Google Scholar
• Pawlik K, Piotrowska A, Kwiatkowski K, et al. The blockade of CC chemokine receptor type 1 influences the level of nociceptive factors and enhances opioid analgesic potency in a rat model of neuropathic pain. Immunology. 2020;159:413–428.
   PubMed Web of Science ®Google Scholar
• Wennerberg K, Der CJ. Rho-family GTPases: it’s not only Rac and Rho (and I like it). J Cell Sci. 2004;117:1301–1312.
   PubMed Web of Science ®Google Scholar
• Yang YK, Lu XB, Wang YH, et al. Identification crucial genes in peripheral neuropathic pain induced by spared nerve injury. Eur Rev Med Pharmacol Sci. 2014;18:2152–2159.
   PubMed Web of Science ®Google Scholar
• Wang J, Ma SH, Tao R, et al. Gene expression profile changes in rat dorsal horn after sciatic nerve injury. Neurol Res. 2017;39:176–182.
   PubMed Web of Science ®Google Scholar
• Diebold BA, Bokoch GM. Molecular basis for Rac2 regulation of phagocyte NADPH oxidase. Nat Immunol. 2001;2:211–215.
   PubMed Web of Science ®Google Scholar
• Dooley JL, Abdel-Latif D, St Laurent CD, et al. Regulation of inflammation by Rac2 in immune complex-mediated acute lung injury. Am J Physiol Lung Cell Mol Physiol. 2009;297:L1091–102.
   PubMed Web of Science ®Google Scholar
• Zotova E, Holmes C, Johnston D, et al. Microglial alterations in human Alzheimer’s disease following Aβ42 immunization. Neuropathol Appl Neurobiol. 2011;37:513–524.
   PubMed Web of Science ®Google Scholar
• Haruwaka K, Ikegami A, Tachibana Y, et al. Dual microglia effects on blood brain barrier permeability induced by systemic inflammation. Nat Commun. 2019;10:5816.
   PubMed Web of Science ®Google Scholar
• Bui TM, Wiesolek HL, Sumagin R. ICAM-1: a master regulator of cellular responses in inflammation, injury resolution, and tumorigenesis. J Leukoc Biol. 2020;108:787–799.
   PubMed Web of Science ®Google Scholar
• Jean-Toussaint R, Tian Y, Chaudhuri AD, et al. Proteome characterization of small extracellular vesicles from spared nerve injury model of neuropathic pain. J Proteomics. 2020;211:103540.
   PubMed Web of Science ®Google Scholar
• Machelska H, Mousa SA, Brack A, et al. Opioid control of inflammatory pain regulated by intercellular adhesion molecule-1. J Neurosci. 2002;22:5588–5596.
   PubMed Web of Science ®Google Scholar
• Chen J, Zhang B, Pan C, et al. Effects of monocyte chemotactic protein-3 on ICAM-1, VCAM-1, TF, and TFPI expression and apoptosis in human umbilical vein endothelial cells. Nan Fang Yi Ke Da Xue Xue Bao. 2013;33:86–92.
   PubMedGoogle Scholar
• Gu W, Yao L, Li L, et al. ICAM-1 regulates macrophage polarization by suppressing MCP-1 expression via miR-124 upregulation. Oncotarget. 2017;8:111882–111901.
   PubMedGoogle Scholar
• Sousa C, Golebiewska A, Poovathingal SK, et al. Single-cell transcriptomics reveals distinct inflammation-induced microglia signatures. EMBO Rep. 2018;19. DOI:10.15252/embr.201846171
   PubMedGoogle Scholar
• Gris D, Marsh DR, Oatway MA, et al. Transient blockade of the CD11d/CD18 integrin reduces secondary damage after spinal cord injury, improving sensory, autonomic, and motor function. J Neurosci. 2004;24:4043–4051.
   PubMed Web of Science ®Google Scholar
• Tsuda M, Koga K, Chen T, et al. Neuronal and microglial mechanisms for neuropathic pain in the spinal dorsal horn and anterior cingulate cortex. J Neurochem. 2017;141:486–498.
   PubMed Web of Science ®Google Scholar
• Chen T, Koga K, Descalzi G, et al. Postsynaptic potentiation of corticospinal projecting neurons in the anterior cingulate cortex after nerve injury. Mol Pain. 2014;10:33.
   PubMed Web of Science ®Google Scholar
• Chen T, Wang W, Dong YL, et al. Postsynaptic insertion of AMPA receptor onto cortical pyramidal neurons in the anterior cingulate cortex after peripheral nerve injury. Mol Brain. 2014;7:76.
   PubMed Web of Science ®Google Scholar
• Cohen SP, Mao J. Neuropathic pain: mechanisms and their clinical implications. BMJ. 2014;348:f7656.
   PubMed Web of Science ®Google Scholar
• Nie Y, Huang H, Guo M, et al. Breast phyllodes tumors recruit and repolarize tumor-associated macrophages via secreting CCL5 to promote malignant progression, which can be inhibited by CCR5 inhibition therapy. Clin Cancer Res off J Am Assoc Cancer Res. 2019;25:3873–3886.
   PubMed Web of Science ®Google Scholar
• Piotrowska A, Kwiatkowski K, Rojewska E, et al. Maraviroc reduces neuropathic pain through polarization of microglia and astroglia - Evidence from in vivo and in vitro studies. Neuropharmacology. 2016;108:207–219.
   PubMed Web of Science ®Google Scholar
• Hoggatt J, Singh P, Tate TA, et al. Rapid mobilization reveals a highly engraftable hematopoietic stem cell. Cell. 2018;172:191–204.e10.
   PubMed Web of Science ®Google Scholar
• Liu ZY, Song ZW, Guo SW, et al. CXCL12/CXCR4 signaling contributes to neuropathic pain via central sensitization mechanisms in a rat spinal nerve ligation model. CNS Neurosci Ther. 2019;25:922–936.
   PubMed Web of Science ®Google Scholar
• Kasamon YL, Chen H, de Claro RA, et al. FDA approval summary: mogamulizumab-kpkc for mycosis fungoides and sézary syndrome. Clin Cancer Res off J Am Assoc Cancer Res. 2019;25:7275–7280.
   PubMed Web of Science ®Google Scholar