Human Plasma Metabolomics Identify 9-cis-retinoic Acid and Dehydrophytosphingosine Levels as Novel biomarkers for Early Ventricular Fibrillation after ST-elevated Myocardial Infarction

References

• Kolettis TM. Coronary artery disease and ventricular tachyarrhythmia: pathophysiology and treatment. Curr Opin Pharmacol. 2013;13(2):210–217.
   PubMed Web of Science ®Google Scholar
• Di Diego JM, Antzelevitch C. Ischemic ventricular arrhythmias: experimental models and their clinical relevance. Heart Rhythm. 2011;8(12):1963–1968.
   PubMed Web of Science ®Google Scholar
• Aouizerat BE, Vittinghoff E, Musone SL, et al. GWAS for discovery and replication of genetic loci associated with sudden cardiac arrest in patients with coronary artery disease. BMC Cardiovasc Disord. 2011;11(1):29.
   PubMedGoogle Scholar
• Hreybe H, Singla I, Razak E, et al. Predictors of cardiac arrest occurring in the context of acute myocardial infarction. Pacing Clin Electrophysiol. 2007;30(10):1262–1266.
   PubMed Web of Science ®Google Scholar
• Gheeraert PJ, De Buyzere ML, Taeymans YM, et al. Risk factors for primary ventricular fibrillation during acute myocardial infarction: a systematic review and meta-analysis. Eur Heart J. 2006;27(21):2499–2510.
   PubMed Web of Science ®Google Scholar
• Mączewski M, Duda M, Marciszek M, et al. Omega-3 Fatty Acids Do Not Protect Against Arrhythmias in Acute Nonreperfused Myocardial Infarction Despite Some Antiarrhythmic Effects. J Cell Biochem. 2016;117(11):2570–2582.
   PubMed Web of Science ®Google Scholar
• Pazoki R, de Jong JS, Marsman RF, et al. SNPs identified as modulators of ECG traits in the general population do not markedly affect ECG traits during acute myocardial infarction nor ventricular fibrillation risk in this condition. PloS One. 2013;8(2):e57216.
   PubMed Web of Science ®Google Scholar
• Barderas MG, Laborde CM, Posada M, et al. Metabolomic profiling for identification of novel potential biomarkers in cardiovascular diseases. J Biomed Biotechnol. 2011;2011:790132.
   PubMedGoogle Scholar
• Lan H, Hong W, Qian D, et al. Quercetin modulates the gut microbiota as well as the metabolome in a rat model of osteoarthritis. Bioengineered. 2021;12(1):6240–6250.
   PubMed Web of Science ®Google Scholar
• Chen J, Zhou Q, Zhang Y, et al. Discovery of novel serum metabolic biomarkers in patients with polycystic ovarian syndrome and premature ovarian failure. Bioengineered. 2021;12(1):8778–8792.
   PubMed Web of Science ®Google Scholar
• Hong W, Mo Q, Wang L, et al. Changes in the gut microbiome and metabolome in a rat model of pulmonary arterial hypertension. Bioengineered. 2021;12(1):5173–5183.
   PubMed Web of Science ®Google Scholar
• Huang L, Li T, Liu YW, et al. Plasma Metabolic Profile Determination in Young ST-segment Elevation Myocardial Infarction Patients with Ischemia and Reperfusion: ultra-performance Liquid Chromatography and Mass Spectrometry for Pathway Analysis. Chin Med J (Engl). 2016;129(9):1078–1086.
   PubMed Web of Science ®Google Scholar
• Thygesen K, Alpert JS, Jaffe AS, et al. Third universal definition of myocardial infarction. J Am Coll Cardiol. 2012;60(16):1581–1598.
   PubMed Web of Science ®Google Scholar
• Huang L, Zhang L, Li T, et al. Human Plasma Metabolomics Implicates Modified 9-cis-Retinoic Acid in the Phenotype of Left Main Artery Lesions in Acute ST-Segment Elevated Myocardial Infarction. Sci Rep. 2018;8(1):12958.
   PubMedGoogle Scholar
• Dunn WB, Broadhurst D, Brown M, et al. Metabolic profiling of serum using Ultra Performance Liquid Chromatography and the LTQ-Orbitrap mass spectrometry system. J Chromatogr B Analyt Technol Biomed Life Sci. 2008;871(2):288–298.
   PubMed Web of Science ®Google Scholar
• Katajamaa M, Oresic M. Processing methods for differential analysis of LC/MS profile data. BMC Bioinformatics. 2005;6(1):179.
   PubMedGoogle Scholar
• Bagai A, Dangas GD, Stone GW, et al. Reperfusion strategies in acute coronary syndromes. Circ Res. 2014;114(12):1918–1928.
   PubMed Web of Science ®Google Scholar
• Bhar-Amato J, Davies W, Agarwal S. Ventricular Arrhythmia after Acute Myocardial Infarction: ‘The Perfect Storm’. Arrhythm Electrophysiol Rev. 2017;6(3):134–139.
   PubMed Web of Science ®Google Scholar
• Piccini JP, Berger JS, Brown DL. Early sustained ventricular arrhythmias complicating acute myocardial infarction. Am J Med. 2008;121(9):797–804.
   PubMed Web of Science ®Google Scholar
• Luqman N, Sung RJ, Wang CL, et al. Myocardial ischemia and ventricular fibrillation: pathophysiology and clinical implications. Int J Cardiol. 2007;119(3):283–290.
   PubMed Web of Science ®Google Scholar
• Sattler SM, Skibsbye L, Linz D, et al. Ventricular Arrhythmias in First Acute Myocardial Infarction: epidemiology, Mechanisms, and Interventions in Large Animal Models. Front Cardiovasc Med. 2019;6:158.
   PubMed Web of Science ®Google Scholar
• Dekker LR, Bezzina CR, Henriques JP, et al. Familial sudden death is an important risk factor for primary ventricular fibrillation: a case-control study in acute myocardial infarction patients. Circulation. 2006;114(11):1140–1145.
   PubMed Web of Science ®Google Scholar
• Oliva A, Hu D, Viskin S, et al. SCN5A mutation associated with acute myocardial infarction. Legal medicine(Tokyo, Japan). 2009;1 1 Suppl 1.;(Suppl 1):S206–209.
   Google Scholar
• Boehringer T, Bugert P, Borggrefe M, et al. SCN5A mutations and polymorphisms in patients with ventricular fibrillation during acute myocardial infarction. Mol Med Rep. 2014;10(4):2039–2044.
   PubMed Web of Science ®Google Scholar
• Jeron A, Hengstenberg C, Holmer S, et al. KCNJ11 polymorphisms and sudden cardiac death in patients with acute myocardial infarction. J Mol Cell Cardiol. 2004;36(2):287–293.
   PubMed Web of Science ®Google Scholar
• Novotny T, Kadlecova J, Raudenska M, et al. Mutation analysis ion channel genes ventricular fibrillation survivors with coronary artery disease. Pacing Clin Electrophysiol. 2011;34(6):742–749.
   PubMed Web of Science ®Google Scholar
• Surendran A, Aliani M, Ravandi A. Metabolomic characterization of myocardial ischemia-reperfusion injury in ST-segment elevation myocardial infarction patients undergoing percutaneous coronary intervention. Sci Rep. 2019;9(1):11742.
   PubMedGoogle Scholar
• Lin J, Zhou J, Xie G, et al. Functional analysis of ceRNA network of lncRNA TSIX/miR-34a-5p/RBP2 in acute myocardial infarction based on GEO database. Bioengineered. 2021. DOI:10.1080/21655979.2021.2006865
   Google Scholar
• Wu J, Yang R, Zhang L, et al. Metabolomics research on potential role for 9-cis-retinoic acid in breast cancer progression. Cancer Sci. 2018;109(7):2315–2326.
   PubMed Web of Science ®Google Scholar
• Kane MA. Analysis, occurrence, and function of 9-cis-retinoic acid. Biochim Biophys Acta. 2012;1821(1):10–20.
   PubMed Web of Science ®Google Scholar
• Lefebvre P, Benomar Y, Staels B. Retinoid X receptors: common heterodimerization partners with distinct functions. Trends Endocrinol Metab. 2010;21(11):676–683.
   PubMed Web of Science ®Google Scholar
• Nohara A, Kobayashi J, Mabuchi H. Retinoid X receptor heterodimer variants and cardiovascular risk factors. J Atheroscler Thromb. 2009;16(4):303–318.
   PubMed Web of Science ®Google Scholar
• Kihara A. Sphingosine 1-phosphate is a key metabolite linking sphingolipids to glycerophospholipids. Biochim Biophys Acta. 2014;1841(5):766–772.
   PubMed Web of Science ®Google Scholar
• Hla T, Dannenberg AJ. Sphingolipid signaling in metabolic disorders. Cell Metab. 2012;16(4):420–434.
   PubMed Web of Science ®Google Scholar
• Holthuis JC, Pomorski T, Raggers RJ, et al. The organizing potential of sphingolipids in intracellular membrane transport. Physiol Rev. 2001;81(4):1689–1723.
   PubMed Web of Science ®Google Scholar
• Hadas Y, Vincek AS, Youssef E, et al. Altering Sphingolipid Metabolism Attenuates Cell Death and Inflammatory Response After Myocardial Infarction. Circulation. 2020;141(11):916–930.
   PubMed Web of Science ®Google Scholar
• Park JY, Lee SH, Shin MJ, et al. Alteration in metabolic signature and lipid metabolism in patients with angina pectoris and myocardial infarction. PloS One. 2015;10(8):e0135228.
   PubMed Web of Science ®Google Scholar
• Hua T, Bao Q, He X, et al. Lipidomics Revealed Alteration of Sphingolipid Metabolism During the Reparative Phase After Myocardial Infarction Injury. Front Physiol. 2021;12:663480.
   PubMed Web of Science ®Google Scholar
• Kovilakath A, Jamil M, Cowart LA. Sphingolipids in the Heart: from Cradle to Grave. Front Endocrinol (Lausanne). 2020;11:652.
   PubMed Web of Science ®Google Scholar
• How CW, Ong YS, Low SS, et al. How far have we explored fungi to fight cancer? Semin Cancer Biol. 2021. DOI:10.1016/j.semcancer.2021.03.009
   PubMed Web of Science ®Google Scholar
• Zamith-Miranda D, Peres Da Silva R, Couvillion SP, et al. Omics Approaches for Understanding Biogenesis, Composition and Functions of Fungal Extracellular Vesicles. Front Genet. 2021;12:648524.
   PubMed Web of Science ®Google Scholar
• Looi QH, Foo JB, Lim MT, et al. How far have we reached in development of effective influenza vaccine? Int Rev Immunol. 2018;37(5):266–276.
   PubMed Web of Science ®Google Scholar
• Tan KL, Chia WC, How CW, et al. Benchtop Isolation and Characterisation of Small Extracellular Vesicles from Human Mesenchymal Stem Cells. Mol Biotechnol. 2021;63(9):780–791.
   PubMed Web of Science ®Google Scholar