MiRNA-99a alleviates inflammation and oxidative stress in lipopolysaccharide-stimulated PC-12 cells and rats post spinal cord injury

References

• Liu M, Chen Y, Song G, et al. MicroRNA-29c overexpression inhibits proliferation and promotes apoptosis and differentiation in P19 embryonal carcinoma cells. Gene. 2016;576(1):304–311.
   PubMed Web of Science ®Google Scholar
• Tator C, Fehlings M. Review of the secondary injury theory of acute spinal cord trauma with emphasis on vascular mechanisms. J Neurosurg. 1991;75(1):15–26.
   PubMed Web of Science ®Google Scholar
• Bermudez S, Khayrullina G, Zhao Y, et al. NADPH oxidase isoform expression is temporally regulated and may contribute to microglial/macrophage polarization after spinal cord injury. Mol Cell Neurosci. 2016;77:53–64.
   PubMed Web of Science ®Google Scholar
• Miller M, Lin A, Wolf E, et al. Oxidative stress, inflammation, and neuroprogression in chronic PTSD. Harv Rev Psychiatry. 2018;26(2):57–69.
   PubMed Web of Science ®Google Scholar
• Khayrullina G, Bermudez S, Byrnes K. Inhibition of NOX2 reduces locomotor impairment, inflammation, and oxidative stress after spinal cord injury. J Neuroinflammation. 2015;12(1):172.
   PubMedGoogle Scholar
• Ma M, Wang J, Zhang Q, et al. NADPH oxidase in brain injury and neurodegenerative disorders. Mol Neurodegener. 2017;12:7.
   PubMed Web of Science ®Google Scholar
• Moon J, Nakahira K, Chung K, et al. NOX4-dependent fatty acid oxidation promotes NLRP3 inflammasome activation in macrophages. Nat Med. 2016;22(9):1002–1012.
   PubMed Web of Science ®Google Scholar
• Gao H, Zhou H, Hong J. NADPH oxidases: novel therapeutic targets for neurodegenerative diseases. Trends Pharmacol Sci. 2012;33(6):295–303.
   PubMed Web of Science ®Google Scholar
• McCrann D, Yang D, Chen H, et al. Upregulation of Nox4 in the aging vasculature and its association with smooth muscle cell polyploidy. Cell Cycle (Georgetown, Tex). 2009;8(6):902–908.
   PubMed Web of Science ®Google Scholar
• Pajoohesh-Ganji A, Knoblach S, Faden A, et al. Characterization of inflammatory gene expression and galectin-3 function after spinal cord injury in mice. Brain Res. 2012;1475:96–105.
   PubMed Web of Science ®Google Scholar
• Iorio M, Croce C. MicroRNA dysregulation in cancer: diagnostics, monitoring and therapeutics. A comprehensive review. EMBO Mol Med. 2012;4(3):143–159.
   PubMed Web of Science ®Google Scholar
• Shi Z, Zhou H, Lu L, et al. The roles of microRNAs in spinal cord injury. Int J Neurosci. 2017;127(12):1104–1115.
   PubMed Web of Science ®Google Scholar
• Dai J, Xu L, Han G, et al. MiR-137 attenuates spinal cord injury by modulating NEUROD4 through reducing inflammation and oxidative stress. Eur Rev Med Pharmacol Sci. 2018;22:1884–1890.
   PubMed Web of Science ®Google Scholar
• Tan Y, Yu L, Zhang C, et al. in vitromiRNA-146a attenuates inflammation in an spinal cord injury model via inhibition of TLR4 signaling. Exp Ther Med. 2018;16:3703–3709.
   PubMed Web of Science ®Google Scholar
• Li L, Qi C, Liu Y, et al. MicroRNA miR-27b-3p regulate microglial inflammation response and cell apoptosis by inhibiting A20 (TNF-α-induced protein 3). Bioengineered. 2021;12(2):9902–9913.
   PubMed Web of Science ®Google Scholar
• Jia D, Niu Y, Li D, et al. MicroRNA-223 alleviates lipopolysaccharide-induced PC-12 cells apoptosis and autophagy by targeting RPH1 in spinal cord injury. Int J Clin Exp Pathol. 2017;10:9223–9232.
   PubMed Web of Science ®Google Scholar
• Yunta M, Nieto-Díaz M, Esteban FJ, et al. MicroRNA dysregulation in the spinal cord following traumatic injury. PloS One. 2012;7(4):e34534.
   PubMed Web of Science ®Google Scholar
• Bao M, Li J, Luo H, et al. NF-κB-Regulated miR-99a modulates endothelial cell inflammation. Mediators Inflamm. 2016;2016:5308170.
   PubMed Web of Science ®Google Scholar
• Tao Z, Zhao H, Wang R, et al. Neuroprotective effect of microRNA-99a against focal cerebral ischemia-reperfusion injury in mice. J Neurol Sci. 2015;355:113–119.
   PubMed Web of Science ®Google Scholar
• Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods. 2001;25:402–408.
   PubMed Web of Science ®Google Scholar
• Austin JW, Kang CE, Baumann MD, et al. The effects of intrathecal injection of a hyaluronan-based hydrogel on inflammation, scarring and neurobehavioural outcomes in a rat model of severe spinal cord injury associated with arachnoiditis. Biomaterials. 2012;33:4555–4564.
   PubMed Web of Science ®Google Scholar
• Austin JW, Afshar M, Fehlings MG. The relationship between localized subarachnoid inflammation and parenchymal pathophysiology after spinal cord injury. J Neurotrauma. 2012;29(10):1838–1849.
   PubMed Web of Science ®Google Scholar
• Basso DM, Beattie MS, Bresnahan JC. A sensitive and reliable locomotor rating scale for open field testing in rats. J Neurotrauma. 1995;12(1):1–21.
   PubMed Web of Science ®Google Scholar
• Kolb J, Oguin T, Oberst A, et al. Programmed cell death and inflammation: winter is coming. Trends Immunol. 2017;38(10):705–718.
   PubMed Web of Science ®Google Scholar
• Wang C, Wang Q, Lou Y, et al. Salidroside attenuates neuroinflammation and improves functional recovery after spinal cord injury through microglia polarization regulation. J Cell Mol Med. 2018;22:1148–1166.
   PubMed Web of Science ®Google Scholar
• Martinez B, Peplow P. Blood microRNAs as potential diagnostic and prognostic markers in cerebral ischemic injury. Neural Regen Res. 2016;11(9):1375–1378.
   PubMed Web of Science ®Google Scholar
• He J, Zhao J, Peng X, et al. Molecular mechanism of MiR-136-5p Targeting NF-κB/A20 in the IL-17-mediated inflammatory response after spinal cord injury. Cell Physiol Biochem. 2017;44(3):1224–1241.
   PubMedGoogle Scholar
• Zhang K, Wu S, and Li Z, et al. MicroRNA-211/BDNF axis regulates LPS-induced proliferation of normal human astrocyte through PI3K/AKT pathway. Biosci Rep. 2017;37(4):BSR20170755. doi:10.1042/BSR20170755.
   Web of Science ®Google Scholar
• Fan Y, Wu Y. Tetramethylpyrazine alleviates neural apoptosis in injured spinal cord via the downregulation of miR-214-3p. Biomed Pharmacothe. 2017;94:827–833.
   PubMed Web of Science ®Google Scholar
• Rodrigues L, Moura-Neto V, Spohr E. Biomarkers in spinal cord injury: from prognosis to treatment. Mol Neurobiol. 2018;55:6436–6448.
   PubMed Web of Science ®Google Scholar
• Jaiswal A, Reddy S, Maurya M, et al. MicroRNA-99a mimics inhibit M1 macrophage phenotype and adipose tissue inflammation by targeting TNFα. Cell Mol Immunol. 2019;16(5):495–507.
   PubMed Web of Science ®Google Scholar
• Jing R, Zhou Z, Kuang F, et al. microRNA-99a reduces lipopolysaccharide-induced oxidative injury by activating notch pathway in H9c2 cells. Int Heart J. 2017;58(3):422–427.
   PubMed Web of Science ®Google Scholar
• Li Q, Xie J, Li R, et al. Overexpression of microRNA-99a attenuates heart remodelling and improves cardiac performance after myocardial infarction. J Cell Mol Med. 2014;18:919–928.
   PubMed Web of Science ®Google Scholar
• Takac I, Schröder K, Zhang L, et al. The E-loop is involved in hydrogen peroxide formation by the NADPH oxidase Nox4. J Biol Chem. 2011;286(15):13304–13313.
   PubMed Web of Science ®Google Scholar
• Yang Z, Tan B, Li T, et al. Protective effect of vitexin compound B-1 against hypoxia/reoxygenation-induced injury in differentiated PC12 cells via NADPH oxidase inhibition. Naunyn-Schmiedeberg’s Arch Pharmacol. 2014;387:861–871.
   Google Scholar
• Xie J, Hong E, Ding B, et al. Inhibition of NOX4/ROS suppresses neuronal and blood-brain barrier injury by attenuating oxidative stress after intracerebral hemorrhage. Front Cell Neurosci. 2020;14:578060.
   PubMed Web of Science ®Google Scholar
• Qin Y, Li M, Feng X, et al. Combined NADPH and the NOX inhibitor apocynin provides greater anti-inflammatory and neuroprotective effects in a mouse model of stroke. Free Radic Biol Med. 2017;104:333–345.
   PubMed Web of Science ®Google Scholar