1,963
Views
6
CrossRef citations to date
0
Altmetric
Research Paper

LncRNA miR-17-92a-1 cluster host gene (MIR17HG) promotes neuronal damage and microglial activation by targeting the microRNA-153-3p/alpha-synuclein axis in Parkinson’s disease

, , , , , & show all
Pages 4493-4516 | Received 26 Oct 2021, Accepted 19 Jan 2022, Published online: 09 Feb 2022

References

  • Yao L, Wei L, Sha X, et al. Highly stabilized nanocrystals delivering ginkgolide B in protecting against the Parkinson’s disease. Int J Pharm. 2020: undefined: 119053. DOI: 10.1016/j.ijpharm.2020.119053.
  • Ya-Shuo F, Si-Dong Y, Zi-Xuan T, et al. The benefits and mechanisms of exercise training for Parkinson’s disease. Life Sci. 2020: undefined: 117345. DOI:10.1016/j.lfs.2020.117345.
  • Cong Y, Yousheng M, Erjin X, et al. Astragaloside IV ameliorates motor deficits and dopaminergic neuron degeneration via inhibiting neuroinflammation and oxidative stress in a Parkinson’s disease mouse model. Int Immunopharmacol. 2019;75:105651.
  • Sijia P, Jingjing J, Jingjing S, et al. LXW7 attenuates inflammation via suppressing Akt/nuclear factor kappa B and mitogen-activated protein kinases signaling pathways in lipopolysaccharide-stimulated BV2 microglial cells. Int Immunopharmacol. 2019;77:105963.
  • Ying L, Lin B, Chuan Q. Long noncoding RNAs in neurodevelopment and Parkinson’s disease. Animal Model Exp Med. 2019;2:239–251.
  • Riva P, Ratti A, Venturin M. The long noncoding RNAs in neurodegenerative diseases: novel mechanisms of pathogenesis. Curr Alzheimer Res. 2016;13(11):1219–1231.
  • Ni Y, Huang H, Chen Y, et al. Investigation of long noncoding RNA expression profiles in the substantia Nigra of Parkinson’s disease. Cell Mol Neurobiol. 2017 Mar;37(2):329–338. Epub 2016 May 5.
  • Guo Y, Liu Y, Wang H, et al. Long noncoding RNA SRY-box transcription factor 2 overlapping transcript participates in Parkinson’s disease by regulating the microRNA-942-5p/nuclear apoptosis-inducing factor 1 axis. Bioengineered. 2021 Dec;12(1):8570–8582.
  • Yan L, Li L, Lei J. Long noncoding RNA small nucleolar RNA host gene 12/microRNA-138-5p/nuclear factor I/B regulates neuronal apoptosis, inflammatory response, and oxidative stress in Parkinson’s disease. Bioengineered. 2021 Nov 16. DOI:10.1080/21655979.2021.2005928.
  • Wei S, Liu J, Li X, et al. LncRNA MIR17HG inhibits non-small cell lung cancer by up-regulating miR-142-3p to downregulate Bach-1. BMC Pulm Med. 2020 Mar 30;20(1):78.
  • Xu J, Meng Q, Li X, et al. Long noncoding RNA MIR17HG promotes colorectal cancer progression via miR-17-5p. Cancer Res. 2019 Oct 1;79(19):4882–4895.
  • Chen L, Heikkinen L, Wang C, et al. Trends in the development of miRNA bioinformatics tools. Brief Bioinform. 2019 Sep 27;20(5):1836–1852.
  • Goh SY, Chao YX, Dheen ST, et al. Role of MicroRNAs in Parkinson’s disease. Int J Mol Sci. 2019 Nov 12;20(22):5649.
  • Wang HJ, Tang XL, Huang G, et al. Long noncoding KCNQ1OT1 promotes oxygen-glucose-deprivation/reoxygenation-induced neurons injury through regulating MIR-153-3p/FOXO3 axis. J Stroke Cerebrovasc Dis. 2020 Oct;29(10):105126.
  • Zhao J, Geng L, Chen Y, et al. SNHG1 promotes MPP+-induced cytotoxicity by regulating PTEN/AKT/mTOR signaling pathway in SH-SY5Y cells via sponging miR-153-3p. Biol Res. 2020 Jan 6;53(1):1.
  • Furlong Rachel M, Gerard W O, Cora O, et al. Alterations in α-synuclein and PINK1 expression reduce neurite length and induce mitochondrial fission and Golgi fragmentation in midbrain neurons. Neurosci Lett. 2020;720:134777.
  • Zheng F, Yu-Ting P, Zhi-Yuan Z, et al. Systemic activation of NLRP3 inflammasome and plasma α-synuclein levels are correlated with motor severity and progression in Parkinson’s disease. J Neuroinflammation. 2020;17:11.
  • Li-Min Z, Meng-Han W, He-Cheng Y, et al. Dopaminergic neuron injury in Parkinson’s disease is mitigated by interfering lncRNA SNHG14 expression to regulate the miR-133b/ α-synuclein pathway. Aging (Albany NY). 2019;11:9264–9279.
  • Xiaonan X, Chengle Z, Zimu W, et al. LincRNA-p21 inhibits cell viability and promotes cell apoptosis in Parkinson’s disease through activating α-synuclein expression. Biomed Res Int. 2018;2018:8181374.
  • Zhang W, Sun C, Shao Y, et al. Partial depletion of dopaminergic neurons in the substantia nigra impairs olfaction and alters neural activity in the olfactory bulb. Sci Rep. 2019 Jan 22;9(1):254.
  • Jiang J, Piao X, Hu S, et al. LncRNA H19 diminishes dopaminergic neuron loss by mediating microRNA-301b-3p in Parkinson’s disease via the HPRT1-mediated Wnt/β-catenin signaling pathway. Aging (Albany NY). 2020 May 20;12(10):8820–8836. Epub 2020 May 20.
  • Rosa I, Di Censo D, Ranieri B, et al. Comparison between tail suspension swing test and standard rotation test in revealing early motor behavioral changes and neurodegeneration in 6-OHDA hemiparkinsonian rats. Int J Mol Sci. 2020 Apr 20;21(8):2874.
  • Burgaz S, García C, Gómez-Cañas M, et al. Development of an oral treatment with the PPAR-γ-acting cannabinoid VCE-003.2 against the inflammation-driven neuronal deterioration in experimental Parkinson’s disease. Molecules. 2019 Jul 25;24(15):2702.
  • Jo S, Yarishkin O, Hwang YJ, et al. GABA from reactive astrocytes impairs memory in mouse models of Alzheimer’s disease. Nat Med. 2014 Aug;20(8):886–896. Epub 2014 Jun 29.
  • Li Y, Fang J, Zhou Z, et al. Downregulation of lncRNA BACE1-AS improves dopamine-dependent oxidative stress in rats with Parkinson’s disease by up-regulating microRNA-34b-5p and downregulating BACE1. Cell Cycle. 2020 May;19(10):1158–1171. Epub 2020 Apr 19.
  • Wang C, Wang Q, Lou Y, et al. Salidroside attenuates neuroinflammation and improves functional recovery after spinal cord injury through microglia polarization regulation. J Cell Mol Med. 2018 Feb;22(2):1148–1166. Epub 2017 Nov 17.
  • Cai LJ, Tu L, Huang XM, et al. LncRNA MALAT1 facilitates inflammasome activation via epigenetic suppression of Nrf2 in Parkinson’s disease. Mol Brain. 2020 Sep 24;13(1):130.
  • Chen J, Jiang C, Du J, et al. MiR-142-5p protects against 6-OHDA-Induced SH-SY5Y cell injury by downregulating BECN1 and autophagy. Dose Response. 2020 Feb 20;18(1):1559325820907016.
  • Urrutia PJ, Hirsch EC, González-Billault C, et al. Hepcidin attenuates amyloid beta-induced inflammatory and pro-oxidant responses in astrocytes and microglia. J Neurochem. 2017 Jul;142(1):140–152.
  • Zhuang J, Cai P, Chen Z, et al. Long noncoding RNA MALAT1 and its target microRNA-125b are potential biomarkers for Alzheimer’s disease management via interactions with FOXQ1, PTGS2 and CDK5. Am J Transl Res. 2020 Sep 15;12(9):5940–5954.
  • Zhang LM, Wang MH, Yang HC, et al. Dopaminergic neuron injury in Parkinson’s disease is mitigated by interfering lncRNA SNHG14 expression to regulate the miR-133b/ α-synuclein pathway. Aging (Albany NY). 2019 Nov 4;11(21):9264–9279. Epub 2019 Nov 4.
  • Rong S, Wan D, Fan Y, et al. Amentoflavone affects epileptogenesis and exerts neuroprotective effects by inhibiting NLRP3 inflammasome. Front Pharmacol. 2019 Jul 30;10: 856.
  • Chi H, Guan Y, Li F, et al. The effect of human umbilical cord mesenchymal stromal cells in protection of dopaminergic neurons from apoptosis by reducing oxidative stress in the early stage of a 6-OHDA-induced Parkinson’s disease model. Cell Transplant. 2019 Dec;28(1_suppl):87S–99S. Epub 2019 Nov 28.
  • Yan JQ, Ma YJ, Sun JC, et al. Neuroprotective effect of lovastatin by inhibiting NMDA receptor1 in 6-hydroxydopamine treated PC12 cells. Int J Clin Exp Med. 2014 Oct 15;7(10):3313–3319.
  • Liu XY, Zhou XY, Hou JC, et al. Ginsenoside Rd promotes neurogenesis in rat brain after transient focal cerebral ischemia via activation of PI3K/Akt pathway. Acta Pharmacol Sin. 2015 Apr;36(4):421–428. Epub 2015 Mar 16.
  • Rodriguez-Blanco J, Martín V, Herrera F, et al. Intracellular signaling pathways involved in post-mitotic dopaminergic PC12 cell death induced by 6-hydroxydopamine. J Neurochem. 2008 Oct;107(1):127–140. Epub 2008 Jul 28.
  • Chen G, Liu J, Jiang L, et al. Peiminine protects dopaminergic neurons from inflammation-induced cell death by inhibiting the ERK1/2 and NF-κB signalling pathways. Int J Mol Sci. 2018 Mar 12;19(3):ii: E821.
  • Xueyan Z, Ming D, Ping Z, et al. New insights into the Nrf-2/HO-1 signaling axis and its application in pediatric respiratory diseases. Oxid Med Cell Longev. 2019;2019:3214196.
  • Song Y, Liu Y, Chen X. MiR-212 attenuates MPP⁺-induced neuronal damage by targeting KLF4 in SH-SY5Y cells. Yonsei Med J. 2018;59(3):416–424.
  • Chinta Shankar J, Subramanian R, Abirami G, et al. A possible novel anti-inflammatory mechanism for the pharmacological prolyl hydroxylase inhibitor 3,4-dihydroxybenzoate: implications for use as a therapeutic for Parkinson’s disease. Parkinsons Dis. 2012;2012:364684.
  • Yan MH, Wang X, Zhu X. Mitochondrial defects and oxidative stress in Alzheimer disease and Parkinson disease. Free Radic Biol Med. 2013;62:90–101.
  • Kempuraj D, Thangavel R, Natteru PA, et al. Neuroinflammation induces neurodegeneration. J Neurol Neurosurg Spine. 2016;1(1):1003.
  • Wang S1, Zhang X1, Guo Y1, et al. The long noncoding RNA HOTAIR promotes Parkinson’s disease by up-regulating LRRK2 expression. Oncotarget. 2017 Apr 11;8(15):24449–24456.
  • Qingxin S, Yunming G, Yue L, et al. Long noncoding RNA NORAD regulates MPP+-induced Parkinson’s disease model cells. J Chem Neuroanat. 2019;101:101668.
  • Chen MY, Fan K, Zhao LJ, et al. Long noncoding RNA nuclear enriched abundant transcript 1 (NEAT1) sponges microRNA-124-3p to up-regulate phosphodiesterase 4B (PDE4B) to accelerate the progression of Parkinson’s disease. Bioengineered. 2021 Dec;12(1):708–719.
  • Liu H, Zhu C, Xu Z, et al. lncRNA PART1 and MIR17HG as ΔNp63α direct targets regulate tumor progression of cervical squamous cell carcinoma. Cancer Sci. 2020 Nov;111(11):4129–4141. Epub 2020 Sep 29.
  • Meng Y, Hao D, Huang Y, et al. Positive feedback loop SP1/MIR17HG/miR-130a-3p promotes osteosarcoma proliferation and cisplatin resistance. Biochem Biophys Res Commun. 2020 Jan 15;521(3):739–745.
  • Jinbo C, Yajin L, Yuan D, et al. Microglial autophagy defect causes Parkinson disease-like symptoms by accelerating inflammasome activation in mice. Autophagy. 2020. DOI:10.1080/15548627.2020.1719723.
  • Mingda W, Hongming S, Yina Y, et al. MicroRNA-217/138-5p downregulation inhibits inflammatory response, oxidative stress and the induction of neuronal apoptosis in MPP-induced SH-SY5Y cells. Am J Transl Res. 2019;11:6619–6631.
  • Ruili W, Ying Y, Hui W, et al. MiR-29c protects against inflammation and apoptosis in Parkinson’s disease model in vivo and in vitro by targeting SP1. Clin Exp Pharmacol Physiol. 2020;47:372–382.
  • Si-Yi L, Yi-Le Z, Dan-Hua H, et al. Centipeda minima extract exerts antineuroinflammatory effects via the inhibition of NF-κB signaling pathway. Phytomedicine. 2019;67:153164.
  • Tian W, Cuiting L, Bing H, et al. Neuroprotective effects of Danshensu on rotenone-induced Parkinson’s disease models in vitro and in vivo. BMC Compl Med Ther. 2020;20:20.
  • Wu F, Poon WS, Lu G, et al. Alpha-synuclein knockdown attenuates MPP+ induced mitochondrial dysfunction of SH-SY5Y cells. Brain Res. 2009 Oct 6;1292:173–179. Epub 2009 Jul 29.
  • Takuya U, Chi-Jing C, Masayuki N, et al. Amido-bridged nucleic acid (AmNA)-modified antisense oligonucleotides targeting α-synuclein as a novel therapy for Parkinson’s disease. Sci Rep. 2019;9:7567.
  • Chen Y, Lian YJ, Ma YQ, et al. LncRNA SNHG1 promotes α-synuclein aggregation and toxicity by targeting miR-15b-5p to activate SIAH1 in human neuroblastoma SH-SY5Y cells. Neurotoxicology. 2018 Sep;68:212–221.