1,443
Views
5
CrossRef citations to date
0
Altmetric
Research Paper

Metformin attenuates high glucose-induced injury in islet microvascular endothelial cells

, , , &
Pages 4385-4396 | Received 26 Oct 2021, Accepted 19 Jan 2022, Published online: 09 Feb 2022

References

  • Xie S, Huang L, Cao W, et al. Association between serum 25-hydroxyvitamin D and diabetic kidney disease in Chinese patients with type 2 diabetes [J]. PLoS One. 2019;14(4):e0214728.
  • Aamodt KI, Powers AC. Signals in the pancreatic islet microenvironment influence β-cell proliferation [J]. Diabetes Obes Metab. 2017;1:124–136. 9 Suppl 1(Suppl 1).
  • Amarteifio E, Wormsbecher S, Demirel S, et al. Assessment of skeletal muscle microcirculation in type 2 diabetes mellitus using dynamic contrast-enhanced ultrasound: a pilot study [J]. Diab Vasc Dis Res. 2013;10(5):468–470.
  • Heimhalt-El Hamriti M, Schreiver C, Noerenberg A, et al. Impaired skin microcirculation in paediatric patients with type 1 diabetes mellitus [J]. Cardiovasc Diabetol. 2013;12(1):115.
  • Eberhard D, Kragl M, Lammert E. ‘Giving and taking’: endothelial and beta-cells in the islets of Langerhans [J]. Trends Endocrinol Metab. 2010;21(8):457–463.
  • Emami Riedmaier A, Fisel P, Nies AT, et al. Metformin and cancer: from the old medicine cabinet to pharmacological pitfalls and prospects [J]. Trends Pharmacol Sci. 2013;34(2):126–135.
  • Wang Y-D, Chen W-D, Huang W. FXR, a target for different diseases [J]. Histol Histopathol. 2008;23(5):621–627.
  • Ahn KS, Sethi G, Sung B, et al. Guggulsterone, a farnesoid X receptor antagonist, inhibits constitutive and inducible STAT3 activation through induction of a protein tyrosine phosphatase SHP-1 [J]. Cancer Res. 2008;68(11):4406–4415.
  • Brissova M, Shostak A, Shiota M, et al. Pancreatic islet production of vascular endothelial growth factor–a is essential for islet vascularization, revascularization, and function [J]. Diabetes. 2006;55(11):2974–2985.
  • Wang Y, Wang JW, Li Y, et al. Bone marrow-derived mesenchymal stem cells improve rat islet graft revascularization by upregulating ISL1 [J]. Stem Cells. 2021;39(8):1033–1048.
  • Staels W, Heremans Y, Heimberg H, et al. VEGF-A and blood vessels: a beta cell perspective [J]. Diabetologia. 2019;62(11):1961–1968.
  • Burganova G, Bridges C, Thorn P, et al. The role of vascular cells in pancreatic beta-cell function [J]. Front Endocrinol (Lausanne). 2021;12:667170.
  • Xu JH, Zhao JX, Jiang MY, et al. MiR-193 promotes cell proliferation and invasion by ING5/PI3K/AKT pathway of triple-negative breast cancer [J]. Eur Rev Med Pharmacol Sci. 2020;24(6):3122–3129.
  • Hu X, Li M, Zhang C, et al. Constitutive androstane receptor-mediated inhibition of metformin on phase II metabolic enzyme SULT2A1 [J]. Int J Endocrinol. 2021;2021:8867218.
  • Yao X, Jing X, Guo J, et al. Icariin protects bone marrow mesenchymal stem cells against iron overload induced dysfunction through mitochondrial fusion and fission, PI3K/AKT/mTOR and MAPK pathways [J]. Front Pharmacol. 2019;10:163.
  • Sun L, Sun C, Zhou S, et al. Tamsulosin attenuates high glucose- induced injury in glomerular endothelial cells [J]. Bioengineered. 2021;12(1):5184–5194.
  • Wu HH, Meng TT, and Chen JM, et al. Asenapine maleate inhibits angiotensin II-induced proliferation and activation of cardiac fibroblasts via the ROS/TGFβ1/MAPK signaling pathway [J]. Biochem Biophys Res Commun. 2021;553:172-179.
  • Gao Y, Zhao D, Xie W-Z, et al. Rap1GAP mediates angiotensin II-induced cardiomyocyte hypertrophy by inhibiting autophagy and increasing oxidative stress [J]. Oxid Med Cell Longev. 2021;2021:7848027.
  • In’t Veld P, and Marichal M. Microscopic anatomy of the human islet of Langerhans [J]. Adv Exp Med Biol. 2010;654:1-19.
  • Kahn SE, Hull RL, Utzschneider KM. Mechanisms linking obesity to insulin resistance and type 2 diabetes [J]. Nature. 2006;444(7121):840–846.
  • Hogan MF, Liu AW, Peters MJ, et al. Markers of islet endothelial dysfunction occur in male B6.BKS(D)-Leprdb/J mice and may contribute to reduced insulin release [J]. Endocrinology. 2017;158(2):293–303.
  • Lu T, Zhou D, Gao P, et al. Resveratrol attenuates high glucose-induced endothelial cell apoptosis via mediation of store-operated calcium entry [J]. Mol Cell Biochem. 2018;442(1–2):73–80.
  • Guo Y, Zhuang X, Huang Z, et al. Klotho protects the heart from hyperglycemia-induced injury by inactivating ROS and NF-κB-mediated inflammation both in vitro and in vivo [J]. Biochimica Et Biophysica Acta Mol Basis Dis. 2018;1864(1):238–251.
  • Liu D, Wu M, Lu Y, et al. Protective effects of 6-Gingerol on vascular endothelial cell injury induced by high glucose via activation of PI3K-AKT-eNOS pathway in human umbilical vein endothelial cells [J]. Biomed Pharmacothe. 2017;93:788–795.
  • Driver C, Bamitale KDS, Kazi A, et al. Cardioprotective effects of metformin [J]. J Cardiovasc Pharmacol. 2018;72(2):121–127.
  • Venu VKP, Saifeddine M, Mihara K, et al. Metformin prevents hyperglycemia-associated, oxidative stress-induced vascular endothelial dysfunction: essential role for the orphan nuclear receptor human nuclear receptor 4A1 (Nur77) [J]. Mol Pharmacol. 2021;100(5):428–455.
  • Han CY. Update on FXR biology: promising therapeutic target? [J]. Int J Mol Sci. 2018;19(7):2069.
  • Popescu IR, Helleboid-Chapman A, Lucas A, et al. The nuclear receptor FXR is expressed in pancreatic beta-cells and protects human islets from lipotoxicity [J]. FEBS Lett. 2010;584(13):2845–2851.
  • Guizoni DM, Vettorazzi JF, Carneiro EM, et al. Modulation of endothelium-derived nitric oxide production and activity by taurine and taurine-conjugated bile acids [J]. Nitric Oxide. 2020;94:48–53.
  • Lv H, Liu Q, Zhou J, et al. Daphnetin-mediated Nrf2 antioxidant signaling pathways ameliorate tert-butyl hydroperoxide (t-BHP)-induced mitochondrial dysfunction and cell death [J]. Free Radic Biol Med. 2017;106:38–52.
  • Jung KA, Lee S, Kwak MK. NFE2L2/NRF2 activity is linked to mitochondria and AMP-activated protein kinase signaling in cancers through miR-181c/mitochondria-encoded cytochrome c oxidase regulation [J]. Antioxid Redox Signal. 2017;27(13):945–961.
  • Dong L, Yin L, Li R, et al. Dioscin alleviates lung ischemia/reperfusion injury by regulating FXR-mediated oxidative stress, apoptosis, and inflammation [J]. Eur J Pharmacol. 2021;908:174321.
  • Xiong Y, Scerbo MJ, Seelig A, et al. Islet vascularization is regulated by primary endothelial cilia via VEGF-A-dependent signaling [J]. Elife. 2020;9. DOI:10.7554/eLife.56914.
  • Brissova M, Aamodt K, Brahmachary P, et al. Islet microenvironment, modulated by vascular endothelial growth factor-A signaling, promotes β cell regeneration [J]. Cell Metab. 2014;19(3):498–511.
  • Song YS, Joo HW, Park IH, et al. Bone marrow mesenchymal stem cell-derived vascular endothelial growth factor attenuates cardiac apoptosis via regulation of cardiac miRNA-23a and miRNA-92a in a rat model of myocardial infarction [J]. PLoS One. 2017;12(6):e0179972.
  • Huang L, Liu Z, Liu H, et al. Iron overload impairs bone marrow mesenchymal stromal cells from higher-risk MDS patients by regulating the ROS-related Wnt/β-Catenin pathway [J]. Stem Cells Int. 2020;2020:8855038.
  • Chen XY, Huang WL, Peng XP, et al. miR-140-5p mediates bevacizumab-induced cytotoxicity to cardiomyocytes by targeting the VEGFA/14-3-3γ signal pathway [J]. Toxicol Res (Camb). 2019;8(6):875–884.
  • Le Y, Wei R, Yang K, et al. Liraglutide ameliorates palmitate-induced oxidative injury in islet microvascular endothelial cells through GLP-1 receptor/PKA and GTPCH1/eNOS signaling pathways [J]. Peptides. 2020;124:170212.
  • Zhen CL, Yan J, Zhao Y, et al. Taurochenodeoxycholate relaxes rat mesenteric arteries through activating eNOS: comparing with glycochenodeoxycholate and tauroursodeoxycholate [J]. Eur J Pharmacol. 2016;774:118–126.
  • Pourbagher-Shahri AM, Farkhondeh T, Talebi M, et al. An overview of no signaling pathways in aging [J]. Molecules. 2021;26(15):4533.
  • Wierońska JM, Cieślik P, Kalinowski L. Nitric oxide-dependent pathways as critical factors in the consequences and recovery after brain ischemic hypoxia [J]. Biomolecules. 2021;11(8):1097.