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Research Paper

Human umbilical cord mesenchymal stem cells contribute to the reconstruction of bladder function after acute spinal cord injury via p38 mitogen-activated protein kinase/nuclear factor-kappa B pathway

, , , & ORCID Icon
Pages 4844-4856 | Received 16 Aug 2021, Accepted 25 Jan 2022, Published online: 13 Feb 2022

References

  • Galeiras Vazquez R, Ferreiro Velasco ME, Mourelo Farina M, et al. Update on traumatic acute spinal cord injury. Part 1. Med Intensiva. 2017;41:237–247.
  • Kjell J, Olson L. Rat models of spinal cord injury: from pathology to potential therapies. Dis Model Mech. 2016;9:1125–1137.
  • Karsy M, Hawryluk G. Modern medical management of spinal cord injury. Curr Neurol Neurosci Rep. 2019;19:65.
  • Gater DR. Neurogenic bowel and bladder evaluation strategies in spinal cord injury: new directions. J Spinal Cord Med. 2020;43:139–140.
  • Hubscher CH, Wyles J, Gallahar A, et al. Effect of different forms of activity-based recovery training on bladder, bowel, and sexual function after spinal cord injury. Arch Phys Med Rehabil. 2021;102:865–873.
  • Hu HZ, Granger N, Jeffery ND. Pathophysiology, clinical importance, and management of neurogenic lower urinary tract dysfunction caused by suprasacral spinal cord injury. J Vet Intern Med. 2016;30:1575–1588.
  • Rude T, Moghalu O, Stoffel J, et al. The role of health insurance in patient reported satisfaction with bladder management in neurogenic lower urinary tract dysfunction due to spinal cord injury. J Urol. 2021;205:213–218.
  • Romo PGB, Smith CP, Cox A, et al. Non-surgical urologic management of neurogenic bladder after spinal cord injury. World J Urol. 2018;36:1555–1568.
  • Wyndaele JJ, Birch B, Borau A, et al. Surgical management of the neurogenic bladder after spinal cord injury. World J Urol. 2018;36:1569–1576.
  • Hachem LD, Ahuja CS, Fehlings MG. Assessment and management of acute spinal cord injury: from point of injury to rehabilitation. J Spinal Cord Med. 2017;40:665–675.
  • Liau LL, Looi QH, Chia WC, et al. Treatment of spinal cord injury with mesenchymal stem cells. Cell Biosci. 2020;10:112.
  • Gao L, Peng Y, Xu W, et al. Progress in stem cell therapy for spinal cord injury. Stem Cells Int. 2020;2020:2853650.
  • Ahuja CS, Mothe A, Khazaei M, et al. The leading edge: emerging neuroprotective and neuroregenerative cell-based therapies for spinal cord injury. Stem Cells Transl Med. 2020;9:1509–1530.
  • Deng WS, Ma K, Liang B, et al. Collagen scaffold combined with human umbilical cord-mesenchymal stem cells transplantation for acute complete spinal cord injury. Neural Regen Res. 2020;15:1686–1700.
  • Xiao Z, Tang F, Zhao Y, et al. Significant improvement of acute complete spinal cord injury patients diagnosed by a combined criteria implanted with neuroregen scaffolds and mesenchymal stem cells. Cell Transplant. 2018;27:907–915.
  • Xie Q, Liu R, Jiang J, et al. What is the impact of human umbilical cord mesenchymal stem cell transplantation on clinical treatment? Stem Cell Res Ther. 2020;11:519.
  • Yamazaki K, Kawabori M, Seki T, et al. FTY720 attenuates neuropathic pain after spinal cord injury by decreasing systemic and local inflammation in a rat spinal cord compression model. J Neurotrauma. 2020;37:1720–1728.
  • Zhang L, Zhuang X, Chen Y, et al. Intravenous transplantation of olfactory bulb ensheathing cells for a spinal cord hemisection injury rat model. Cell Transplant. 2019;28:1585–1602.
  • Munoz A, Yazdi IK, Tang X, et al. Localized inhibition of P2X7R at the spinal cord injury site improves neurogenic bladder dysfunction by decreasing urothelial P2X3R expression in rats. Life Sci. 2017;171:60–67.
  • Sun L, Wang F, Chen H, et al. Co-transplantation of human umbilical cord mesenchymal stem cells and human neural stem cells improves the outcome in rats with spinal cord injury. Cell Transplant. 2019;28:893–906.
  • Basso DM, Beattie MS, Bresnahan JC. A sensitive and reliable locomotor rating scale for open field testing in rats. J Neurotrauma. 1995;12:1–21.
  • Basso DM, Beattie MS, Bresnahan JC, et al. MASCIS evaluation of open field locomotor scores: effects of experience and teamwork on reliability. Multicenter Animal Spinal Cord Injury Study. J Neurotrauma. 1996;13:343–359.
  • Bao CS, Li XL, Liu L, et al. Transplantation of Human umbilical cord mesenchymal stem cells promotes functional recovery after spinal cord injury by blocking the expression of IL-7. Eur Rev Med Pharmacol Sci. 2018;22:6436–6447.
  • Fan B, Wei Z, Yao X, et al. Microenvironment imbalance of spinal cord injury. Cell Transplant. 2018;27:853–866.
  • Salehi-Pourmehr H, Hajebrahimi S, Rahbarghazi R, et al. Stem cell therapy for neurogenic bladder dysfunction in rodent models: a systematic review. Int Neurourol J. 2020;24:241–257.
  • Yang Y, Cao TT, Tian ZM, et al. Subarachnoid transplantation of human umbilical cord mesenchymal stem cell in rodent model with subacute incomplete spinal cord injury: preclinical safety and efficacy study. Exp Cell Res. 2020;395:112184.
  • Li X, Tan J, Xiao Z, et al. Transplantation of hUC-MSCs seeded collagen scaffolds reduces scar formation and promotes functional recovery in canines with chronic spinal cord injury. Sci Rep. 2017;7:43559.
  • Wu LL, Pan XM, Chen HH, et al. Repairing and analgesic effects of umbilical cord mesenchymal stem cell transplantation in mice with spinal cord injury. Biomed Res Int. 2020;2020:7650354.
  • Yang Y, Pang M, Du C, et al. Repeated subarachnoid administrations of allogeneic human umbilical cord mesenchymal stem cells for spinal cord injury: a phase 1/2 pilot study. Cytotherapy. 2021;23:57–64.
  • Fowler CJ, Griffiths D, de Groat WC. The neural control of micturition. Nat Rev Neurosci. 2008;9:453–466.
  • WenBo W, Fei Z, YiHeng D, et al. Human umbilical cord mesenchymal stem cells overexpressing nerve growth factor ameliorate diabetic cystopathy in rats. Neurochem Res. 2017;42:3537–3547.
  • Shunmugavel A, Khan M, Hughes FM Jr., et al. S-Nitrosoglutathione protects the spinal bladder: novel therapeutic approach to post-spinal cord injury bladder remodeling. Neurourol Urodyn. 2015;34:519–526.
  • Xu S, Wang J, Jiang J, et al. TLR4 promotes microglial pyroptosis via lncRNA-F630028O10Rik by activating PI3K/AKT pathway after spinal cord injury. Cell Death Dis. 2020;11:693.
  • Ji S, Xiao J, Liu J, et al. Human umbilical cord mesenchymal stem cells attenuate ocular hypertension-induced retinal neuroinflammation via toll-like receptor 4 pathway. Stem Cells Int. 2019;2019:9274585.
  • Wang Y, Liu J, Zhang Q, et al. Human umbilical cord mesenchymal stem cells attenuate podocyte injury under high glucose via TLR2 and TLR4 signaling. Diabetes Res Clin Pract. 2021;173:108702.
  • Zhou J, Liu Q, Qian R, et al. Paeonol antagonizes oncogenesis of osteosarcoma by inhibiting the function of TLR4/MAPK/NF-kappaB pathway. Acta Histochem. 2020;122:151455.
  • Falcicchia C, Tozzi F, Arancio O, et al. Involvement of p38 MAPK in synaptic function and dysfunction. Int J Mol Sci. 2020;21(16):5624.
  • Chen G, Fan XY, Zheng XP, et al. Human umbilical cord-derived mesenchymal stem cells ameliorate insulin resistance via PTEN-mediated crosstalk between the PI3K/Akt and Erk/MAPKs signaling pathways in the skeletal muscles of db/db mice. Stem Cell Res Ther. 2020;11:401.
  • Kasuya Y, Umezawa H, Hatano M. Stress-activated protein kinases in spinal cord injury: focus on roles of p38. Int J Mol Sci. 2018;19(3):867.
  • Shimizu N, Wada N, Shimizu T, et al. Role of p38 MAP kinase signaling pathways in storage and voiding dysfunction in mice with spinal cord injury. Neurourol Urodyn. 2020;39:108–115.
  • Caterina MJ, Julius D. The vanilloid receptor: a molecular gateway to the pain pathway. Annu Rev Neurosci. 2001;24:487–517.