MicroRNA miR-3646 promotes malignancy of lung adenocarcinoma cells by suppressing sorbin and SH3 domain-containing protein 1 via the c-Jun NH2-terminal kinase signaling pathway

References

• Sung H, Ferlay J, Siegel RL, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021;71(3):209–249.
   PubMed Web of Science ®Google Scholar
• Chen J, Yang H, Teo ASM, et al. Genomic landscape of lung adenocarcinoma in East Asians. Nat Genet. 2020;52:177–186.
   PubMed Web of Science ®Google Scholar
• Weiss FU, Marques IJ, Woltering JM, et al. Retinoic acid receptor antagonists inhibit miR-10a expression and block metastatic behavior of pancreatic cancer. Gastroenterology. 2009;137:2136–45.e1-7.
   Web of Science ®Google Scholar
• Wong QW, Lung RW, Law PT, et al. MicroRNA-223 is commonly repressed in hepatocellular carcinoma and potentiates expression of Stathmin1. Gastroenterology. 2008;135:257–269.
   PubMed Web of Science ®Google Scholar
• Rogler A, Hoja S, Socher E, et al. Role of two single nucleotide polymorphisms in secreted frizzled related protein 1 and bladder cancer risk. Int J Clin Exp Pathol. 2013;6(10):1984–1998.
   PubMed Web of Science ®Google Scholar
• Zhang K, Wang YW, Ma R. Bioinformatics analysis of dysregulated microRNAs in the nipple discharge of patients with breast cancer. Oncol Lett. 2017;13(5):3100–3108.
   PubMed Web of Science ®Google Scholar
• Zhang K, Zhao S, Wang Q, et al. Identification of microRNAs in nipple discharge as potential diagnostic biomarkers for breast cancer. Ann Surg Oncol. 2015;22(Suppl 3):S536–44.
   PubMed Web of Science ®Google Scholar
• Gong C, Hu Y, Zhou M, et al. Identification of specific modules and hub genes associated with the progression of gastric cancer. Carcinogenesis. 2019;40(10):1269–1277.
   PubMed Web of Science ®Google Scholar
• Vanaja DK, Ballman KV, Morlan BW, et al. PDLIM4 repression by hypermethylation as a potential biomarker for prostate cancer. Clin Cancer Res. 2006;12:1128–1136.
   PubMed Web of Science ®Google Scholar
• Kim SC, Hong CW, Jang SG, et al. Establishment and characterization of paired primary and peritoneal seeding human colorectal cancer cell lines: identification of genes that mediate metastatic potential. Transl Oncol. 2018;11(5):1232–1243.
   PubMed Web of Science ®Google Scholar
• Aakula A, Kohonen P, Leivonen SK, et al. Systematic identification of MicroRNAs that impact on proliferation of prostate cancer cells and display changed expression in tumor tissue. Eur Urol. 2016;69(6):1120–1128.
   PubMed Web of Science ®Google Scholar
• Xu Y, Xin R, Sun H, et al. Long non-coding RNAs LOC100126784 and POM121L9P derived from bone marrow mesenchymal stem cells enhance osteogenic differentiation via the miR-503-5p/SORBS1 Axis. Front Cell Dev Biol. 2021;9:723759.
   PubMed Web of Science ®Google Scholar
• Yu W, Li D, Zhang Y, et al. MiR-142-5p acts as a significant regulator through promoting proliferation, invasion, and migration in breast cancer modulated by targeting SORBS1. Technol Cancer Res Treat. 2019;18:1533033819892264.
   Web of Science ®Google Scholar
• He F, Huang L, Xu Q, et al. Microarray profiling of differentially expressed lncRNAs and mRNAs in lung adenocarcinomas and bioinformatics analysis. Cancer Med. 2020;9(20):7717–7728.
   PubMed Web of Science ®Google Scholar
• Pu HY, Xu R, Zhang MY, et al. Identification of microRNA-615-3p as a novel tumor suppressor in non-small cell lung cancer. Oncol Lett. 2017;13(4):2403–2410.
   PubMed Web of Science ®Google Scholar
• Tang Z, Li C, Kang B, et al. GEPIA: a web server for cancer and normal gene expression profiling and interactive analyses. Nucleic Acids Res. 2017;45(W1):W98–w102.
   PubMed Web of Science ®Google Scholar
• Szklarczyk D, Gable AL, Lyon D, et al. STRING v11: protein-protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets. Nucleic Acids Res. 2019;47(D1):D607–d13.
   PubMed Web of Science ®Google Scholar
• Lánczky A, Győrffy B. Web-based survival analysis tool tailored for medical research (KMplot): development and implementation. J Med Internet Res. 2021;23:e27633.
   PubMed Web of Science ®Google Scholar
• Agarwal V, Bell GW, Nam JW, et al. Predicting effective microRNA target sites in mammalian mRNAs. eLife. 2015;4. DOI:10.7554/eLife.05005
   Web of Science ®Google Scholar
• Liu W, Wang X. Prediction of functional microRNA targets by integrative modeling of microRNA binding and target expression data. Genome Biol. 2019;20:18.
   PubMed Web of Science ®Google Scholar
• Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 2001;25(4):402–408.
   PubMed Web of Science ®Google Scholar
• Geng X, Sun Y, Fu J, et al. MicroRNA-17-5p inhibits thyroid cancer progression by suppressing early growth response 2 (EGR2). Bioengineered. 2021;12:2713–2722.
   PubMed Web of Science ®Google Scholar
• Liu H, Wang Y, Wang Y, et al. miR-199a-3p plays an anti-tumorigenic role in lung adenocarcinoma by suppressing anterior gradient 2. Bioengineered. 2021;12(1):7859–7871.
   PubMed Web of Science ®Google Scholar
• Xu H, Jin L, Chen Y, et al. Downregulation of microRNA-429 protects cardiomyocytes against hypoxia-induced apoptosis by increasing Notch1 expression. Int J Mol Med. 2016;37(6):1677–1685.
   PubMed Web of Science ®Google Scholar
• He T, Shen H, Wang S, et al. MicroRNA-3613-5p promotes lung adenocarcinoma cell proliferation through a RELA and AKT/MAPK positive feedback loop. Molecular Therapy - Nucleic Acids. 2020;22:572–583.
   Google Scholar
• Li L, Li Q. miR-543 impairs breast cancer cell phenotypes by targeting and suppressing ubiquitin-conjugating enzyme E2T (UBE2T). Bioengineered. 2021;12(2):12394–12406.
   PubMed Web of Science ®Google Scholar
• Chen H, Wei L, Luo M, et al. LINC00324 suppresses apoptosis and autophagy in nasopharyngeal carcinoma through upregulation of PAD4 and activation of the PI3K/AKT signaling pathway. Cell Biol Toxicol. 2021. DOI:10.1007/s10565-021-09632-x.
   Web of Science ®Google Scholar
• Shen D, Li J, Tao K, et al. Long non-coding RNA MCM3AP antisense RNA 1 promotes non-small cell lung cancer progression through targeting microRNA-195-5p. Bioengineered. 2021;12(1):3525–3538.
   PubMed Web of Science ®Google Scholar
• Tao S, Liu YB, Zhou ZW, et al. miR-3646 promotes cell proliferation, migration, and invasion via regulating G2/M transition in human breast cancer cells. Am J Transl Res. 2016;8:1659–1677.
   PubMed Web of Science ®Google Scholar
• Song L, Chang R, Dai C, et al. SORBS1 suppresses tumor metastasis and improves the sensitivity of cancer to chemotherapy drug. Oncotarget. 2017;8(6):9108–9122.
   PubMedGoogle Scholar
• Zhao H, Zheng C, Wang Y, et al. miR-1323 promotes cell migration in lung adenocarcinoma by targeting Cbl-b and is an early prognostic biomarker. Front Oncol. 2020;10:181.
   PubMed Web of Science ®Google Scholar
• Li Y, Zhang H, Fan L, et al. MiR-629-5p promotes the invasion of lung adenocarcinoma via increasing both tumor cell invasion and endothelial cell permeability. Oncogene. 2020;39(17):3473–3488.
   PubMed Web of Science ®Google Scholar
• Wang J, Yao S, Diao Y, et al. miR-15b enhances the proliferation and migration of lung adenocarcinoma by targeting BCL2. Thorac Cancer. 2020;11(6):1396–1405.
   PubMed Web of Science ®Google Scholar
• Zhao Y, Zhang W, Yang Y, et al. Diagnostic and prognostic value of microRNA-2355-3p and contribution to the progression in lung adenocarcinoma. Bioengineered. 2021;12(1):4747–4756.
   PubMed Web of Science ®Google Scholar
• Zhang X, Zhong S, Xu Y, et al. MicroRNA-3646 contributes to docetaxel resistance in human breast cancer cells by GSK-3β/β-catenin signaling pathway. PloS one. 2016;11(4):e0153194.
   PubMed Web of Science ®Google Scholar
• Genua M, Pandini G, Cassarino MF, et al. c-Abl and insulin receptor signalling. Vitam Horm. 2009;80:77–105.
   PubMed Web of Science ®Google Scholar
• Chen YZ, Xue JY, Chen CM, et al. PPAR signaling pathway may be an important predictor of breast cancer response to neoadjuvant chemotherapy. Cancer Chemother Pharmacol. 2012;70(5):637–644.
   PubMed Web of Science ®Google Scholar
• Cho WC, Jang JE, Kim KH, et al. SORBS1 serves a metastatic role via suppression of AHNAK in colorectal cancer cell lines. Int J Oncol. 2020;56(5):1140–1151.
   PubMed Web of Science ®Google Scholar