Serine hydroxymethyltransferase 2 (SHMT2) potentiates the aggressive process of oral squamous cell carcinoma by binding to interleukin enhancer-binding factor 2 (ILF2)

References

• Lindemann A, Takahashi H, Patel AA, et al. Targeting the DNA damage response in OSCC with TP53 mutations. J Dent Res. 2018;97:635–644.
   PubMed Web of Science ®Google Scholar
• Sasahira T, Bosserhoff AK, Kirita T. The importance of melanoma inhibitory activity gene family in the tumor progression of oral cancer. Pathol Int. 2018;68:278–286.
   PubMed Web of Science ®Google Scholar
• Gonzalez-Garcia R, Naval-Gias L, Rodriguez-Campo FJ, et al. Contralateral lymph neck node metastasis of squamous cell carcinoma of the oral cavity: a retrospective analytic study in 315 patients. J Oral Maxillofac Surg. 2008;66:1390–1398.
   PubMed Web of Science ®Google Scholar
• Sasahira T, Kirita T. Hallmarks of cancer-related newly prognostic factors of oral squamous cell carcinoma. Int J Mol Sci. 2018;19:2413.
   PubMed Web of Science ®Google Scholar
• Bugshan A, Farooq I. Oral squamous cell carcinoma: metastasis, potentially associated malignant disorders, etiology and recent advancements in diagnosis. F1000Res 9: 229, 2020.
   Google Scholar
• Di Salvo ML, Contestabile R, Paiardini A, et al. Glycine consumption and mitochondrial serine hydroxymethyltransferase in cancer cells: the heme connection. Med Hypotheses. 2013;80:633–636.
   PubMed Web of Science ®Google Scholar
• Liu C, Wang L, Liu X, et al. Cytoplasmic SHMT2 drives the progression and metastasis of colorectal cancer by inhibiting beta-catenin degradation. Theranostics. 2021;11:2966–2986.
   PubMed Web of Science ®Google Scholar
• Lee GY, Haverty PM, Li L, et al. Comparative oncogenomics identifies PSMB4 and SHMT2 as potential cancer driver genes. Cancer Res. 2014;74:3114–3126.
   PubMed Web of Science ®Google Scholar
• Ding J, Li T, Wang X, et al. The histone H3 methyltransferase G9A epigenetically activates the serine-glycine synthesis pathway to sustain cancer cell survival and proliferation. Cell Metab. 2013;18:896–907.
   PubMed Web of Science ®Google Scholar
• Anderson DD, Quintero CM, Stover PJ. Identification of a de novo thymidylate biosynthesis pathway in mammalian mitochondria. Proc Natl Acad Sci U S A. 2011;108:15163–15168.
   PubMed Web of Science ®Google Scholar
• Nguyen TH, Vemu PL, Hoy GE, et al. Serine hydroxymethyltransferase 2 expression promotes tumorigenesis in rhabdomyosarcoma with 12q13-q14 amplification. J Clin Invest. 2021;131.
   Web of Science ®Google Scholar
• Wu ZZ, Wang S, Yang QC, et al. Increased expression of SHMT2 is associated with poor prognosis and advanced pathological grade in oral squamous cell carcinoma. Front Oncol. 2020;10:588530.
   PubMed Web of Science ®Google Scholar
• Du H, Le Y, Sun F, et al. ILF2 directly binds and stabilizes creb to stimulate malignant phenotypes of liver cancer cells. Anal Cell Pathol (Amst). 2019;1575031. DOI:10.1155/2019/1575031
   PubMedGoogle Scholar
• Marcoulatos P, Avgerinos E, Tsantzalos DV, et al. Mapping interleukin enhancer binding factor 3 gene (ILF3) to human chromosome 19 (19q11-qter and 19p11-p13.1) by polymerase chain reaction amplification of human-rodent somatic cell hybrid DNA templates. J Interferon Cytokine Res. 1998;18:351–355.
   PubMed Web of Science ®Google Scholar
• Huang Q, He X, Qiu X, et al. Expression of NF45 correlates with malignant grade in gliomas and plays a pivotal role in tumor growth. Tumour Biol. 2014;35:10149–10157.
   PubMedGoogle Scholar
• Ni T, Mao G, Xue Q, et al. Upregulated expression of ILF2 in non-small cell lung cancer is associated with tumor cell proliferation and poor prognosis. J Mol Histol. 2015;46:325–335.
   PubMed Web of Science ®Google Scholar
• Ni S, Zhu J, Zhang J, et al. Expression and clinical role of NF45 as a novel cell cycle protein in esophageal squamous cell carcinoma (ESCC). Tumour Biol. 2015;36:747–756.
   PubMedGoogle Scholar
• Haskins WE, Eedala S, Jadhav YL, et al. Insights on neoplastic stem cells from gel-based proteomics of childhood germ cell tumors. Pediatr Blood Cancer. 2012;58:722–728.
   PubMed Web of Science ®Google Scholar
• Yin ZH, Jiang XW, Shi WB, et al. Expression and clinical significance of ILF2 in gastric cancer. Dis Markers. 2017;2017:4387081.
   PubMed Web of Science ®Google Scholar
• Liu Y, Yin C, Deng MM, et al. High expression of SHMT2 is correlated with tumor progression and predicts poor prognosis in gastrointestinal tumors. Eur Rev Med Pharmacol Sci. 2019;23:9379–9392.
   PubMed Web of Science ®Google Scholar
• Calderone A, Iannuccelli M, Peluso D, et al. Using the MINT database to search protein interactions. Curr Protoc Bioinformatics. 2020;69:e93.
   PubMedGoogle Scholar
• Oughtred R, Stark C, Breitkreutz BJ, et al. The BioGRID interaction database: 2019 update. Nucleic Acids Res. 2019;47:D529–D541.
   PubMed Web of Science ®Google Scholar
• Bartha A, Gyorffy B. TNMplot.com: a web tool for the comparison of gene expression in normal, tumor and metastatic tissues. Int J Mol Sci 2021;22:2622.
   PubMed Web of Science ®Google Scholar
• Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-delta delta C(T)) method. Methods. 2001;25:402–408.
   PubMed Web of Science ®Google Scholar
• Bhattacharya A, Roy R, Snijders AM, et al. Two distinct routes to oral cancer differing in genome instability and risk for cervical node metastasis. Clin Cancer Res. 2011;17:7024–7034.
   PubMed Web of Science ®Google Scholar
• Bernhardt S, Bayerlova M, Vetter M, et al. Proteomic profiling of breast cancer metabolism identifies SHMT2 and ASCT2 as prognostic factors. Breast Cancer Res. 2017;19:112.
   PubMed Web of Science ®Google Scholar
• Woo CC, Chen WC, Teo XQ, et al. Downregulating serine hydroxymethyltransferase 2 (SHMT2) suppresses tumorigenesis in human hepatocellular carcinoma. Oncotarget. 2016;7:53005–53017.
   PubMedGoogle Scholar
• Wu M, Wanggou S, Li X, et al. Overexpression of mitochondrial serine hydroxyl-methyltransferase 2 is associated with poor prognosis and promotes cell proliferation and invasion in gliomas. Onco Targets Ther. 2017;10:3781–3788.
   PubMed Web of Science ®Google Scholar
• Jin M, Lee WK, You MH, et al. SHMT2 expression as a diagnostic and prognostic marker for thyroid cancer. Endocr Connect. 2021;10:630–636.
   PubMed Web of Science ®Google Scholar
• Dwivedi N, Chandra S, Kashyap B, et al. Suprabasal expression of Ki-67 as a marker for the severity of oral epithelial dysplasia and oral squamous cell carcinoma. Contemp Clin Dent. 2013;4:7–12.
   PubMedGoogle Scholar
• Jain M, Nilsson R, Sharma S, et al. Metabolite profiling identifies a key role for glycine in rapid cancer cell proliferation. Science. 2012;336:1040–1044.
   PubMed Web of Science ®Google Scholar
• Cui X, Cui Y, Du T, et al. SHMT2 drives the progression of colorectal cancer by regulating UHRF1 expression. Can J Gastroenterol Hepatol. 2022;2022:3758697.
   PubMed Web of Science ®Google Scholar
• Wei Z, Song J, Wang G, et al. Deacetylation of serine hydroxymethyl-transferase 2 by SIRT3 promotes colorectal carcinogenesis. Nat Commun. 2018;9:4468.
   PubMed Web of Science ®Google Scholar
• Dijk SN, Protasoni M, Elpidorou M, et al. Mitochondria as target to inhibit proliferation and induce apoptosis of cancer cells: the effects of doxycycline and gemcitabine. Sci Rep. 2020;10:4363.
   PubMed Web of Science ®Google Scholar
• Kato K, Kawashiri S, Yoshizawa K, et al. Apoptosis-associated markers and clinical outcome in human oral squamous cell carcinomas. J Oral Pathol Med. 2008;37:364–371.
   PubMed Web of Science ®Google Scholar
• Zhang P, Yang Q. Overexpression of SHMT2 predicts a poor prognosis and promotes tumor cell growth in bladder cancer. Front Genet. 2021;12:682856.
   PubMed Web of Science ®Google Scholar
• Carnielli CM, Macedo CCS, De Rossi T, et al. Combining discovery and targeted proteomics reveals a prognostic signature in oral cancer. Nat Commun. 2018;9:3598.
   PubMed Web of Science ®Google Scholar
• Wang L, Ge S, Zhou F. MicroRNA-487a-3p inhibits the growth and invasiveness of oral squamous cell carcinoma by targeting PPM1A. Bioengineered. 2021;12:937–947.
   PubMed Web of Science ®Google Scholar
• Miyo M, Konno M, Colvin H, et al. The importance of mitochondrial folate enzymes in human colorectal cancer. Oncol Rep. 2017;37:417–425.
   PubMed Web of Science ®Google Scholar
• Ning S, Ma S, Saleh AQ, et al. SHMT2 overexpression predicts poor prognosis in intrahepatic cholangiocarcinoma. Gastroenterol Res Pract. 2018;2018:4369253.
   PubMed Web of Science ®Google Scholar
• Noguchi K, Konno M, Koseki J, et al. The mitochondrial one-carbon metabolic pathway is associated with patient survival in pancreatic cancer. Oncol Lett. 2018;16:1827–1834.
   PubMed Web of Science ®Google Scholar
• Ji L, Tang Y, Pang X, et al. Increased expression of serine hydroxymethyltransferase 2 (SHMT2) is a negative prognostic marker in patients with hepatocellular carcinoma and is associated with proliferation of hepg2 cells. Med Sci Monit. 2019;25:5823–5832.
   PubMed Web of Science ®Google Scholar
• Qi C, Qin X, Zhou Z, et al. Circ_0072995 promotes cell carcinogenesis via up-regulating miR-149-5p-mediated SHMT2 in breast cancer. Cancer Manag Res. 2020;12:11169–11181.
   PubMed Web of Science ®Google Scholar
• Sasahira T, Kirita T, Kuniyasu H. Update of molecular pathobiology in oral cancer: a review. Int J Clin Oncol. 2014;19:431–436.
   PubMed Web of Science ®Google Scholar
• Jia Y, Li X, Nan A, et al. Circular RNA 406961 interacts with ILF2 to regulate PM2.5-induced inflammatory responses in human bronchial epithelial cells via activation of STAT3/JNK pathways. Environ Int. 2020;141:105755.
   PubMed Web of Science ®Google Scholar
• Marrocco I, Altieri F, Rubini E, et al. Shmt2: a stat3 signaling new player in prostate cancer energy metabolism. Cells 2019;8:1048.
   PubMed Web of Science ®Google Scholar
• Bi Y, Shen W, Min M, et al. MicroRNA-7 functions as a tumor-suppressor gene by regulating ILF2 in pancreatic carcinoma. Int J Mol Med. 2017;39:900–906.
   PubMed Web of Science ®Google Scholar
• Shamanna RA, Hoque M, Pe’ery T, et al. Induction of p53, p21 and apoptosis by silencing the NF90/NF45 complex in human papilloma virus-transformed cervical carcinoma cells. Oncogene. 2013;32:5176–5185.
   PubMed Web of Science ®Google Scholar
• Cheng S, Jiang X, Ding C, et al. Expression and critical role of interleukin enhancer binding factor 2 in hepatocellular carcinoma. Int J Mol Sci. 2016;17:1373.
   PubMed Web of Science ®Google Scholar
• Zhang X, Bustos MA, Gross R, et al. Interleukin enhancer-binding factor 2 promotes cell proliferation and DNA damage response in metastatic melanoma. Clin Transl Med. 2021;11:e608.
   PubMed Web of Science ®Google Scholar