Dexmedetomidine prevents cardiomyocytes from hypoxia/reoxygenation injury via modulating tetmethylcytosine dioxygenase 1-mediated DNA demethylation of Sirtuin1

References

• Wang L, Niu H, Zhang J. Homocysteine induces mitochondrial dysfunction and oxidative stress in myocardial ischemia/reperfusion injury through stimulating ROS production and the ERK1/2 signaling pathway. Exp Ther Med. 2020Aug;20(2):938–944. Epub 2020 May 12. PMID: 32742337.
   PubMed Web of Science ®Google Scholar
• Hu J, Su B, Li X, et al. Klotho overexpression suppresses apoptosis by regulating the Hsp70/Akt/Bad pathway in H9c2(2-1) cells. Exp Ther Med. 2021May;21(5):486. Epub 2021 Mar 16. PMID: 33790995.
   PubMed Web of Science ®Google Scholar
• Zhao L, Cheng L, Wu Y. Ambra1 alleviates Hypoxia/Reoxygenation injury in H9C2 cells by regulating autophagy and reactive oxygen species. Biomed Res Int. 2020;2020:3062689. PMID: 33083461.
   PubMed Web of Science ®Google Scholar
• Gao JM, Meng XW, Zhang J, et al. Dexmedetomidine protects cardiomyocytes against Hypoxia/Reoxygenation injury by suppressing TLR4-MyD88-NF-κB signaling. Biomed Res Int. 2017;2017:1674613. Epub 2017 Nov 22. PMID: 29359143.
   PubMed Web of Science ®Google Scholar
• Yuan M, Meng XW, Ma J, et al. Dexmedetomidine protects H9c2 cardiomyocytes against oxygen-glucose deprivation/reoxygenation-induced intracellular calcium overload and apoptosis through regulatingFKBP12.6/RyR2 signaling. Drug Des Devel Ther. 2019Sep;13:3137–3149 PMID: 31564830
   PubMed Web of Science ®Google Scholar
• Yu W, Lyu J, Jia L, et al. Dexmedetomidine ameliorates hippocampus injury and cognitive dysfunction induced by Hepatic Ischemia/Reperfusion by activating SIRT3-mediated mitophagy and inhibiting activation of the NLRP3 inflammasome in young rats. Oxid Med Cell Longev. 2020;2020:7385458.
   PubMed Web of Science ®Google Scholar
• Wu Y, Qiu G, Zhang H, et al. Dexmedetomidine alleviates hepatic ischaemia-reperfusion injury via the PI3K/AKT/Nrf2-NLRP3 pathway. J Cell Mol Med. 2021;25(21):9983–9994.
   PubMed Web of Science ®Google Scholar
• Zhang B, Zhang J, Ainiwaer Y, et al. Dexmedetomidine attenuates myocardial injury induced by renal Ischemia/Reperfusion by inhibiting the HMGB1-TLR4-MyD88-NF-κB signaling pathway. Ann Clin Lab Sci. 2021;51(3):376–384.
   PubMed Web of Science ®Google Scholar
• Zhong Y, Li YP, Yin YQ, et al. Dexmedetomidine inhibits pyroptosis by down-regulating miR-29b in myocardial ischemia reperfusion injury in rats. Int Immunopharmacol. 2020Sep;86:106768 Epub 2020 Jul 14. PMID: 32679539
   PubMed Web of Science ®Google Scholar
• Shao Z, Shen Q, Kong M, et al. Involvement of GPR30 in protection effect of Dexmedetomidine against myocardial ischemia/reperfusion injury in rat via AKT pathway. Acta Biochim Pol. 2021 Feb 25;68(1):119–126. PMID: 33629579.
   PubMed Web of Science ®Google Scholar
• Zhu Z, Ling X, Zhou H, et al. Dexmedetomidine attenuates cellular injury and apoptosis in H9c2 cardiomyocytes by regulating p-38MAPK and endoplasmic reticulum stress. Drug Des Devel Ther. 2020Oct;14:4231–4243 PMID: 33116411
   PubMed Web of Science ®Google Scholar
• Shi X, Liu Z, Li J. Protective effects of dexmedetomidine on hypoxia/reoxygenation injury in cardiomyocytes by regulating the CHOP signaling pathway. Mol Med Rep. 2020 Oct;22(4):3307–3315.
   PubMed Web of Science ®Google Scholar
• Lee S. Dexmedetomidine: present and future directions. Korean J Anesthesiol. 2019;72(4):323–330.
   PubMed Web of Science ®Google Scholar
• Mahmoud M, Mason KP. Dexmedetomidine: review, update, and future considerations of paediatric perioperative and periprocedural applications and limitations. Br J Anaesth. 2015;115(2):171–182.
   PubMed Web of Science ®Google Scholar
• Xue P, Zhao J, Zheng A, et al. Chrysophanol alleviates myocardial injury in diabetic db/db mice by regulating the SIRT1/HMGB1/NF-κB signaling pathway. Exp Ther Med. 2019Dec;18(6):4406–4412. Epub 2019 Oct 7. PMID: 31772635; PMCID: PMC6862128.
   PubMed Web of Science ®Google Scholar
• Yang H, Wang C, Zhang L, et al. Rutin alleviates hypoxia/reoxygenation-induced injury in myocardial cells by up-regulating SIRT1 expression. Chem Biol Interact. 2019Jan;297:44–49 Epub 2018 Oct 23. PMID: 30365940
   PubMed Web of Science ®Google Scholar
• Zhang Y, Zhao Q, Li X, et al. Dexmedetomidine reversed hypoxia/reoxygenation injury-induced oxidative stress and endoplasmic reticulum stress-dependent apoptosis of cardiomyocytes via SIRT1/CHOP signaling pathway. Mol Cell Biochem. 2021 Jul;476(7):2803–2812.
   PubMed Web of Science ®Google Scholar
• Alharbi KS, Fuloria NK, Fuloria S, et al. Gupta G.Nuclear factor-kappa B and its role in inflammatory lung disease. Chem Biol Interact. 2021Jun;345:109568 Epub ahead of print. PMID: 34181887
   PubMed Web of Science ®Google Scholar
• Huang P, Yang D, Yu L, et al. Downregulation of lncRNA ZFAS1 protects H9c2 cardiomyocytes from ischemia/reperfusion‑induced apoptosis via the miR‑590‑3p/NF‑κB signaling pathway. Mol Med Rep. 2020Sep;22(3):2300–2306. Epub 2020 Jul 13. PMID: 32705215.
   PubMed Web of Science ®Google Scholar
• Chen L, Zhang D, Yu L, et al. Targeting MIAT reduces apoptosis of cardiomyocytes after ischemia/reperfusion injury. Bioengineered. 2019Dec;10(1):121–132. PMID: 30971184.
   PubMed Web of Science ®Google Scholar
• Lin B, Zhao H, Li L, et al. Sirt1 improves heart failure through modulating the NF-κB p65/microRNA-155/BNDF signaling cascade. Aging (Albany NY). 2020 Nov 18;13(10):14482–14498. Epub 2020 Nov 18. PMID:33206628.
   PubMedGoogle Scholar
• Collignon E, Canale A, Al Wardi C, et al. Immunity drives TET1regulation in cancer through NF-κB. Sci Adv. 2018 Jun 20;4(6): eaap7309. PMID: 29938218.
   PubMed Web of Science ®Google Scholar
• Wang K, Li Y, Qiang T, et al. Role of epigenetic regulation in myocardial ischemia/reperfusion injury. Pharmacol Res. 2021Jun;170:105743 Epub ahead of print. PMID: 34182132
   PubMed Web of Science ®Google Scholar
• Wang Y, Hao Y, Zhang H, et al. DNA Hypomethylation of miR-30a mediated the protection of hypoxia postconditioning against aged cardiomyocytes Hypoxia/Reoxygenation injury through inhibiting autophagy. Circ J. 2020Mar;84(4):616–625. Epub 2020 Feb 29. PMID:32115441.
   PubMed Web of Science ®Google Scholar
• Chen Z, Gong L, Zhang P, et al. Epigenetic down-regulation of Sirt 1 via DNA methylation and oxidative stress signaling contributes to the gestational diabetes mellitus-induced fetal programming of heart Ischemia-sensitive phenotype in late life. Int J Biol Sci. 2019May;15(6):1240–1251. PMID: 31223283.
   PubMed Web of Science ®Google Scholar
• Lu M, Qin X, Yao J, et al. MiR-134-5p targeting XIAP modulates oxidative stress and apoptosis in cardiomyocytes under hypoxia/reperfusion-induced injury. IUBMB Life. 2020Oct;72(10):2154–2166. Epub 2020 Aug 14. PMID: 32797709.
   PubMed Web of Science ®Google Scholar
• He L, Yang H, Feng J, et al. Knockdown of G protein-coupled receptor-17 (GPR17) facilitates the regeneration and repair of myelin sheath post-periventricular leukomalacia (PVL). Bioengineered. 2021;12(1):7314–7324.
   PubMed Web of Science ®Google Scholar
• Yang FY, Zhang L, Zheng Y, et al. Dexmedetomidine attenuates ischemia and reperfusion-induced cardiomyocyte injury through p53 and forkhead box O3a (FOXO3a)/p53-upregulated modulator of apoptosis (PUMA) signaling signaling. Bioengineered. 2022Jan;13(1):1377–1387. PMID: 34974801; PMCID: PMC8805856.
   PubMed Web of Science ®Google Scholar
• Zhi W, Li K, Wang H, et al. Melatonin elicits protective effects on OGD/R‑insulted H9c2 cells by activating PGC‑1α/Nrf2 signaling. Int J Mol Med. 2020May;45(5):1294–1304. Epub 2020 Feb 25. PMID: 32323734.
   PubMed Web of Science ®Google Scholar
• Liu P, Huang J, Mei W, et al. Epigallocatechin-3-gallate protects cardiomyocytes from hypoxia-reoxygenation damage via raising autophagy related 4C expression. Bioengineered. 2021 Oct 26; Epub ahead of print. PMID: 34699312.10.1080/21655979.2021.1996018.
   Web of Science ®Google Scholar
• Li Y, Zhang L, Zhang P, et al. Dehydrocorydaline protects against sepsis-induced myocardial injury through modulating the TRAF6/NF-κB pathway. Front Pharmacol. 2021 Aug 19;12:709604. PMID: 34489703.
   PubMed Web of Science ®Google Scholar
• Nie S, Cui X, Guo J, et al. Long non-coding RNA AK006774 inhibits cardiac ischemia-reperfusion injury via sponging miR-448. Bioengineered. 2021Dec;12(1):4972–4982. PMID: 34369259.
   PubMed Web of Science ®Google Scholar
• Wu ZL, Davis JRJ, Zhu Y. Dexmedetomidine protects against Myocardial Ischemia/Reperfusion injury by ameliorating oxidative stress and cell apoptosis through the Trx1-dependent Akt pathway. Biomed Res Int. 2020Nov25;2020:8979270. PMID: 33299886.
   PubMed Web of Science ®Google Scholar
• Hernandes LC, Machado ART, Tuttis K, et al. Caffeic acid and chlorogenic acid cytotoxicity, genotoxicity and impact on global DNA methylation in human leukemic cell lines. Genet Mol Biol. 2020 Jul 3;43(3):e20190347. PMID: 32644097.
   PubMed Web of Science ®Google Scholar
• Li LT, Wang X, Zhu WT, et al. Reciprocal role of DNA Methylation and Sp1 binding In Ki-67 gene transcription. Cancer Manag Res. 2019Nov;11:9749–9759 PMID: 31819613
   PubMed Web of Science ®Google Scholar
• Tang C, Hu Y, Gao J, et al. Dexmedetomidine pretreatment attenuates myocardial ischemia reperfusion induced acute kidney injury and endoplasmic reticulum stress in human and rat. Life Sci. 2020 Sep 15;257:118004. Epub 2020 Jul 2. PMID: 32621918.
   PubMed Web of Science ®Google Scholar
• Peng K, Chen WR, Xia F, et al. Dexmedetomidine post-treatment attenuates cardiac ischaemia/reperfusion injury by inhibiting apoptosis through HIF-1α signalling. J Cell Mol Med. 2020 Jan;24(1):850–861.
   PubMed Web of Science ®Google Scholar
• Yu SY, Dong B, Fang ZF, et al. Knockdown of lncRNA AK139328 alleviates myocardial ischaemia/reperfusion injury in diabetic mice via modulating miR-204-3p and inhibiting autophagy. J Cell Mol Med. 2018Oct;22(10):4886–4898. Epub 2018 Jul 25. PMID: 30047214.
   PubMed Web of Science ®Google Scholar
• Yi Z, Ke J, Wang Y, et al. Fluvastatin protects myocardial cells in mice with acute myocardial infarction through inhibiting RhoA/ROCK pathway. Exp Ther Med. 2020Mar;19(3):2095–2102. Epub 2020 Jan 3. PMID: 32104271.
   PubMed Web of Science ®Google Scholar
• Hu L, Xu Y, Wang Q, et al. Yiqi Huoxue Recipe inhibits cardiomyocyte apoptosis caused by heart failure through Keap1/Nrf2/HIF-1α signaling pathway. Bioengineered. 2021Dec;12(1):969–978. PMID: 33739243.
   PubMed Web of Science ®Google Scholar
• Tsai KL, Chou WC, Cheng HC, et al. Anti-IL-20 antibody protects against Ischemia/Reperfusion-Impaired myocardial function through modulation of oxidative injuries. Inflammation Cardiac Remodeling Antioxidants (Basel). 2021 Feb 10;10(2):275.
   Google Scholar
• Zhu Z, Ling X, Zhou H, et al. Dexmedetomidine at a dose of 1 µM attenuates H9c2 cardiomyocyte injury under 3 h of hypoxia exposure and 3 h of reoxygenation through the inhibition of endoplasmic reticulum stress. Exp Ther Med. 2021Feb;21(2):132. Epub 2020 Dec 10. PMID: 33376514.
   PubMed Web of Science ®Google Scholar
• Yuan T, Yang Z, Xian S, et al. Che Y.Dexmedetomidine-mediated regulation of miR-17-3p in H9C2 cells after hypoxia/reoxygenation injury. ExpTherMed. 2020Aug;20(2):917–925. Epub 2020 May 20. PMID:32742334.
   Google Scholar
• Chen J, Jiang Z, Zhou X, et al. Dexmedetomidine preconditioning protects cardiomyocytes against Hypoxia/Reoxygenation-Induced necroptosis by inhibiting HMGB1-mediated inflammation. Cardiovasc Drugs Ther. 2019Feb;33(1):45–54. PMID: 30675709.
   PubMed Web of Science ®Google Scholar
• Ke J, Dong N, Wang L, et al. Role of DNA methylation in perinatal nicotine-induced development of heart ischemia-sensitive phenotype in rat offspring. Oncotarget. 2017 Aug 10;8(44):76865–76880. PMID: 29100355.
   PubMedGoogle Scholar
• Yang R, Yu T, Kou X, et al. Tet1 and Tet2 maintain mesenchymal stem cell homeostasis via demethylation of the P2rX7 promoter. Nat Commun. 2018 Jun 1;9(1):2143. 29858571.
   PubMedGoogle Scholar
• Han D, Wang J, Ma S, et al. SIRT1 as a promising novel therapeutic target for myocardial ischemia reperfusion injury and cardiometabolic disease. Curr Drug Targets. 2017;18(15):1746–1753.
   PubMed Web of Science ®Google Scholar
• Akhondzadeh F, Astani A, Najjari R, et al. Resveratrol suppresses interleukin-6 expression through activation of sirtuin 1 in hypertrophied H9c2 cardiomyoblasts. J Cell Physiol. 2020Oct;235(10):6969–6977. Epub 2020 Feb 5. PMID: 32026477.
   PubMed Web of Science ®Google Scholar
• Ning S, Li Z, Ji Z, et al. MicroRNA‑494 suppresses hypoxia/reoxygenation‑induced cardiomyocyte apoptosis and autophagy via the PI3K/AKT/mTOR signaling pathway by targeting SIRT1. Mol Med Rep. 2020 Dec;22(6):5231–5242.
   PubMed Web of Science ®Google Scholar
• Xing PC, An P, Hu GY, et al. LncRNA MIAT promotes inflammation and oxidative stress in sepsis-induced cardiac injury by targeting miR-330-5p/TRAF6/NF-κB axis. Biochem Genet. 2020Oct;58(5):783–800. Epub 2020 Jun 15. PMID: 32556678.
   PubMed Web of Science ®Google Scholar
• Furrer A, Hottiger MO, Valaperti A. Absent in Melanoma 2 (AIM2) limits pro-inflammatory cytokine transcription in cardiomyocytes by inhibiting STAT1 phosphorylation. Mol Immunol. 2016 Jun;74:47–58.
   PubMed Web of Science ®Google Scholar
• Wu BW, Wu MS, Liu Y, et al. SIRT1-mediated deacetylation of NF-κB inhibits the MLCK/MLC2 pathway and the expression of ET-1, thus alleviating the development of coronary artery spasm. Am J Physiol Heart Circ Physiol. 2021Jan;320(1):H458–H468. Epub 2020 Oct 23. PMID: 33095054.
   PubMed Web of Science ®Google Scholar
• Zhu Q, Tang T, Liu H, et al. Pterostilbene attenuates cocultured BV-2 microglial inflammation-mediated SH-SY5Y neuronal oxidative injury via SIRT-1 signalling.oxid med cell longev. 2020 Aug 4; 2020:3986348. PMID:32831997.
   Google Scholar
• Li D, Wang X, Huang Q, et al. Cardioprotection of CAPE-oNO2 against myocardial ischemia/reperfusion induced ROS generation via regulating the SIRT1/eNOS/NF-κB pathway in vivo and in vitro. Redox Biol. 2018May;15:62–73.
   PubMed Web of Science ®Google Scholar
• Simó-Mirabet P, Perera E, Calduch-Giner JA, et al. Local DNA methylation helps to regulate muscle sirtuin 1 gene expression across seasons and advancing age in gilthead sea bream (Sparus aurata). Front Zool. 2020May;17(1):15. PMID: 32467713.
   PubMed Web of Science ®Google Scholar