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Research Paper

Chrysophanol exerts a protective effect against sepsis-induced acute myocardial injury through modulating the microRNA-27b-3p/Peroxisomal proliferating-activated receptor gamma axis

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Pages 12673-12690 | Received 12 Oct 2021, Accepted 02 Apr 2022, Published online: 21 May 2022

References

  • Jawad I, Lukšić I, Rafnsson SB. Assessing available information on the burden of sepsis: global estimates of incidence, prevalence and mortality. J Glob Health. 2012;2(1):010404.
  • Sato R, Nasu M. A review of sepsis-induced cardiomyopathy. J Intensive Care. 2015;3(1):48.
  • Merx MW, Weber C. Sepsis and the heart. Circulation. 2007;116(7):793–802.
  • Prateeksha YMA, Singh BN, Sudheer S, et al. Chrysophanol: a natural anthraquinone with multifaceted biotherapeutic potential. Biomolecules. 2019;9(2):68.
  • Hsu PC, Cheng CF, Hsieh PC, et al. Chrysophanol regulates cell death, metastasis, and reactive oxygen species production in oral cancer cell lines. Evid Based Complement Alternat Med. 2020;2020:5867064.
  • Lin F, Zhang C, Chen X, et al. Chrysophanol affords neuroprotection against microglial activation and free radical-mediated oxidative damage in BV2 murine microglia. Int J Clin Exp Med. 2015;8(3):3447–3455.
  • Lu J, Li J, Hu Y, et al. Chrysophanol protects against doxorubicin-induced cardiotoxicity by suppressing cellular parylation. Acta Pharm Sin B. 2019;9(4):782–793.
  • Moore CC, McKillop IH, Huynh T. MicroRNA expression following activated protein C treatment during septic shock.J Surg Res. 2013 [Jun 1];182(1):116–126.
  • Benz F, Roy S, Trautwein C, et al. Circulating microRNAs as biomarkers for sepsis.Int J Mol Sci. 2016 [Jan 9];17(1):78.
  • Song W, Zhang T, Yang N, et al. Inhibition of micro RNA miR-122-5p prevents lipopolysaccharide-induced myocardial injury by inhibiting oxidative stress, inflammation and apoptosis via targeting GIT1. Bioengineered. 2021 Dec;12(1):1902–1915.
  • Wang H, Bei Y, Shen S, et al. miR-21-3p controls sepsis-associated cardiac dysfunction via regulating SORBS2. J Mol Cell Cardiol. 2016 May;94:43–53.
  • Li L, Qi C, Liu Y, et al. MicroRNA miR-27b-3p regulate microglial inflammation response and cell apoptosis by inhibiting A20 (TNF-α-induced protein 3). Bioengineered. 2021 Dec;12(2):9902–9913.
  • Lv X, Li J, Hu Y, et al. Overexpression of miR-27b-3p targeting wnt3a regulates the signaling pathway of Wnt/ β-Catenin and attenuates atrial fibrosis in rats with atrial fibrillation. Oxid Med Cell Longev. 2019;2019:5703764.
  • Agostini M, Schoenmakers E, Beig J, et al. PPARGA pharmacogenetic approach to the treatment of patients with mutations. Diabetes. 2018;67(6):1086–1092.
  • Liu X, Yu Z, Huang X, et al. Peroxisome proliferator-activated receptor γ (PPARγ) mediates the protective effect of quercetin against myocardial ischemia-reperfusion injury via suppressing the NF-κB pathway. Am J Transl Res. 2016;8(12):5169–5186.
  • Peng S, Xu J, Ruan W, et al. PPAR- γ activation prevents septic cardiac dysfunction via inhibition of apoptosis and necroptosis. Oxid Med Cell Longev. 2017;2017(8326749):1–11.
  • Zhang B, Yu L, Sheng Y. Clinical value and role of microRNA-29c-3p in sepsis-induced inflammation and cardiac dysfunction. Eur J Med Res. 2021;26(1):90.
  • Tong L, Tang C, Cai C, et al. Upregulation of the microRNA rno-miR-146b-5p may be involved in the development of intestinal injury through inhibition of kruppel-like factor 4 in intestinal sepsis. Bioengineered. 2020 Dec;11(1):1334–1349.
  • Zeng XM, Liu DH, Han Y, et al. Assessment of inflammatory markers and mitochondrial factors in a rat model of sepsis-induced myocardial dysfunction. Am J Transl Res. 2020 [Mar 15];12(3):901–911.
  • Zhang X, Li Y, Wang Y, et al. Dexmedetomidine postconditioning suppresses myocardial ischemia/reperfusion injury by activating the SIRT1/mTOR axis.Biosci Rep. 2020 [May 29];40(5):BSR20194030.
  • Li R, Ren T, Zeng J. Mitochondrial coenzyme Q protects sepsis-induced acute lung injury by activating PI3K/Akt/GSK-3β/mTOR pathway in rats. Biomed Res Int. 2019;2019:5240898. Nov 13.
  • Zheng Y, Lu H, Huang H. Desflurane preconditioning protects against renal ischemia-reperfusion injury and inhibits inflammation and oxidative stress in rats through regulating the Nrf2-Keap1-ARE signaling pathway. Drug Des Devel Ther. 2020;14:1351–1362. Apr 3.
  • Wang L, Ge S, Zhou F. MicroRNA-487a-3p inhibits the growth and invasiveness of oral squamous cell carcinoma by targeting PPM1A. Bioengineered. 2021 Dec;12(1):937–947.
  • Baradaran Rahim V, Khammar MT, Rakhshandeh H, et al. Crocin protects cardiomyocytes against LPS-Induced inflammation. Pharmacol Rep. 2019 Dec;71(6):1228–1234.
  • Liu J, Yang Y, Lu R, et al. MicroRNA-381-3p signatures as a diagnostic marker in patients with sepsis and modulates sepsis-steered cardiac damage and inflammation by binding HMGB1. Bioengineered. 2021 Dec;12(2):11936–11946.
  • Wang C, Yuan W, Hu A, et al. Dexmedetomidine alleviated sepsis induced myocardial ferroptosis and septic heart injury. Mol Med Rep. 2020 Jul;22(1):175–184.
  • Yang S, Wang Y, Gao H, et al. MicroRNA-30a-3p overexpression improves sepsis-induced cell apoptosis in vitro and in vivo via the PTEN/PI3K/AKT signaling pathway. Exp Ther Med. 2018 Feb;15(2):2081–2087.
  • Guo Y, Zhu X, Sun X. COTI-2 induces cell apoptosis in pediatric acute lymphoblastic leukemia via upregulation of miR-203. Bioengineered. 2020 Dec;11(1):201–208.
  • Han B, Ge Y, Cui J, et al. Down-regulation of lncRNA DNAJC3-AS1 inhibits colon cancer via regulating miR-214-3p/LIVIN axis. Bioengineered. 2020 Dec;11(1):524–535.
  • Zhu X, Jiang S, Wu Z, et al. Long non-coding RNA TTN antisense RNA 1 facilitates hepatocellular carcinoma progression via regulating miR-139-5p/SPOCK1 axis. Bioengineered. 2021 Dec;12(1):578–588.
  • Li J, Shi W, Zhang J, et al. To explore the protective mechanism of PTEN-induced kinase 1 (PINK1)/Parkin mitophagy-mediated extract of Periplaneta americana on lipopolysaccharide-induced cardiomyocyte injury. Med Sci Monit. 2019;25:1383–1391. Feb 21.
  • Sun W, Li J, Zhou L, et al. The c-Myc/miR-27b-3p/ATG10 regulatory axis regulates chemoresistance in colorectal cancer. Theranostics. 2020;10(5):1981–1996.
  • Zanotti-Cavazzoni SL, Hollenberg SM. Hemodynamic optimization of sepsis-induced tissue hypoperfusion. Crit Care. 2006;10(Suppl 3):S2.
  • Chen Q, He H, Luo S, et al. A novel GC-MS method for determination of chrysophanol in rat plasma and tissues: application to the pharmacokinetics, tissue distribution and plasma protein binding studies. J Chromatogr B Analyt Technol Biomed Life Sci. 2014;973:76–83.
  • Liu Y, Liu C, Zhang X, et al. Chrysophanol protects PC12 cells against oxygen glucose deprivation-evoked injury by up-regulating miR-216a. Cell Cycle. 2020 Jun;19(12):1433–1442.
  • Lim YJ, Kim KM, Jang WG. Chrysophanol increases osteoblast differentiation via AMPK/Smad1/5/9 phosphorylation in vitro and in vivo. Clin Exp Pharmacol Physiol. 2021Apr;48(4):515–523. Epub 2020 Dec 9. PMID: 33300218.
  • Gu M, Lu L, Wei Q, et al. Improved oral bioavailability and anti-chronic renal failure activity of chrysophanol via mixed polymeric micelles. J Microencapsul. 2021Jan;38(1):47–60. Epub 2020 Nov 19. PMID: 33175576.
  • Zarbock A, Gomez H, Kellum JA. Sepsis-induced acute kidney injury revisited: pathophysiology, prevention and future therapies. Curr Opin Crit Care. 2014;20(6):588–595.
  • Takehara K, Murakami T, Kuwahara-Arai K, et al. Evaluation of the effect of recombinant thrombomodulin on a lipopolysaccharide-induced murine sepsis model. Exp Ther Med. 2017;13(6):2969–2974.
  • Kakihana Y, Ito T, Nakahara M, et al. Sepsis-induced myocardial dysfunction: pathophysiology and management. J Intensive Care. 2016;4(1):22.
  • De Schryver N, Hoton D, Castanares-Zapatero D, et al. Acute ventricular wall thickening: sepsis, thrombotic microangiopathy, or myocarditis? Case Rep Cardiol. 2015;2015:275825.
  • Chen L, Liu P, Feng X, et al. Salidroside suppressing LPS-induced myocardial injury by inhibiting ROS-mediated PI3K/Akt/mTOR pathway in vitro and in vivo. J Cell Mol Med. 2017;21(12):3178–3189.
  • Wang SM, Liu GQ, Xian HB, et al. LncRNA NEAT1 alleviates sepsis-induced myocardial injury by regulating the TLR2/NF-κB signaling pathway. Eur Rev Med Pharmacol Sci. 2019;23(11):4898–4907.
  • Selim NM, Elgazar AA, Abdel-Hamid NM, et al. Chrysophanol, physcion, hesperidin and curcumin modulate the gene expression of pro-inflammatory mediators induced by LPS in HepG2: in silico and molecular studies. Antioxidants (Basel). 2019;8(9):371.
  • Kim SJ, Kim MC, Lee BJ, et al. Anti-inflammatory activity of chrysophanol through the suppression of NF-kappaB/caspase-1 activation in vitro and in vivo. Molecules. 2010;15(9):6436–6451.
  • Zhang N, Zhang X, Liu X, et al. Chrysophanol inhibits NALP3 inflammasome activation and ameliorates cerebral ischemia/reperfusion in mice. Mediators Inflamm. 2014;2014:370530.
  • Yuan J, Hong H, Zhang Y, et al. Chrysophanol attenuated isoproterenol-induced cardiac hypertrophy by inhibiting Janus kinase 2/signal transducer and activator of transcription 3 signaling pathway. Cell Biol Int. 2019;43(6):695–705.
  • Lian Y, Xia X, Zhao H, et al. The potential of chrysophanol in protecting against high fat-induced cardiac injury through Nrf2-regulated anti-inflammation, anti-oxidant and anti-fibrosis in Nrf2 knockout mice. Biomed Pharmacother. 2017;93:1175–1189.
  • Xue P, Zhao J, Zheng AB, et al. Chrysophanol alleviates myocardial injury in diabetic db/db mice by regulating the SIRT1/HMGB1/NF-κB signaling pathway. Exp Ther Med. 2019;18(6):4406–4412.
  • Dexheimer PJ, Cochella L. MicroRNAs: from mechanism to organism. Front Cell Dev Biol. 2020;8:409.
  • Sun B, Luan C, Guo L, et al. Low expression of microRNA-328 can predict sepsis and alleviate sepsis-induced cardiac dysfunction and inflammatory response. Braz J Med Biol Res. 2020;53(8):e9501.
  • Ouyang H, Tan Y, Li Q, et al. MicroRNA-208-5p regulates myocardial injury of sepsis mice via targeting SOCS2-mediated NF-κB/HIF-1α pathway. Int Immunopharmacol. 2020;81:106204.
  • Zhu Y, Sun A, Meng T, et al. Protective role of long noncoding RNA CRNDE in myocardial tissues from injury caused by sepsis through the microRNA-29a/SIRT1 axis. Life Sci. 2020;255:117849.
  • Kim MK, Lee SK, Park JH, et al. Ginsenoside Rg3 decreases fibrotic and invasive nature of endometriosis by modulating miRNA-27b. Vitro and in Vivo Studies. Sci Rep. 2017;7(1): 17670
  • Xu Y, Han YF, Ye B, et al. miR-27b-3p is involved in doxorubicin resistance of human anaplastic thyroid cancer cells via targeting peroxisome proliferator-activated receptor gamma. Basic Clin Pharmacol Toxicol. 2018;123(6):670–677.
  • Zou R, Zhang D, Lv L, et al. Bioinformatic gene analysis for potential biomarkers and therapeutic targets of atrial fibrillation-related stroke. J Transl Med. 2019;17(1):45.
  • Huss JM, Kelly DP. Nuclear receptor signaling and cardiac energetics. Circ Res. 2004;95(6):568–578.
  • Liu J, Zhao N, Shi G, et al. Geniposide ameliorated sepsis-induced acute kidney injury by activating PPARγ.Aging (Albany NY). 2020 [Nov 10];12(22):22744–22758.
  • Zhou Y, Zhang MJ, Li BH, et al. PPARγ inhibits VSMC proliferation and migration via attenuating oxidative stress through upregulating UCP2. PLoS One. 2016;11(5):e0154720.
  • Rani N, Arya DS. Chrysin rescues rat myocardium from ischemia-reperfusion injury via PPAR-γ/Nrf2 activation. Eur J Pharmacol. 2020;883:173389.
  • Chu X, Wang Y, Pang L, et al. miR-130 aggravates acute myocardial infarction-induced myocardial injury by targeting PPAR-γ. J Cell Biochem. 2018;119(9):7235–7244.
  • Agrawal YO, Sharma PK, Shrivastava B, et al. Hesperidin blunts streptozotocin-isoproternol induced myocardial toxicity in rats by altering of PPAR-γ receptor. Chem Biol Interact. 2014;219:211–220.