Dexpanthenol attenuates inflammatory damage and apoptosis in kidney and liver tissues of septic mice

References

• David S, Brunkhorst FM. [Sepsis-3: what has been confirmed in therapy?]. Internist (Berl). 2017;58(12):1264–1271.
   PubMed Web of Science ®Google Scholar
• Suarez De La Rica A, Gilsanz F, Maseda E. Epidemiologic trends of sepsis in western countries. Ann Transl Med. 2016;4(17):325.
   PubMed Web of Science ®Google Scholar
• Cohen J, Vincent JL, Adhikari NK, et al. Sepsis: a roadmap for future research. Lancet Infect Dis. 2015;15(5):581–614.
   PubMed Web of Science ®Google Scholar
• O’Leary MM, Taylor J, Eckel L. Psychopathic personality traits and cortisol response to stress: the role of sex, type of stressor, and menstrual phase. Horm Behav. 2010;58(2):250–256.
   PubMed Web of Science ®Google Scholar
• D’Elia RV, Harrison K, Oyston PC, et al. Targeting the “cytokine storm” for therapeutic benefit. Clin Vaccine Immunol. 2013;20(3):319–327.
   PubMedGoogle Scholar
• Cao C, Yu M, Chai Y. Pathological alteration and therapeutic implications of sepsis-induced immune cell apoptosis. Cell Death Dis. 2019;10(10):782.
   PubMedGoogle Scholar
• Sun J, Zhang J, Wang X, et al. Gut-liver crosstalk in sepsis-induced liver injury. Crit Care. 2020;24(1):614.
   PubMed Web of Science ®Google Scholar
• Wang Z, Yang X, Qin T, et al. Efficient removal of oxytetracycline from aqueous solution by a novel magnetic clay-biochar composite using natural attapulgite and cauliflower leaves. Environ Sci Pollut Res Int. 2019;26(8):7463–7475.
   PubMed Web of Science ®Google Scholar
• Bilgic Y, Akbulut S, Aksungur Z, et al. Protective effect of dexpanthenol against cisplatin-induced hepatotoxicity. Exp Ther Med. 2018;16(5):4049–4057.
   PubMed Web of Science ®Google Scholar
• Altintas R, Parlakpinar H, Beytur A, et al. Protective effect of dexpanthenol on ischemia-reperfusion-induced renal injury in rats. Kidney Blood Press Res. 2012;36(1):220–230.
   PubMed Web of Science ®Google Scholar
• Aydin O, Pehlivanli F, Karaca G, et al. May dexpanthenol, platelet-rich plasma, and thymoquinone provide new hope to maintain liver regeneration after partial hepatectomy? Turk J Gastroenterol. 2019;30(9):826–834.
   PubMed Web of Science ®Google Scholar
• Kose A, Parlakpinar H, Ozhan O, et al. Therapeutic effects of dexpanthenol on the cardiovascular and respiratory systems following cecal ligation and puncture-induced sepsis in rats. Biotech Histochem. 2020;95(6):428–437.
   PubMed Web of Science ®Google Scholar
• Rittirsch D, Huber-Lang MS, Flierl MA, et al. Immunodesign of experimental sepsis by cecal ligation and puncture. Nat Protoc. 2009;4(1):31–36.
   PubMed Web of Science ®Google Scholar
• Wang C, Yuan W, Hu A, et al. Dexmedetomidine alleviated sepsis induced myocardial ferroptosis and septic heart injury. Mol Med Rep. 2020;22(1):175–184.
   PubMed Web of Science ®Google Scholar
• Li-Mei W, Jie T, Shan-He W, et al. Anti-inflammatory and anti-oxidative effects of dexpanthenol on lipopolysaccharide induced acute lung injury in mice. Inflammation. 2016;39(5):1757–1763.
   PubMed Web of Science ®Google Scholar
• Xiao Z, Kong B, Fang J, et al. Ferrostatin-1 alleviates lipopolysaccharide-induced cardiac dysfunction. Bioengineered. 2021;12(2):9367–9376.
   PubMed Web of Science ®Google Scholar
• Wu Y, Zhao M, Lin Z. Pyrroloquinoline quinone (PQQ) alleviated sepsis-induced acute liver injury, inflammation, oxidative stress and cell apoptosis by downregulating CUL3 expression. Bioengineered. 2021;12(1):2459–2468.
   PubMed Web of Science ®Google Scholar
• Seibert FS, Sitz M, Passfall J, et al. Prognostic value of urinary calprotectin, NGAL and KIM-1 in chronic kidney disease. Kidney Blood Press Res. 2018;43(4):1255–1262.
   PubMed Web of Science ®Google Scholar
• Huang M, Cai S, Su J. The pathogenesis of sepsis and potential therapeutic targets. Int J Mol Sci. 2019;20(21):5376.
   PubMed Web of Science ®Google Scholar
• Hotchkiss RS, Monneret G, Payen D. Sepsis-induced immunosuppression: from cellular dysfunctions to immunotherapy. Nat Rev Immunol. 2013;13(12):862–874.
   PubMed Web of Science ®Google Scholar
• Ayala A, Perl M, Venet F, et al. Apoptosis in sepsis: mechanisms, clinical impact and potential therapeutic targets. Curr Pharm Des. 2008;14(19):1853–1859.
   PubMed Web of Science ®Google Scholar
• Yan J, Li S, Li S. The role of the liver in sepsis. Int Rev Immunol. 2014;33(6):498–510.
   PubMed Web of Science ®Google Scholar
• Poston JT, Koyner JL. Sepsis associated acute kidney injury. BMJ. 2019;364:k4891.
   PubMedGoogle Scholar
• Alverdy JC, Keskey R, Thewissen R. Can the cecal ligation and puncture model be repurposed to better inform therapy in human sepsis? Infect Immun. 2020;88(9):e00942–19.
   PubMed Web of Science ®Google Scholar
• Hawiger J, Veach RA, Zienkiewicz J. New paradigms in sepsis: from prevention to protection of failing microcirculation. J Thromb Haemost. 2015;13(10):1743–1756.
   PubMed Web of Science ®Google Scholar
• Zhu T, Liao X, Feng T, et al. Plasma monocyte chemoattractant protein 1 as a predictive marker for sepsis prognosis: a prospective cohort study. Tohoku J Exp Med. 2017;241(2):139–147.
   PubMed Web of Science ®Google Scholar
• Hong TH, Chang CH, Ko WJ, et al. Biomarkers of early sepsis may be correlated with outcome. J Transl Med. 2014;12:146.
   PubMed Web of Science ®Google Scholar
• Holub M, Dzupova O, Ruzkova M, et al. Selected biomarkers correlate with the origin and severity of sepsis. Mediators Inflamm. 2018;2018:7028267.
   PubMed Web of Science ®Google Scholar
• Maiese A, Bolino G, Mastracchio A, et al. An immunohistochemical study of the diagnostic value of TREM-1 as marker for fatal sepsis cases. Biotech Histochem. 2019;94(3):159–166.
   PubMed Web of Science ®Google Scholar
• La Russa R, Maiese A, Viola RV, et al. Searching for highly sensitive and specific biomarkers for sepsis: state-of-the-art in post-mortem diagnosis of sepsis through immunohistochemical analysis. Int J Immunopathol Pharmacol. 2019;33:2058738419855226.
   Web of Science ®Google Scholar
• Thieme U, Muller K, Bergmann C, et al. Randomised trial on performance, safety and clinical benefit of hyaluronic acid, hyaluronic acid plus dexpanthenol and isotonic saline nasal sprays in patients suffering from dry nose symptoms. Auris Nasus Larynx. 2020;47(3):425–434.
   PubMed Web of Science ®Google Scholar
• Ping F, Guo Y, Cao Y, et al. Metabolomics analysis of the renal cortex in rats with acute kidney injury induced by sepsis. Front Mol Biosci. 2019;6:152.
   PubMed Web of Science ®Google Scholar
• Dogan EE, Erkoc R, Ekinci I, et al. Protective effect of dexpanthenol against nephrotoxic effect of amikacin: an experimental study. Biomed Pharmacother. 2017;89:1409–1414.
   PubMed Web of Science ®Google Scholar
• Mishra J, Ma Q, Prada A, et al. Identification of neutrophil gelatinase-associated lipocalin as a novel early urinary biomarker for ischemic renal injury. J Am Soc Nephrol. 2003;14(10):2534–2543.
   PubMed Web of Science ®Google Scholar
• Supavekin S, Zhang W, Kucherlapati R, et al. Differential gene expression following early renal ischemia/reperfusion. Kidney Int. 2003;63(5):1714–1724.
   PubMed Web of Science ®Google Scholar
• Amin RP, Vickers AE, Sistare F, et al. Identification of putative gene based markers of renal toxicity. Environ Health Perspect. 2004;112(4):465–479.
   PubMed Web of Science ®Google Scholar
• Prozialeck WC, Vaidya VS, Liu J, et al. Kidney injury molecule-1 is an early biomarker of cadmium nephrotoxicity. Kidney Int. 2007;72(8):985–993.
   PubMed Web of Science ®Google Scholar
• Schrezenmeier EV, Barasch J, Budde K, et al. Biomarkers in acute kidney injury - pathophysiological basis and clinical performance. Acta Physiol (Oxf). 2017;219(3):554–572.
   PubMed Web of Science ®Google Scholar
• Nogueira SAR, Oliveira SCS, Carvalho AFM, et al. Renal changes and acute kidney injury in covid-19: a systematic review. Rev Assoc Med Bras (1992). 2020;66(Suppl 2):112–7.0.
   PubMedGoogle Scholar
• Lala V, Goyal A, Bansal P, et al. Liver function tests. Treasure Island (FL): StatPearls; 2021.
   Google Scholar
• Koop AC, Thiele ND, Steins D, et al. Therapeutic targeting of myeloperoxidase attenuates NASH in mice. Hepatol Commun. 2020;4(10):1441–1458.
   PubMed Web of Science ®Google Scholar
• Tutun B, Elbe H, Vardi N, et al. Dexpanthenol reduces diabetic nephropathy and renal oxidative stress in rats. Biotech Histochem. 2019;94(2):84–91.
   PubMed Web of Science ®Google Scholar
• Slyshenkov VS, Rakowska M, Moiseenok AG, et al. Pantothenic acid and its derivatives protect Ehrlich ascites tumor cells against lipid peroxidation. Free Radic Biol Med. 1995;19(6):767–772.
   PubMed Web of Science ®Google Scholar
• Ye S, Zhou X, Lin J, et al. Asymmetric dimethylarginine induced apoptosis and dysfunction of endothelial progenitor cells: role of endoplasmic reticulum stress pathway. Biomed Res Int. 2017;2017:6395601.
   PubMed Web of Science ®Google Scholar