Helicobacter pylori promotes inflammatory factor secretion and lung injury through VacA exotoxin-mediated activation of NF-κB signaling

References

• Burkitt MD, Duckworth CA, Williams JM. Helicobacter pylori -induced gastric pathology: insights from in vivo and ex vivo models. Dis Model Mech. 2017;10(2):89–104.
   PubMed Web of Science ®Google Scholar
• Wroblewski LE, Peek RM Jr. Helicobacter pylori, cancer, and the gastric microbiota. Adv Exp Med Biol. 2016;908:393–408.
   PubMed Web of Science ®Google Scholar
• Pei Y, Tang Z, Cai M, et al. MicroRNA miR-425 promotes tumor progression by inhibiting Dickkopf-related protein-3 in gastric cancer. Bioengineered. 2021;12(1):2045–2054.
   PubMed Web of Science ®Google Scholar
• de Brito BB, da Silva FAF, Soares AS, et al. Pathogenesis and clinical management of Helicobacter pylori gastric infection. World J Gastroenterol. 2019;25(37):5578–5589.
   PubMed Web of Science ®Google Scholar
• Kyburz A, Müller A. Helicobacter pylori and Extragastric Diseases. Curr Top Microbiol Immunol. 2017;400:325–347.
   PubMed Web of Science ®Google Scholar
• Wang F, Liu J, Zhang Y, et al. Association of Helicobacter pylori infection with chronic obstructive pulmonary disease and chronic bronchitis: a meta-analysis of 16 studies. Infect Dis (Lond). 2015;47(9):597–603.
   PubMed Web of Science ®Google Scholar
• Salama NR, Hartung ML, Müller A. Life in the human stomach: persistence strategies of the bacterial pathogen Helicobacter pylori. Nat Rev Microbiol. 2013;11(6):385–399.
   PubMed Web of Science ®Google Scholar
• Arismendi Sosa AC, Salinas Ibáñez AG, Pérez Chaca MV, et al. Study of Helicobacter pylori infection on lung using an animal model. Microb Pathog. 2018;123:410–418.
   PubMed Web of Science ®Google Scholar
• Palframan SL, Kwok T, Gabriel K. Vacuolating cytotoxin A (VacA), a key toxin for Helicobacter pylori pathogenesis. Front Cell Infect Microbiol. 2012;2:92.
   PubMed Web of Science ®Google Scholar
• Chambers MG, Pyburn TM, González-Rivera C, et al. Structural analysis of the oligomeric states of Helicobacter pylori VacA toxin. J Mol Biol. 2013;425(3):524–535.
   PubMed Web of Science ®Google Scholar
• Nakashima S, Kakugawa T, Yura H, et al. Identification of Helicobacter pylori VacA in human lung and its effects on lung cells. Biochem Biophys Res Commun. 2015;460(3):721–726.
   PubMed Web of Science ®Google Scholar
• Durazzo M, Adriani A, Fagoonee S, et al. Helicobacter pylori and respiratory diseases: 2021 update. Microorganisms. 2021;9(10):2033.
   PubMed Web of Science ®Google Scholar
• Maubach G, Vieth M, Boccellato F, et al. Helicobacter pylori-induced NF-κB: trailblazer for gastric pathophysiology. Trends Mol Med. 2022;28(3):210–222.
   PubMed Web of Science ®Google Scholar
• Lawrence T. The nuclear factor NF-kappaB pathway in inflammation. Cold Spring Harb Perspect Biol. 2009;1(6):a001651.
   PubMed Web of Science ®Google Scholar
• Luo JJ, Li CY, Liu S, et al. Overexpression of Helicobacter pylori VacA N-terminal fragment induces proinflammatory cytokine expression and apoptosis in human monocytic cell line through activation of NF-κB. Can J Microbiol. 2013;59(8):523–533.
   PubMed Web of Science ®Google Scholar
• Xie J, Yuan Y, Yao G, et al. Nucleoporin 160 (NUP160) inhibition alleviates diabetic nephropathy by activating autophagy. Bioengineered. 2021;12(1):6390–6402.
   PubMed Web of Science ®Google Scholar
• Wang WB, Li JT, Hui Y, et al. Combination of pseudoephedrine and emodin ameliorates LPS-induced acute lung injury by regulating macrophage M1/M2 polarization through the VIP/cAMP/PKA pathway. Chin Med. 2022;17(1):19.
   PubMed Web of Science ®Google Scholar
• Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 2001;25(4):402–408.
   PubMed Web of Science ®Google Scholar
• Zhang L, Lv Y, Rong Y, et al. Downregulated expression of RACK1 results in pancreatic cancer growth and metastasis. Onco Targets Ther. 2019;12:1007–1020.
   PubMed Web of Science ®Google Scholar
• de Korwin JD, Ianiro G, Gibiino G, et al. Helicobacter pylori infection and extragastric diseases in 2017. Helicobacter. 2017;22(Suppl 1):e12411.
   Google Scholar
• Lee HY, Kang HR, Lee JK, et al. The effect of Helicobacter pylori infection on the decline of lung function in a health screening population. Ann Palliat Med. 2020;9(5):3115–3122.
   PubMed Web of Science ®Google Scholar
• He M, Zheng Y, Ma A, et al. Helicobacter pylori is associated with weakened pulmonary function and reduced incidence of allergic conditions in patients with chronic cough. Exp Ther Med. 2020;20(5):47.
   PubMed Web of Science ®Google Scholar
• Wang L, Guan Y, Li Y, et al. Association between chronic respiratory diseases and Helicobacter pylori: a Meta-Analysis. Arch Bronconeumol. 2015;51(6):273–278.
   PubMed Web of Science ®Google Scholar
• Dela Pena-Ponce MG, Jimenez MT, Hansen LM, et al. The Helicobacter pylori type IV secretion system promotes IL-8 synthesis in a model of pediatric airway epithelium via p38 MAP kinase. PLoS One. 2017;12(8):e0183324.
   PubMed Web of Science ®Google Scholar
• Samareh-Fekri M, Hashemi Bajgani SM, Shafahi A, et al. Detection of Helicobacter pylori in the Bronchoalveolar Lavage of Patients with Lung Cancer Using Real-Time PCR. Jundishapur J Microbiol. 2016;9(11):e32144.
   PubMed Web of Science ®Google Scholar
• Gopal GJ, Kumar A, Pal J, et al. Molecular characterization and polyclonal antibody generation against core component CagX protein of Helicobacter pylori type IV secretion system. Bioengineered. 2014;5(2):107–113.
   PubMed Web of Science ®Google Scholar
• Sun SC. The non-canonical NF-κB pathway in immunity and inflammation. Nat Rev Immunol. 2017;17(9):545–558.
   PubMed Web of Science ®Google Scholar
• Ma SQ, Wei HL, Zhang X. TLR2 regulates allergic airway inflammation through NF-κB and MAPK signaling pathways in asthmatic mice. Eur Rev Med Pharmacol Sci. 2018;22(10):3138–3146.
   PubMed Web of Science ®Google Scholar
• Castaño-Rodríguez N, Kaakoush NO, Mitchell HM. Pattern-recognition receptors and gastric cancer. Front Immunol. 2014;5:336.
   PubMed Web of Science ®Google Scholar
• Choi HR, Lim H, Lee JH, et al. Interruption of Helicobacter pylori -Induced NLRP3 Inflammasome Activation by Chalcone Derivatives. Biomol Ther (Seoul). 2021;29(4):410–418.
   PubMed Web of Science ®Google Scholar
• Yang JY, Kim JB, Lee P, et al. Evodiamine Inhibits Helicobacter pylori Growth and Helicobacter pylori-Induced Inflammation. Int J Mol Sci. 2021;225 3385.
   PubMedGoogle Scholar
• Eslami M, Yousefi B, Kokhaei P, et al. Current information on the association of Helicobacter pylori with autophagy and gastric cancer. J Cell Physiol. 2019;234(9):14800–14811.
   PubMed Web of Science ®Google Scholar
• Nakayama M, Hisatsune J, Yamasaki E, et al. Helicobacter pylori VacA-induced inhibition of GSK3 through the PI3K/Akt signaling pathway. J Biol Chem. 2009;284(3):1612–1619.
   PubMed Web of Science ®Google Scholar