1,813
Views
0
CrossRef citations to date
0
Altmetric
Research Paper

Mitochondrial transcription factor B2 overexpression increases M2 macrophage infiltration via cytosolic mitochondrial DNA-stimulated Interleukin-6 secretion in ovarian cancer

, , &
Pages 12211-12223 | Received 24 Nov 2021, Accepted 01 May 2022, Published online: 16 May 2022

References

  • Siegel RL, Miller KD, Fuchs HE, et al. Cancer statistics, 2021. CA Cancer J Clin. 2021;71(1):7–33.
  • Ledermann JA, Raja FA, Fotopoulou C, et al. Newly diagnosed and relapsed epithelial ovarian carcinoma: ESMO clinical practice guidelines for diagnosis, treatment and follow-up. Ann Oncol. 2018;29(Suppl 4):iv259.
  • Armstrong DK, Alvarez RD, Bakkum-Gamez JN, et al. Ovarian cancer,version 2.2020,NCCN clinical practice guidelines in oncology. J Natl Compr Canc Netw. 2021;19(2):191–226.
  • De Angelis R, Sant M, Coleman MP, et al. Cancer survival in Europe 1999-2007 by country and age: results of EUROCARE–5-a population-based study. Lancet Oncol. 2014;15(1):23–34.
  • Maiorano BA, Maiorano MFP, Lorusso D, et al. Ovarian cancer in the era of immune checkpoint inhibitors: state of the art and future perspectives. Cancers (Basel). 2021;13(17):4438.
  • Robert C. A decade of immune-checkpoint inhibitors in cancer therapy. Nat Commun. 2020;11(1):3801.
  • Doo DW, Norian LA, Arend RC. Checkpoint inhibitors in ovarian cancer: a review of preclinical data. Gynecol Oncol Rep. 2019;29:48–54.
  • Zou D, Wang Y, Wang M, et al. Bioinformatics analysis reveals the competing endogenous RNA (ceRNA) coexpression network in the tumor microenvironment and prognostic biomarkers in soft tissue sarcomas. Bioengineered. 2021;12(1):496–506.
  • Zhang C, Liu J, Guo H, et al. m6A RNA methylation regulators were associated with the malignancy and prognosis of ovarian cancer. Bioengineered. 2021;12(1):3159–3176.
  • Yang Y, Yang Y, Yang J, et al. Tumor microenvironment in ovarian cancer: function and therapeutic strategy. Front Cell Dev Biol. 2020;8:758.
  • Hinshaw DC, Shevde LA. The tumor microenvironment innately modulates cancer progression. Cancer Res. 2019;79(18):4557–4566.
  • Luo X, Xu J, Yu J, et al. Shaping immune responses in the tumor microenvironment of ovarian cancer. Front Immunol. 2021;12:692360.
  • Kim J, Bae JS. Tumor-associated macrophages and neutrophils in tumor microenvironment. Mediators Inflamm. 2016;2016:6058147.
  • Xu Y, Shen J, Ran Z. Emerging views of mitophagy in immunity and autoimmune diseases. Autophagy. 2020;16(1):3–17.
  • Wu Z, Oeck S, West AP, et al. Mitochondrial DNA stress signalling protects the nuclear genome. Nat Metab. 2019;1(12):1209–1218.
  • Falkenberg M, Gaspari M, Rantanen A, et al. Mitochondrial transcription factors B1 and B2 activate transcription of human mtDNA. Nat Genet. 2002;31(3):289–294.
  • Bonekamp NA, Jiang M, Motori E, et al. High levels of TFAM repress mammalian mitochondrial DNA transcription in vivo. Life Sci Alliance. 2021;4(11):e202101034.
  • Kanki T, Ohgaki K, Gaspari M, et al. Architectural role of mitochondrial transcription factor A in maintenance of human mitochondrial DNA. Mol Cell Biol. 2004;24(22):9823–9834.
  • Watanabe A, Arai M, Koitabashi N, et al. Mitochondrial transcription factors TFAM and TFB2M regulate Serca2 gene transcription. Cardiovasc Res. 2011;90(1):57–67.
  • Nicholas LM, Valtat B, Medina A, et al. Mitochondrial transcription factor B2 is essential for mitochondrial and cellular function in pancreatic beta-cells. Mol Metab. 2017;6(7):651–663.
  • West AP, Khoury-Hanold W, Staron M, et al. Mitochondrial DNA stress primes the antiviral innate immune response. Nature. 2015;520(7548):553–557.
  • Bao D, Zhao J, Zhou X, et al. Mitochondrial fission-induced mtDNA stress promotes tumor-associated macrophage infiltration and HCC progression. Oncogene. 2019;38(25):5007–5020.
  • Perez-Trevino P, Velasquez M, Garcia N. Mechanisms of mitochondrial DNA escape and its relationship with different metabolic diseases. Biochim Biophys Acta Mol Basis Dis. 2020;1866(6):165761.
  • Szczesny B, Marcatti M, Ahmad A, et al. Mitochondrial DNA damage and subsequent activation of Z-DNA binding protein 1 links oxidative stress to inflammation in epithelial cells. Sci Rep. 2018;8(1):914.
  • Goldman MJ, Craft B, Hastie M, et al. Visualizing and interpreting cancer genomics data via the Xena platform. Nat Biotechnol. 2020;38(6):675–678.
  • Gyorffy B, Lanczky A, Szallasi Z. Implementing an online tool for genome-wide validation of survival-associated biomarkers in ovarian-cancer using microarray data from 1287 patients. Endocr Relat Cancer. 2012;19(2):197–208.
  • Uhlen M, Oksvold P, Fagerberg L, et al. Towards a knowledge-based Human Protein Atlas. Nat Biotechnol. 2010;28(12):1248–1250.
  • Hu JM, Liu K, Liu JH, et al. CD163 as a marker of M2 macrophage, contribute to predict aggressiveness and prognosis of Kazakh esophageal squamous cell carcinoma. Oncotarget. 2017;8(13):21526–21538.
  • Yang M, Li Z, Ren M, et al. Stromal infiltration of tumor-associated macrophages conferring poor prognosis of patients with basal-like breast carcinoma. J Cancer. 2018;9(13):2308–2316.
  • Weng YS, Tseng HY, Chen YA, et al. MCT-1/miR-34a/IL-6/IL-6R signaling axis promotes EMT progression, cancer stemness and M2 macrophage polarization in triple-negative breast cancer. Mol Cancer. 2019;18(1):42.
  • Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 2001;25(4):402–408.
  • Jauhari A, Baranov SV, Suofu Y, et al. Melatonin inhibits cytosolic mitochondrial DNA-induced neuroinflammatory signaling in accelerated aging and neurodegeneration. J Clin Invest. 2021;131(9). DOI:10.1172/JCI150328.
  • Guo Y, Gu R, Gan D, et al. Mitochondrial DNA drives noncanonical inflammation activation via cGAS-STING signaling pathway in retinal microvascular endothelial cells. Cell Commun Signal. 2020;18(1):172.
  • Liu SY, Wei W, Yue H, et al. Nanoparticles-based multi-adjuvant whole cell tumor vaccine for cancer immunotherapy. Biomaterials. 2013;34(33):8291–8300.
  • Smith MP, Young H, Hurlstone A, et al. Differentiation of THP1 cells into macrophages for transwell co-culture assay with melanoma cells. Biol Protoc. 2015;5(21). DOI:10.21769/BioProtoc.1638
  • Ashley N, Harris D, Poulton J. Detection of mitochondrial DNA depletion in living human cells using PicoGreen staining. Exp Cell Res. 2005;303(2):432–446.
  • Zhang JZ, Liu Z, Liu J, et al. Mitochondrial DNA induces inflammation and increases TLR9/NF-kappaB expression in lung tissue. Int J Mol Med. 2014;33(4):817–824.
  • Zeng Z, Li D, Liu F, et al. Mitochondrial DNA plays an important role in lung injury induced by sepsis. J Cell Biochem. 2018.
  • Echem C, Costa TJD, Oliveira V, et al. Mitochondrial DNA: a new driver for sex differences in spontaneous hypertension. Pharmacol Res. 2019;144:142–150.
  • Franco DG, Moretti IF, Marie SKN. Mitochondria transcription factor a: a putative target for the effect of Melatonin on U87MG malignant glioma cell line. Molecules. 2018;23(5):1129.
  • Geng X, Geng Z, Li H, et al. Over-expression of TFB2M facilitates cell growth and metastasis via activating ROS-Akt-NF-kappaB signalling in hepatocellular carcinoma. Liver Int. 2020;40(7):1756–1769.
  • Chang H, Li J, Luo Y, et al. TFB2M activates aerobic glycolysis in hepatocellular carcinoma cells through the NAD(+) /SIRT3/HIF-1alpha signaling. J Gastroenterol Hepatol. 2021;36(10):2978–2988.
  • Wang Y, Liu VW, Xue WC, et al. Association of decreased mitochondrial DNA content with ovarian cancer progression. Br J Cancer. 2006;95(8):1087–1091.
  • Bao X, Zhang J, Huang G, et al. The crosstalk between HIFs and mitochondrial dysfunctions in cancer development. Cell Death Dis. 2021;12(2):215.
  • Dai W, Jiang L. Dysregulated mitochondrial dynamics and metabolism in obesity, diabetes, and cancer. Front Endocrinol (Lausanne). 2019;10:570.
  • Tanwar DK, Parker DJ, Gupta P, et al. Crosstalk between the mitochondrial fission protein, Drp1, and the cell cycle is identified across various cancer types and can impact survival of epithelial ovarian cancer patients. Oncotarget. 2016;7(37):60021–60037.
  • Braune J, Weyer U, Hobusch C, et al. IL-6 regulates M2 polarization and local proliferation of adipose tissue macrophages in obesity. J Immunol. 2017;198(7):2927–2934.
  • Kwon J, Bakhoum SF. The cytosolic DNA-Sensing cGAS-STING pathway in cancer. Cancer Discov. 2020;10(1):26–39.
  • West AP, Shadel GS. Mitochondrial DNA in innate immune responses and inflammatory pathology. Nat Rev Immunol. 2017;17(6):363–375.
  • Dou Z, Ghosh K, Vizioli MG, et al. Cytoplasmic chromatin triggers inflammation in senescence and cancer. Nature. 2017;550(7676):402–406.
  • Park JH, Zhuang J, Li J, et al. p53 as guardian of the mitochondrial genome. FEBS Lett. 2016;590(7):924–934.
  • Blandino G, Valenti F, Sacconi A, et al. Wild type- and mutant p53 proteins in mitochondrial dysfunction: emerging insights in cancer disease. Semin Cell Dev Biol. 2020;98:105–117.