Immunomodulatory effects of icariin in a myocardial infarction mouse model

References

• Xiong YY, Gong ZT, Tang RJ, et al. The pivotal roles of exosomes derived from endogenous immune cells and exogenous stem cells in myocardial repair after acute myocardial infarction. Theranostics. 2021;11:1046–1058.
   PubMed Web of Science ®Google Scholar
• Bahit MC, Kochar A, Granger CB. Post-Myocardial infarction heart failure. JACC Heart Fail. 2018;6:179–186.
   PubMed Web of Science ®Google Scholar
• Wu J, Chen S, Liu Y, et al. Therapeutic perspectives of heat shock proteins and their protein-protein interactions in myocardial infarction. Pharmacol Res. 2020;160:105162.
   PubMed Web of Science ®Google Scholar
• Del Re DP, Amgalan D, Linkermann A, et al. Fundamental mechanisms of regulated cell death and implications for heart disease. Physiol Rev. 2019;99:1765–1817.
   PubMed Web of Science ®Google Scholar
• Cui C, Fan J, Zeng Q, et al. CD4(+) T-Cell endogenous cystathionine gamma lyase-hydrogen sulfide attenuates hypertension by sulfhydrating liver kinase B1 to promote t regulatory cell differentiation and proliferation. Circulation. 2020;142:1752–1769.
   PubMed Web of Science ®Google Scholar
• DeBerge M, Yu S, Dehn S, et al. Monocytes prime autoreactive T cells after myocardial infarction. Am J Physiol Heart Circ Physiol. 2020;318:H116–H23.
   PubMed Web of Science ®Google Scholar
• Zhang Q, Cui T, Chang Y, et al. HO-1 regulates the function of treg: association with the immune intolerance in vitiligo. J Cell Mol Med. 2018;22:4335–4343.
   PubMed Web of Science ®Google Scholar
• Wei HJ, Gupta A, Kao WM, et al. Nrf2-mediated metabolic reprogramming of tolerogenic dendritic cells is protective against aplastic anemia. J Autoimmun. 2018;94:33–44.
   PubMed Web of Science ®Google Scholar
• Shaito A, Thuan DTB, Phu HT, et al. Herbal medicine for cardiovascular diseases: efficacy, mechanisms, and safety. Front Pharmacol. 2020;11:422.
   PubMed Web of Science ®Google Scholar
• Reed GW, Rossi JE, Cannon CP. Acute myocardial infarction. Lancet. 2017;389:197–210.
   PubMed Web of Science ®Google Scholar
• Pokkula S, Thakur SR. Icariin ameliorates partial sciatic nerve ligation induced neuropathic pain in rats: an evidence of in silico and in vivo studies. J Pharm Pharmacol. 2021;73:874–880.
   PubMed Web of Science ®Google Scholar
• Huang Z, Wei H, Wang X, et al. Icariin promotes osteogenic differentiation of BMSCs by upregulating BMAL1 expression via BMP signaling. Mol Med Rep. 2020;21:1590–1596.
   PubMed Web of Science ®Google Scholar
• Zheng J, Hu S, Wang J, et al. Icariin improves brain function decline in aging rats by enhancing neuronal autophagy through the AMPK/mTOR/ULK1 pathway. Pharm Biol. 2021;59:183–191.
   PubMed Web of Science ®Google Scholar
• Jin J, Wang H, Hua X, et al. An outline for the pharmacological effect of icariin in the nervous system. Eur J Pharmacol. 2019;842:20–32.
   PubMed Web of Science ®Google Scholar
• Chen C, Yu L-T, Cheng B-R, et al. Promising therapeutic candidate for myocardial ischemia/reperfusion injury: what are the possible mechanisms and roles of phytochemicals? Front Cardiovasc Med. 2021;8:792592.
   PubMed Web of Science ®Google Scholar
• Zhou H, Yuan Y, Liu Y, et al. Icariin protects H9c2 cardiomyocytes from lipopolysaccharide induced injury via inhibition of the reactive oxygen species dependent cJun N terminal kinases/nuclear factor-kappaB pathway. Mol Med Rep. 2015;11:4327–4332.
   PubMed Web of Science ®Google Scholar
• Zhao H, You X, Chen Q, et al. Icariin improves age-related testicular dysfunction by alleviating sertoli cell injury via upregulation of the ERalpha/Nrf2-signaling pathway. Front Pharmacol. 2020;11:677.
   PubMed Web of Science ®Google Scholar
• El-Shitany NA, Eid BG. Icariin modulates carrageenan-induced acute inflammation through HO-1/Nrf2 and NF-kB signaling pathways. Biomed Pharmacother. 2019;120:109567.
   PubMed Web of Science ®Google Scholar
• Wei Y, Liu B, Sun J, et al. Regulation of Th17/Treg function contributes to the attenuation of chronic airway inflammation by icariin in ovalbumin-induced murine asthma model. Immunobiology. 2015;220:789–797.
   PubMed Web of Science ®Google Scholar
• Miller DL, Lu X, Dou C, et al. Multiple ultrasound cavitation-enabled treatments for myocardial reduction. J Ther Ultrasound. 2017;5:29.
   PubMedGoogle Scholar
• Zeng Z, Wang Q, Yang X, et al. Qishen granule attenuates cardiac fibrosis by regulating TGF-beta /Smad3 and GSK-3beta pathway. Phytomedicine. 2019;62:152949.
   PubMed Web of Science ®Google Scholar
• Abdel-Kader MS, Soliman GA, Alqarni MH, et al. Chemical composition and protective effect of Juniperus sabina L. essential oil against CCl4 induced hepatotoxicity. Saudi Pharm J. 2019;27:945–951.
   PubMed Web of Science ®Google Scholar
• Hoffman RA, Maino VC, Recktenwald DJ, et al. BD Biosciences contributions in CD4 counting and immune status for HIV/AIDS. Cytometry. 2002;50:129–132.
   PubMedGoogle Scholar
• Crone M, Hallman K, Lloyd V, et al. The antiestrogenic effects of black cohosh on BRCA1 and steroid receptors in breast cancer cells. Breast Cancer (Dove Med Press). 2019;11:99–110.
   PubMed Web of Science ®Google Scholar
• Campbell KK, Gardner JM, Hall K, et al. Consecutive immunohistochemical staining on a single slide is effective in confirming melanocytic derivation. Appl Immunohistochem Mol Morphol. 2020;28:e76–e81.
   PubMedGoogle Scholar
• Song YH, Cai H, Zhao ZM, et al. Icariin attenuated oxidative stress induced-cardiac apoptosis by mitochondria protection and ERK activation. Biomed Pharmacother. 2016;83:1089–1094.
   PubMed Web of Science ®Google Scholar
• Bao H, Chen L. Icariin reduces mitochondrial oxidative stress injury in diabetic rat hearts. Zhongguo Zhong Yao Za Zhi. 2011;36:1503–1507.
   PubMedGoogle Scholar
• Henning RJ, Bourgeois M, Harbison RD. Poly(ADP-ribose) polymerase (PARP) and PARP inhibitors: mechanisms of action and role in cardiovascular disorders. Cardiovasc Toxicol. 2018;18:493–506.
   PubMed Web of Science ®Google Scholar
• Hoffmann J, Shmeleva EV, Boag SE, et al. Myocardial ischemia and reperfusion leads to transient CD8 immune deficiency and accelerated immunosenescence in CMV-seropositive patients. Circ Res. 2015;116(1):87–98.
   PubMed Web of Science ®Google Scholar
• Zhang M, Zhang S. T cells in fibrosis and fibrotic diseases. Front Immunol. 2020;11:1142.
   PubMed Web of Science ®Google Scholar
• Ilatovskaya DV, Pitts C, Clayton J, et al. CD8(+) T-cells negatively regulate inflammation post-myocardial infarction. Am J Physiol Heart Circ Physiol. 2019;317:H581–H96.
   PubMed Web of Science ®Google Scholar
• Zaidi Y, Corker A, Vasileva VY, et al. Chronic Porphyromonas gingivalis lipopolysaccharide induces adverse myocardial infarction wound healing through activation of CD8(+) T cells. Am J Physiol Heart Circ Physiol. 2021;321:H948–H62.
   PubMed Web of Science ®Google Scholar
• Wolska K, Michalska-Jakubus M, Pietrzak A, et al. Metabolic syndrome in patients with psoriasis. Pol Merkur Lekarski. 2014;36:215–219.
   PubMedGoogle Scholar
• Yan X, Shichita T, Katsumata Y, et al. Deleterious effect of the IL-23/IL-17A axis and gammadeltaT cells on left ventricular remodeling after myocardial infarction. J Am Heart Assoc. 2012;1:e004408.
   PubMed Web of Science ®Google Scholar
• Van Nguyen T, Piao CH, Fan YJ, et al. Anti-allergic rhinitis activity of alpha-lipoic acid via balancing Th17/Treg expression and enhancing Nrf2/HO-1 pathway signaling. Sci Rep. 2020;10:12528.
   PubMed Web of Science ®Google Scholar
• Wong TH, Chen HA, Gau RJ, et al. Heme oxygenase-1-expressing dendritic cells promote foxp3+ regulatory t cell differentiation and induce less severe airway inflammation in murine models. PLoS One. 2016;11:e0168919.
   PubMed Web of Science ®Google Scholar
• Xie S, Deng W, Chen J, et al. Andrographolide protects against adverse cardiac remodeling after myocardial infarction through enhancing Nrf2 signaling pathway. Int J Biol Sci. 2020;16:12–26.
   PubMed Web of Science ®Google Scholar
• Arab HH, Al-Shorbagy MY, Saad MA. Activation of autophagy and suppression of apoptosis by dapagliflozin attenuates experimental inflammatory bowel disease in rats: targeting AMPK/mTOR, HMGB1/RAGE and Nrf2/HO-1 pathways. Chem Biol Interact. 2021;335:109368.
   PubMed Web of Science ®Google Scholar
• Ding M, Li M, Zhang EM, et al. FULLEROL alleviates myocardial ischemia-reperfusion injury by reducing inflammation and oxidative stress in cardiomyocytes via activating the Nrf2/HO-1 signaling pathway. Eur Rev Med Pharmacol Sci. 2020;24:9665–9674.
   PubMed Web of Science ®Google Scholar