Paeoniflorin alleviates the progression of retinal vein occlusion via inhibiting hypoxia inducible factor-1α/vascular endothelial growth factor/STAT3 pathway

References

• Brand CS. Management of retinal vascular diseases: a patient-centric approach. Eye (Lond). 2012;26(2):S1–16.
   PubMed Web of Science ®Google Scholar
• Bertelsen M, Linneberg A, Rosenberg T, et al. Comorbidity in patients with branch retinal vein occlusion: case-control study. BMJ (Clin Res Ed). 2012;345:e7885.
   PubMed Web of Science ®Google Scholar
• Pagès G, Pouysségur J. Transcriptional regulation of the vascular endothelial growth factor concert of activating factors. Cardiovasc Res. 2005;65:564–573.
   PubMed Web of Science ®Google Scholar
• Isner JM, Pieczek A, Schainfeld R, et al. Clinical evidence of angiogenesis after arterial gene transfer of phVEGF165 in patient with ischaemic limb. Lancet. 1996;348:370–374.
   PubMed Web of Science ®Google Scholar
• Ferrara N, Gerber HP, LeCouter J. The biology of VEGF and its receptors. Nat Med. 2003;9:669–676.
   PubMed Web of Science ®Google Scholar
• Sengupta S, Toh SA, Sellers LA, et al. Modulating angiogenesis: the yin and the yang in ginseng. Circulation. 2004;110:1219–1225.
   PubMed Web of Science ®Google Scholar
• Heiss M, Hellström M, Kalén M, et al. Endothelial cell spheroids as a versatile tool to study angiogenesis in vitro. FASEB J. 2015;29:3076–3084.
   PubMed Web of Science ®Google Scholar
• Viallard C, Larrivée B. Tumor angiogenesis and vascular normalization: alternative therapeutic targets. Angiogenesis. 2017;20(4):409–426.
   PubMed Web of Science ®Google Scholar
• Ferrara N, Henzel WJ. Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cells. 1989. Biochem Biophys Res Commun. 2012;425:540–547.
   PubMed Web of Science ®Google Scholar
• Zhang K, Lu J, Mori T, et al. Baicalin increases VEGF expression and angiogenesis by activating the ERR{alpha}/PGC-1{alpha} pathway. Cardiovasc Res. 2011;89:426–435.
   PubMed Web of Science ®Google Scholar
• Sohn EJ, Jung DB, Lee H, et al. CNOT2 promotes proliferation and angiogenesis via VEGF signaling in MDA-MB-231 breast cancer cells. Cancer Lett. 2018;412:88–98.
   PubMed Web of Science ®Google Scholar
• Storkebaum E, Lambrechts D, Carmeliet P. VEGF: once regarded as a specific angiogenic factor, now implicated in neuroprotection. BioEssays. 2004;26:943–954.
   PubMed Web of Science ®Google Scholar
• Springer ML, Chen AS, Kraft PE, et al. VEGF gene delivery to muscle: potential role for vasculogenesis in adults. Mol Cell. 1998;2:549–558.
   PubMed Web of Science ®Google Scholar
• Zhang LD, Chen L, Zhang M, et al. Downregulation of ERRα inhibits angiogenesis in human umbilical vein endothelial cells through regulating VEGF production and PI3K/Akt/STAT3 signaling pathway. Eur J Pharmacol. 2015;769:167–176.
   PubMed Web of Science ®Google Scholar
• Semenza GL. Targeting HIF-1 for cancer therapy. Nat Rev Cancer. 2003;3:721–732.
   PubMed Web of Science ®Google Scholar
• Lu J, Zhang K, Chen S, et al. Grape seed extract inhibits VEGF expression via reducing protein expression. Carcinogenesis. 2009;30:636–644.
   PubMed Web of Science ®Google Scholar
• Arany Z, Foo SY, Ma Y, et al. HIF-independent regulation of VEGF and angiogenesis by the transcriptional coactivator . Nature. 2008;451:1008–1012.
   PubMed Web of Science ®Google Scholar
• Tang M, Chen M, Li Q. Paeoniflorin ameliorates chronic stress-induced depression-like behavior in mice model by affecting ERK1/2 pathway. Bioengineered. 2021;12:11329–11341.
   PubMed Web of Science ®Google Scholar
• Zhang L, Wei W. Anti-inflammatory and immunoregulatory effects of paeoniflorin and total glucosides of paeony. Pharmacol Ther. 2020;207:107452.
   PubMed Web of Science ®Google Scholar
• Wang J, Lv P. Chrysophanol inhibits the osteoglycin/mTOR and activates NF2 signaling pathways to reduce viability and proliferation of malignant meningioma cells. Bioengineered. 2021;12:755–762.
   PubMed Web of Science ®Google Scholar
• Meneghelli C, Joaquim LS, Félix GL, et al. Southern Brazilian autumnal propolis shows anti-angiogenic activity: an in vitro and in vivo study. Microvasc Res. 2013;88:1–11.
   PubMed Web of Science ®Google Scholar
• Gan H, Xu X, Bai Y. Trametes robiniophila represses angiogenesis and tumor growth of lung cancer via strengthening let-7d-5p and targeting NAP1L1. Bioengineered. 2022;13:6698–6710.
   PubMed Web of Science ®Google Scholar
• Zhang A, Wang G, Jia L, et al. Exosome-mediated microRNA-138 and vascular endothelial growth factor in endometriosis through inflammation and apoptosis via the nuclear factor-κB signaling pathway. Int J Mol Med. 2019;43:358–370.
   PubMed Web of Science ®Google Scholar
• Grada A, Otero-Vinas M, Prieto-Castrillo F, et al. Research techniques made simple: analysis of collective cell migration using the wound healing assay. J Invest Dermatol. 2017;137:e11–e6.
   PubMed Web of Science ®Google Scholar
• Wang Z, Liu A, Zhang H, et al. Inhibition of retinal neovascularization by VEGF siRNA delivered via bioreducible lipid-like nanoparticles. Graefe’s Arch Clin Exp Ophthalmol. 2020;258:2407–2418.
   PubMed Web of Science ®Google Scholar
• Ma Y, Hao H, Xie J, et al. ROSE: a retinal OCT-Angiography vessel segmentation dataset and new model. IEEE Trans Med Imaging. 2021;40:928–939.
   PubMed Web of Science ®Google Scholar
• Szliszka E, Czuba ZP, Domino M, et al. Ethanolic extract of propolis (EEP) enhances the apoptosis- inducing potential of TRAIL in cancer cells. Molecules. 2009;14:738–754.
   PubMed Web of Science ®Google Scholar
• Benz PM, Ding Y, Stingl H, et al. AKAP12 deficiency impairs VEGF-induced endothelial cell migration and sprouting. Acta Physiol (Oxf). 2020;228:e13325.
   PubMed Web of Science ®Google Scholar
• Song S, Xiao X, Guo D, et al. Protective effects of paeoniflorin against AOPP-induced oxidative injury in HUVECs by blocking the ROS-HIF-1α/VEGF pathway. Phytomedicine. 2017;34:115–126.
   PubMed Web of Science ®Google Scholar
• Zhang Z, Yao L, Yang J, et al. PI3K/Akt and HIF‑1 signaling pathway in hypoxia‑ischemia (Review). Mol Med Rep. 2018;18:3547–3554.
   PubMed Web of Science ®Google Scholar
• Feng J, Zhan J, Ma S. LRG1 promotes hypoxia-induced cardiomyocyte apoptosis and autophagy by regulating hypoxia-inducible factor-1α. Bioengineered. 2021;12:8897–8907.
   PubMed Web of Science ®Google Scholar
• Palazon A, Tyrakis PA, Macias D, et al. An HIF-1α/VEGF-A axis in cytotoxic T cells regulates tumor progression. Cancer Cell. 2017;32:669–83.e5.
   PubMed Web of Science ®Google Scholar
• Wu X, Liu S, Hu Z, et al. Enriched housing promotes post-stroke neurogenesis through calpain 1-STAT3/HIF-1α/VEGF signaling. Brain Res Bull. 2018;139:133–143.
   PubMed Web of Science ®Google Scholar