Interleukin-17A attenuates photoreceptor cell apoptosis in streptozotocin-induced diabetic mouse model

References

• Steinmetz JD, Bourne RRA, Briant PS. GBD 2019 Blindness and Vision Impairment Collaborators, Vision Loss Expert Group of the Global Burden of Disease Study. Causes of blindness and vision impairment in 2020 and trends over 30 years, and prevalence of avoidable blindness in relation to VISION 2020: the right to sight: an analysis for the global burden of disease study. Lancet Glob Health. 2021;9:e144–e160.
   PubMed Web of Science ®Google Scholar
• Sergeys J, Etienne I, Van Hove I, et al. Longitudinal in vivo characterization of the streptozotocin-induced diabetic mouse model: focus on early inner retinal responses. Invest Ophthalmol Vis Sci. 2019;60:807–822.
   PubMed Web of Science ®Google Scholar
• Ortiz G, Lopez ES, Salica JP, et al. Alpha-1-antitrypsin ameliorates inflammation and neurodegeneration in the diabetic mouse retina. Exp Eye Res. 2018;174:29–39.
   PubMed Web of Science ®Google Scholar
• Sohn EH, van Dijk HW, Jiao C, et al. Retinal neurodegeneration may precede microvascular changes characteristic of diabetic retinopathy in diabetes mellitus. Proc Natl Acad Sci U S A. 2016;113:E2655–64.
   PubMed Web of Science ®Google Scholar
• Jindal V. Neurodegeneration as a primary change and role of neuroprotection in diabetic retinopathy. Mol Neurobiol. 2015;51:878–884.
   PubMed Web of Science ®Google Scholar
• Zhang H, Liang L, Huang R, et al. Comparison of inflammatory cytokines levels in the aqueous humor with diabetic retinopathy. Int Ophthalmol. 2020;40:2763–2769.
   PubMed Web of Science ®Google Scholar
• Feng S, Yu H, Yu Y, et al. Levels of inflammatory cytokines IL-1beta, IL-6, IL-8, IL-17A, and TNF-alpha in aqueous humour of patients with diabetic retinopathy. J Diabetes Res. 2018;2018:8546423.
   PubMed Web of Science ®Google Scholar
• Chen H, Ren X, Liao N, et al. Th17 cell frequency and IL-17A concentrations in peripheral blood mononuclear cells and vitreous fluid from patients with diabetic retinopathy. J Int Med Res. 2016;44:1403–1413.
   PubMed Web of Science ®Google Scholar
• Takeuchi M, Sato T, Sakurai Y, et al. Association between aqueous humor and vitreous fluid levels of Th17 cell-related cytokines in patients with proliferative diabetic retinopathy. PLoS One. 2017;12:e0178230.
   PubMed Web of Science ®Google Scholar
• Sigurdardottir S, Zapadka TE, Lindstrom SI, et al. Diabetes-mediated IL-17A enhances retinal inflammation, oxidative stress, and vascular permeability. Cell Immunol. 2019;341:103921.
   PubMed Web of Science ®Google Scholar
• Qiu AW, Liu QH, Wang JL. Blocking IL-17A alleviates diabetic retinopathy in rodents. Cell Physiol Biochem. 2017;41:960–972.
   PubMed Web of Science ®Google Scholar
• Qiu AW, Bian Z, Mao PA, et al. IL-17A exacerbates diabetic retinopathy by impairing Muller cell function via Act1 signaling. Exp Mol Med. 2016;48:e280.
   PubMed Web of Science ®Google Scholar
• Li N, Gao S, Wang J, et al. Anti-apoptotic effect of interleukin-17 in a mouse model of oxygen-induced retinopathy. Exp Eye Res. 2019;187:107743.
   PubMed Web of Science ®Google Scholar
• Kezic JM, Glant TT, Rosenbaum JT, et al. Neutralization of IL-17 ameliorates uveitis but damages photoreceptors in a murine model of spondyloarthritis. Arthritis Res Ther. 2012;14:R18.
   PubMed Web of Science ®Google Scholar
• Su L, Ji J, Bian J, et al. Tacrolimus (FK506) prevents early retinal neovascularization in streptozotocin-induced diabetic mice. Int Immunopharmacol. 2012;14:606–612.
   PubMed Web of Science ®Google Scholar
• Kubota S, Ozawa Y, Kurihara T, et al. Roles of AMP-activated protein kinase in diabetes-induced retinal inflammation. Invest Ophthalmol Vis Sci. 2011;52:9142–9148.
   PubMed Web of Science ®Google Scholar
• Li N, Zhu Y, Wang J, et al. Muller cells derived neurotrophin-3 inhibits hypoxia-induced photoreceptor apoptosis via the TrkC/ERK pathway. Cytotechnology. 2020;72:47–56.
   PubMed Web of Science ®Google Scholar
• Carter-Dawson LD, LaVail MM. Rods and cones in the mouse retina. I. Structural analysis using light and electron microscopy. J Comp Neurol. 1979;188:245–262.
   PubMed Web of Science ®Google Scholar
• Arroba AI, Mazzeo A, Cazzoni D, et al. Somatostatin protects photoreceptor cells against high glucose-induced apoptosis. Mol Vis. 2016;22:1522–1531.
   PubMed Web of Science ®Google Scholar
• Seigel GM, Lupien SB, Campbell LM, et al. Systemic IGF-I treatment inhibits cell death in diabetic rat retina. J Diabetes Complications. 2006;20:196–204.
   PubMed Web of Science ®Google Scholar
• Park SH, Park JW, Park SJ, et al. Apoptotic death of photoreceptors in the streptozotocin-induced diabetic rat retina. Diabetologia. 2003;46:1260–1268.
   PubMed Web of Science ®Google Scholar
• Boss JD, Singh PK, Pandya HK, et al. Assessment of neurotrophins and inflammatory mediators in vitreous of patients with diabetic retinopathy. Invest Ophthalmol Vis Sci. 2017;58:5594–5603.
   PubMed Web of Science ®Google Scholar
• Oku H, Ikeda T, Honma Y, et al. Gene expression of neurotrophins and their high-affinity Trk receptors in cultured human Muller cells. Ophthalmic Res. 2002;34:38–42.
   PubMed Web of Science ®Google Scholar
• Shen W, Zhu L, Lee SR, et al. Involvement of NT3 and P75(NTR) in photoreceptor degeneration following selective Muller cell ablation. J Neuroinflammation. 2013;10:137.
   PubMed Web of Science ®Google Scholar
• Qiu AW, Huang DR, Li B, et al. IL-17A injury to retinal ganglion cells is mediated by retinal Muller cells in diabetic retinopathy. Cell Death Dis. 2021;12:1057.
   PubMed Web of Science ®Google Scholar
• Chen X, Yu X, Li X, et al. MiR-126 targets IL-17A to enhance proliferation and inhibit apoptosis in high-glucose-induced human retinal endothelial cells. Biochem Cell Biol. 2020;98:277–283.
   PubMedGoogle Scholar
• Lindstrom SI, Sigurdardottir S, Zapadka TE, et al. Diabetes induces IL-17A-Act1-FADD-dependent retinal endothelial cell death and capillary degeneration. J Diabetes Complications. 2019;33:668–674.
   PubMed Web of Science ®Google Scholar
• Coughlin BA, Feenstra DJ, Mohr S. Muller cells and diabetic retinopathy. Vision Res. 2017;139:93–100.
   PubMed Web of Science ®Google Scholar
• Bringmann A, Wiedemann P. Muller glial cells in retinal disease. Ophthalmologica. 2012;227:1–19.
   PubMed Web of Science ®Google Scholar
• Harada T, Harada C, Nakayama N, et al. Modification of glial-neuronal cell interactions prevents photoreceptor apoptosis during light-induced retinal degeneration. Neuron. 2000;26:533–541.
   PubMed Web of Science ®Google Scholar
• Llamosas MM, Cernuda-Cernuda R, Huerta JJ, et al. Neurotrophin receptors expression in the developing mouse retina: an immunohistochemical study. Anat Embryol (Berl). 1997;195:337–344.
   PubMedGoogle Scholar
• Mohamed R, Shanab AY, El RA. Deletion of the neurotrophin receptor p75(NTR) prevents diabetes-induced retinal acellular capillaries in streptozotocin-induced mouse diabetic model, J Diabetes Metab Disord Control. 2017;4. DOI:10.15406/jdmdc.2017.04.00129
   PubMedGoogle Scholar
• Meeker R, Williams K. Dynamic nature of the p75 neurotrophin receptor in response to injury and disease. J Neuroimmune Pharmacol. 2014;9:615–628.
   PubMed Web of Science ®Google Scholar
• Barcelona PF, Sitaras N, Galan A, et al. p75NTR and its ligand ProNGF activate paracrine mechanisms etiological to the vascular, inflammatory, and neurodegenerative pathologies of diabetic retinopathy. J Neurosci. 2016;36:8826–8841.
   PubMed Web of Science ®Google Scholar
• Mysona BA, Al-Gayyar MM, Matragoon S, et al. Modulation of p75(NTR) prevents diabetes- and proNGF-induced retinal inflammation and blood-retina barrier breakdown in mice and rats. Diabetologia. 2013;56:2329–2339.
   PubMed Web of Science ®Google Scholar