Rho GTPase-activating protein 35 suppresses gastric cancer metastasis by regulating cytoskeleton reorganization and epithelial-to-mesenchymal transition

References

• Chen W, Zheng R, Baade PD, et al. Cancer statistics in China, 2015. CA Cancer J Clin. 2016;66(2):115–132.
   PubMed Web of Science ®Google Scholar
• Siegel RL, Miller KD, Jemal A. Cancer statistics, 2019. CA Cancer J Clin. 2019;69(1):7–34.
   PubMed Web of Science ®Google Scholar
• Bisaria A, Hayer A, Garbett D, et al. Membrane-proximal F-actin restricts local membrane protrusions and directs cell migration. Science. 2020;368(6496):1205–1210.
   PubMed Web of Science ®Google Scholar
• Garcia MA, Nelson WJ, Chavez N. Cell–Cell junctions organize structural and signaling networks. Cold Spring Harb Perspect Biol. 2018;10(4):a029181.
   PubMed Web of Science ®Google Scholar
• Feng Y, Wei G, Zhang L, et al. LncRNA DARS-AS1 aggravates the growth and metastasis of hepatocellular carcinoma via regulating the miR-3200-5p-Cytoskeleton associated protein 2 (CKAP2) axis. Bioengineered. 2021;12(1):8217–8232.
   PubMed Web of Science ®Google Scholar
• Gu Y, Tang S, Wang Z, et al. A pan-cancer analysis of the prognostic and immunological role of β-actin (ACTB) in human cancers. Bioengineered. 2021;12(1):6166–6185.
   PubMed Web of Science ®Google Scholar
• Sens P, Plastino J. Membrane tension and cytoskeleton organization in cell motility. J Phys Condens Matter. 2015;27(27):273103.
   PubMed Web of Science ®Google Scholar
• Fife CM, McCarroll JA, Kavallaris M. Movers and shakers: cell cytoskeleton in cancer metastasis. Br J Pharmacol. 2014;171(24):5507–5523.
   PubMed Web of Science ®Google Scholar
• Ji W, Zhang L, Zhu H. GATA binding protein 5 (GATA5) induces Rho GTPase activating protein 9 (ARHGAP9) to inhibit the malignant process of lung adenocarcinoma cells. Bioengineered. 2022;13(2):2878–2888.
   PubMed Web of Science ®Google Scholar
• Sadok A, Marshall CJ. Rho GTPases: masters of cell migration. Small GTPases. 2014;5(4):e29710.
   PubMedGoogle Scholar
• Spiering D, Hodgson L. Dynamics of the Rho-family small GTPases in actin regulation and motility. Cell Adh Migr. 2011;5(2):170–180.
   PubMed Web of Science ®Google Scholar
• Ridley AJ. Rho GTPase signalling in cell migration. Curr Opin Cell Biol. 2015;36:103–112.
   PubMed Web of Science ®Google Scholar
• DiMeo TA, Anderson K, Phadke P, et al. A novel lung metastasis signature links Wnt signaling with cancer cell self-renewal and epithelial-mesenchymal transition in basal-like breast cancer. Cancer Res. 2009;69(13):4135–5364.
   Web of Science ®Google Scholar
• Nauseef JT, Henry MD. Epithelial-to-mesenchymal transition in prostate cancer: paradigm or puzzle? Nat Rev Urol. 2011;8:428–439.
   PubMed Web of Science ®Google Scholar
• Li D, She J, Hu X, et al. The ELF3-regulated lncRNA UBE2CP3 is over-stabilized by RNA-RNA interactions and drives gastric cancer metastasis via miR-138-5p/ITGA2 axis. Oncogene. 2021;40:5403–5415.
   PubMed Web of Science ®Google Scholar
• Li D, Wang J, Zhang M, et al. LncRNA MAGI2-AS3 is regulated by BRD4 and promotes gastric cancer progression via maintaining ZEB1 overexpression by sponging miR-141/200a. Mol Ther Nucleic Acids. 2020;19:109–123.
   PubMedGoogle Scholar
• Li D, Xu M, Wang Z, et al. The EMT-induced lncRNA NR2F1-AS1 positively modulates NR2F1 expression and drives gastric cancer via miR-29a-3p/VAMP7 axis. Cell Death Dis. 2022;13:84.
   PubMed Web of Science ®Google Scholar
• Shang Y, Cai X, Fan D. Roles of epithelial-mesenchymal transition in cancer drug resistance. Curr Cancer Drug Targets. 2013;13:915–929.
   PubMed Web of Science ®Google Scholar
• Lamouille S, Xu J, Derynck R. Molecular mechanisms of epithelial-mesenchymal transition. Nat Rev Mol Cell Biol. 2014;15:178–196.
   PubMed Web of Science ®Google Scholar
• Thiery JP, Sleeman JP. Complex networks orchestrate epithelial-mesenchymal transitions. Nat Rev Mol Cell Biol. 2006;7:131–142.
   PubMed Web of Science ®Google Scholar
• Ridley AJ. Life at the leading edge. Cell. 2011;145:1012–1022.
   PubMed Web of Science ®Google Scholar
• McNiven MA. Breaking away: matrix remodeling from the leading edge. Trends Cell Biol. 2013;23:16–21.
   PubMed Web of Science ®Google Scholar
• Lu G, Tian S, Sun Y, et al. NEK9, a novel effector of IL-6/STAT3, regulates metastasis of gastric cancer by targeting ARHGEF2 phosphorylation. Theranostics. 2021;11:2460–2474.
   PubMed Web of Science ®Google Scholar
• Ouyang H, Luong P, Frodin M, et al. p190A RhoGAP induces CDH1 expression and cooperates with E-cadherin to activate LATS kinases and suppress tumor cell growth. Oncogene. 2020;39:5570–5587.
   PubMed Web of Science ®Google Scholar
• Kusama T, Mukai M, Endo H, et al. Inactivation of Rho GTPases by p190 RhoGAP reduces human pancreatic cancer cell invasion and metastasis. Cancer Sci. 2006;97:848–853.
   PubMed Web of Science ®Google Scholar
• Notsuda H, Sakurada A, Endo C, et al. p190A RhoGAP is involved in EGFR pathways and promotes proliferation, invasion and migration in lung adenocarcinoma cells. Int J Oncol. 2013;43:1569–1577.
   PubMed Web of Science ®Google Scholar
• Shen CH, Chen HY, Lin MS, et al. Breast tumor kinase phosphorylates p190RhoGAP to regulate rho and ras and promote breast carcinoma growth, migration, and invasion. Cancer Res. 2008;68:7779–7787.
   PubMed Web of Science ®Google Scholar
• Bradley WD, Hernandez SE, Settleman J, et al. Integrin signaling through Arg activates p190RhoGAP by promoting its binding to p120RasGAP and recruitment to the membrane. Mol Biol Cell. 2006;17:4827–4836.
   PubMed Web of Science ®Google Scholar
• Jaber Chehayeb R, Stiegler AL, Boggon TJ. Crystal structures of p120RasGAP N-terminal SH2 domain in its apo form and in complex with a p190RhoGAP phosphotyrosine peptide. PLoS One. 2019;14:e0226113.
   PubMed Web of Science ®Google Scholar
• Haskell MD, Nickles AL, Agati JM, et al. Phosphory-lation of p190 on Tyr1105 by c-Src is necessary but not sufficient for EGF-induced actin disassembly in C3H10T1/2 fibroblasts. J Cell Sci. 2001;114:1699–1708.
   PubMed Web of Science ®Google Scholar
• Frank SR, Kollmann CP, Luong P, et al. Hansen, p190 RhoGAP promotes contact inhibition in epithelial cells by repressing YAP activity. J Cell Biol. 2018;217:3183–3201.
   PubMed Web of Science ®Google Scholar
• Sun Q, Cibas SE, Huang H, et al. Induction of entosis by epithelial cadherin expression. Cell Res. 2014;24:1288–1298.
   PubMed Web of Science ®Google Scholar