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Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration Volume 17, 2016 - Issue 7-8
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Research Article

The role of the FTD-ALS associated C9orf72 expansion in suicide victims

Eino SoljeInstitute of Clinical Medicine – Neurology, University of Eastern Finland, Yliopistonranta, Kuopio, Finland,
,
Pirkko RiipinenDepartment of Psychiatry, Institute of Clinical Medicine, University of Oulu, Peltolantie 17, Oulu, Finland,
,
Seppo HelisalmiInstitute of Clinical Medicine – Neurology, University of Eastern Finland, Yliopistonranta, Kuopio, Finland,
,
Terttu SärkiojaNational Institute for Health and Welfare, Aapistie 1, Oulu, Finland,
,
Marjo LaitinenInstitute of Clinical Medicine – Neurology, University of Eastern Finland, Yliopistonranta, Kuopio, Finland, ;Department of Neurology, Kuopio University Hospital, Puijonlaaksontie 2, Kuopio, Finland,
,
Mikko HiltunenInstitute of Clinical Medicine – Neurology, University of Eastern Finland, Yliopistonranta, Kuopio, Finland, ;Department of Neurology, Kuopio University Hospital, Puijonlaaksontie 2, Kuopio, Finland, ;Institute of Biomedicine, University of Eastern Finland, Yliopistonranta 1, Kuopio, Finland, and
,
Helinä HakkoDepartment of Psychiatry, Oulu University Hospital, Peltolantie 17, Oulu, Finland
&
Anne M. RemesInstitute of Clinical Medicine – Neurology, University of Eastern Finland, Yliopistonranta, Kuopio, Finland, ;Department of Neurology, Kuopio University Hospital, Puijonlaaksontie 2, Kuopio, Finland, Correspondence[email protected]
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Pages 589-592 | Received 10 Mar 2016, Accepted 13 May 2016, Published online: 08 Jul 2016

References

  • Mann JJ. Neurobiology of suicidal behaviour. Nat Rev Neurosci. 2003;4:819–28.
  • Hawton K, van Heeringen K. Suicide. Lancet. 2009;373:1372–81.
  • Erlangsen A, Zarit SH, Conwell Y. Hospital-diagnosed dementia and suicide: a longitudinal study using prospective, nationwide register data. Am J Geriatr Psychiatry. 2008;16:220–8.
  • Fonseca L, Duarte J, Machado A, Sotirpoulos I, Lima C, Sousa N. Suicidal behaviour in frontotemporal dementia patients: a retrospective study. Int J Geriatr Psychiatry. 2014;29:217–18.
  • DeJesus-Hernandez M, Mackenzie IR, Boeve BF, Boxer AL, Baker M, Rutherford NJ, et al. Expanded GGGGCC hexanucleotide repeat in non-coding region of C9orf72 causes chromosome 9p-linked FTD and ALS. Neuron. 2011;72:245–56.
  • Renton AE, Majounie E, Waite A, Simon-Sanchez J, Rollinson S, Gibbs JR, et al. A hexanucleotide repeat expansion in C9orf72 is the cause of chromosome 9p21-linked ALS-FTD. Neuron. 2011;72:257–68.
  • Synofzik M, Biskup S, Leyhe T, Reimold M, Fallgatter AJ, Metzger F. Suicide attempt as the presenting symptom of C9orf72 dementia. Am J Psychiatry. 2012;169:1211–13.
  • Majounie E, Renton AE, Mok K, Dopper EG, Waite A, Rollinson S, et al. Frequency of the C9orf72 hexanucleotide repeat expansion in patients with amyotrophic lateral sclerosis and frontotemporal dementia: a cross-sectional study. Lancet Neurol. 2012;11:323–30.
  • Rascovsky K, Hodges JR, Kipps CM, Johnson JK, Seeley WW, Mendez MF, et al. Diagnostic criteria for the behavioural variant of frontotemporal dementia (bvFTD): current limitations and future directions. Alzheimer Dis Assoc Disord. 2007;21:S14–18.
  • Solje E, Aaltokallio H, Koivumaa-Honkanen H, Suhonen NM, Moilanen V, Kiviharju A, et al. The phenotype of the C9orf72 Expansion Carriers According to Revised Criteria for bvFTD. PLoS One 2015;10:e0131817.
  • Snowden JS, Rollinson S, Thompson JC, Harris JM, Stopford CL, Richardson AM, et al. Distinct clinical and pathological characteristics of frontotemporal dementia associated with C9orf72 mutations. Brain. 2012;135:693–708.
  • Alberici A, Cottini E, Cosseddu M, Borroni B, Padovani A. Suicide risk in frontotemporal lobe degeneration: to be considered, to be prevented. Alzheimer Dis Assoc Disord. 2012;26:194–6.
  • Mendez MF, Bagert BA, Edwards-Lee T. Self-injurous behavior in frontotemporal dementia. Neurocase. 1997;3:231–6.
  • Furczyk K, Schutova B, Michel TM, Thome J, Buttner A. The neurobiology of suicide: a review of post mortem studies. J Mol Psychiatry. 2013;1:2. doi: 10.1186/2049-9256-1-2.
  • Pandey GN. Biological basis of suicide and suicidal behaviour. Bipolar Disord. 2013;15:52–41.
  • Lawrence D, Almeida OP, Hulse GK, Jablensky AV, Holman CD. Suicide and attempted suicide among older adults in Western Australia. Psychol Med. 2000;30:813–21.
  • Cipriani G, Lucetti C, Danti S, Carlesi C, Nuti A. Violent and criminal manifestations in dementia patients. Geriatr Gerontol Int. 2016;16:541–9.
  • Cho SE, Na KS, Cho SJ, Im JS, Kang SG. Geographical and temporal variations in the prevalence of mental disorders in suicide: Systematic review and meta-analysis. J Affect Disord. 2016;190:704–13.

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