The relationship between ventilatory function and cognitive and behavioral impairment in ALS

References

• Chiò A, Ilardi A, Cammarosano S, Moglia C, Montuschi A, Calvo A. Neurobehavioral dysfunction in ALS has a negative effect on outcome and use of PEG and NIV. Neurology. 2012;78:1085–9.
   PubMed Web of Science ®Google Scholar
• Govaarts R, Beeldman E, Kampelmacher MJ, van Tol MJ, van den Berg LH, van der Kooi AJ, et al. The frontotemporal syndrome of ALS is associated with poor survival. J Neurol. 2016;263:2476–83.
   PubMed Web of Science ®Google Scholar
• Ringholz GM, Appel SH, Bradshaw M, Cooke NA, Mosnik DM, Schulz PE. Prevalence and patterns of cognitive impairment in sporadic ALS. Neurology. 2005;65:586–90.
   PubMed Web of Science ®Google Scholar
• Wilson CM, Grace GM, Munoz DG, He BP, Strong MJ. Cognitive impairment in sporadic ALS: a pathologic continuum underlying a multisystem disorder. Neurology. 2001;57:651–7.
   PubMed Web of Science ®Google Scholar
• Lowe J. New pathological findings in amyotrophic lateral sclerosis. J Neurol Sci. 1994;124:38–51.
   PubMed Web of Science ®Google Scholar
• Woolley SC, York MK, Moore DH, Strutt AM, Murphy J, Schulz PE, et al. Detecting frontotemporal dysfunction in ALS: utility of the ALS Cognitive Behavioral Screen (ALS-CBS). Amyotroph Lateral Scler. 2010;11:303–11.
   PubMed Web of Science ®Google Scholar
• Strutt AM, Palcic J, Wager JG, Titus C, Macadam C, Brown J, et al. Cognition, behavior, and respiratory function in amyotrophic lateral sclerosis. ISRN Neurol. 2012;2012:912123.
   PubMedGoogle Scholar
• Huynh W, Sharplin LE, Caga J, Highton-Williamson E, Kiernan MC. Respiratory function and cognitive profile in amyotrophic lateral sclerosis. Eur J Neurol. 2020;27:685–91.
   PubMed Web of Science ®Google Scholar
• Kim S-M, Kim H, Lee J-S, Park KS, Jeon GS, Shon J, et al. Intermittent hypoxia can aggravate motor neuronal loss and cognitive dysfunction in ALS mice. PLoS One. 2013;8:e81808.
   PubMed Web of Science ®Google Scholar
• Newsom-Davis IC, Lyall RA, Leigh PN, Moxham J, Goldstein LH. The effect of non-invasive positive pressure ventilation (NIPPV) on cognitive function in amyotrophic lateral sclerosis (ALS): a prospective study. J Neurol Neurosurg Psychiatry. 2001;71:482–7.
   PubMed Web of Science ®Google Scholar
• Traxinger K, Kelly C, Johnson BA, Lyles RH, Glass JD. Prognosis and epidemiology of amyotrophic lateral sclerosis: analysis of a clinic population, 1997–2011. Neurol Clin Pract. 2013;3:313–20.
   PubMedGoogle Scholar
• Hankinson JL, Odencrantz JR, Fedan KB. Spirometric reference values from a sample of the general U.S. population. Am J Respir Crit Care Med. 1999;159:179–87.
   PubMed Web of Science ®Google Scholar
• Park S-Y, Kim S-M, Sung J-J, Lee K-M, Park K-S, Kim S-Y, et al. Nocturnal hypoxia in ALS is related to cognitive dysfunction and can occur as clusters of desaturations. PLoS One. 2013;8:e75324.
   PubMed Web of Science ®Google Scholar
• Altman DG, Royston P. The cost of dichotomising continuous variables. BMJ. 2006;332:1080.
   PubMed Web of Science ®Google Scholar
• Portet F, Cadilhac C, Touchon J, Camu W. Cognitive impairment in motor neuron disease with bulbar onset. Amyotroph Lateral Scler Other Motor Neuron Disord. 2001;2:23–9.
   PubMed Web of Science ®Google Scholar
• Hadjikoutis S, Wiles CM. Respiratory complications related to bulbar dysfunction in motor neuron disease. Acta Neurol Scand. 2001;103:207–13.
   PubMed Web of Science ®Google Scholar
• Strong MJ, Grace GM, Orange JB, Leeper HA, Menon RS, Aere C. A prospective study of cognitive impairment in ALS. Neurology. 1999;53:1665–70.
   PubMed Web of Science ®Google Scholar
• Perrin C, Unterborn JN, Ambrosio CD, Hill NS. Pulmonary complications of chronic neuromuscular diseases and their management. Muscle Nerve. 2004;29:5–27.
   PubMed Web of Science ®Google Scholar
• Olaithe M, Bucks RS, Hillman DR, Eastwood PR. Cognitive deficits in obstructive sleep apnea: insights from a meta-review and comparison with deficits observed in COPD, insomnia, and sleep deprivation. Sleep Med Rev. 2018;38:39–49.
   PubMed Web of Science ®Google Scholar
• Saunamäki T, Jehkonen M. A review of executive functions in obstructive sleep apnea syndrome. Acta Neurol Scand. 2007;115:1–11.
   PubMed Web of Science ®Google Scholar
• Ji W, Zhang Y, Ge RL, Wan Y, Liu J. NMDA receptor-mediated excitotoxicity is involved in neuronal apoptosis and cognitive impairment induced by chronic hypobaric hypoxia exposure at high altitude. High Alt Med Biol. 2020;22:45–57.
   PubMed Web of Science ®Google Scholar
• Ren H, Qiu W, Lu Q, Peng C, Ding Y, Zhu B, et al. Potential contribution of microRNA-125b targeting p38MAPK to relieving intermittent hypoxia-induced dementia of rat models. J Clin Neurosci. 2019;64:234–41.
   PubMed Web of Science ®Google Scholar
• Lladó J, Tolosa L, Olmos G. Cellular and molecular mechanisms involved in the neuroprotective effects of VEGF on motoneurons. Front Cell Neurosci. 2013;7:181.
   PubMed Web of Science ®Google Scholar
• Bendotti C, Atzori C, Piva R, Tortarolo M, Strong MJ, DeBiasi S, et al. Activated p38MAPK is a novel component of the intracellular inclusions found in human amyotrophic lateral sclerosis and mutant SOD1 transgenic mice. J Neuropathol Exp Neurol. 2004;63:113–9.
   PubMed Web of Science ®Google Scholar
• Bendotti C, Bao Cutrona M, Cheroni C, Grignaschi G, Lo Coco D, Peviani M, et al. Inter- and intracellular signaling in amyotrophic lateral sclerosis: role of p38 mitogen-activated protein kinase. Neurodegener Dis. 2005;2:128–34.
   PubMed Web of Science ®Google Scholar
• Tolosa L, Mir M, Olmos G, Lladó J. Vascular endothelial growth factor protects motoneurons from serum deprivation-induced cell death through phosphatidylinositol 3-kinase-mediated p38 mitogen-activated protein kinase inhibition. Neuroscience. 2009;158:1348–55.
   PubMed Web of Science ®Google Scholar
• Xu L, Guo YS, Liu YL, Wu SY, Yang C, Wu DX, et al. Oxidative stress in immune-mediated motoneuron destruction. Brain Res. 2009;1302:225–32.
   PubMed Web of Science ®Google Scholar
• Heath PR, Shaw PJ. Update on the glutamatergic neurotransmitter system and the role of excitotoxicity in amyotrophic lateral sclerosis. Muscle Nerve. 2002;26:438–58.
   PubMed Web of Science ®Google Scholar
• King AE, Woodhouse A, Kirkcaldie MT, Vickers JC. Excitotoxicity in ALS: overstimulation, or overreaction? Exp Neurol. 2016;275:162–71.
   PubMed Web of Science ®Google Scholar
• Jackson CE, Rosenfeld J, Moore DH, Bryan WW, Barohn RJ, Wrench M, et al. A preliminary evaluation of a prospective study of pulmonary function studies and symptoms of hypoventilation in ALS/MND patients. J Neurol Sci. 2001;191:75–8.
   PubMed Web of Science ®Google Scholar
• Miller RG, Jackson CE, Kasarskis EJ, England JD, Forshew D, Johnston W, et al. Practice parameter update: the care of the patient with amyotrophic lateral sclerosis: multidisciplinary care, symptom management, and cognitive/behavioral impairment (an evidence-based review): report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology. 2009;73:1227–33.
   PubMed Web of Science ®Google Scholar
• Bourke SC, Bullock RE, Williams TL, Shaw PJ, Gibson GJ. Noninvasive ventilation in ALS: indications and effect on quality of life. Neurology. 2003;61:171–7.
   PubMed Web of Science ®Google Scholar
• Bourke SC, Tomlinson M, Williams TL, Bullock RE, Shaw PJ, Gibson GJ. Effects of non-invasive ventilation on survival and quality of life in patients with amyotrophic lateral sclerosis: a randomised controlled trial. Lancet Neurol. 2006;5:140–7.
   PubMed Web of Science ®Google Scholar
• Allen S, Yeung P, Janczewski M, Siddique N. Predicting inadequate spirometry technique and the use of FEV1/FEV3 as an alternative to FEV1/FVC for patients with mild cognitive impairment. Clin Respir J. 2008;2:208–13.
   PubMed Web of Science ®Google Scholar
• Carvalhaes-Neto N, Lorino H, Gallinari C, Escolano S, Mallet A, Zerah F, et al. Cognitive function and assessment of lung function in the elderly. Am J Respir Crit Care Med. 1995;152:1611–5.
   PubMed Web of Science ®Google Scholar