Geographical clusters of amyotrophic lateral sclerosis and the Bradford Hill criteria

References

• van Es MA, Hardiman O, Chio A, Al-Chalabi A, Pasterkamp RJ, Veldink JH, et al. Amyotrophic lateral sclerosis. Lancet. 2017;390:2084–98.
   PubMed Web of Science ®Google Scholar
• Beghi E, Logroscino G, Chiò A, Hardiman O, Mitchell D, Swingler R, et al.; EURALS Consortium. The epidemiology of ALS and the role of population-based registries. Biochim Biophys Acta. 2006;1762:1150–7.
   PubMed Web of Science ®Google Scholar
• Pupillo E, Messina P, Logroscino G, Beghi E.; SLALOM Group. Long-term survival in amyotrophic lateral sclerosis: a population-based study. Ann Neurol. 2014;75:287–97.
   PubMed Web of Science ®Google Scholar
• Belbasis L, Bellou V, Evangelou E. Environmental risk factors and amyotrophic lateral sclerosis: an umbrella review and critical assessment of current evidence from systematic reviews and meta-analyses of observational studies. Neuroepidemiology 2016;46:96–105.
   PubMed Web of Science ®Google Scholar
• Chia R, Chio A, Traynor BJ. Novel genes associated with amyotrophic lateral sclerosis: diagnostic and clinical implications. Lancet Neurol. 2018;17:94–102.
   PubMed Web of Science ®Google Scholar
• Al-Chalabi A, Hardiman O. The epidemiology of ALS: a conspiracy of genes, environment and time. Nat Rev Neurol. 2013;9:617–28.
   PubMed Web of Science ®Google Scholar
• Wartenberg D. Investigating disease clusters: why, when and how? J R Stat Soc Series A. 2001;164:13–22.
   Web of Science ®Google Scholar
• Caller TA, Field NC, Chipman JW, Shi X, Harris BT, Stommel EW. Spatial clustering of amyotrophic lateral sclerosis and the potential role of BMAA. Amyotroph Lateral Scler. 2012;13:25–32.
   PubMed Web of Science ®Google Scholar
• Fedak KM, Bernal A, Capshaw ZA, Gross S. Applying the Bradford Hill criteria in the 21st century: how data integration has changed causal inference in molecular epidemiology. Emerg Themes Epidemiol. 2015;12:14.
   PubMed Web of Science ®Google Scholar
• Hill AB. The environment and disease: association or causation? 1965 J R Soc Med. 2015;108:32–7.
   PubMed Web of Science ®Google Scholar
• Marin B, Boumediene F, Logroscino G, Couratier P, Babron MC, Leutenegger AL, et al. Variation in worldwide incidence of amyotrophic lateral sclerosis: a meta-analysis. Int J Epidemiol. 2017;46:57–74.
   PubMed Web of Science ®Google Scholar
• Spencer PS, Lagrange E, Camu W. ALS and environment: Clues from spatial clustering? Rev Neurol). 2019;175:652–63.
   PubMedGoogle Scholar
• Reed DM, Brody JA. Amyotrophic lateral sclerosis and parkinsonism-dementia on Guam, 1945-1972. I. Descriptive epidemiology. Am J Epidemiol. 1975;101:287–301.
   PubMed Web of Science ®Google Scholar
• Spencer PS, Nunn PB, Hugon J, Ludolph AC, Ross SM, Roy DN, et al. Guam amyotrophic lateral sclerosis-parkinsonism-dementia linked to a plant excitant neurotoxin. Science. 1987;237:517–22.
   PubMed Web of Science ®Google Scholar
• Cox PA, Sacks OW. Cycad neurotoxins, consumption of flying foxes, and ALS-PDC disease in Guam. Neurology 2002;58:956–9.
   PubMed Web of Science ®Google Scholar
• Zimmerman H. Monthly report to the medical officer in command. United States Navy Medical Research Unit 1945.
   Google Scholar
• Kurland LT, Mulder DW. Epidemiologic investigations of amyotrophic lateral sclerosis. I. Preliminary report on geographic distribution and special reference to the Mariana Islands, including clinical and pathologic observations. Neurology 1954;4:438–48.
   PubMed Web of Science ®Google Scholar
• Kokubo Y, Kuzuhara S, Narita Y. Geographical distribution of amyotrophic lateral sclerosis with neurofibrillary tangles in the Kii Peninsula of Japan. J Neurol. 2000;247:850–2.
   PubMed Web of Science ®Google Scholar
• Spencer PS, Kisby GE, Ludolph AC. Slow toxins, biologic markers, and long-latency neurodegenerative disease in the western Pacific region. Neurology 1991;41:62–8.
   PubMed Web of Science ®Google Scholar
• Caller TA, Doolin JW, Haney JF, Murby AJ, West KG, Farrar HE, et al. A cluster of amyotrophic lateral sclerosis in New Hampshire: a possible role for toxic cyanobacteria blooms. Amyotroph Lateral Scler. 2009;10(Suppl 2):101–8.
   PubMedGoogle Scholar
• Banack SA, Caller T, Henegan P, Haney J, Murby A, Metcalf JS, et al. Detection of cyanotoxins, β-N-methylamino-L-alanine and microcystins, from a lake surrounded by cases of amyotrophic lateral sclerosis. Toxins (Basel). 2015;7:322–36.
   PubMed Web of Science ®Google Scholar
• Horner RD, Kamins KG, Feussner JR, Grambow SC, Hoff-Lindquist J, Harati Y, et al. Occurrence of amyotrophic lateral sclerosis among Gulf War veterans. Neurology 2003;61:742–9.
   PubMed Web of Science ®Google Scholar
• Cox PA, Richer R, Metcalf JS, Banack SA, Codd GA, Bradley WG. Cyanobacteria and BMAA exposure from desert dust: a possible link to sporadic ALS among Gulf War veterans. Amyotroph Lateral Scler. 2009;10(Suppl 2):109–17.
   PubMedGoogle Scholar
• Coffman CJ, Horner RD, Grambow SC, Lindquist J.; VA Cooperative Studies Program Project #500. Estimating the occurrence of amyotrophic lateral sclerosis among Gulf War (1990-1991) veterans using capture-recapture methods. Neuroepidemiology 2005;24:141–50.
   PubMed Web of Science ®Google Scholar
• Miranda ML, Alicia Overstreet Galeano M, Tassone E, Allen KD, Horner RD. Spatial analysis of the etiology of amyotrophic lateral sclerosis among 1991 Gulf War veterans. Neurotoxicology 2008;29:964–70.
   PubMed Web of Science ®Google Scholar
• Masseret E, Banack S, Boumediene F, Abadie E, Brient L, Pernet F, et al.; French Network on ALS Clusters Detection and Investigation. Dietary BMAA exposure in an amyotrophic lateral sclerosis cluster from southern France. PloS One. 2013;8:e83406.
   PubMed Web of Science ®Google Scholar
• Caller TA, Chipman JW, Field NC, Stommel EW. Spatial analysis of amyotrophic lateral sclerosis in Northern New England, USA, 1997-2009. Muscle Nerve. 2013;48:235–41.
   PubMed Web of Science ®Google Scholar
• Torbick N, Hession S, Stommel E, Caller T. Mapping amyotrophic lateral sclerosis lake risk factors across northern New England. Int J Health Geogr. 2014;13:1.
   PubMed Web of Science ®Google Scholar
• Turabelidze G, Zhu BP, Schootman M, Malone JL, Horowitz S, Weidinger J, et al. An epidemiologic investigation of amyotrophic lateral sclerosis in Jefferson County, Missouri, 1998-2002. Neurotoxicology 2008;29:81–6.
   PubMed Web of Science ®Google Scholar
• De Benedetti S, Lucchini G, Del Bo C, Deon V, Marocchi A, Penco S, et al. Blood trace metals in a sporadic amyotrophic lateral sclerosis geographical cluster. Biometals. 2017;30:355–65.
   PubMed Web of Science ®Google Scholar
• Riancho J, Bosque-Varela P, Perez-Pereda S, Povedano M, de Munaín AL, Santurtun A. The increasing importance of environmental conditions in amyotrophic lateral sclerosis. Int J Biometeorol. 2018;62:1361–74.
   PubMed Web of Science ®Google Scholar
• Johnson FO, Atchison WD. The role of environmental mercury, lead and pesticide exposure in development of amyotrophic lateral sclerosis. Neurotoxicology 2009;30:761–5.
   PubMed Web of Science ®Google Scholar
• Kihira T, Yoshida S, Kondo T, Iwai K, Wada S, Morinaga S, et al. An increase in ALS incidence on the Kii Peninsula, 1960-2009: a possible link to change in drinking water source. Amyotroph Lateral Scler. 2012;13:347–50.
   PubMed Web of Science ®Google Scholar
• Garruto RM, Gajdusek DC, Chen KM. Amyotrophic lateral sclerosis and parkinsonism-dementia among Filipino migrants to Guam. Ann Neurol. 1981;10:341–50.
   PubMed Web of Science ®Google Scholar
• Araki S, Iwahashi Y, Kuroiwa Y. Epidemiological study of amyotrophic lateral sclerosis and allied disorders in the Kii Peninsula (Japan). J Neurol Sci. 1967;4:279–87.
   PubMed Web of Science ®Google Scholar
• Garruto RM, Gajdusek C, Chen KM. Amyotrophic lateral sclerosis among Chamorro migrants from Guam. Ann Neurol. 1980;8:612–9.
   PubMed Web of Science ®Google Scholar
• Kilness AW, Hichberg FH. Amyotrophic lateral sclerosis in a high selenium environment. Jama. 1977;237:2843.
   PubMed Web of Science ®Google Scholar
• Garruto RM, Yanagihara R, Gajdusek DC. Disappearance of high-incidence amyotrophic lateral sclerosis and parkinsonism-dementia on Guam. Neurology 1985;35:193–8.
   PubMed Web of Science ®Google Scholar
• De Benedetti S, Gianazza E, Banfi C, Marocchi A, Lunetta C, Penco S, et al. Serum proteome in a sporadic amyotrophic lateral sclerosis geographical cluster. Proteom Clin Appl. 2017;11.
   PubMed Web of Science ®Google Scholar
• Fergani A, Oudart H, Gonzalez De Aguilar JL, Fricker B, René F, Hocquette JF, et al. Increased peripheral lipid clearance in an animal model of amyotrophic lateral sclerosis. J Lipid Res. 2007;48:1571–80.
   PubMed Web of Science ®Google Scholar
• Kim SM, Kim H, Kim JE, Park KS, Sung JJ, Kim SH, et al. Amyotrophic lateral sclerosis is associated with hypolipidemia at the presymptomatic stage in mice. PloS One. 2011;6:e17985.
   PubMed Web of Science ®Google Scholar
• Robberecht W, Philips T. The changing scene of amyotrophic lateral sclerosis. Nat Rev Neurosci. 2013;14:248–64.
   PubMed Web of Science ®Google Scholar
• Ticozzi N, LeClerc AL, Keagle PJ, Glass JD, Wills AM, van Blitterswijk M, et al. Paraoxonase gene mutations in amyotrophic lateral sclerosis. Ann Neurol. 2010;68:102–7.
   PubMed Web of Science ®Google Scholar
• Rooney J, Heverin M, Vajda A, Crampsie A, Tobin K, Byrne S, et al. An exploratory spatial analysis of ALS incidence in Ireland over 17.5 years (1995-July 2013). PloS One. 2014;9:e96556.
   PubMed Web of Science ®Google Scholar
• Ceroni M, Malaspina A, Poloni TE, Alimonti D, Rognoni F, Habgood J, et al. Clustering of ALS patients in central Italy due to the occurrence of the L84F SOD1 gene mutation. Neurology 1999;53:1064–71.
   PubMed Web of Science ®Google Scholar
• Saeed M, Siddique N, Hung WY, Usacheva E, Liu E, Sufit RL, et al. Paraoxonase cluster polymorphisms are associated with sporadic ALS. Neurology 2006;67:771–6.
   PubMed Web of Science ®Google Scholar
• Valdmanis PN, Kabashi E, Dyck A, Hince P, Lee J, Dion P, et al. Association of paraoxonase gene cluster polymorphisms with ALS in France, Quebec, and Sweden. Neurology 2008;71:514–20.
   PubMed Web of Science ®Google Scholar
• Chen Y, Huang R, Chen K, Song W, Yang Y, Zhao B, et al. Association analysis of PON polymorphisms in sporadic ALS in a Chinese population. Neurobiol Aging. 2012;33:2949.e1–2949.e3.
   PubMed Web of Science ®Google Scholar
• Gunnarsson LG, Lindberg G, Soderfeldt B, Axelson O. Amyotrophic lateral sclerosis in Sweden in relation to occupation. Acta Neurol Scand. 1991;83:394–8.
   PubMed Web of Science ®Google Scholar
• Mitchell JD, Gatrell AC, Al-Hamad A, Davies RB, Batterby G. Geographical epidemiology of residence of patients with motor neuron disease in Lancashire and south Cumbria. J Neurol Neurosurg Psychiatry. 1998;65:842–7.
   PubMed Web of Science ®Google Scholar
• Scott KM, Abhinav K, Stanton BR, Johnston C, Turner MR, Ampong MA, et al. Geographical clustering of amyotrophic lateral sclerosis in South-East England: a population study. Neuroepidemiology 2009;32:81–8.
   PubMed Web of Science ®Google Scholar
• Migliaretti G, Berchialla P, Dalmasso P, Cavallo F, Chio A. Amyotrophic lateral sclerosis in Piedmont (Italy): a Bayesian spatial analysis of the incident cases. Amyotroph Lateral Scler Frontotemporal Degener. 2013;14:58–65.
   PubMed Web of Science ®Google Scholar
• Gunnarsson LG, Lygner PE, Veiga-Cabo J, de Pedro-Cuesta J. An epidemic-like cluster of motor neuron disease in a Swedish county during the period 1973-1984. Neuroepidemiology 1996;15:142–52.
   PubMed Web of Science ®Google Scholar
• Kalfakis N, Vassilopoulos D, Voumvourakis C, Ndjeveleka M, Papageorgiou C. Amyotrophic lateral sclerosis in southern Greece: an epidemiologic study. Neuroepidemiology 1991;10:170–3.
   PubMed Web of Science ®Google Scholar
• Hochberg FH, Bryan JA, 2nd, Whelan MA. Letter: Clustering of amyotrophic lateral sclerosis. Lancet. 1974;1:34.
   PubMed Web of Science ®Google Scholar
• Hyser CL, Kissel JT, Mendell JR. Three cases of amyotrophic lateral sclerosis in a common occupational environment. J Neurol. 1987;234:443–4.
   PubMed Web of Science ®Google Scholar
• Leone M, Chio A, Mortara P, Rosso MG, Schiffer D. Motor neuron disease in the Province of Turin, Italy, 1971-1980. Acta Neurol Scand. 1983;68:316–27.
   PubMed Web of Science ®Google Scholar
• Taylor JA, Davis JP. Evidence for clustering of amyotrophic lateral sclerosis in Wisconsin. J Clin Epidemiol. 1989;42:569–75.
   PubMed Web of Science ®Google Scholar
• Jokelainen M, Palo J. Amyotrophic lateral sclerosis in Finland: birthplaces of patients, parents and grandparents. Acta Neurol Scand. 1980;62:176–9.
   PubMed Web of Science ®Google Scholar
• Gajdusek DC, Salazar AM. Amyotrophic lateral sclerosis and parkinsonian syndromes in high incidence among the Auyu and Jakai people of West New Guinea. Neurology 1982;32:107–26.
   PubMed Web of Science ®Google Scholar
• Sienko DG, Davis JP, Taylor JA, Brooks BR. Amyotrophic lateral sclerosis. A case-control study following detection of a cluster in a small Wisconsin community. Arch Neurol. 1990;47:38–41.
   PubMedGoogle Scholar
• Mitchell JD, Gibson HN, Gatrell A. Amyotrophic lateral sclerosis in Lancashire and South Cumbria, England, 1976-1986. A geographical study. Arch Neurol. 1990;47:875–80.
   PubMedGoogle Scholar
• Melmed C, Krieger C. A cluster of amyotrophic lateral sclerosis. Arch Neurol. 1982;39:595–6.
   PubMedGoogle Scholar
• Betemps EJ, Buncher CR. Birthplace as a risk factor in motor neurone disease and Parkinson's disease. Int J Epidemiol. 1993;22:898–904.
   PubMed Web of Science ®Google Scholar
• Yoshida S, Uebayashi Y, Kihira T, Kohmoto J, Wakayama I, Taguchi S, et al. Epidemiology of motor neuron disease in the Kii Peninsula of Japan, 1989-1993: active or disappearing focus? J Neurol Sci. 1998;155:146–55.
   PubMed Web of Science ®Google Scholar
• Poloni M, Micheli A, Facchetti D, Mai R, Ceriani F, Cattalini C. Conjugal amyotrophic lateral sclerosis: toxic clustering or change? Ital J Neurol Sci. 1997;18:109–12.
   PubMedGoogle Scholar
• Boumédiène F, Druet-Cabanac M, Marin B, Preux P-M, Allée P, Couratier P. Contribution of geolocalisation to neuroepidemiological studies: incidence of ALS and environmental factors in Limousin, France. J Neurol Sci. 2011;309:115–22.
   PubMed Web of Science ®Google Scholar
• Nicoletti A, Vasta R, Venti V, Mostile G, Lo Fermo S, Patti F, et al. The epidemiology of amyotrophic lateral sclerosis in the Mount Etna region: a possible pathogenic role of volcanogenic metals. Eur J Neurol. 2016;23:964–72.
   PubMed Web of Science ®Google Scholar
• Sanders M. Clustering of amyotrophic lateral sclerosis. JAMA 1980;244:435.
   PubMed Web of Science ®Google Scholar
• Bharucha NE, Schoenberg BS, Raven RH, Pickle LW, Byar DP, Mason TJ. Geographic distribution of motor neuron disease and correlation with possible etiologic factors. Neurology 1983;33:911–5.
   PubMed Web of Science ®Google Scholar
• Kamel F, Umbach DM, Bedlack RS, Richards M, Watson M, Alavanja MC, et al. Pesticide exposure and amyotrophic lateral sclerosis. Neurotoxicology 2012;33:457–62.
   PubMed Web of Science ®Google Scholar
• Malek AM, Barchowsky A, Bowser R, Youk A, Talbott EO. Pesticide exposure as a risk factor for amyotrophic lateral sclerosis: a meta-analysis of epidemiological studies: pesticide exposure as a risk factor for ALS. Environ Res. 2012;117:112–9.
   PubMed Web of Science ®Google Scholar
• Vinceti M, Fiore M, Signorelli C, Odone A, Tesauro M, Consonni M, et al. Environmental risk factors for amyotrophic lateral sclerosis: methodological issues in epidemiologic studies. Annali di Igiene: medicina Preventiva e di Comunita 2012;24:407–15.
   PubMedGoogle Scholar
• Sutedja NA, Fischer K, Veldink JH, van der Heijden GJ, Kromhout H, Heederik D, et al. What we truly know about occupation as a risk factor for ALS: a critical and systematic review. Amyotroph Lateral Scler. 2009;10:295–301.
   PubMed Web of Science ®Google Scholar
• Uccelli R, Binazzi A, Altavista P, Belli S, Comba P, Mastrantonio M, et al. Geographic distribution of amyotrophic lateral sclerosis through motor neuron disease mortality data. Eur J Epidemiol. 2007;22:781–90.
   PubMed Web of Science ®Google Scholar
• Sabel CE, Boyle PJ, Loytonen M, Gatrell AC, Jokelainen M, Flowerdew R, et al. Spatial clustering of amyotrophic lateral sclerosis in Finland at place of birth and place of death. Am J Epidemiol. 2003;157:898–905.
   PubMed Web of Science ®Google Scholar
• Doi Y, Yokoyama T, Tango T, Takahashi K, Fujimoto K, Nakano I. Temporal trends and geographic clusters of mortality from amyotrophic lateral sclerosis in Japan, 1995-2004. J Neurol Sci. 2010;298:78–84.
   PubMed Web of Science ®Google Scholar
• Vasta R, Calvo A, Moglia C, Cammarosano S, Manera U, Canosa A, et al. Spatial epidemiology of Amyotrophic Lateral Sclerosis in Piedmont and Aosta Valley, Italy: a population-based cluster analysis. Eur J Neurol. 2018;25:756–61.
   PubMed Web of Science ®Google Scholar
• Noonan CW, White MC, Thurman D, Wong LY. Temporal and geographic variation in United States motor neuron disease mortality, 1969-1998. Neurology 2005;64:1215–21.
   PubMed Web of Science ®Google Scholar
• Corcia P, Jafari-Schluep HF, Lardillier D, Mazyad H, Giraud P, Clavelou P, et al. A clustering of conjugal amyotrophic lateral sclerosis in southeastern France. Arch Neurol. 2003;60:553–7.
   PubMedGoogle Scholar
• Camu W, Cadilhac J, Billiard M. Conjugal amyotrophic lateral sclerosis: a report on two couples from southern France. Neurology 1994;44:547–8.
   PubMed Web of Science ®Google Scholar
• Alonso V, Villaverde-Hueso A, Hens MJ, Morales-Piga A, Abaitua I, de la Paz MP. Increase in motor neuron disease mortality in Spain: temporal and geographical analysis (1990-2005). Amyotroph Lateral Scler. 2011;12:192–8.
   PubMed Web of Science ®Google Scholar
• Lannuzel A, Mecharles S, Tressieres B, Demoly A, Alhendi R, Hedreville-Tablon MA, et al. Clinical varieties and epidemiological aspects of amyotrophic lateral sclerosis in the Caribbean island of Guadeloupe: A new focus of ALS associated with Parkinsonism. Amyotroph Lateral Scler Frontotemporal Degener. 2015;16:216–23.
   PubMed Web of Science ®Google Scholar
• Schwartz GG, Rundquist BC, Simon IJ, Swartz SE. Geographic distributions of motor neuron disease mortality and well water use in U.S. counties. Amyotroph Lateral Scler Frontotemporal Degener. 2017;18:279–83.
   PubMed Web of Science ®Google Scholar
• Okumiya K, Wada T, Fujisawa M, Ishine M, Garcia Del Saz E, Hirata Y, et al. Amyotrophic lateral sclerosis and parkinsonism in Papua, Indonesia: 2001-2012 survey results. BMJ Open. 2014;4:e004353.
   PubMed Web of Science ®Google Scholar
• Murphy M, Quinn S, Young J, Parkin P, Taylor B. Increasing incidence of ALS in Canterbury, New Zealand: a 22-year study. Neurology 2008;71:1889–95.
   PubMed Web of Science ®Google Scholar
• Joensen P. Incidence of amyotrophic lateral sclerosis in the Faroe Islands. Acta Neurol Scand. 2012;126:62–6.
   PubMed Web of Science ®Google Scholar
• Rooney J, Vajda A, Heverin M, Crampsie A, Tobin K, McLaughlin R, et al. No association between soil constituents and amyotrophic lateral sclerosis relative risk in Ireland. Environ Res. 2016;147:102–7.
   PubMed Web of Science ®Google Scholar
• Beghi E, SLALOM Group, Millul A, Micheli A, Vitelli E, Logroscino G. Incidence of ALS in Lombardy, Italy. Neurology 2007;68:141–5.
   PubMed Web of Science ®Google Scholar
• Vazquez MC, Ketzoian C, Legnani C, Rega I, Sanchez N, Perna A, et al. Incidence and prevalence of amyotrophic lateral sclerosis in Uruguay: a population-based study. Neuroepidemiology 2008;30:105–11.
   PubMed Web of Science ®Google Scholar
• Tesauro M, Consonni M, Filippini T, Mazzini L, Pisano F, Chio A, et al. Incidence of amyotrophic lateral sclerosis in the province of Novara, Italy, and possible role of environmental pollution. Amyotroph Lateral Scler Frontotemporal Degener. 2017;18:284–90.
   PubMed Web of Science ®Google Scholar
• Forsgren L, Almay BG, Holmgren G, Wall S. Epidemiology of motor neuron disease in northern Sweden. Acta Neurol Scand. 1983;68:20–9.
   PubMed Web of Science ®Google Scholar
• Proctor SP, Feldman RG, Wolf PA, Brent B, Wartenberg D. A perceived cluster of amyotrophic lateral sclerosis cases in a Massachusetts community. Neuroepidemiology 1992;11:277–81.
   PubMed Web of Science ®Google Scholar
• Mundt DJ, Dell LD, Luippold RS, Sulsky SI, Skillings A, Gross R, et al. Cause-specific mortality among Kelly Air Force Base civilian employees, 1981-2001. J Occup Environ Med. 2002;44:989–96.
   PubMed Web of Science ®Google Scholar
• Demetriou CA, Hadjivasiliou PM, Kleopa KA, Christou YP, Leonidou E, Kyriakides T, et al. Epidemiology of Amyotrophic Lateral Sclerosis in the Republic of Cyprus: A 25-Year Retrospective Study. Neuroepidemiology 2017;48:79–85.
   PubMed Web of Science ®Google Scholar
• Fang F, Valdimarsdottir U, Bellocco R, Ronnevi LO, Sparen P, Fall K, et al. Amyotrophic lateral sclerosis in Sweden, 1991-2005. Arch Neurol. 2009;66:515–9.
   PubMed Web of Science ®Google Scholar
• Uenal H, ALS registry Study Group, Rosenbohm A, Kufeldt J, Weydt P, Goder K, Ludolph A, et al. Incidence and geographical variation of amyotrophic lateral sclerosis (ALS) in Southern Germany-completeness of the ALS registry Swabia. PloS One. 2014;9:e93932.
   PubMed Web of Science ®Google Scholar
• Henry KA, Fagliano J, Jordan HM, Rechtman L, Kaye WE. Geographic Variation of Amyotrophic Lateral Sclerosis Incidence in New Jersey, 2009-2011. Am J Epidemiol. 2015;182:512–9.
   PubMed Web of Science ®Google Scholar
• Hardiman O, Al-Chalabi A, Chio A, Corr EM, Logroscino G, Robberecht W, et al. Amyotrophic lateral sclerosis. Nat Rev Dis Primers. 2017;3:17085.
   PubMed Web of Science ®Google Scholar
• Phillips CV, Goodman KJ. The missed lessons of Sir Austin Bradford Hill. Epidemiol Perspect Innov. 2004;1:3.
   PubMedGoogle Scholar
• Rothman KJ, Greenland S, Lash TL. Modern epidemiology: Lippincott Williams & Wilkins, Philadelphia, USA; 2008.
   Google Scholar
• Longinetti E, Fang F. Epidemiology of amyotrophic lateral sclerosis: an update of recent literature. Curr Opin Neurol. 2019;32:771–6.
   PubMed Web of Science ®Google Scholar
• Jokelainen M. The epidemiology of amyotrophic lateral sclerosis in Finland. A study based on the death certificates of 421 patients. J Neurol Sci. 1976;29:55–63.
   PubMed Web of Science ®Google Scholar
• Gajdusek DC. Motor-neuron disease in natives of New Guinea. N Engl J Med. 1963;268:474–6.
   PubMed Web of Science ®Google Scholar
• Sejvar JJ, Holman RC, Bresee JS, Kochanek KD, Schonberger LB. Amyotrophic lateral sclerosis mortality in the United States, 1979-2001. Neuroepidemiology 2005;25:144–52.
   PubMed Web of Science ®Google Scholar
• Rachele MG, Mascia V, Tacconi P, Dessi N, Marrosu F, Giagheddu M. Conjugal amyotrophic lateral sclerosis: a report on a couple from Sardinia, Italy. Ital J Neurol Sci. 1998;19:97–100.
   PubMedGoogle Scholar
• Traynor BJ, Codd MB, Corr B, Forde C, Frost E, Hardiman O. Incidence and prevalence of ALS in Ireland, 1995-1997: a population-based study. Neurology 1999;52:504–9.
   PubMed Web of Science ®Google Scholar
• Bersano E, Servo S, Cantello R, Mazzini L. A rare case of conjugal amyotrophic lateral sclerosis. J Neurol. 2014;261:1216–7.
   PubMed Web of Science ®Google Scholar
• Dewitt JD, Kwon J, Burton R, Stroup JS. Conjugal amyotrophic lateral sclerosis. Proc (Bayl Univ Med Cent). 2012;25:31–3.
   PubMedGoogle Scholar