Therapeutic effect of a novel curcumin derivative GT863 on a mouse model of amyotrophic lateral sclerosis

References

• Braak H, Braak E. Demonstration of amyloid deposits and neurofibrillary changes in whole brain sections. Brain Pathol. 1991;1:213–6.
   PubMed Web of Science ®Google Scholar
• Spillantini MG, Crowther RA, Jakes R, Hasegawa M, Goedert M. Alpha-synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with Lewy bodies. Proc Natl Acad Sci USA. 1998;95:6469–73.
   PubMed Web of Science ®Google Scholar
• Paré B, Lehmann M, Beaudin M, Nordström U, Saikali S, Julien JP, et al. Misfolded SOD1 pathology in sporadic amyotrophic lateral sclerosis. Sci Rep. 2018;8:14223–30242181.
   PubMed Web of Science ®Google Scholar
• Rosen DR, Siddique T, Patterson D, Figlewicz DA, Sapp P, Hentati A, et al. Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis. Nature. 1993;362:59–62.
   PubMed Web of Science ®Google Scholar
• Arai T, Hasegawa M, Akiyama H, Ikeda K, Nonaka T, Mori H, et al. TDP-43 is a component of ubiquitin-positive tau-negative inclusions in frontotemporal lobar degeneration and amyotrophic lateral sclerosis. Biochem Biophys Res Commun. 2006;351:602–11.
   PubMed Web of Science ®Google Scholar
• Okuda M, Hijikuro I, Fujita Y, Wu X, Nakayama S, Sakata Y, et al. PE859, a novel tau aggregation inhibitor, reduces aggregated tau and prevents onset and progression of neural dysfunction in vivo. PLOS One. 2015;10:e0117511.
   PubMed Web of Science ®Google Scholar
• Okuda M, Fujita Y, Hijikuro I, Wada M, Uemura T, Kobayashi Y, et al. PE859, a novel curcumin derivative, inhibits amyloid-β and tau aggregation, and ameliorates cognitive dysfunction in senescence-accelerated mouse prone 8. J Alzheimers Dis. 2017;59:313–28.
   PubMed Web of Science ®Google Scholar
• Okuda M, Hijikuro I, Fujita Y, Teruya T, Kawakami H, Takahashi T, et al. Design and synthesis of curcumin derivatives as tau and amyloid β dual aggregation inhibitors. Bioorg Med Chem Lett. 2016;26:5024–8.
   PubMed Web of Science ®Google Scholar
• Levine H. Thioflavine T Interaction with synthetic Alzheimer's disease beta-amyloid peptides: detection of amyloid aggregation in solution. Protein Sci. 1993;2:404–10.
   PubMed Web of Science ®Google Scholar
• Bitan G, Lomakin A, Teplow DB. Amyloid beta-protein oligomerization: prenucleation interactions revealed by photo-induced cross-linking of unmodified proteins. J Biol Chem. 2001;276:35176–84.
   PubMed Web of Science ®Google Scholar
• Izumi Y, Matsumura A, Wakita S, Akagi K, Fukuda H, Kume T, et al. Isolation, identification, and biological evaluation of Nrf2-ARE activator from the leaves of green perilla (Perilla frutescens var. crispa f. viridis). Free Radic Biol Med. 2012;53:669–79.
   PubMed Web of Science ®Google Scholar
• Goto Y, Niidome T, Akaike A, Kihara T, Sugimoto H. Amyloid beta-peptide preconditioning reduces glutamate-induced neurotoxicity by promoting endocytosis of NMDA receptor. Biochem Biophys Res Commun. 2006;351:259–65.
   PubMed Web of Science ®Google Scholar
• Sasaki S, Nagai M, Aoki M, Komori T, Itoyama Y, Iwata M. Motor neuron disease in transgenic mice with an H46R mutant SOD1 gene. Neuron 2020;108:822–42.
   PubMedGoogle Scholar
• Arawaka S, Hasegawa H, Tandon A, Janus C, Chen F, Yu G, et al. The levels of mature glycosylated nicastrin are regulated and correlate with gamma-secretase processing of amyloid beta-precursor protein. J Neurochem. 2002;83:1065–71.
   PubMed Web of Science ®Google Scholar
• Chang-Hong R, Wada M, Koyama S, Kimura H, Arawaka S, Kawanami T, et al. Neuroprotective effect of oxidized galectin-1 in a transgenic mouse model of amyotrophic lateral sclerosis. Exp Neurol. 2005;194:203–11.
   PubMed Web of Science ®Google Scholar
• Scapagnini G, Vasto S, Sonya V, Abraham NG, Nader AG, Caruso C, et al. Modulation of Nrf2/ARE pathway by food polyphenols: a nutritional neuroprotective strategy for cognitive and neurodegenerative disorders. Mol Neurobiol. 2011;44:192–201.
   PubMed Web of Science ®Google Scholar
• Anzai I, Tokuda E, Handa S, Misawa H, Akiyama S, Furukawa Y. Oxidative misfolding of Cu/Zn-superoxide dismutase triggered by non-canonical intramolecular disulfide formation. Free Radic Biol Med. 2020;147:187–99.
   PubMed Web of Science ®Google Scholar
• Lange DJ, Andersen PM, Remanan R, Marklund S, Benjamin D. Pyrimethamine decreases levels of SOD1 in leukocytes and cerebrospinal fluid of ALS patients: a phase I pilot study. Amyotroph Lateral Scler Frontotemporal Degener. 2013;14:199–204.
   PubMed Web of Science ®Google Scholar
• Miller T, Cudkowicz M, Shaw PJ, Andersen PM, Atassi N, Bucelli RC, et al. Phase 1-2 trial of antisense oligonucleotide tofersen for SOD1 ALS. N Engl J Med. 2020;383:109–19.
   PubMed Web of Science ®Google Scholar
• Zhao ZY, Luan P, Huang SX, Xiao SH, Zhao J, Zhang B, et al. Edaravone protects HT22 neurons from H2O2-induced apoptosis by inhibiting the MAPK signaling pathway. CNS Neurosci Ther. 2013;19:163–9.
   PubMed Web of Science ®Google Scholar
• Liu Z, Yang C, Meng X, Li Z, Lv C, Cao P. Neuroprotection of edaravone on the hippocampus of kainate-induced epilepsy rats through Nrf2/HO-1 pathway. Neurochem Int. 2018;112:159–65.
   PubMed Web of Science ®Google Scholar
• Malgouris C, Daniel M, Doble A. Neuroprotective effects of riluzole on N-methyl-D-aspartate- or veratridine-induced neurotoxicity in rat hippocampal slices. Neurosci Lett. 1994;177:95–9.
   PubMed Web of Science ®Google Scholar
• Lin X, Bai D, Wei Z, Zhang Y, Huang Y, Deng H, et al. Curcumin attenuates oxidative stress in RAW264.7 cells by increasing the activity of antioxidant enzymes and activating the Nrf2-Keap1 pathway. PLOS One. 2019;14:e0216711.
   PubMed Web of Science ®Google Scholar
• Liao L, Shi J, Jiang C, Zhang L, Feng L, Liu J, et al. Activation of anti-oxidant of curcumin pyrazole derivatives through preservation of mitochondria function and Nrf2 signaling pathway. Neurochem Int. 2019;125:82–90.
   PubMed Web of Science ®Google Scholar
• Bhatia NK, Srivastava A, Katyal N, Jain N, Khan MA, Kundu B, Deep S. Curcumin binds to the pre-fibrillar aggregates of Cu/Zn superoxide dismutase (SOD1) and alters its amyloidogenic pathway resulting in reduced cytotoxicity. Biochim Biophys Acta. 2015;1854:426–36.
   PubMed Web of Science ®Google Scholar
• Dong H, Xu L, Wu L, Wang X, Duan W, Li H, et al. Curcumin abolishes mutant TDP-43 induced excitability in a motoneuron-like cellular model of ALS. Neuroscience 2014;272:141–53.
   PubMed Web of Science ®Google Scholar
• Ohno M, Nishida A, Sugitani Y, Nishino K, Inatomi O, Sugimoto M, Kawahara M, et al. Nanoparticle curcumin ameliorates experimental colitis via modulation of gut microbiota and induction of regulatory T cells. PLOS One. 2017;12:e0185999.
   PubMed Web of Science ®Google Scholar
• Ludolph AC, Bendotti C, Blaugrund E, Chio A, Greensmith L, Loeffler JP, et al. Guidelines for preclinical animal research in ALS/MND: a consensus meeting. Amyotroph. Lateral Scler. 2010;11:38–45.
   PubMed Web of Science ®Google Scholar
• Faul F, Erdfelder E, Lang AG, Buchner A. G*Power 3: A flexible statistical power analysis program for the social, behavioral, and biomedical sciences. Behav Res Methods. 2007;39:175–191.
   PubMed Web of Science ®Google Scholar
• Nelson K, Dahlin J, Bisson J, Graham J, Pauli G, Walters M. The essential medicinal chemistry of curcumin. J Med Chem. 2017;60:1620–37.
   PubMed Web of Science ®Google Scholar
• Anand P, Kunnumakkara AB, Newman RA, Aggarwal BB. Bioavailability of curcumin: problems and promises. Mol Pharm. 2007;4:807–18.
   PubMed Web of Science ®Google Scholar
• Ahmadi M, Elmira A, Nafissi S, Jaafari MR, Harirchian MH, Sarraf P, Faghihi-Kashani S, et al. Safety and efficacy of nanocurcumin as add-on therapy to riluzole in patients with amyotrophic lateral sclerosis: a pilot randomized clinical trial. Neurotherapeutics. 2018;15:430–8.
   PubMed Web of Science ®Google Scholar
• Chico L, Ienco EC, Bisordi C, Lo Gerfo A, Petrozzi L, Petrucci A, et al. Amyotrophic lateral sclerosis and oxidative stress: a double-blind therapeutic trial after curcumin supplementation. Cnsnddt. 2018;17:767–79.
   Google Scholar