Portal vein thrombosis in cirrhotic and non cirrhotic patients: from diagnosis to treatment

References

• Liver EAFTSOT. EASL clinical practice guidelines: vascular diseases of the liver. J Hepatol 2016;64:179–202.
   Google Scholar
• DeLeve LD, Valla D-C, Garcia-Tsao G. Vascular disorders of the liver. Hepatology. 2009;49:1729–1764.
   PubMed Web of Science ®Google Scholar
• Rodriguez-Castro KI, Porte RJ, Nadal E, et al. Management of nonneoplastic portal vein thrombosis in the setting of liver transplantation. Transplantation. 2012;94:1145–1153.
   PubMed Web of Science ®Google Scholar
• Kumar A, Sharma P, Arora A. Review article: portal vein obstruction - epidemiology, pathogenesis, natural history, prognosis and treatment. Aliment Pharmacol Ther. 2015;41:276–292.
   PubMed Web of Science ®Google Scholar
• Ponziani FR. Portal vein thrombosis: insight into physiopathology, diagnosis, and treatment. World J Gastroenterol. 2010;16:143.
   PubMed Web of Science ®Google Scholar
• De Gaetano AM, Lafortune M, Patriquin H, et al. Cavernous transformation of the portal vein: patterns of lntrahepatic and splanchnic collateral circulation detectedwith Doppler sonography. AJR Am J Roentgenology. 1995;165:1151–1155.
   PubMed Web of Science ®Google Scholar
• Valla D. Splanchnic vein thrombosis. Semin Thromb Hemost. 2015;41:494–502.
   PubMed Web of Science ®Google Scholar
• Ogren M, Bergqvist D, Björck M, et al. Portal vein thrombosis: prevalence, patient characteristics and lifetime risk: a population study based on 23,796 consecutive autopsies. World J Gastroenterol. 2006;12:2115–2119.
   PubMed Web of Science ®Google Scholar
• Rajani R, Björnsson E, Bergquist A, et al. The epidemiology and clinical features of portal vein thrombosis: a multicentre study. Aliment Pharmacol Ther. 2010;32:1154–1162.
   PubMed Web of Science ®Google Scholar
• Violi F, Corazza RG, Caldwell SH, et al. Portal vein thrombosis relevance on liver cirrhosis: Italian venous thrombotic events registry. Intern Emerg Med. 2016;1–8.
   PubMed Web of Science ®Google Scholar
• Nery F, Chevret S, Condat B, et al. Causes and consequences of portal vein thrombosis in 1,243 patients with cirrhosis: results of a longitudinal study. Hepatology. 2015;61:660–667.
   PubMed Web of Science ®Google Scholar
• Plessier A, Darwish Murad S, Hernandez-Guerra M, et al. Acute portal vein thrombosis unrelated to cirrhosis: a prospective multicenter follow-up study. Hepatology. 2010;51:210–218.
   PubMed Web of Science ®Google Scholar
• Amitrano L, Guardascione MA, Scaglione MP, et al. Prognostic factors in noncirrhotic patients with splanchnic vein thromboses. Am J Gastroenterology. 2007;102:2464–2470.
   PubMed Web of Science ®Google Scholar
• Francoz C. Splanchnic vein thrombosis in candidates for liver transplantation: usefulness of screening and anticoagulation. Gut. 2005;54:691–697.
   PubMed Web of Science ®Google Scholar
• Condat B, Pessione F, Hillaire S, et al. Current outcome of portal vein thrombosis in adults: risk and benefit of anticoagulant therapy. Gastroenterology. 2001;120:490–497.
   PubMed Web of Science ®Google Scholar
• Amitrano L, Brancaccio V, Guardascione MA, et al. Portal vein thrombosis after variceal endoscopic sclerotherapy in cirrhotic patients: role of genetic thrombophilia. Endoscopy. 2002;34:535–538.
   PubMed Web of Science ®Google Scholar
• Zocco MA, Di Stasio E, De Cristofaro R, et al. Thrombotic risk factors in patients with liver cirrhosis: correlation with MELD scoring system and portal vein thrombosis development. J Hepatol. 2009;51:682–689.
   PubMed Web of Science ®Google Scholar
• Orr DW, Harrison PM, Devlin J, et al. Chronic mesenteric venous thrombosis: evaluation and determinants of survival during long-term follow-up. Clin Gastroenterol Hepatol. 2007;5:80–86.
   PubMed Web of Science ®Google Scholar
• Maruyama H, Okugawa H, Takahashi M, et al. De novo portal vein thrombosis in virus-related cirrhosis: predictive factors and long-term outcomes. Am J Gastroenterology. 2013;108:568–574.
   PubMed Web of Science ®Google Scholar
• Tripodi A, Anstee QM, Sogaard KK, et al. Hypercoagulability in cirrhosis: causes and consequences1. J Thromb Haemostasis. 2011;9:1713–1723.
   PubMed Web of Science ®Google Scholar
• Okuda K, Ohnishi K, Kimura K, et al. Incidence of portal vein thrombosis in liver cirrhosis. An angiographic study in 708 patients. Gastroenterology. 1985;89:279–286.
   PubMed Web of Science ®Google Scholar
• Pieri G, Theocharidou E. Best practice & research clinical gastroenterology. Best Pract Res Clin Gastroenterol. 2013;27:513–530.
   PubMed Web of Science ®Google Scholar
• Plessier A, Rautou P-E, Valla D-C. Management of hepatic vascular diseases. J Hepatol. 2012;56:S25–S38.
   PubMed Web of Science ®Google Scholar
• Turnes J, García-Pagán JC, González M, et al. Portal ion. Chypertension–related complications after acute portal vein thrombosis: impact of early anticoagulatlin Gastroenterol Hepatol. 2008;6:1412–1417.
   Google Scholar
• Condat B, Pessione F, Helene Denninger M, et al. Recent portal or mesenteric venous thrombosis: increased recognition and frequent recanalization on anticoagulant therapy. Hepatology. 2000;32:466–470.
   PubMed Web of Science ®Google Scholar
• Kumar S, Sarr MG, Kamath PS. Mesenteric venous thrombosis. N Engl J Med. 2001;345:1683–1688.
   PubMed Web of Science ®Google Scholar
• Acosta S, Alhadad A, Svensson P, et al. Epidemiology, risk and prognostic factors in mesenteric venous thrombosis. Br J Surg. 2008;95:1245–1251.
   PubMed Web of Science ®Google Scholar
• Clavien PA, Dürig M, Harder F. Venous mesenteric infarction: a particular entity. Br J Surg. 1988;75:252–255.
   PubMed Web of Science ®Google Scholar
• Elkrief L, Corcos O, Bruno O, et al. Type 2 diabetes mellitus as a risk factor for intestinal resection in patients with superior mesenteric vein thrombosis. Liver Int. 2013;9:1314–1321.
   Google Scholar
• Ferreira CN, Seijo S, Plessier A, et al. Natural history and management of esophagogastric varices in chronic noncirrhotic, nontumoral portal vein thrombosis. Hepatology. 2016;63:1640–1650.
   PubMed Web of Science ®Google Scholar
• de Franchis R, Faculty Baveno VI. Expanding consensus in portal hypertension. J Hepatol. 2015;63:743–752.
   PubMed Web of Science ®Google Scholar
• Garcia-Pagan J, Hernandez-Guerra M, Bosch J. Extrahepatic portal vein thrombosis. Semin Liver Dis. 2008;28:282–292.
   PubMed Web of Science ®Google Scholar
• Spaander MCW, van Buuren H, Hansen BE, et al. Ascites in patients with noncirrhotic nonmalignant extrahepatic portal vein thrombosis. Aliment Pharmacol Ther. 2010;32:529–534.
   PubMed Web of Science ®Google Scholar
• Rangari M, Gupta R, Jain M, et al. Hepatic dysfunction in patients with extrahepatic portal venous obstruction. Liver Int. 2003;23:434–439.
   PubMed Web of Science ®Google Scholar
• Mínguez B, Garcia-Pagan JC, Bosch J, et al. Noncirrhotic portal vein thrombosis exhibits neuropsychological and MR changes consistent with minimal hepatic encephalopathy. Hepatology. 2006;43:707–714.
   PubMed Web of Science ®Google Scholar
• Sharma P, Sharma BC, Puri V, et al. Natural history of minimal hepatic encephalopathy in patients with extrahepatic portal vein obstruction. Am J Gastroenterology. 2009;104:885–890.
   PubMed Web of Science ®Google Scholar
• Marin D, Galluzzo A, Plessier A, et al. Focal nodular hyperplasia-like lesions in patients with cavernous transformation of the portal vein: prevalence, MR findings and natural history. Eur Radiol. 2011;21:2074–2082.
   PubMed Web of Science ®Google Scholar
• Lautz TB, Sundaram SS, Whitington PF, et al. Growth impairment in children with extrahepatic portal vein obstruction is improved by mesenterico-left portal vein bypass. J Pediatr Surg. 2009;44:2067–2070.
   PubMed Web of Science ®Google Scholar
• Spaander MCW, Hoekstra J, Hansen BE, et al. Anticoagulant therapy in patients with non-cirrhotic portal vein thrombosis: effect on new thrombotic events and gastrointestinal bleeding. J Thromb Haemostasis. 2013;11:452–459.
   PubMed Web of Science ®Google Scholar
• Hoekstra J, Bresser EL, Smalberg JH, et al. Long-term follow-up of patients with portal vein thrombosis and myeloproliferative neoplasms. J Thromb Haemostasis. 2011;9:2208–2214.
   PubMed Web of Science ®Google Scholar
• Amitrano L. Risk factors and clinical presentation of portal vein thrombosis in patients with liver cirrhosis. J Hepatol. 2004;40:736–741.
   PubMed Web of Science ®Google Scholar
• Tsochatzis EA, Senzolo M, Germani G, et al. Systematic review: portal vein thrombosis in cirrhosis. Aliment Pharmacol Ther. 2010;31:366–374.
   PubMed Web of Science ®Google Scholar
• D’Amico G, de Franchis R, Group AAC. Upper digestive bleeding in cirrhosis. Post-therapeutic outcome and prognostic indicators. Hepatology. 2003;38:599–612.
   PubMed Web of Science ®Google Scholar
• Dhiman RK, Behera A, Chawla YK, et al. Portal hypertensive biliopathy. Gut. 2007;56:1001–1008.
   PubMed Web of Science ®Google Scholar
• Condat B. Portal cavernoma-associated cholangiopathy: a clinical and MR cholangiography coupled with MR portography imaging study. Hepatology. 2003;37:1302–1308.
   PubMed Web of Science ®Google Scholar
• Llop E, de Juan C, Seijo S, et al. Portal cholangiopathy: radiological classification and natural history. Gut. 2011;60:853–860.
   PubMed Web of Science ®Google Scholar
• Chawla Y, Agrawal S. Portal cavernoma cholangiopathy – history, definition and nomenclature. J Clin Exp Hepatol. 2014;4:S15–S17.
   Google Scholar
• Malkan G, Bhatia SJ, Khan BA, et al. Cholangiopathy associated with portal hypertension: diagnostic evaluation and clinical implications. Gastrointest Endosc. 1999;49:344–348.
   PubMed Web of Science ®Google Scholar
• Dilawari JB, Chawla YK. Pseudosclerosing cholangitis in extrahepatic portal venous obstruction. Gut. 1992;33:272–276.
   PubMed Web of Science ®Google Scholar
• Khuroo MS, Yattoo GN, Zargar SA, et al. Biliary abnormalities associated with extrahepatic portal venous obstruction. Hepatology. 1993;17:807–813.
   PubMed Web of Science ®Google Scholar
• Nagi B, Kochhar R, Bhasin D, et al. Cholangiopathy in extrahepatic portal venous obstruction. Radiological appearances. Acta Radiol. 2000;41:612–615.
   PubMed Web of Science ®Google Scholar
• Sezgin O, Oğuz D, Altintaş E, et al. Endoscopic management of biliary obstruction caused by cavernous transformation of the portal vein. Gastrointest Endosc. 2003;58:602–608.
   PubMed Web of Science ®Google Scholar
• Chandra R, Kapoor D, Tharakan A, et al. Portal biliopathy. J Gastroenterol Hepatol. 2001;16:1086–1092.
   PubMed Web of Science ®Google Scholar
• Sarin SK, Kumar A. Noncirrhotic portal hypertension. Clin Liver Dis. 2006;10:627–651.
   PubMedGoogle Scholar
• Agarwal AK, Sharma D, Singh S, et al. Portal biliopathy: a study of 39 surgically treated patients. Mhpb. 2011;13:33–39.
   Web of Science ®Google Scholar
• Duseja A. Portal cavernoma cholangiopathy—clinical characteristics. J Clin Exp Hepatol. 2014;4:S34–S36.
   Google Scholar
• Oo YH, Olliff S, Haydon G, et al. Symptomatic portal biliopathy: a single centre experience from the UK. Eur J Gastroenterol Hepatol. 2009;21:206–213.
   PubMed Web of Science ®Google Scholar
• Khare R, Sikora SQ, Srikanth G, et al. Extrahepatic portal venous obstruction and obstructive jaundice: approach to management. J Hepatol. 2005;20:56–61.
   Web of Science ®Google Scholar
• Walser EM, Runyan BR, Heckman MG, et al. Extrahepatic portal biliopathy: proposed etiology on the basis of anatomic and clinical features. Radiology. 2010;258:146–153.
   PubMed Web of Science ®Google Scholar
• Perarnau J-M, Bacq Y. Hepatic vascular involvement related to pregnancy, oral contraceptives, and estrogen replacement therapy. Semin Liver Dis. 2008;28:315–327.
   PubMed Web of Science ®Google Scholar
• Berzigotti A, García-Criado A, Darnell A, et al. Imaging in clinical decision-making for portal vein thrombosis. Nat Rev Gastroenterol Hepatol. 2014;11:308–316.
   PubMed Web of Science ®Google Scholar
• Bittencourt PL, Couto CA, Ribeiro DD. Portal vein thrombosis and Budd-Chiari syndrome. Hematology. 2011;25:1049–1066.
   Web of Science ®Google Scholar
• Ueno N, Sasaki A, Tomiyama T, et al. Color Doppler ultrasonography inthe diagnosis of cavernous transformation of the portal vein. Clin Ultrasound. 1997;25:227–233.
   PubMed Web of Science ®Google Scholar
• Lee H-K, Park SJ, Yi B-H, et al. Portal vein thrombosis: CT features. Abdom Imaging. 2008;33:72–79.
   PubMedGoogle Scholar
• Hall TC, Garcea G, Metcalfe M, et al. Management of acute non-cirrhotic and non-malignant portal vein thrombosis: a systematic review. world J Surg. 2011;35:2510–2520.
   PubMed Web of Science ®Google Scholar
• Kalra N, Shankar S, Khandelwal N. Imaging of portal cavernoma cholangiopathy. J Clin Exp Hepatol. 2014;4:S44–S52.
   Google Scholar
• El-Karaksy H, El-Raziky M. Splachnic vein thrombosis in the Mediterranean area in children. Mediterr J Hematol Infect Dis. 2011;3:e2011027.
   Google Scholar
• Pinto RB, Silveira TR, Bandinelli E, et al. Portal vein thrombosis in children and adolescents: the low prevalence of hereditary thrombophilic disorders. J Pediatr Surg. 2004;39:1356–1361.
   PubMed Web of Science ®Google Scholar
• El-Karaksy HM, El-Koofy N, Mohsen N, et al. Extrahepatic portal vein obstruction in Egyptian children. J Pediatr Gastroenterol Nutr. 2015;60:105–109.
   PubMed Web of Science ®Google Scholar
• Yadav S, Dutta AK, Sarin SK. Do umbilical vein catheterization and sepsis lead to portal vein thrombosis? A prospective, clinical and sonographic evaluation. J Pediatr Gastroenterol Nutr. 1993;17:392–396.
   PubMed Web of Science ®Google Scholar
• Vilgrain V, Condat B, Bureau C, et al. Atrophy-hypertrophy complex in patients with cavernous transformation of the portal vein: CT evaluation. Radiology. 2006;241:149–155.
   PubMed Web of Science ®Google Scholar
• Hall TC, Garcea G, Metcalfe M, et al. Impact of anticoagulation on outcomes in acute non-cirrhotic and non-malignant portal vein thrombosis: a retrospective observational study. Hepatogastroenterology. 2013;60:317–232.
   Web of Science ®Google Scholar
• Primignani M, Mannucci P. The role of thrombophilia in splanchnic vein thrombosis. Semin Liver Dis. 2008;28:293–301.
   PubMed Web of Science ®Google Scholar
• Chait Y, Condat B, Cazals-Hatem D, et al. Relevance of the criteria commonly used to diagnose myeloproliferative disorder in patients with splanchnic vein thrombosis. Br J Haematol. 2005;129:553–560.
   PubMed Web of Science ®Google Scholar
• Hernandez-Guerra M, López E, Bellot P, et al. Systemic hemodynamics, vasoactive systems, and plasma volume in patients with severe Budd-Chiari syndrome. Hepatology. 2005;43:27–33.
   Web of Science ®Google Scholar
• Kiladjian JJ, Cervantes F, Leebeek FWG, et al. The impact of JAK2 and MPL mutations on diagnosis and prognosis of splanchnic vein thrombosis: a report on 241 cases. Blood. 2008;111:4922–4929.
   PubMed Web of Science ®Google Scholar
• Tefferi A, Thiele J, Orazi A, et al. Proposals and rationale for revision of the World Health Organization diagnostic criteria for polycythemia vera, essential thrombocythemia, and primary myelofibrosis: recommendations from an ad hoc international expert panel. Blood. 2007;110:1092–1097.
   PubMed Web of Science ®Google Scholar
• Primignani M, Barosi G, Bergamaschi G, et al. Role of theJAK2 mutation in the diagnosis of chronic myeloproliferative disorders in splanchnic vein thrombosis. Hepatology. 2006;44:1528–1534.
   PubMed Web of Science ®Google Scholar
• Smalberg JH, Arends LR, Valla D-C, et al. Myeloproliferative neoplasms in Budd-Chiari syndrome and portal vein thrombosis: a meta-analysis. Blood. 2012;120:4921–4928.
   PubMed Web of Science ®Google Scholar
• Nangalia J, Massie CE, Baxter EJ, et al. Somatic CALRMutations in myeloproliferative neoplasms with nonmutated JAK2. N Engl J Med. 2013;369:2391–2405.
   PubMed Web of Science ®Google Scholar
• Klampfl T, Gisslinger H, Harutyunyan AS, et al. Somatic mutations of calreticulin in myeloproliferative neoplasms. N Engl J Med. 2013;369:2379–2390.
   PubMed Web of Science ®Google Scholar
• Turón F, Cervantes F, Colomer D, et al. Role of calreticulin mutations in the etiological diagnosis of splanchnic vein thrombosis. J Hepatol. 2014;62:72–74.
   PubMed Web of Science ®Google Scholar
• Plompen EPC, Valk PJM, Chu I, et al. Somatic calreticulin mutations in patients with Budd-Chiari syndrome and portal vein thrombosis. Haematologica. 2015;100:e226–e228.
   PubMed Web of Science ®Google Scholar
• Denninger M-H, Chaït Y, Casadevall N, et al. Cause of portal or hepatic venous thrombosis in adults: the role of multiple concurrent factors. Hepatology. 2000;31:587–591.
   PubMed Web of Science ®Google Scholar
• Tripodi A, Primignani M, Chantarangkul V, et al. An imbalance of pro- vs anti-coagulation factors in plasma from patients with cirrhosis. Gastroenterology. 2009;137:2105–2111.
   PubMed Web of Science ®Google Scholar
• Gulley D, Teal E, Suvannasankha A, et al. Deep vein thrombosis and pulmonary embolism in cirrhosis patients. Dig Dis Sci. 2008;53:3012–3017.
   PubMed Web of Science ®Google Scholar
• Northup PG, McMahon MM, Ruhl AP, et al. Coagulopathy does not fully protect hospitalized cirrhosis patients from peripheral venous thromboembolism. Am J Gastroenterology. 2006;101:1524–1528.
   PubMed Web of Science ®Google Scholar
• Amitrano L, Brancaccio V, Guardascione MA, et al. Inherited coagulation disorders in cirrhotic patients with portal vein thrombosis. Hepatology. 2000;31:345–348.
   PubMed Web of Science ®Google Scholar
• Tripodi A, Primignani M, Lemma L, et al. Evidence that low protein C contributes to the procoagulant imbalance in cirrhosis. J Hepatol. 2013;59:265–270.
   PubMed Web of Science ®Google Scholar
• Colaizzo D, Amitrano L, Guardascione MA, et al. Janus kinase-2 mutation, cirrhosis and splanchnic vein thrombosis. Eur J Gastroenterol Hepatol. 2008;20:245–246.
   PubMed Web of Science ®Google Scholar
• Abdel-Razik A, Mousa N, Elhelaly R, et al. De-novo portal vein thrombosis in liver cirrhosis. Eur J Gastroenterol Hepatol. 2015;27:585–592.
   PubMed Web of Science ®Google Scholar
• Qi X, Han G, Yin Z, et al. Transjugular intrahepatic portosystemic shunt for portal cavernoma with symptomatic portal hypertension in non-cirrhotic patients. Dig Dis Sci. 2011;57:1072–1082.
   PubMed Web of Science ®Google Scholar
• Uflacker R. Applications of percutaneous mechanical thrombectomy in transjugular intrahepatic portosystemic shunt and portal vein thrombosis. Tech Vasc Interv Radiol. 2003;6:59–69.
   PubMedGoogle Scholar
• Chawla Y, Duseja A, Dhiman RK. Review article: the modern management of portal vein thrombosis. Aliment Pharmacol Ther. 2009;30:881–894.
   PubMed Web of Science ®Google Scholar
• Lopera JE, Correa G, Brazzini A, et al. Percutaneous transhepatic treatment of symptomatic mesenteric venous thrombosis. J Vasc Surg. 2002;36:1058–1061.
   PubMed Web of Science ®Google Scholar
• Smalberg JH, Spaander MV, Jie K-SG, et al. Risks and benefits of transcatheter thrombolytic therapy in patients with splanchnic venous thrombosis. Thromb Haemost. 2008;100:1084–1088.
   PubMed Web of Science ®Google Scholar
• Hollingshead M, Burke CT, Mauro MA, et al. Transcatheter thrombolytic therapy for acute mesenteric and portal vein thrombosis. J Vasc Interv Radiol. 2005;16:651–661.
   PubMed Web of Science ®Google Scholar
• Saraswat VA, Rai P, Kumar T, et al. Endoscopic management of portal cavernoma cholangiopathy: practice, principles and strategy. J Clin Exp Hepatol. 2014;4:S67–S76.
   Google Scholar
• Dhiman RK, Saraswat VA, Valla DC, et al. Portal cavernoma cholangiopathy: consensus statement of a working party of the Indian National Association for study of the liver. J Clin Exp Hepatol. 2014;4:S2–S14.
   Google Scholar
• Varma V, Behera A, Kaman L, et al. Surgical management of portal cavernoma cholangiopathy. J Clin Exp Hepatol. 2014;4:S77–S84.
   Google Scholar
• Thatipelli MR, McBane RD, Hodge DO, et al. Survival and recurrence in patients with splanchnic vein thromboses. Clin Gastroenterol Hepatol. 2010;8:200–205.
   PubMed Web of Science ®Google Scholar
• Luca A, Caruso S, Milazzo M, et al. Natural course of extrahepatic nonmalignant partial portal vein thrombosis in patients with cirrhosis. Radiology. 2012;265:124–132.
   PubMed Web of Science ®Google Scholar
• John BV, Konjeti R, Aggarwal A, et al. Impact of untreated portal vein thrombosison pre and post liver transplant outcomes in cirrhosis. Ann Hepatol. 2013;12:952–958.
   PubMed Web of Science ®Google Scholar
• Yerdel MA, Gunson B, Mirza D, et al. Portal vein thrombosis in adults undergoing liver transplantation: risk factors, screening, management, and outcome. Transplantation. 2000;69:1873–1881.
   PubMed Web of Science ®Google Scholar
• Gimeno F, Calvo J, Loinaz C, et al. Comparative analysis of the results of orthotopic liver transplantation in patients with and without portal vein thrombosis. Transplant Proc. 2005;37:3899–3903.
   PubMed Web of Science ®Google Scholar
• Lendoire J, Raffin G, Cejas N, et al. Liver transplantation in adult patients with portal vein thrombosis: risk factors, management and outcome. Mhpb. 2007;9:352–356.
   Google Scholar
• Tao Y-F, Teng F, Wang Z-X, et al. Liver transplant recipients with portal vein thrombosis: a single center retrospective study. Hbpd Int. 2009;8:34–39.
   Google Scholar
• Amitrano L, Guardascione MA, Menchise A, et al. Safety and efficacy of anticoagulation therapy with low molecular weight heparin for portal vein thrombosis in patients with liver cirrhosis. J Clin Gastroenterol. 2010;44:448–451.
   PubMed Web of Science ®Google Scholar
• Delgado MG, Seijo S, Yepes I, et al. Efficacy and safety of anticoagulation on patients with cirrhosis and portal vein thrombosis. Clin Gastroenterol Hepatol. 2012;10:776–783.
   PubMed Web of Science ®Google Scholar
• Senzolo M, M Sartori T, Rossetto V, et al. Prospective evaluation of anticoagulation and transjugular intrahepatic portosistemic shunt for the management of portal vein thrombosis in cirrhosis. Liver Int. 2012;6:919–927.
   Web of Science ®Google Scholar
• Werner KT, Sando S, Carey EJ, et al. Portal vein thrombosis in patients with end stage liver disease awaiting liver transplantation: outcome of anticoagulation. Dig Dis Sci. 2013;58:1776–1780.
   PubMed Web of Science ®Google Scholar
• Naeshiro N, Aikata H, Hyogo H, et al. Efficacy and safety of the anticoagulant drug, danaparoid sodium, in the treatment of portal vein thrombosis in patients with liver cirrhosis. Hepatol Res. 2015;45:656–662.
   PubMed Web of Science ®Google Scholar
• Chen H, Liu L, Qi X, et al. Efficacy and safety of anticoagulation in more advanced portal vein thrombosis in patients with liver cirrhosis. Eur J Gastroenterol Hepatol. 2016;28:82–89.
   PubMed Web of Science ®Google Scholar
• Chung JW, Kim GH, Lee JH, et al. Safety, efficacy, and response predictors of anticoagulation for the treatment of nonmalignant portal-vein thrombosis in patients with cirrhosis: a propensity score matching analysis. Clin Mol Hepatol. 2014;20:384.
   PubMedGoogle Scholar
• De Santis A, Moscatelli R, Catalano C, et al. Systemic thrombolysis of portal vein thrombosis in cirrhotic patients: a pilot study. Dig Liver Dis. 2010;42:451–455.
   PubMedGoogle Scholar
• Liu F-Y. Interventional treatment for symptomatic acute-subacute portal and superior mesenteric vein thrombosis. World J Gastroenterol. 2009;15:5028.
   PubMed Web of Science ®Google Scholar
• Blum U, Hagg K, Rössle M, et al. Noncavernomatous portal vein thrombosis in hepatic cirrhosis: treatment with transjugular intrahepatic portosystemic shunt and local thrombolysis. Radiology. 1995;165:153–157.
   Google Scholar
• Senzolo M, Tibbals J, Cholongitas E, et al. Transjugular intrahepatic portosystemic shunt for portal vein thrombosis with and without cavernous transformation. Aliment Pharmacol Ther. 2006;23:767–775.
   PubMed Web of Science ®Google Scholar
• Van Ha TG, Hodge J, Funaki B, et al. Transjugular intrahepatic portosystemic shunt placement in patients with cirrhosis and concomitant portal vein thrombosis. Cvir. 2006;29:785–790.
   Web of Science ®Google Scholar
• Perarnau J-M, Baju A, DʼAlteroche L, et al. Feasibility and long-term evolution of TIPS in cirrhotic patients with portal thrombosis. Eur J Gastroenterol Hepatol. 2010;22:1093–1098.
   PubMed Web of Science ®Google Scholar
• Han G, Qi X, He C, et al. Transjugular intrahepatic portosystemic shunt for portal vein thrombosis with symptomatic portal hypertensionin liver cirrhosis. J Hepatol. 2011;54:78–88.
   PubMed Web of Science ®Google Scholar
• Luca A, Miraglia R, Caruso S, et al. Short- and long-term effects of the transjugular intrahepatic portosystemic shunt on portal vein thrombosis in patients with cirrhosis. Gut. 2011;60:846–852.
   PubMed Web of Science ®Google Scholar
• Wang Z, Zhao H, Wang X, et al. Clinical outcome comparison between TIPS and EBL in patients with cirrhosis and portal vein thrombosis. Abdom Imaging. 2015;40:1813–1820.
   PubMedGoogle Scholar
• Qi X, He C, Guo W, et al. Transjugular intrahepatic portosystemic shunt for portal vein thrombosis with variceal bleeding in liver cirrhosis: outcomes and predictors in a prospective cohort study. Liver Int. 2016;36:667–676.
   PubMed Web of Science ®Google Scholar
• Habib A, Desai K, Hickey R, et al. Portal vein recanalization–transjugular intrahepatic portosystemic shunt using the transsplenic approach to achieve transplant candidacy in patients with chronic portal vein thrombosis. J Vasc Interv Radiol. 2015;26:499–506.
   PubMed Web of Science ®Google Scholar
• Wang Z, Jiang M-S, Zhang H-L, et al. Is post-TIPS anticoagulation therapy necessary in patients with cirrhosis and portal vein thrombosis? A randomized controlled trial. Radiology. 2016;279:943–951.
   PubMed Web of Science ®Google Scholar
• Rosenqvist K, Eriksson LG, Rorsman F, et al. Endovascular treatment of acute and chronic portal vein thrombosis in patients with cirrhotic and non-cirrhotic liver. Acta Radiol. 2016;5:572–579.
   Web of Science ®Google Scholar
• Seijo S, García-Criado A, Darnell A, et al. Diagnóstico y tratamiento de la trombosis portal en la cirrosis hepática. Gastroenterologia Y Hepatologia. 2012;35:660–666.
   PubMed Web of Science ®Google Scholar
• Bosch J, Abraldes JG, Albillos A, et al. Hipertensión portal: recomendaciones para su evaluación y tratamiento: Documento de consenso auspiciado por la AEEH y el CIBERehd. Gastroenterologia Y Hepatologia. 2012;35:421–450.
   PubMed Web of Science ®Google Scholar
• Spaander MCW, Murad SD, Van Buuren HR, et al. Endoscopic treatment of esophagogastric variceal bleeding in patients with noncirrhotic extrahepatic portal vein thrombosis: a long-term follow-up study. Gastrointest Endosc. 2008;67:821–827.
   PubMed Web of Science ®Google Scholar
• Perlemuter G, Béjanin H, Fritsch J, et al. Biliary obstruction caused by portal cavernoma: a study of 8 cases. J Hepatol. 1996;25:58–63.
   PubMed Web of Science ®Google Scholar
• Gupta S, Taneja S. Liver transplantation for portal cavernoma cholangiopathy. J Clin Exp Hepatol. 2014;4:S85–S87.
   Google Scholar
• Janssen HL, Wijnhoud A, Haagsma EB, et al. Extrahepatic portal vein thrombosis: aetiology and determinants of survival. Gut. 2001;49:720–724.
   PubMed Web of Science ®Google Scholar
• Qi X-S. Prognostic factors in non-malignant and non-cirrhotic patients with portal cavernoma: an 8-year retrospective single-center study. Wjg. 2013;19:7447.
   PubMed Web of Science ®Google Scholar
• Englesbe MJ, Schaubel DE, Cai S, et al. Portal vein thrombosis and liver transplant survival benefit. Liver Transpl. 2010;16:999–1005.
   PubMed Web of Science ®Google Scholar
• Sarfeh IJ. Portal vein thrombosis associated with cirrhosis. Arch Surg. 1979;114:902–905.
   PubMedGoogle Scholar
• Ferreira CN, Rodrigues T, Alexandrino P, et al. Portal vein thrombosis in cirrhotic patients is associated with advanced liver disease and prodicts long-term prognosis. Hepatology. 2010;52:1072.
   Web of Science ®Google Scholar
• Berry K, Taylor J, Liou IW, et al. Portal vein thrombosis is not associated with increased mortality among patients with cirrhosis. Clin Gastroenterol Hepatol. 2015;13:585–593.
   PubMed Web of Science ®Google Scholar
• Chen H, Turón F, Hernandez-Gea V, et al. Nontumoral portal vein thrombosis in patients awaiting liver transplantation. Liver Transpl. 2016;22:352–365.
   PubMed Web of Science ®Google Scholar
• Ghabril M, Agarwal S, Lacerda M, et al. Portal vein thrombosis is a risk factor for poor early outcomes after liver transplantation. Transplantation. 2016;100:126–133.
   PubMed Web of Science ®Google Scholar
• John BV, Konjeti R, Aggarwal A, et al. The impact of portal vein thrombosis (PVT) on cirrhotics awaiting liver transplantation. Hepatology. 2010;52:888A.
   Google Scholar
• Ponziani FR, Zocco MA, Senzolo M, et al. Transplantation reviews. Transplant Rev. 2014;28:92–101.
   Web of Science ®Google Scholar
• Gao PJ, Gao J, Li Z, et al. Liver transplantation in adults with portal vein thrombosis: data from the China liver transplant registry. Clin Res Hepatol Gastroenterol. 2016;40:327–332.
   Web of Science ®Google Scholar
• Qi X, Dai J, Jia J, et al. Association between portal vein thrombosis and survival of liver transplant recipients: a systematic review and meta-analysis of observational studies. J Gastrointestin Liver Dis. 2015;24:51–59.
   PubMed Web of Science ®Google Scholar
• Doenecke A, Tsui T-Y, Zuelke C, et al. Pre-existent portal vein thrombosis in liver transplantation: influence of pre-operative disease severity. Clin Transplant. 2010;24:48–55.
   PubMed Web of Science ®Google Scholar
• John BV, Konjeti R, Aggarwal A, et al. Post transplant outcomes of cirrhosis with portal vein thrombosis who are not anticoagulated is similar to cirrhotics without portal vein thrombosis. Hepatology. 2010;52:373A.
   Google Scholar
• Hibi T, Nishida S, Levi DM, et al. Letter to the editor: when and why portal vein thrombosis matters in liver transplantation. Ann Surg. 2014;259:760–766.
   PubMed Web of Science ®Google Scholar
• Paskonis M, Jurgaitis J, Mehrabi A, et al. Surgical strategies for liver transplantation in the case of portal vein thrombosis? Current role of cavoportal hemitransposition and renoportal anastomosis. Clin Transplant. 2006;20:551–562.
   PubMed Web of Science ®Google Scholar
• Yan M-L, Zeng Y, Li B, et al. Postoperative complications after liver transplantation with cavoportal hemitransposition. Hbpd Int. 2008;7:322–324.
   Google Scholar
• Englesbe MJ, Kubus J, Muhammad W, et al. Portal vein thrombosis and survival in patients with cirrhosis. Liver Transpl. 2010;16:83–90.
   PubMed Web of Science ®Google Scholar
• Qi X, Dai J, Yang M, et al. Association between portal vein thrombosis and survival in non-liver-transplant patients with liver cirrhosis: a systematic review of the literature. Gastroenterol Res Pract. 2015;2015:1–7.
   Web of Science ®Google Scholar
• Cardin F, Graffeo M, McCormick PA, et al. Adult “idiopathic” extrahepatic venous thrombosis. Importance of putative “latent” myeloproliferative disorders and comparison with cases with known etiology. Dig Dis Sci. 1992;37:335–339.
   PubMed Web of Science ®Google Scholar
• Webb LJ, Sherlock S. The aetiology, presentation and natural history of extra-hepatic portal venous obstruction. Q J Med. 1979;48:627–639.
   PubMedGoogle Scholar
• Voorhees AB, Price JB. Extrahepatic portal hypertension. A retrospective analysis of 127 cases and associated clinical implications. Arch Surg. 1974;108:338–341.
   PubMedGoogle Scholar