The potential of oxytocin for the treatment of hyperphagia in Prader-Willi Syndrome

References

• Driscoll DJ, Miller JL, Schwartz S, et al. In: Adam MP, Ardinger HH, Pagon RA, et al., editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle;1998 Oct 6. [cited 2017 Dec 14]. p. 1993–2018.
   Google Scholar
• Sanjeeva GN, Maganthi M, Kodishala H, et al. Clinical and molecular characterization of Prader-Willi syndrome. Indian J Pediatr. 2017 Nov;84(11):815–821.
   PubMed Web of Science ®Google Scholar
• Bittel DC, Kibiryeva N, Sell SM, et al. Whole genome microarray analysis of gene expression in Prader-Willi syndrome. Am J Med Genet A. 2007;1(5):415–421.
   Google Scholar
• Buiting K, Cassidy SB, Driscoll DJ, et al. Clinical utility gene card for: Prader-Willi syndrome. Eur J Hum Genet. 2014;22:9.
   Web of Science ®Google Scholar
• Miller JL, Lynn CH, Driscoll DC, et al. Nutritional phases in Prader-Willi syndrome. Am J Med Genet A. 2011;155A(5):1040–1049.
   PubMed Web of Science ®Google Scholar
• Martínez Michel L, Haqq AM, Wismer WV. A review of chemosensory perceptions, food preferences and food-related behaviours in subjects with Prader-Willi syndrome. Appetite. 2016 Apr;1(99):17–24.
   Google Scholar
• Joseph B, Egli M, Koppekin A, et al. Food choice in people with Prader-Willi syndrome: quantity and relative preference. Am J Ment Retard. 2002 Mar;107(2):128–135.
   PubMedGoogle Scholar
• Hoybye C, Barkeling B, Naslund E, et al. Eating behavior and gastric emptying in adults with Prader-Willi syndrome. Ann Nutr Metab. 2007;51(3):264–269.
   PubMed Web of Science ®Google Scholar
• Tanaka Y, Abe Y, Oto Y, et al. Characterization of fat distribution in Prader-Willi syndrome: relationships with adipocytokines and influence of growth hormone treatment. Am J Med Genet A. 2013 Jan;161A(1):27–33.
   PubMed Web of Science ®Google Scholar
• Sode-Carlsen R, Farholt S, Rabben KF, et al. Höybye C body composition, endocrine and metabolic profiles in adults with Prader-Willi syndrome. Growth Horm IGF Res. 2010 Jun;20(3):179–184.
   PubMed Web of Science ®Google Scholar
• Heymsfield SB, Avena NM, Baier L, et al. Hyperphagia: current concepts and future directions proceedings of the 2nd international conference on hyperphagia. Obesity (Silver Spring). 2014 Feb;22(Suppl 1):S1–S17.
   PubMedGoogle Scholar
• Kuppens RJ, Diène G, Bakker NE, et al. Elevated ratio of acylated to unacylated ghrelin in children and young adults with Prader-Willi syndrome. Endocrine. 2015 Dec;50(3):633–642.
   PubMed Web of Science ®Google Scholar
• Haqq AM, Grambow SC, Muehlbauer M, et al. Ghrelin concentrations in Prader-Willi syndrome (PWS) infants and children: changes during development. Clin Endocrinol (Oxf). 2008 Dec;69(6):911–920.
   PubMed Web of Science ®Google Scholar
• Bizzarri C, Rigamonti AE, Luce A, et al. Children with Prader-Willi syndrome exhibit more evident meal-induced responses in plasma ghrelin and peptide YY levels than obese and lean children. Eur J Endocrinol. 2010 Mar;162(3):499–505.
   PubMed Web of Science ®Google Scholar
• Kweh FA, Miller JL, Sulsona CR, et al. Hyperghrelinemia in Prader-Willi syndrome begins in early infancy long before the onset of hyperphagia. Am J Med Genet A. 2015;167A(1(Jan):69–79.
   Google Scholar
• Holsen LM, Zarcone JR, Brooks WM, et al. Neural mechanisms underlying hyperphagia in Prader-Willi syndrome. Obesity (Silver Spring). 2006 Jun;14(6):1028–1037.
   PubMed Web of Science ®Google Scholar
• Lukoshe A, van Dijk SE, van den Bosch GE, et al. Altered functional resting-state hypothalamic connectivity and abnormal pituitary morphology in children with Prader-Willi syndrome. J Neurodev Disord. 2017 Feb;9(1):12.
   PubMedGoogle Scholar
• Spetter MS, Feld GB, Thienel M, et al. Oxytocin curbs calorie intake via food-specific increases in the activity of brain areas that process reward and establish cognitive control. Sci Rep. 2018 Feb 9;8(1):2736.
   PubMedGoogle Scholar
• Olszewski PK, Klockars A, Levine AS. Oxytocin and potential benefits for obesity treatment. Curr Opin Endocrinol Diabetes Obes. 2017 Oct;24(5):320–325.
   PubMed Web of Science ®Google Scholar
• Ohlsson B, Truedsson M, Djerf P, et al. Oxytocin is expressed throughout the human gastrointestinal tract. Regul Pept. 2006 Jul 15;135(1–2):7–11.
   PubMedGoogle Scholar
• Swaab DF, Purba JS, Hofman MA. Alterations in the hypothalamic paraventricular nucleus and its oxytocin neurons (putative satiety cells) in Prader-Willi syndrome: a study of five cases. J Clin Endocrinol Metab. 1995 Feb;80(2):573–579.
   PubMed Web of Science ®Google Scholar
• Martin A, State M, Anderson GM, et al. Cerebrospinal fluid levels of oxytocin in Prader-Willi syndrome: a preliminary report. Biol Psychiatry. 1998 Dec 15;44(12):1349–1352.
   PubMed Web of Science ®Google Scholar
• Tauber M, Boulanouar K, Diene G, et al. The use of oxytocin to improve feeding and social skills in infants with Prader-Willi syndrome. Pediatrics. 2017;139(2):Feb.
   Web of Science ®Google Scholar
• Kuppens RJ, Donze SH, Hokken-Koelega AC. Promising effects of oxytocin on social and food-related behaviour in young children with Prader-Willi syndrome: a randomized, double-blind, controlled crossover trial. Clin Endocrinol (Oxf). 2016 Dec;85(6):979–987.
   PubMed Web of Science ®Google Scholar
• Schorr M, Marengi DA, Pulumo RL, et al. Oxytocin and its relationship to body composition, bone mineral density, and hip geometry across the weight spectrum. J Clin Endocrinol Metab. 2017 Aug 1;102(8):2814–2824.
   PubMed Web of Science ®Google Scholar
• Iwasaki Y, Maejima Y, Suyama S, et al. Peripheral oxytocin activates vagal afferent neurons to suppress feeding in normal and leptin-resistant mice: a route for ameliorating hyperphagia and obesity. Am J Physiol Regul Integr Comp Physiol. 2015 Mar 1;308(5):R360–9.
   PubMed Web of Science ®Google Scholar
• Striepens N, Schröter F, Stoffel-Wagner B, et al. Scheele D oxytocin enhances cognitive control of food craving in women. Hum Brain Mapp. 2016 Dec;37(12):4276–4285.
   PubMed Web of Science ®Google Scholar
• Ho JM, Blevins JE. Coming full circle: contributions of central and peripheral oxytocin actions to energy balance. Endocrinology. 2013 Feb;154(2):589–596.
   PubMed Web of Science ®Google Scholar
• Stevenson DA, Heinemann J, Angulo M, et al. Gastric rupture and necrosis in Prader-Willi syndrome. J Pediatr Gastroenterol Nutr. 2007 Aug;45(2):272–274.
   PubMed Web of Science ®Google Scholar
• Glover D, Maltzman I, Williams C. Food preferences among individuals with and without Prader-Willi syndrome. Am J Ment Retard. 1996 Sep;101(2):195–205.
   PubMedGoogle Scholar
• Roberts ZS, Wolden-Hanson T, Matsen ME, et al. Chronic hindbrain administration of oxytocin is sufficient to elicit weight loss in diet-induced obese rats. Am J Physiol Regul Integr Comp Physiol. 2017 Oct 1;313(4):R357–R371.
   PubMed Web of Science ®Google Scholar
• Blevins JE, Graham JL, Morton GJ, et al. Chronic oxytocin administration inhibits food intake, increases energy expenditure, and produces weight loss in fructose-fed obese rhesus monkeys. Am J Physiol Regul Integr Comp Physiol. 2015 Mar 1;308(5):R431–-8.
   PubMed Web of Science ®Google Scholar
• Ott V, Finlayson G, Lehnert H, et al. Oxytocin reduces reward-driven food intake in humans. Diabetes. 2013 Oct;62(10):3418–3425.
   PubMed Web of Science ®Google Scholar
• Cai D, Purkayastha S. A new horizon: oxytocin as a novel therapeutic option for obesity and diabetes. Drug Discov Today Dis Mech. 2013 Jun 1;10(1–2):e63–e68.
   PubMedGoogle Scholar
• Maejima Y, Iwasaki Y, Yamahara Y, et al. Peripheral oxytocin treatment ameliorates obesity by reducing food intake and visceral fat mass. Aging (Albany NY). 2011 Dec;3(12):1169–1177.
   PubMedGoogle Scholar
• Lee ES, Uhm KO, Lee YM, et al. Oxytocin stimulates glucose uptake in skeletal muscle cells through the calcium-CaMKK-AMPK pathway. Regul Pept. 2008 Nov 29;151(1–3):71–74.
   PubMedGoogle Scholar
• Stanić D, Plećaš-Solarović B, Mirković D, et al. Oxytocin in corticosterone-induced chronic stress model: focus on adrenal gland function. Psychoneuroendocrinology. 2017 Jun;80:137–146.
   PubMed Web of Science ®Google Scholar
• Wirth MM, Gaffey AE, Martinez BS. Effects of intranasal oxytocin on steroid hormones in men and women. Neuropsychobiology. 2015;71(4):202–211.
   PubMed Web of Science ®Google Scholar
• Tauber M, Mantoulan C, Copet P, et al. Oxytocin may be useful to increase trust in others and decrease disruptive behaviours in patients with Prader-Willi syndrome: a randomised placebo-controlled trial in 24 patients. Orphanet J Rare Dis. 2011 Jun 24;6:47.
   PubMed Web of Science ®Google Scholar
• Miller JL, Tamura R, Butler MG, et al. Oxytocin treatment in children with Prader-Willi syndrome: a double-blind, placebo-controlled, crossover study. Am J Med Genet A. 2017 May;173(5):1243–1250.
   PubMed Web of Science ®Google Scholar
• Einfeld SL, Smith E, McGregor IS, et al. A double-blind randomized controlled trial of oxytocin nasal spray in Prader Willi syndrome. Am J Med Genet A. 2014 Sep;164A(9):2232–2239.
   PubMedGoogle Scholar
• Francis SM, Sagar A, Levin-Decanini T, et al. Oxytocin and vasopressin systems in genetic syndromes and neurodevelopmental disorders. Brain Res. 2014 Sep;11(1580):199–218.
   Google Scholar
• Song Z, Albers HE. Cross-talk among oxytocin and arginine-vasopressin receptors: relevance for basic and clinical studies of the brain and periphery. Front Neuroendocrinol. 2017 Oct 18.
   PubMedGoogle Scholar
• Striepens N, Kendrick KM, Hanking V, et al. Elevated cerebrospinal fluid and blood concentrations of oxytocin following its intranasal administration in humans. Sci Rep. 2013 Dec;6(3):3440.
   Google Scholar
• Kagerbauer SM, Martin J, Schuster T, et al. Plasma oxytocin and vasopressin do not predict neuropeptide concentrations in human cerebrospinal fluid. J Neuroendocrinol. 2013 Jul;25(7):668–673.
   PubMed Web of Science ®Google Scholar
• Szeto A, McCabe PM, Nation DA, et al. Evaluation of enzyme immunoassay and radioimmunoassay methods for the measurement of plasma oxytocin. Psychosom Med. 2011 Jun;73(5):393–400.
   PubMed Web of Science ®Google Scholar