The efficacy of multimodal physiotherapy and usual care in chronic whiplash-associated disorders with facet-mediated pain undergoing platelet rich plasma (PRP) treatment: a series of single case experimental designs (SCEDs)

References

• Carroll LJ, Holm LW, Hogg-Johnson S, et al. Course and prognostic factors for neck pain in whiplash-associated disorders (WAD): results of the bone and joint decade 2000-2010 task force on neck pain and its associated disorders. Spine (Phila Pa 1976). 2008;33(4 Suppl):S83–S92. doi:10.1097/BRS.0b013e3181643eb8.
   PubMed Web of Science ®Google Scholar
• Kamper SJ, Rebbeck TJ, Maher CG, et al. Course and prognostic factors of whiplash: a systematic review and meta-analysis. Pain. 2008;138(3):617–629. doi:10.1016/j.pain.2008.02.019.
   PubMed Web of Science ®Google Scholar
• Shearer HM, Carroll LJ, Wong JJ, et al. Are psychological interventions effective for the management of neck pain and whiplash-associated disorders? A systematic review by the Ontario protocol for traffic injury management (OPTIMa) collaboration. Spine J. 2016;16(12):1566–1581. doi:10.1016/j.spinee.2015.08.011.
   Web of Science ®Google Scholar
• Teasell RW, McClure JA, Walton D, et al. A research synthesis of therapeutic interventions for whiplash-associated disorder: part 1 - overview and summary. Pain Res Manag. 2010;15(5):287–294. doi:10.1155/2010/106593.
   PubMed Web of Science ®Google Scholar
• Blanpied PR, Gross AR, Elliott JM, et al. Neck pain: revision 2017. J Orthop Sports Phys Ther. 2017;47(7):A1–A83. doi:10.2519/jospt.2017.0302.
   PubMed Web of Science ®Google Scholar
• The South Australian Centre for Trauma and Injury Recovery (TRACsa). Clinical guidelines for best practice management of acute and chronic whiplash-associated disorders. Adelaide: TRACsa; 2008.
   Google Scholar
• Sutton DA, Côté P, Wong JJ, et al. Is multimodal care effective for the management of patients with whiplash-associated disorders or neck pain and associated disorders? A systematic review by the Ontario protocol for traffic injury management (OPTIMa) collaboration. Spine J. 2014;16(12):1541–1565. doi:10.1016/j.spinee.2014.06.019.
   PubMed Web of Science ®Google Scholar
• Peterson G, Peolsson A. Efficacy of neck-specific exercise with internet support versus neck-specific exercise at a physiotherapy clinic in chronic whiplash-associated disorders: multicenter randomized controlled noninferiority trial. J Med Internet Res. 2023;25:e43888. doi:10.2196/43888.
   PubMed Web of Science ®Google Scholar
• Jull G, Sterling M, Kenardy J, et al. Does the presence of sensory hypersensitivity influence outcomes of physical rehabilitation for chronic whiplash?–a preliminary RCT. Pain. 2007;129(1-2):28–34. doi:10.1016/j.pain.2006.09.030.
   PubMed Web of Science ®Google Scholar
• Ludvigsson ML, Peterson G, O’Leary S, et al. The effect of neck-specific exercise with, or without a behavioral approach, on pain, disability, and self-efficacy in chronic whiplash-associated disorders: a randomized clinical trial. Clin J Pain. 2015;31(4):294–303. doi:10.1097/AJP.0000000000000123.
   PubMed Web of Science ®Google Scholar
• Michaleff ZA, Maher CG, Lin CW, et al. Comprehensive physiotherapy exercise programme or advice for chronic whiplash (PROMISE): a pragmatic randomised controlled trial. Lancet. 2014;384(9938):133–141. doi:10.1016/S0140-6736(14)60457-8.
   PubMed Web of Science ®Google Scholar
• Ris I, Søgaard K, Gram B, et al. Does a combination of physical training, specific exercises and pain education improve health-related quality of life in patients with chronic neck pain? A randomised control trial with a 4-month follow up. Man Ther. 2016;26:132–140. doi:10.1016/j.math.2016.08.004.
   PubMedGoogle Scholar
• Stewart MJ, Maher CG, Refshauge KM, et al. Randomized controlled trial of exercise for chronic whiplash-associated disorders. Pain. 2007;128(1-2):59–68. doi:10.1016/j.pain.2006.08.030.
   PubMed Web of Science ®Google Scholar
• Smith AD, Jull G, Schneider G, et al. A comparison of physical and psychological features of responders and non-responders to cervical facet blocks in chronic whiplash. BMC Musculoskelet Disord. 2013;14(1):313. doi:10.1186/1471-2474-14-313.
   PubMedGoogle Scholar
• Smith AD, Jull G, Schneider GM, et al. Modulation of cervical facet joint nociception and pain attenuates physical and psychological features of chronic whiplash: a prospective study. Pm R. 2015;7(9):913–921. doi:10.1016/j.pmrj.2015.03.014.
   PubMedGoogle Scholar
• Barnsley L. Percutaneous radiofrequency neurotomy for chronic neck pain: outcomes in a series of consecutive patients. Pain Med. 2005;6(4):282–286. doi:10.1111/j.1526-4637.2005.00047.x.
   PubMed Web of Science ®Google Scholar
• Lord SM, Barnsley L, Wallis BJ, et al. Percutaneous radio-frequency neurotomy for chronic cervical zygapophyseal-joint pain. N Engl J Med. 1996;335(23):1721–1726. doi:10.1056/NEJM199612053352302.
   PubMed Web of Science ®Google Scholar
• Wu J, Zhou J, Liu C, et al. A prospective study comparing Platelet-Rich plasma and local anesthetic (LA)/corticosteroid in Intra-Articular injection for the treatment of lumbar facet joint syndrome. Pain Pract. 2017;17(7):914–924. doi:10.1111/papr.12544.
   PubMed Web of Science ®Google Scholar
• Kirchner F, Milani I, Martinez A, et al. Plasma rich in growth factors (PRGF) in the treatment of cervical and lumbar back pain: a retrospective observational clinical study. Pain Phys. 2021;24: e 649–E660. doi:10.36076/ppj.2021.24.E649.
   Web of Science ®Google Scholar
• Smith A, Andruski B, Deng G, et al. Cervical facet joint Platelet-Rich plasma in people with chronic whiplash-Assocated disorders: a prospective case series of Short-Term outcomes. Int Pain Med. 2022;1(2):100078. doi:10.1016/j.inpm.2022.100078.
   Google Scholar
• Williams C, Jerome M, Fausel C, et al. Regenerative injection treatments utilizing platelet products and prolotherapy for cervical spine pain: a functional spinal unit approach. Cureus. 2021;13(10):e18608. doi:10.7759/cureus.18608.
   PubMed Web of Science ®Google Scholar
• Murray IR, Geeslin AG, Goudie EB, et al. Minimum information for studies evaluating biologics in orthopaedics (MIBO): platelet-Rich plasma and mesenchymal stem cells. J Bone Joint Surg Am. 2017;99(10):809–819. doi:10.2106/JBJS.16.00793.
   PubMed Web of Science ®Google Scholar
• Jull G, Sterling M, Falla D, et al. Whiplash, headache and neck pain: Research-based directions for physical therapies. 1 Churchill Livingstone. 2008.
   Google Scholar
• Lillie EO, Patay B, Diamant J, et al. The n-of-1 clinical trial: the ultimate strategy for individualizing medicine? Per Med. 2011;8(2):161–173. doi:10.2217/pme.11.7.
   PubMed Web of Science ®Google Scholar
• Nikles J. What are N-of-1 trials? In The essential guide to N-of-1 trials in health.Dordrecht. Netherlands: Springer; 2015. pp. 9–17.
   Google Scholar
• Romeiser Logan L, Hickman RR, Harris SR, et al. Single-subject research design: recommendations for levels of evidence and quality rating. Dev Med Child Neurol. 2008;50(2):99–103. doi:10.1111/j.1469-8749.2007.02005.x.
   PubMed Web of Science ®Google Scholar
• Kratochwill TR, Hitchcock JH, Horner RH, et al. Single-case intervention research design standards. Remedial Special Educ. 2013;34(1):26–38. doi:10.1177/0741932512452794.
   Web of Science ®Google Scholar
• Kazdin A. Single-case research designs: methods for clinical and applied settings. 2nd ed. New York (NY): Oxford University Press; 2011.
   Google Scholar
• Spitzer WO, Skovron ML, Salmi LR, et al. Scientific monograph of the Quebec task force on whiplash-associated disorders: redefining "whiplash" and its management. Spine (Phila Pa 1976). 1995;20(8 Suppl):1S–73S.
   PubMed Web of Science ®Google Scholar
• Jull G, Sterling M, The University of Queensland. Whiplash injury recovery: self-Help guide. 3rd ed. Motor Accident Insurance Commission; 2019.
   Google Scholar
• Krebs EE, Lorenz KA, Bair MJ, et al. Development and initial validation of the PEG, a three-item scale assessing pain intensity and interference. J Gen Intern Med. 2009;24(6):733–738. doi:10.1007/s11606-009-0981-1.
   PubMed Web of Science ®Google Scholar
• Bandura A, Adams NE, Beyer J. Cognitive processes mediating behavioral change. J Pers Soc Psychol. 1977;35(3):125–139. doi:10.1037/0022-3514.35.3.125.
   PubMed Web of Science ®Google Scholar
• Ritchie C, Clanchy K, Sterling M, et al. Evaluation of a physical activity promotion intervention for adults with whiplash associated disorders: a single-case experimental design study. Disabil Rehabil. 2021;44(23):7255–7268.
   PubMed Web of Science ®Google Scholar
• Hurst H, Bolton J. Assessing the clinical significance of change scores recorded on subjective outcome measures. J Manipulative Physiol Ther. 2004;27(1):26–35. doi:10.1016/j.jmpt.2003.11.003.
   PubMed Web of Science ®Google Scholar
• Kamper S. Global rating of change scales. Aust J Physiother. 2009;55(4):289. doi:10.1016/s0004-9514(09)70015-7.
   PubMed Web of Science ®Google Scholar
• Young IA, Dunning J, Butts R, et al. Psychometric properties of the numeric pain rating scale and neck disability index in patients with cervicogenic headache. Cephalalgia. 2019;39(1):44–51. doi:10.1177/0333102418772584.
   PubMed Web of Science ®Google Scholar
• Vernon H, Mior S. The neck disability index: a study of reliability and validity. J Manipulative Physiol Ther. 1991;14(7):409–415.
   PubMed Web of Science ®Google Scholar
• Lovibond S, Lovibond P. Manual for the depression anxiety stress scales. 2nd. Sydney: psychology Foundation; 1995.
   Google Scholar
• Sullivan M, Bishop S, Pivik J. The pain catastrophizing scale: development and validation. Psychol Assess. 1995;7(4):524–532. doi:10.1037/1040-3590.7.4.524.
   Web of Science ®Google Scholar
• Díaz-Arribas MJ, Fernández-Serrano M, Royuela A, et al. Minimal clinically important difference in quality of life for patients with low back pain. Spine (Phila Pa 1976). 2017;42(24):1908–1916. doi:10.1097/BRS.0000000000002298.
   PubMed Web of Science ®Google Scholar
• Lane JD, Gast DL. Visual analysis in single case experimental design studies: brief review and guidelines. Neuropsychol Rehabil. 2014;24(3-4):445–463. doi:10.1080/09602011.2013.815636.
   PubMed Web of Science ®Google Scholar
• Heyvaert M, Wendt O, Van den Noortgate W, et al. Randomization and data-analysis items in quality standards for single-case experimental studies. J Spec Educ. 2015;49(3):146–156. doi:10.1177/0022466914525239.
   Web of Science ®Google Scholar
• Parker RI, Vannest KJ, Davis JL, et al. Combining nonoverlap and trend for single-case research: tau-U. Behav Ther. 2011;42(2):284–299. doi:10.1016/j.beth.2010.08.006.
   PubMed Web of Science ®Google Scholar
• Vannest KJ, Ninci J. Evaluating intervention effects in single-case research designs. J Counsel Develop. 2015;93(4):403–411. doi:10.1002/jcad.12038.
   Web of Science ®Google Scholar
• Jull G, Falla D, Treleaven J, et al. Management of neck pain disorders: a research informed approach. UK: Elsevier; 2018.
   Google Scholar
• Campbell L, Smith A, McGregor L, et al. Psychological factors and the development of chronic whiplash-associated disorder(s): a systematic review. Clin J Pain. 2018;34(8):755–768. doi:10.1097/AJP.0000000000000597.
   PubMed Web of Science ®Google Scholar
• Carroll LJ, Cassidy JD, Côté P. The role of pain coping strategies in prognosis after whiplash injury: passive coping predicts slowed recovery. Pain. 2006;124(1-2):18–26. doi:10.1016/j.pain.2006.03.012.
   PubMed Web of Science ®Google Scholar
• Sterling M, Smeets R, Keijzers G, et al. Physiotherapist-delivered stress inoculation training integrated with exercise versus physiotherapy exercise alone for acute whiplash-associated disorder (StressModex): a randomised controlled trial of a combined psychological/physical intervention. Br J Sports Med. 2019;53(19):1240–1247. doi:10.1136/bjsports-2018-100139.
   PubMed Web of Science ®Google Scholar
• Söderlund A, Lindberg P. An integrated physiotherapy/cognitive-behavioural approach to the analysis and treatment of chronic whiplash associated disorders, WAD. Disabil Rehabil. 2001;23(10):436–447. doi:10.1080/09638280010008870.
   PubMed Web of Science ®Google Scholar
• Wicksell RK, Ahlqvist J, Bring A, et al. Can exposure and acceptance strategies improve functioning and life satisfaction in people with chronic pain and whiplash-associated disorders (WAD)? a randomized controlled trial. Cogn Behav Ther. 2008;37(3):169–182. doi:10.1080/16506070802078970.
   PubMedGoogle Scholar
• Andersen TE, Ravn SL, Armfield N, et al. Trauma-focused cognitive behavioural therapy and exercise for chronic whiplash with comorbid posttraumatic stress disorder: a randomised controlled trial. Pain. 2021;162(4):1221–1232. doi:10.1097/j.pain.0000000000002117.
   PubMed Web of Science ®Google Scholar
• Gross AR, Goldsmith C, Hoving JL, et al. Conservative management of mechanical neck disorders: a systematic review. J Rheumatol. 2007;34(5):1083–1102.
   PubMed Web of Science ®Google Scholar
• Gross AR, Kay T, Hondras M, et al. Manual therapy for mechanical neck disorders: a systematic review. Man Ther. 2002;7(3):131–149. doi:10.1054/math.2002.0465.
   PubMed Web of Science ®Google Scholar
• Sterling M, Vicenzino B, Souvlis T, et al. Dry-needling and exercise for chronic whiplash-associated disorders: a randomized single-blind placebo-controlled trial. Pain. 2015;156(4):635–643. doi:10.1097/01.j.pain.0000460359.40116.c1.
   PubMed Web of Science ®Google Scholar
• Curatolo M, Bogduk N, Ivancic PC, et al. The role of tissue damage in whiplash-associated disorders: discussion paper 1. Spine (Phila Pa 1976). 2011;36(25 Suppl):S309–S315. doi:10.1097/BRS.0b013e318238842a.
   PubMed Web of Science ®Google Scholar
• Dong L, Odeleye AO, Jordan-Sciutto KL, et al. Painful facet joint injury induces neuronal stress activation in the DRG: implications for cellular mechanisms of pain. Neurosci Lett. 2008;443(2):90–94. doi:10.1016/j.neulet.2008.07.059.
   PubMed Web of Science ®Google Scholar
• Dong L, Quindlen JC, Lipschutz DE, et al. Whiplash-like facet joint loading initiates glutamatergic responses in the DRG and spinal cord associated with behavioral hypersensitivity. Brain Res. 2012;1461:51–63. doi:10.1016/j.brainres.2012.04.026.
   PubMed Web of Science ®Google Scholar
• Kras JV, Dong L, Winkelstein BA. Increased interleukin-1alpha and prostaglandin e2 expression in the spinal cord at 1 day after painful facet joint injury: evidence of early spinal inflammation. Spine (Phila Pa 1976). 2014;39(3):207–212. doi:10.1097/BRS.0000000000000107.
   PubMed Web of Science ®Google Scholar
• Quinn KP, Dong L, Golder FJ, et al. Neuronal hyperexcitability in the dorsal horn after painful facet joint injury. Pain. 2010;151(2):414–421. doi:10.1016/j.pain.2010.07.034.
   PubMed Web of Science ®Google Scholar
• Quinn KP, Winkelstein BA. Detection of altered collagen fiber alignment in the cervical facet capsule after whiplash-like joint retraction. Ann Biomed Eng. 2011;39(8):2163–2173. doi:10.1007/s10439-011-0316-3.
   PubMed Web of Science ®Google Scholar
• Amable PR, Carias RB, Teixeira MV, et al. Platelet-rich plasma preparation for regenerative medicine: optimization and quantification of cytokines and growth factors. Stem Cell Res Ther. 2013;4(3):67. doi:10.1186/scrt218.
   PubMed Web of Science ®Google Scholar
• Sampson S, Gerhardt M, Mandelbaum B. Platelet rich plasma injection grafts for musculoskeletal injuries: a review. Curr Rev Musculoskelet Med. 2008;1(3-4):165–174. doi:10.1007/s12178-008-9032-5.
   PubMedGoogle Scholar
• Podd D. Platelet-rich plasma therapy: origins and applications investigated: hyperphysiologic concentrations of growth factors stored in the platelets may hold the key to expedited healing of cutaneous ulcers and tendon and muscle injury. Jaapa. 2012;25(6):44–49. doi:10.1097/01720610-201206000-00009.
   PubMedGoogle Scholar
• Farrell SF, de Zoete RMJ, Cabot PJ, et al. Systemic inflammatory markers in neck pain: a systematic review with meta-analysis. Eur J Pain. 2020;24(9):1666–1686. doi:10.1002/ejp.1630.
   PubMed Web of Science ®Google Scholar
• Braveman PA, Cubbin C, Egerter S, et al. Socioeconomic disparities in health in the united states: what the patterns tell us. Am J Public Health. 2010;100(S1):S186–S196. doi:10.2105/AJPH.2009.166082.
   PubMed Web of Science ®Google Scholar