Connections between cadherin-catenin proteins, spindle misorientation, and cancer

References

• Farquhar MG, Palade GE. Junctional complexes in various epithelia. J Cell Biol 1963; 17:375-412; PMID:13944428; http://dx.doi.org/10.1083/jcb.17.2.375
   PubMed Web of Science ®Google Scholar
• Gumbiner BM. Regulation of cadherin-mediated adhesion in morphogenesis. Nat Rev Mol Cell Biol 2005; 6:622-34; PMID:16025097; http://dx.doi.org/10.1038/nrm1699
   PubMed Web of Science ®Google Scholar
• Perez-Moreno M, Jamora C, Fuchs E. Sticky business: orchestrating cellular signals at adherens junctions. Cell 2003; 112:535-48; PMID:12600316; http://dx.doi.org/10.1016/S0092-8674(03)00108-9
   PubMed Web of Science ®Google Scholar
• Pieters T, van Roy F. Role of cell-cell adhesion complexes in embryonic stem cell biology. J Cell Sci 2014; 127:2603-13; PMID:24931943; http://dx.doi.org/10.1242/jcs.146720
   PubMed Web of Science ®Google Scholar
• Takeichi M. Cadherin cell adhesion receptors as a morphogenetic regulator. Science 1991; 251:1451-5; PMID:2006419; http://dx.doi.org/10.1126/science.2006419
   PubMed Web of Science ®Google Scholar
• Brieher WM, Yap AS. Cadherin junctions and their cytoskeleton(s). Curr Opin Cell Biol 2013; 25:39-46; PMID:23127608; http://dx.doi.org/10.1016/j.ceb.2012.10.010
   PubMed Web of Science ®Google Scholar
• Niessen CM, Leckband D, Yap AS. Tissue organization by cadherin adhesion molecules: dynamic molecular and cellular mechanisms of morphogenetic regulation. Physiol Rev 2011; 91:691-731; PMID:21527735; http://dx.doi.org/10.1152/physrev.00004.2010
   PubMed Web of Science ®Google Scholar
• Perrais M, Chen X, Perez-Moreno M, Gumbiner BM. E-cadherin homophilic ligation inhibits cell growth and epidermal growth factor receptor signaling independently of other cell interactions. Mol Biol Cell 2007; 18:2013-25; PMID:17392517; http://dx.doi.org/10.1091/mbc.E06-04-0348
   PubMed Web of Science ®Google Scholar
• Birchmeier W, Behrens J. Cadherin expression in carcinomas: role in the formation of cell junctions and the prevention of invasiveness. Biochim Biophys Acta 1994; 1198:11-26; PMID:8199193
   PubMed Web of Science ®Google Scholar
• Berx G, Nollet F, van Roy F. Dysregulation of the E-cadherin/catenin complex by irreversible mutations in human carcinomas. Cell Adhes Commun 1998; 6:171-84; PMID:9823469; http://dx.doi.org/10.3109/15419069809004474
   PubMed Web of Science ®Google Scholar
• Jeanes A, Gottardi CJ, Yap AS. Cadherins and cancer: how does cadherin dysfunction promote tumor progression? Oncogene 2008; 27:6920-9; PMID:19029934; http://dx.doi.org/10.1038/onc.2008.343
   PubMed Web of Science ®Google Scholar
• Thiery JP, Acloque H, Huang RY, Nieto MA. Epithelial-mesenchymal transitions in development and disease. Cell 2009; 139:871-90; PMID:19945376; http://dx.doi.org/10.1016/j.cell.2009.11.007
   PubMed Web of Science ®Google Scholar
• Muthuswamy SK, Xue B. Cell polarity as a regulator of cancer cell behavior plasticity. Annu Rev Cell Dev Biol 2012; 28:599-625; PMID:22881459; http://dx.doi.org/10.1146/annurev-cellbio-092910-154244
   PubMed Web of Science ®Google Scholar
• Martin-Belmonte F, Perez-Moreno M. Epithelial cell polarity, stem cells and cancer. Nat Rev Cancer 2012; 12:23-38.
   Web of Science ®Google Scholar
• Bornens M. Organelle positioning and cell polarity. Nat Rev Mol Cell Biol 2008; 9:874-86; PMID:18946476; http://dx.doi.org/10.1038/nrm2524
   PubMed Web of Science ®Google Scholar
• Knoblich JA. Mechanisms of asymmetric stem cell division. Cell 2008; 132:583-97; PMID:18295577; http://dx.doi.org/10.1016/j.cell.2008.02.007
   PubMed Web of Science ®Google Scholar
• Knoblich JA. Asymmetric cell division: recent developments and their implications for tumour biology. Nat Rev Mol Cell Biol 2010; 11:849-60; PMID:21102610; http://dx.doi.org/10.1038/nrm3010
   PubMed Web of Science ®Google Scholar
• Quyn AJ, Appleton PL, Carey FA, Steele RJ, Barker N, Clevers H, Ridgway RA, Sansom OJ, Näthke IS. Spindle orientation bias in gut epithelial stem cell compartments is lost in precancerous tissue. Cell Stem Cell 2010; 6:175-81; PMID:20144789; http://dx.doi.org/10.1016/j.stem.2009.12.007
   PubMed Web of Science ®Google Scholar
• De Mey JR, Freund JN. Understanding epithelial homeostasis in the intestine: An old battlefield of ideas, recent breakthroughs and remaining controversies. Tissue Barriers 2013; 1:e24965; PMID:24665395; http://dx.doi.org/10.4161/tisb.24965
   PubMedGoogle Scholar
• Cicalese A, Bonizzi G, Pasi CE, Faretta M, Ronzoni S, Giulini B, Brisken C, Minucci S, Di Fiore PP, Pelicci PG. The tumor suppressor p53 regulates polarity of self-renewing divisions in mammary stem cells. Cell 2009; 138:1083-95; PMID:19766563; http://dx.doi.org/10.1016/j.cell.2009.06.048
   PubMed Web of Science ®Google Scholar
• Regan JL, Sourisseau T, Soady K, Kendrick H, McCarthy A, Tang C, Brennan K, Linardopoulos S, White DE, Smalley MJ. Aurora A kinase regulates mammary epithelial cell fate by determining mitotic spindle orientation in a Notch-dependent manner. Cell Rep 2013; 4:110-23; PMID:23810554; http://dx.doi.org/10.1016/j.celrep.2013.05.044
   PubMed Web of Science ®Google Scholar
• El-Hashash AH, Turcatel G, Al Alam D, Buckley S, Tokumitsu H, Bellusci S, Warburton D. Eya1 controls cell polarity, spindle orientation, cell fate and Notch signaling in distal embryonic lung epithelium. Development 2011; 138:1395-407; PMID:21385765; http://dx.doi.org/10.1242/dev.058479
   PubMed Web of Science ®Google Scholar
• El-Hashash AH, Warburton D. Cell polarity and spindle orientation in the distal epithelium of embryonic lung. Dev Dyn 2011; 240:441-5; PMID:21246661; http://dx.doi.org/10.1002/dvdy.22551
   PubMed Web of Science ®Google Scholar
• Lechler T, Fuchs E. Asymmetric cell divisions promote stratification and differentiation of mammalian skin. Nature 2005; 437:275-80; PMID:16094321; http://dx.doi.org/10.1038/nature03922
   PubMed Web of Science ®Google Scholar
• Luxenburg C, Pasolli HA, Williams SE, Fuchs E. Developmental roles for Srf, cortical cytoskeleton and cell shape in epidermal spindle orientation. Nat Cell Biol 2011; 13:203-14; PMID:21336301; http://dx.doi.org/10.1038/ncb2163
   PubMed Web of Science ®Google Scholar
• Williams SE, Beronja S, Pasolli HA, Fuchs E. Asymmetric cell divisions promote Notch-dependent epidermal differentiation. Nature 2011; 470:353-8; PMID:21331036; http://dx.doi.org/10.1038/nature09793
   PubMed Web of Science ®Google Scholar
• Niessen MT, Scott J, Zielinski JG, Vorhagen S, Sotiropoulou PA, Blanpain C, Leitges M, Niessen CM. aPKClambda controls epidermal homeostasis and stem cell fate through regulation of division orientation. J Cell Biol 2013; 202:887-900; PMID:24019538; http://dx.doi.org/10.1083/jcb.201307001
   PubMed Web of Science ®Google Scholar
• Williams SE, Ratliff LA, Postiglione MP, Knoblich JA, Fuchs E. Par3-mInsc and Galphai3 cooperate to promote oriented epidermal cell divisions through LGN. Nat Cell Biol 2014; 16:758-69; PMID:25016959; http://dx.doi.org/10.1038/ncb3001
   PubMed Web of Science ®Google Scholar
• Pease JC, Tirnauer JS. Mitotic spindle misorientation in cancer–out of alignment and into the fire. J Cell Sci 2011; 124:1007-16; PMID:21402874; http://dx.doi.org/10.1242/jcs.081406
   PubMed Web of Science ®Google Scholar
• Pece S, Tosoni D, Confalonieri S, Mazzarol G, Vecchi M, Ronzoni S, Bernard L, Viale G, Pelicci PG, Di Fiore PP. Biological and molecular heterogeneity of breast cancers correlates with their cancer stem cell content. Cell 2010; 140:62-73; PMID:20074520; http://dx.doi.org/10.1016/j.cell.2009.12.007
   PubMed Web of Science ®Google Scholar
• O'Brien CA, Kreso A, Ryan P, Hermans KG, Gibson L, Wang Y, Tsatsanis A, Gallinger S, Dick JE. ID1 and ID3 regulate the self-renewal capacity of human colon cancer-initiating cells through p21. Cancer Cell 2012; 21:777-92; PMID:22698403; http://dx.doi.org/10.1016/j.ccr.2012.04.036
   PubMedGoogle Scholar
• Schepers AG, Snippert HJ, Stange DE, van den Born M, van Es JH, van de Wetering M, Clevers H. Lineage tracing reveals Lgr5+ stem cell activity in mouse intestinal adenomas. Science 2012; 337:730-5; PMID:22855427; http://dx.doi.org/10.1126/science.1224676
   PubMed Web of Science ®Google Scholar
• Pine SR, Ryan BM, Varticovski L, Robles AI, Harris CC. Microenvironmental modulation of asymmetric cell division in human lung cancer cells. Proc Natl Acad Sci U S A 2010; 107:2195-200; PMID:20080668; http://dx.doi.org/10.1073/pnas.0909390107
   PubMedGoogle Scholar
• Driessens G, Beck B, Caauwe A, Simons BD, Blanpain C. Defining the mode of tumour growth by clonal analysis. Nature 2012; 488:527-30; PMID:22854777; http://dx.doi.org/10.1038/nature11344
   PubMed Web of Science ®Google Scholar
• Luders J, Stearns T. Microtubule-organizing centres: a re-evaluation. Nat Rev Mol Cell Biol 2007; 8:161-7; PMID:17245416; http://dx.doi.org/10.1038/nrm2100
   PubMed Web of Science ®Google Scholar
• Bornens M. The centrosome in cells and organisms. Science 2012; 335:422-6; PMID:22282802; http://dx.doi.org/10.1126/science.1209037
   PubMed Web of Science ®Google Scholar
• Tanaka TU. Kinetochore-microtubule interactions: steps towards bi-orientation. EMBO J 2010; 29:4070-82; PMID:21102558; http://dx.doi.org/10.1038/emboj.2010.294
   PubMed Web of Science ®Google Scholar
• Yamashita YM. The centrosome and asymmetric cell division. Prion 2009; 3:84-8; PMID:19458491; http://dx.doi.org/10.4161/pri.3.2.8821
   PubMed Web of Science ®Google Scholar
• Pelletier L, Yamashita YM. Centrosome asymmetry and inheritance during animal development. Curr Opin Cell Biol 2012; 24:541-6; PMID:22683192; http://dx.doi.org/10.1016/j.ceb.2012.05.005
   PubMed Web of Science ®Google Scholar
• Malumbres M. Physiological relevance of cell cycle kinases. Physiol Rev 2011; 91:973-1007; PMID:21742793; http://dx.doi.org/10.1152/physrev.00025.2010
   PubMed Web of Science ®Google Scholar
• Elric J, Etienne-Manneville S. Centrosome positioning in polarized cells: common themes and variations. Exp Cell Res 2014; 328:240-8; PMID:25218948; http://dx.doi.org/10.1016/j.yexcr.2014.09.004
   PubMed Web of Science ®Google Scholar
• Morin X, Bellaiche Y. Mitotic spindle orientation in asymmetric and symmetric cell divisions during animal development. Dev Cell 2011; 21:102-19; PMID:21763612; http://dx.doi.org/10.1016/j.devcel.2011.06.012
   PubMed Web of Science ®Google Scholar
• Siller KH, Doe CQ. Spindle orientation during asymmetric cell division. Nat Cell Biol 2009; 11:365-74; PMID:19337318; http://dx.doi.org/10.1038/ncb0409-365
   PubMed Web of Science ®Google Scholar
• Williams SE, Fuchs E. Oriented divisions, fate decisions. Curr Opin Cell Biol 2013; 25:749-58; PMID:24021274; http://dx.doi.org/10.1016/j.ceb.2013.08.003
   PubMed Web of Science ®Google Scholar
• Culurgioni S, Alfieri A, Pendolino V, Laddomada F, Mapelli M. Inscuteable and NuMA proteins bind competitively to Leu-Gly-Asn repeat-enriched protein (LGN) during asymmetric cell divisions. Proc Natl Acad Sci U S A 2011; 108:20998-1003; PMID:22171003; http://dx.doi.org/10.1073/pnas.1113077108
   PubMedGoogle Scholar
• Mapelli M, Gonzalez C. On the inscrutable role of Inscuteable: structural basis and functional implications for the competitive binding of NuMA and Inscuteable to LGN. Open Biol 2012; 2:120102; PMID:22977735; http://dx.doi.org/10.1098/rsob.120102
   PubMed Web of Science ®Google Scholar
• Hao Y, Du Q, Chen X, Zheng Z, Balsbaugh JL, Maitra S, Shabanowitz J, Hunt DF, Macara IG. Par3 controls epithelial spindle orientation by aPKC-mediated phosphorylation of apical Pins. Curr Biol 2010; 20:1809-18; PMID:20933426; http://dx.doi.org/10.1016/j.cub.2010.09.032
   PubMed Web of Science ®Google Scholar
• Zheng Z, Zhu H, Wan Q, Liu J, Xiao Z, Siderovski DP, Du Q. LGN regulates mitotic spindle orientation during epithelial morphogenesis. J Cell Biol 2010; 189:275-88; PMID:20385777; http://dx.doi.org/10.1083/jcb.200910021
   PubMed Web of Science ®Google Scholar
• Peyre E, Jaouen F, Saadaoui M, Haren L, Merdes A, Durbec P, Morin X. A lateral belt of cortical LGN and NuMA guides mitotic spindle movements and planar division in neuroepithelial cells. J Cell Biol 2011; 193:141-54; PMID:21444683; http://dx.doi.org/10.1083/jcb.201101039
   PubMed Web of Science ®Google Scholar
• Konno D, Shioi G, Shitamukai A, Mori A, Kiyonari H, Miyata T, Matsuzaki F. Neuroepithelial progenitors undergo LGN-dependent planar divisions to maintain self-renewability during mammalian neurogenesis. Nat Cell Biol 2008; 10:93-101; PMID:18084280; http://dx.doi.org/10.1038/ncb1673
   PubMed Web of Science ®Google Scholar
• Desai RA, Gao L, Raghavan S, Liu WF, Chen CS. Cell polarity triggered by cell-cell adhesion via E-cadherin. J Cell Sci 2009; 122:905-11; PMID:19258396; http://dx.doi.org/10.1242/jcs.028183
   PubMed Web of Science ®Google Scholar
• Dupin I, Camand E, Etienne-Manneville S. Classical cadherins control nucleus and centrosome position and cell polarity. J Cell Biol 2009; 185:779-86; PMID:19487453; http://dx.doi.org/10.1083/jcb.200812034
   PubMed Web of Science ®Google Scholar
• den Elzen N, Buttery CV, Maddugoda MP, Ren G, Yap AS. Cadherin adhesion receptors orient the mitotic spindle during symmetric cell division in mammalian epithelia. Mol Biol Cell 2009; 20:3740-50; PMID:19553471; http://dx.doi.org/10.1091/mbc.E09-01-0023
   PubMed Web of Science ®Google Scholar
• Song X, Zhu CH, Doan C, Xie T. Germline stem cells anchored by adherens junctions in the Drosophila ovary niches. Science 2002; 296:1855-7; PMID:12052957; http://dx.doi.org/10.1126/science.1069871
   PubMed Web of Science ®Google Scholar
• Inaba M, Yuan H, Salzmann V, Fuller MT, Yamashita YM. E-cadherin is required for centrosome and spindle orientation in Drosophila male germline stem cells. PLoS One 2010; 5:e12473; PMID:20824213; http://dx.doi.org/10.1371/journal.pone.0012473
   PubMed Web of Science ®Google Scholar
• Le Borgne R, Bellaiche Y, Schweisguth F. Drosophila E-cadherin regulates the orientation of asymmetric cell division in the sensory organ lineage. Curr Biol 2002; 12:95-104; PMID:11818059; http://dx.doi.org/10.1016/S0960-9822(01)00648-0
   PubMed Web of Science ®Google Scholar
• Kim S, Ishidate T, Sharma R, Soto MC, Conte D, Jr., Mello CC, Shirayama M. Wnt and CDK-1 regulate cortical release of WRM-1/beta-catenin to control cell division orientation in early Caenorhabditis elegans embryos. Proc Natl Acad Sci U S A 2013; 110:E918-27; PMID:23431196; http://dx.doi.org/10.1073/pnas.1300769110
   PubMedGoogle Scholar
• Marthiens V, ffrench-Constant C. Adherens junction domains are split by asymmetric division of embryonic neural stem cells. EMBO Rep 2009; 10:515-20; PMID:19373255; http://dx.doi.org/10.1038/embor.2009.36
   PubMed Web of Science ®Google Scholar
• Zhang J, Woodhead GJ, Swaminathan SK, Noles SR, McQuinn ER, Pisarek AJ, Stocker AM, Mutch CA, Funatsu N, Chenn A. Cortical neural precursors inhibit their own differentiation via N-cadherin maintenance of beta-catenin signaling. Dev Cell 2010; 18:472-9; PMID:20230753; http://dx.doi.org/10.1016/j.devcel.2009.12.025
   PubMed Web of Science ®Google Scholar
• Humar B, Guilford P. Hereditary diffuse gastric cancer: a manifestation of lost cell polarity. Cancer Sci 2009; 100:1151-7; PMID:19432899; http://dx.doi.org/10.1111/j.1349-7006.2009.01163.x
   PubMed Web of Science ®Google Scholar
• Wu M, Smith CL, Hall JA, Lee I, Luby-Phelps K, Tallquist MD. Epicardial spindle orientation controls cell entry into the myocardium. Dev Cell 2010; 19:114-25; PMID:20643355; http://dx.doi.org/10.1016/j.devcel.2010.06.011
   PubMed Web of Science ®Google Scholar
• Bergstralh DT, Lovegrove HE, St Johnston D. Discs large links spindle orientation to apical-basal polarity in Drosophila epithelia. Curr Biol 2013; 23:1707-12; PMID:23891112; http://dx.doi.org/10.1016/j.cub.2013.07.017
   PubMed Web of Science ®Google Scholar
• Woolner S, Papalopulu N. Spindle position in symmetric cell divisions during epiboly is controlled by opposing and dynamic apicobasal forces. Dev Cell 2012; 22:775-87; PMID:22406140; http://dx.doi.org/10.1016/j.devcel.2012.01.002
   PubMed Web of Science ®Google Scholar
• Nakajima Y, Meyer EJ, Kroesen A, McKinney SA, Gibson MC. Epithelial junctions maintain tissue architecture by directing planar spindle orientation. Nature 2013; 500:359-62; PMID:23873041; http://dx.doi.org/10.1038/nature12335
   PubMed Web of Science ®Google Scholar
• Tinkle CL, Lechler T, Pasolli HA, Fuchs E. Conditional targeting of E-cadherin in skin: insights into hyperproliferative and degenerative responses. Proc Natl Acad Sci U S A 2004; 101:552-7; PMID:14704278; http://dx.doi.org/10.1073/pnas.0307437100
   PubMedGoogle Scholar
• Tunggal JA, Helfrich I, Schmitz A, Schwarz H, Gunzel D, Fromm M, Kemler R, Krieg T, Niessen CM. E-cadherin is essential for in vivo epidermal barrier function by regulating tight junctions. EMBO J 2005; 24:1146-56; PMID:15775979; http://dx.doi.org/10.1038/sj.emboj.7600605
   PubMed Web of Science ®Google Scholar
• Derksen PW, Liu X, Saridin F, van der Gulden H, Zevenhoven J, Evers B, van Beijnum JR, Griffioen AW, Vink J, Krimpenfort P, et al. Somatic inactivation of E-cadherin and p53 in mice leads to metastatic lobular mammary carcinoma through induction of anoikis resistance and angiogenesis. Cancer Cell 2006; 10:437-49; PMID:17097565; http://dx.doi.org/10.1016/j.ccr.2006.09.013
   PubMed Web of Science ®Google Scholar
• Le Bras S, Le Borgne R. Epithelial cell division - multiplying without losing touch. J Cell Sci 2014; 127:5127-37; PMID:25344250; http://dx.doi.org/10.1242/jcs.151472
   PubMed Web of Science ®Google Scholar
• Ragkousi K, Gibson MC. Cell division and the maintenance of epithelial order. J Cell Biol 2014; 207:181-8; PMID:25349258; http://dx.doi.org/10.1083/jcb.201408044
   PubMed Web of Science ®Google Scholar
• Founounou N, Loyer N, Le Borgne R. Septins regulate the contractility of the actomyosin ring to enable adherens junction remodeling during cytokinesis of epithelial cells. Dev Cell 2013; 24:242-55; PMID:23410939; http://dx.doi.org/10.1016/j.devcel.2013.01.008
   PubMed Web of Science ®Google Scholar
• Guillot C, Lecuit T. Adhesion disengagement uncouples intrinsic and extrinsic forces to drive cytokinesis in epithelial tissues. Dev Cell 2013; 24:227-41; PMID:23410938; http://dx.doi.org/10.1016/j.devcel.2013.01.010
   PubMed Web of Science ®Google Scholar
• Herszterg S, Leibfried A, Bosveld F, Martin C, Bellaiche Y. Interplay between the dividing cell and its neighbors regulates adherens junction formation during cytokinesis in epithelial tissue. Dev Cell 2013; 24:256-70; PMID:23410940; http://dx.doi.org/10.1016/j.devcel.2012.11.019
   PubMed Web of Science ®Google Scholar
• Baker J, Garrod D. Epithelial cells retain junctions during mitosis. J Cell Sci 1993; 104 (Pt 2):415-25; PMID:7685036
   PubMed Web of Science ®Google Scholar
• Reinsch S, Karsenti E. Orientation of spindle axis and distribution of plasma membrane proteins during cell division in polarized MDCKII cells. J Cell Biol 1994; 126:1509-26; PMID:8089182; http://dx.doi.org/10.1083/jcb.126.6.1509
   PubMed Web of Science ®Google Scholar
• Kirschner MW, Mitchison T. Microtubule dynamics. Nature 1986; 324:621; PMID:3796729; http://dx.doi.org/10.1038/324621a0
   PubMed Web of Science ®Google Scholar
• Stehbens SJ, Akhmanova A, Yap AS. Microtubules and cadherins: a neglected partnership. Front Biosci (Landmark Ed) 2009; 14:3159-67; PMID:19273264; http://dx.doi.org/10.2741/3442
   PubMed Web of Science ®Google Scholar
• Akhmanova A, Stehbens SJ, Yap AS. Touch, grasp, deliver and control: functional cross-talk between microtubules and cell adhesions. Traffic 2009; 10:268-74; PMID:19175539; http://dx.doi.org/10.1111/j.1600-0854.2008.00869.x
   PubMed Web of Science ®Google Scholar
• Bellett G, Carter JM, Keynton J, Goldspink D, James C, Moss DK, Mogensen MM. Microtubule plus-end and minus-end capture at adherens junctions is involved in the assembly of apico-basal arrays in polarised epithelial cells. Cell Motil Cytoskeleton 2009; 66:893-908; PMID:19479825; http://dx.doi.org/10.1002/cm.20393
   PubMed Web of Science ®Google Scholar
• Karakesisoglou I, Yang Y, Fuchs E. An epidermal plakin that integrates actin and microtubule networks at cellular junctions. J Cell Biol 2000; 149:195-208; PMID:10747097; http://dx.doi.org/10.1083/jcb.149.1.195
   PubMed Web of Science ®Google Scholar
• Mogensen MM, Tucker JB, Mackie JB, Prescott AR, Nathke IS. The adenomatous polyposis coli protein unambiguously localizes to microtubule plus ends and is involved in establishing parallel arrays of microtubule bundles in highly polarized epithelial cells. J Cell Biol 2002; 157:1041-8; PMID:12058019; http://dx.doi.org/10.1083/jcb.200203001
   PubMed Web of Science ®Google Scholar
• Bienz M. Spindles cotton on to junctions, APC and EB1. Nat Cell Biol 2001; 3:E67-8; PMID:11231588; http://dx.doi.org/10.1038/35060140
   PubMedGoogle Scholar
• Ligon LA, Karki S, Tokito M, Holzbaur EL. Dynein binds to beta-catenin and may tether microtubules at adherens junctions. Nat Cell Biol 2001; 3:913-7; PMID:11584273; http://dx.doi.org/10.1038/ncb1001-913
   PubMed Web of Science ®Google Scholar
• Ligon LA, Holzbaur EL. Microtubules tethered at epithelial cell junctions by dynein facilitate efficient junction assembly. Traffic 2007; 8:808-19; PMID:17550375; http://dx.doi.org/10.1111/j.1600-0854.2007.00574.x
   PubMed Web of Science ®Google Scholar
• Shahbazi MN, Megias D, Epifano C, Akhmanova A, Gundersen GG, Fuchs E, Perez-Moreno M. CLASP2 interacts with p120-catenin and governs microtubule dynamics at adherens junctions. J Cell Biol 2013; 203:1043-61; PMID:24368809; http://dx.doi.org/10.1083/jcb.201306019
   PubMed Web of Science ®Google Scholar
• Shahbazi MN, Perez-Moreno M. Microtubules CLASP to Adherens Junctions in epidermal progenitor cells. Bioarchitecture 2014; 4:25-30; PMID:24522006; http://dx.doi.org/10.4161/bioa.28177
   PubMedGoogle Scholar
• Meng W, Mushika Y, Ichii T, Takeichi M. Anchorage of microtubule minus ends to adherens junctions regulates epithelial cell-cell contacts. Cell 2008; 135:948-59; PMID:19041755; http://dx.doi.org/10.1016/j.cell.2008.09.040
   PubMed Web of Science ®Google Scholar
• Kaplan DD, Meigs TE, Kelly P, Casey PJ. Identification of a role for beta-catenin in the establishment of a bipolar mitotic spindle. J Biol Chem 2004; 279:10829-32; PMID:14744872; http://dx.doi.org/10.1074/jbc.C400035200
   PubMed Web of Science ®Google Scholar
• Mbom BC, Nelson WJ, Barth A. beta-catenin at the centrosome: discrete pools of beta-catenin communicate during mitosis and may co-ordinate centrosome functions and cell cycle progression. Bioessays 2013; 35:804-9; PMID:23804296; http://dx.doi.org/10.1002/bies.201300045
   PubMed Web of Science ®Google Scholar
• Mbom BC, Siemers KA, Ostrowski MA, Nelson WJ, Barth AI. Nek2 phosphorylates and stabilizes beta-catenin at mitotic centrosomes downstream of Plk1. Mol Biol Cell 2014; 25:977-91; PMID:24501426; http://dx.doi.org/10.1091/mbc.E13-06-0349
   PubMed Web of Science ®Google Scholar
• Chilov D, Sinjushina N, Rita H, Taketo MM, Makela TP, Partanen J. Phosphorylated beta-catenin localizes to centrosomes of neuronal progenitors and is required for cell polarity and neurogenesis in developing midbrain. Dev Biol 2011; 357:259-68; PMID:21736876; http://dx.doi.org/10.1016/j.ydbio.2011.06.029
   PubMed Web of Science ®Google Scholar
• Bahmanyar S, Kaplan DD, Deluca JG, Giddings TH, Jr., O'Toole ET, Winey M, Salmon ED, Casey PJ, Nelson WJ, Barth AI. beta-Catenin is a Nek2 substrate involved in centrosome separation. Genes Dev 2008; 22:91-105; PMID:18086858; http://dx.doi.org/10.1101/gad.1596308
   PubMed Web of Science ®Google Scholar
• Berrueta L, Kraeft SK, Tirnauer JS, Schuyler SC, Chen LB, Hill DE, Pellman D, Bierer BE. The adenomatous polyposis coli-binding protein EB1 is associated with cytoplasmic and spindle microtubules. Proc Natl Acad Sci U S A 1998; 95:10596-601; PMID:9724749; http://dx.doi.org/10.1073/pnas.95.18.10596
   PubMedGoogle Scholar
• Askham JM, Vaughan KT, Goodson HV, Morrison EE. Evidence that an interaction between EB1 and p150(Glued) is required for the formation and maintenance of a radial microtubule array anchored at the centrosome. Mol Biol Cell 2002; 13:3627-45; PMID:12388762; http://dx.doi.org/10.1091/mbc.E02-01-0061
   PubMed Web of Science ®Google Scholar
• Fodde R, Kuipers J, Rosenberg C, Smits R, Kielman M, Gaspar C, van Es JH, Breukel C, Wiegant J, Giles RH, et al. Mutations in the APC tumour suppressor gene cause chromosomal instability. Nat Cell Biol 2001; 3:433-8; PMID:11283620; http://dx.doi.org/10.1038/35070129
   PubMed Web of Science ®Google Scholar
• Kaplan KB, Burds AA, Swedlow JR, Bekir SS, Sorger PK, Nathke IS. A role for the Adenomatous Polyposis Coli protein in chromosome segregation. Nat Cell Biol 2001; 3:429-32; PMID:11283619; http://dx.doi.org/10.1038/35070123
   PubMed Web of Science ®Google Scholar
• McCartney BM, Dierick HA, Kirkpatrick C, Moline MM, Baas A, Peifer M, Bejsovec A. Drosophila APC2 is a cytoskeletally-associated protein that regulates wingless signaling in the embryonic epidermis. J Cell Biol 1999; 146:1303-18; PMID:10491393; http://dx.doi.org/10.1083/jcb.146.6.1303
   PubMed Web of Science ®Google Scholar
• Miller RK, Rose MD. Kar9p is a novel cortical protein required for cytoplasmic microtubule orientation in yeast. J Cell Biol 1998; 140:377-90; PMID:9442113; http://dx.doi.org/10.1083/jcb.140.2.377
   PubMed Web of Science ®Google Scholar
• Lu B, Roegiers F, Jan LY, Jan YN. Adherens junctions inhibit asymmetric division in the Drosophila epithelium. Nature 2001; 409:522-5; PMID:11206549; http://dx.doi.org/10.1038/35054077
   PubMed Web of Science ®Google Scholar
• Yamashita YM, Jones DL, Fuller MT. Orientation of asymmetric stem cell division by the APC tumor suppressor and centrosome. Science 2003; 301:1547-50; PMID:12970569; http://dx.doi.org/10.1126/science.1087795
   PubMed Web of Science ®Google Scholar
• Clevers H, Loh KM, Nusse R. Stem cell signaling. An integral program for tissue renewal and regeneration: Wnt signaling and stem cell control. Science 2014; 346:1248012; PMID:25278615; http://dx.doi.org/10.1126/science.1248012
   PubMed Web of Science ®Google Scholar
• Habib SJ, Chen BC, Tsai FC, Anastassiadis K, Meyer T, Betzig E, Nusse R. A localized Wnt signal orients asymmetric stem cell division in vitro. Science 2013; 339:1445-8; PMID:23520113; http://dx.doi.org/10.1126/science.1231077
   PubMed Web of Science ®Google Scholar
• Nelson WJ, Nusse R. Convergence of Wnt, beta-catenin, and cadherin pathways. Science 2004; 303:1483-7; PMID:15001769; http://dx.doi.org/10.1126/science.1094291
   PubMed Web of Science ®Google Scholar
• Clevers H. Wnt/beta-catenin signaling in development and disease. Cell 2006; 127:469-80; PMID:17081971; http://dx.doi.org/10.1016/j.cell.2006.10.018
   PubMed Web of Science ®Google Scholar
• Fleming ES, Temchin M, Wu Q, Maggio-Price L, Tirnauer JS. Spindle misorientation in tumors from APC(min/+) mice. Mol Carcinog 2009; 48:592-8; PMID:19123231; http://dx.doi.org/10.1002/mc.20506
   PubMed Web of Science ®Google Scholar
• Reya T, Clevers H. Wnt signalling in stem cells and cancer. Nature 2005; 434:843-50; PMID:15829953; http://dx.doi.org/10.1038/nature03319
   PubMed Web of Science ®Google Scholar
• Franz CM, Ridley AJ. p120 catenin associates with microtubules: inverse relationship between microtubule binding and Rho GTPase regulation. J Biol Chem 2004; 279:6588-94; PMID:14660598; http://dx.doi.org/10.1074/jbc.M312812200
   PubMed Web of Science ®Google Scholar
• Yanagisawa M, Kaverina IN, Wang A, Fujita Y, Reynolds AB, Anastasiadis PZ. A novel interaction between kinesin and p120 modulates p120 localization and function. J Biol Chem 2004; 279:9512-21; PMID:14676216; http://dx.doi.org/10.1074/jbc.M310895200
   PubMed Web of Science ®Google Scholar
• Chartier NT, Oddou CI, Laine MG, Ducarouge B, Marie CA, Block MR, Jacquier-Sarlin MR. Cyclin-dependent kinase 2/cyclin E complex is involved in p120 catenin (p120ctn)-dependent cell growth control: a new role for p120ctn in cancer. Cancer Res 2007; 67:9781-90; PMID:17942908; http://dx.doi.org/10.1158/0008-5472.CAN-07-0233
   PubMed Web of Science ®Google Scholar
• Daniel JM, Reynolds AB. The catenin p120(ctn) interacts with Kaiso, a novel BTB/POZ domain zinc finger transcription factor. Mol Cell Biol 1999; 19:3614-23; PMID:10207085
   PubMed Web of Science ®Google Scholar
• Kantidze OL, Kamalyukova IM, Razin SV. Association of the mammalian transcriptional regulator kaiso with centrosomes and the midbody. Cell Cycle 2009; 8:2303-4; PMID:19502788; http://dx.doi.org/10.4161/cc.8.14.8944
   PubMed Web of Science ®Google Scholar
• Soubry A, Staes K, Parthoens E, Noppen S, Stove C, Bogaert P, van Hengel J, van Roy F. The transcriptional repressor Kaiso localizes at the mitotic spindle and is a constituent of the pericentriolar material. PLoS One 2010; 5:e9203; PMID:20169156; http://dx.doi.org/10.1371/journal.pone.0009203
   PubMedGoogle Scholar
• Anastasiadis PZ, Moon SY, Thoreson MA, Mariner DJ, Crawford HC, Zheng Y, Reynolds AB. Inhibition of RhoA by p120 catenin. Nat Cell Biol 2000; 2:637-44; PMID:10980705; http://dx.doi.org/10.1038/35023588
   PubMed Web of Science ®Google Scholar
• Anastasiadis PZ, Reynolds AB. Regulation of Rho GTPases by p120-catenin. Curr Opin Cell Biol 2001; 13:604-10; PMID:11544030; http://dx.doi.org/10.1016/S0955-0674(00)00258-1
   PubMed Web of Science ®Google Scholar
• Perez-Moreno M, Song W, Pasolli HA, Williams SE, Fuchs E. Loss of p120 catenin and links to mitotic alterations, inflammation, and skin cancer. Proc Natl Acad Sci U S A 2008; 105:15399-404; PMID:18809907; http://dx.doi.org/10.1073/pnas.0807301105
   PubMedGoogle Scholar
• Pereira AL, Pereira AJ, Maia AR, Drabek K, Sayas CL, Hergert PJ, Lince-Faria M, Matos I, Duque C, Stepanova T, et al. Mammalian CLASP1 and CLASP2 cooperate to ensure mitotic fidelity by regulating spindle and kinetochore function. Mol Biol Cell 2006; 17:4526-42; PMID:16914514; http://dx.doi.org/10.1091/mbc.E06-07-0579
   PubMed Web of Science ®Google Scholar
• Logarinho E, Maffini S, Barisic M, Marques A, Toso A, Meraldi P, Maiato H. CLASPs prevent irreversible multipolarity by ensuring spindle-pole resistance to traction forces during chromosome alignment. Nat Cell Biol 2012; 14:295-303; PMID:22307330; http://dx.doi.org/10.1038/ncb2423
   PubMed Web of Science ®Google Scholar
• Samora CP, Mogessie B, Conway L, Ross JL, Straube A, McAinsh AD. MAP4 and CLASP1 operate as a safety mechanism to maintain a stable spindle position in mitosis. Nat Cell Biol 2011; 13:1040-50; PMID:21822276; http://dx.doi.org/10.1038/ncb2297
   PubMed Web of Science ®Google Scholar
• Bird SL, Heald R, Weis K. RanGTP and CLASP1 cooperate to position the mitotic spindle. Mol Biol Cell 2013; 24:2506-14; PMID:23783028; http://dx.doi.org/10.1091/mbc.E13-03-0150
   PubMed Web of Science ®Google Scholar
• Thery M, Bornens M. Cell shape and cell division. Curr Opin Cell Biol 2006; 18:648-57; PMID:17046223; http://dx.doi.org/10.1016/j.ceb.2006.10.001
   PubMed Web of Science ®Google Scholar
• Grill SW, Hyman AA. Spindle positioning by cortical pulling forces. Dev Cell 2005; 8:461-5; PMID:15809029; http://dx.doi.org/10.1016/j.devcel.2005.03.014
   PubMed Web of Science ®Google Scholar
• Palmer RE, Sullivan DS, Huffaker T, Koshland D. Role of astral microtubules and actin in spindle orientation and migration in the budding yeast, Saccharomyces cerevisiae. J Cell Biol 1992; 119:583-93; PMID:1400594; http://dx.doi.org/10.1083/jcb.119.3.583
   PubMed Web of Science ®Google Scholar
• Vasioukhin V, Bauer C, Yin M, Fuchs E. Directed actin polymerization is the driving force for epithelial cell-cell adhesion. Cell 2000; 100:209-19; PMID:10660044; http://dx.doi.org/10.1016/S0092-8674(00)81559-7
   PubMed Web of Science ®Google Scholar
• Adams CL, Chen YT, Smith SJ, Nelson WJ. Mechanisms of epithelial cell-cell adhesion and cell compaction revealed by high-resolution tracking of E-cadherin-green fluorescent protein. J Cell Biol 1998; 142:1105-19; PMID:9722621; http://dx.doi.org/10.1083/jcb.142.4.1105
   PubMed Web of Science ®Google Scholar
• Perez-Moreno M, Fuchs E. Catenins: keeping cells from getting their signals crossed. Dev Cell 2006; 11:601-12; PMID:17084354; http://dx.doi.org/10.1016/j.devcel.2006.10.010
   PubMed Web of Science ®Google Scholar
• Scott JA, Yap AS. Cinderella no longer: alpha-catenin steps out of cadherin's shadow. J Cell Sci 2006; 119:4599-605; PMID:17093264; http://dx.doi.org/10.1242/jcs.03267
   PubMed Web of Science ®Google Scholar
• Kovacs EM, Goodwin M, Ali RG, Paterson AD, Yap AS. Cadherin-directed actin assembly: E-cadherin physically associates with the Arp2/3 complex to direct actin assembly in nascent adhesive contacts. Curr Biol 2002; 12:379-82; PMID:11882288; http://dx.doi.org/10.1016/S0960-9822(02)00661-9
   PubMed Web of Science ®Google Scholar
• Padrick SB, Rosen MK. Physical mechanisms of signal integration by WASP family proteins. Annu Rev Biochem 2010; 79:707-35; PMID:20533885; http://dx.doi.org/10.1146/annurev.biochem.77.060407.135452
   PubMed Web of Science ®Google Scholar
• Verma S, Han SP, Michael M, Gomez GA, Yang Z, Teasdale RD, Ratheesh A, Kovacs EM, Ali RG, Yap AS. A WAVE2-Arp2/3 actin nucleator apparatus supports junctional tension at the epithelial zonula adherens. Mol Biol Cell 2012; 23:4601-10; PMID:23051739; http://dx.doi.org/10.1091/mbc.E12-08-0574
   PubMed Web of Science ®Google Scholar
• Zhou K, Muroyama A, Underwood J, Leylek R, Ray S, Soderling SH, Lechler T. Actin-related protein2/3 complex regulates tight junctions and terminal differentiation to promote epidermal barrier formation. Proc Natl Acad Sci U S A 2013; 110:E3820-9; PMID:24043783; http://dx.doi.org/10.1073/pnas.1308419110
   PubMedGoogle Scholar
• Lechler T. Arp2/3 complex function in the epidermis. Tissue Barriers 2014; 2:e944445; PMID:25610753
   PubMedGoogle Scholar
• Gladden AB, Hebert AM, Schneeberger EE, McClatchey AI. The NF2 tumor suppressor, Merlin, regulates epidermal development through the establishment of a junctional polarity complex. Dev Cell 2010; 19:727-39; PMID:21074722; http://dx.doi.org/10.1016/j.devcel.2010.10.008
   PubMed Web of Science ®Google Scholar
• Ingber DE. The riddle of morphogenesis: a question of solution chemistry or molecular cell engineering? Cell 1993; 75:1249-52; PMID:8269508; http://dx.doi.org/10.1016/0092-8674(93)90612-T
   PubMed Web of Science ®Google Scholar
• Wang N, Tytell JD, Ingber DE. Mechanotransduction at a distance: mechanically coupling the extracellular matrix with the nucleus. Nat Rev Mol Cell Biol 2009; 10:75-82; PMID:19197334; http://dx.doi.org/10.1038/nrm2594
   PubMed Web of Science ®Google Scholar
• Jaalouk DE, Lammerding J. Mechanotransduction gone awry. Nat Rev Mol Cell Biol 2009; 10:63-73; PMID:19197333; http://dx.doi.org/10.1038/nrm2597
   PubMed Web of Science ®Google Scholar
• DuFort CC, Paszek MJ, Weaver VM. Balancing forces: architectural control of mechanotransduction. Nat Rev Mol Cell Biol 2011; 12:308-19; PMID:21508987; http://dx.doi.org/10.1038/nrm3112
   PubMed Web of Science ®Google Scholar
• Humphrey JD, Dufresne ER, Schwartz MA. Mechanotransduction and extracellular matrix homeostasis. Nat Rev Mol Cell Biol 2014; 15:802-12; PMID:25355505; http://dx.doi.org/10.1038/nrm3896
   PubMed Web of Science ®Google Scholar
• Harris TJ, Tepass U. Adherens junctions: from molecules to morphogenesis. Nat Rev Mol Cell Biol 2010; 11:502-14; PMID:20571587; http://dx.doi.org/10.1038/nrm2927
   PubMed Web of Science ®Google Scholar
• le Duc Q, Shi Q, Blonk I, Sonnenberg A, Wang N, Leckband D, de Rooij J. Vinculin potentiates E-cadherin mechanosensing and is recruited to actin-anchored sites within adherens junctions in a myosin II-dependent manner. J Cell Biol 2010; 189:1107-15; PMID:20584916; http://dx.doi.org/10.1083/jcb.201001149
   PubMed Web of Science ®Google Scholar
• Leckband DE, de Rooij J. Cadherin adhesion and mechanotransduction. Annu Rev Cell Dev Biol 2014; 30:291-315; PMID:25062360; http://dx.doi.org/10.1146/annurev-cellbio-100913-013212
   PubMed Web of Science ®Google Scholar
• Yonemura S, Wada Y, Watanabe T, Nagafuchi A, Shibata M. alpha-Catenin as a tension transducer that induces adherens junction development. Nat Cell Biol 2010; 12:533-42; PMID:20453849; http://dx.doi.org/10.1038/ncb2055
   PubMed Web of Science ®Google Scholar
• Buckley CD, Tan J, Anderson KL, Hanein D, Volkmann N, Weis WI, Nelson WJ, Dunn AR. Cell adhesion. The minimal cadherin-catenin complex binds to actin filaments under force. Science 2014; 346:1254211; PMID:25359979; http://dx.doi.org/10.1126/science.1254211
   PubMed Web of Science ®Google Scholar
• Huveneers S, Oldenburg J, Spanjaard E, van der Krogt G, Grigoriev I, Akhmanova A, Rehmann H, de Rooij J. Vinculin associates with endothelial VE-cadherin junctions to control force-dependent remodeling. J Cell Biol 2012; 196:641-52; PMID:22391038; http://dx.doi.org/10.1083/jcb.201108120
   PubMed Web of Science ®Google Scholar
• Gumbiner BM, Kim NG. The Hippo-YAP signaling pathway and contact inhibition of growth. J Cell Sci 2014; 127:709-17; PMID:24532814; http://dx.doi.org/10.1242/jcs.140103
   PubMed Web of Science ®Google Scholar
• Pan D. The hippo signaling pathway in development and cancer. Dev Cell 2010; 19:491-505; PMID:20951342; http://dx.doi.org/10.1016/j.devcel.2010.09.011
   PubMed Web of Science ®Google Scholar
• Halder G, Dupont S, Piccolo S. Transduction of mechanical and cytoskeletal cues by YAP and TAZ. Nat Rev Mol Cell Biol 2012; 13:591-600; PMID:22895435; http://dx.doi.org/10.1038/nrm3416
   PubMed Web of Science ®Google Scholar
• Aragona M, Panciera T, Manfrin A, Giulitti S, Michielin F, Elvassore N, Dupont S, Piccolo S. A mechanical checkpoint controls multicellular growth through YAP/TAZ regulation by actin-processing factors. Cell 2013; 154:1047-59; PMID:23954413; http://dx.doi.org/10.1016/j.cell.2013.07.042
   PubMed Web of Science ®Google Scholar
• Dupont S, Morsut L, Aragona M, Enzo E, Giulitti S, Cordenonsi M, Zanconato F, Le Digabel J, Forcato M, Bicciato S, et al. Role of YAP/TAZ in mechanotransduction. Nature 2011; 474:179-83; PMID:21654799; http://dx.doi.org/10.1038/nature10137
   PubMed Web of Science ®Google Scholar
• Tepass U. The apical polarity protein network in Drosophila epithelial cells: regulation of polarity, junctions, morphogenesis, cell growth, and survival. Annu Rev Cell Dev Biol 2012; 28:655-85; PMID:22881460; http://dx.doi.org/10.1146/annurev-cellbio-092910-154033
   PubMed Web of Science ®Google Scholar
• Boggiano JC, Fehon RG. Growth control by committee: intercellular junctions, cell polarity, and the cytoskeleton regulate Hippo signaling. Dev Cell 2012; 22:695-702; PMID:22516196; http://dx.doi.org/10.1016/j.devcel.2012.03.013
   PubMed Web of Science ®Google Scholar
• Grusche FA, Richardson HE, Harvey KF. Upstream regulation of the hippo size control pathway. Curr Biol 2010; 20:R574-82; PMID:20619814; http://dx.doi.org/10.1016/j.cub.2010.05.023
   PubMed Web of Science ®Google Scholar
• Gaspar P, Tapon N. Sensing the local environment: actin architecture and Hippo signalling. Curr Opin Cell Biol 2014; 31:74-83; PMID:25259681; http://dx.doi.org/10.1016/j.ceb.2014.09.003
   PubMed Web of Science ®Google Scholar
• Wada K, Itoga K, Okano T, Yonemura S, Sasaki H. Hippo pathway regulation by cell morphology and stress fibers. Development 2011; 138:3907-14; PMID:21831922; http://dx.doi.org/10.1242/dev.070987
   PubMed Web of Science ®Google Scholar
• Yang S, Zhang L, Liu M, Chong R, Ding SJ, Chen Y, Dong J. CDK1 phosphorylation of YAP promotes mitotic defects and cell motility and is essential for neoplastic transformation. Cancer Res 2013; 73:6722-33; PMID:24101154; http://dx.doi.org/10.1158/0008-5472.CAN-13-2049
   PubMed Web of Science ®Google Scholar
• Tsukahara T, Tanno Y, Watanabe Y. Phosphorylation of the CPC by Cdk1 promotes chromosome bi-orientation. Nature 2010; 467:719-23; PMID:20739936; http://dx.doi.org/10.1038/nature09390
   PubMed Web of Science ®Google Scholar
• Saburi S, Hester I, Fischer E, Pontoglio M, Eremina V, Gessler M, Quaggin SE, Harrison R, Mount R, McNeill H. Loss of Fat4 disrupts PCP signaling and oriented cell division and leads to cystic kidney disease. Nat Genet 2008; 40:1010-5; PMID:18604206; http://dx.doi.org/10.1038/ng.179
   PubMed Web of Science ®Google Scholar
• Mao Y, Tournier AL, Bates PA, Gale JE, Tapon N, Thompson BJ. Planar polarization of the atypical myosin Dachs orients cell divisions in Drosophila. Genes Dev 2011; 25:131-6; PMID:21245166; http://dx.doi.org/10.1101/gad.610511
   PubMed Web of Science ®Google Scholar
• Wei C, Bhattaram VK, Igwe JC, Fleming E, Tirnauer JS. The LKB1 tumor suppressor controls spindle orientation and localization of activated AMPK in mitotic epithelial cells. PLoS One 2012; 7:e41118; PMID:22815934; http://dx.doi.org/10.1371/journal.pone.0041118
   PubMedGoogle Scholar
• Mohseni M, Sun J, Lau A, Curtis S, Goldsmith J, Fox VL, Wei C, Frazier M, Samson O, Wong KK, et al. A genetic screen identifies an LKB1-MARK signalling axis controlling the Hippo-YAP pathway. Nat Cell Biol 2014; 16:108-17; PMID:24362629; http://dx.doi.org/10.1038/ncb2884
   PubMed Web of Science ®Google Scholar
• Thaiparambil JT, Eggers CM, Marcus AI. AMPK regulates mitotic spindle orientation through phosphorylation of myosin regulatory light chain. Mol Cell Biol 2012; 32:3203-17; PMID:22688514; http://dx.doi.org/10.1128/MCB.00418-12
   PubMed Web of Science ®Google Scholar
• Poon CL, Lin JI, Zhang X, Harvey KF. The sterile 20-like kinase Tao-1 controls tissue growth by regulating the Salvador-Warts-Hippo pathway. Dev Cell 2011; 21:896-906; PMID:22075148; http://dx.doi.org/10.1016/j.devcel.2011.09.012
   PubMed Web of Science ®Google Scholar
• Wojtala RL, Tavares IA, Morton PE, Valderrama F, Thomas NS, Morris JD. Prostate-derived sterile 20-like kinases (PSKs/TAOKs) are activated in mitosis and contribute to mitotic cell rounding and spindle positioning. J Biol Chem 2011; 286:30161-70; PMID:21705329; http://dx.doi.org/10.1074/jbc.M111.228320
   PubMed Web of Science ®Google Scholar
• Yue T, Tian A, Jiang J. The cell adhesion molecule echinoid functions as a tumor suppressor and upstream regulator of the Hippo signaling pathway. Dev Cell 2012; 22:255-67; PMID:22280890; http://dx.doi.org/10.1016/j.devcel.2011.12.011
   PubMed Web of Science ®Google Scholar
• Marie H, Pratt SJ, Betson M, Epple H, Kittler JT, Meek L, Moss SJ, Troyanovsky S, Attwell D, Longmore GD, et al. The LIM protein Ajuba is recruited to cadherin-dependent cell junctions through an association with alpha-catenin. J Biol Chem 2003; 278:1220-8; PMID:12417594; http://dx.doi.org/10.1074/jbc.M205391200
   PubMed Web of Science ®Google Scholar
• Das Thakur M, Feng Y, Jagannathan R, Seppa MJ, Skeath JB, Longmore GD. Ajuba LIM proteins are negative regulators of the Hippo signaling pathway. Curr Biol 2010; 20:657-62; PMID:20303269; http://dx.doi.org/10.1016/j.cub.2010.02.035
   PubMed Web of Science ®Google Scholar
• Kim NG, Koh E, Chen X, Gumbiner BM. E-cadherin mediates contact inhibition of proliferation through Hippo signaling-pathway components. Proc Natl Acad Sci U S A 2011; 108:11930-5; PMID:21730131; http://dx.doi.org/10.1073/pnas.1103345108
   PubMedGoogle Scholar
• Leung CY, Zernicka-Goetz M. Angiomotin prevents pluripotent lineage differentiation in mouse embryos via Hippo pathway-dependent and -independent mechanisms. Nat Commun 2013; 4:2251; PMID:23903990; http://dx.doi.org/10.1038/ncomms3251
   PubMed Web of Science ®Google Scholar
• Hirate Y, Hirahara S, Inoue K, Suzuki A, Alarcon VB, Akimoto K, Hirai T, Hara T, Adachi M, Chida K, et al. Polarity-dependent distribution of angiomotin localizes Hippo signaling in preimplantation embryos. Curr Biol 2013; 23:1181-94; PMID:23791731; http://dx.doi.org/10.1016/j.cub.2013.05.014
   PubMed Web of Science ®Google Scholar
• Hirate Y, Sasaki H. The role of angiomotin phosphorylation in the Hippo pathway during preimplantation mouse development. Tissue Barriers 2014; 2:e28127; PMID:24843842; http://dx.doi.org/10.4161/tisb.28127
   PubMedGoogle Scholar
• Schlegelmilch K, Mohseni M, Kirak O, Pruszak J, Rodriguez JR, Zhou D, Kreger BT, Vasioukhin V, Avruch J, Brummelkamp TR, et al. Yap1 acts downstream of alpha-catenin to control epidermal proliferation. Cell 2011; 144:782-95; PMID:21376238; http://dx.doi.org/10.1016/j.cell.2011.02.031
   PubMed Web of Science ®Google Scholar
• Silvis MR, Kreger BT, Lien WH, Klezovitch O, Rudakova GM, Camargo FD, Lantz DM, Seykora JT, Vasioukhin V. alpha-catenin is a tumor suppressor that controls cell accumulation by regulating the localization and activity of the transcriptional coactivator Yap1. Sci Signal 2011; 4:ra33; PMID:21610251; http://dx.doi.org/10.1126/scisignal.2001823
   PubMed Web of Science ®Google Scholar