Plant derived edible nanoparticles as a new therapeutic approach against diseases

References

• Xiao B, Laroui H, Viennois E, Ayyadurai S, Charania MA, Zhang Y, Zhang Z, Baker MT, Zhang B, Gewirtz AT, et al. Nanoparticles with surface antibody against CD98 and carrying CD98 small interfering RNA reduce colitis in mice. Gastroenterology 2014; 146:1289-300 e1–19; PMID:24503126; http://dx.doi.org/10.1053/j.gastro.2014.01.056
   PubMed Web of Science ®Google Scholar
• Xiao B, Yang Y, Viennois E, Zhang Y, Ayyadurai S, Baker M, Laroui H, Merlin D. Glycoprotein CD98 as a receptor for colitis-targeted delivery of nanoparticle. J Mater Chem B 2014; 2(11):1499-508; http://dx.doi.org/10.1039/c3tb21564d
   PubMed Web of Science ®Google Scholar
• Laroui H, Viennois E, Xiao B, Canup BS, Geem D, Denning TL, Merlin D. Fab'-bearing siRNA TNFα-loaded nanoparticles targeted to colonic macrophages offer an effective therapy for experimental colitis. J Control Release 2014; 186: 41-53; PMID:24810114; http://dx.doi.org/10.1016/j.jconrel.2014.04.046
   PubMed Web of Science ®Google Scholar
• Xiao B, Zhang M, Viennois E, Zhang Y, Wei N, Baker MT, Jung Y, Merlin D. Inhibition of MDR1 gene expression and enhancing cellular uptake for effective colon cancer treatment using dual-surface-functionalized nanoparticles. Biomaterials 2015; 48:147-60; PMID:25701040; http://dx.doi.org/10.1016/j.biomaterials.2015.01.014
   PubMed Web of Science ®Google Scholar
• Laroui H, Geem D, Xiao B, Viennois E, Rakhya P, Denning T, Merlin D. Targeting intestinal inflammation with CD98 siRNA/PEI-loaded nanoparticles. Mol Ther 2014; 22(1):69-80; PMID:24025751; http://dx.doi.org/10.1038/mt.2013.214
   PubMed Web of Science ®Google Scholar
• Xiao B, Laroui H, Ayyadurai S, Viennois E, Charania MA, Zhang Y, Merlin D. Mannosylated bioreducible nanoparticle-mediated macrophage-specific TNF-α RNA interference for IBD therapy. Biomaterials 2013; 34(30):7471-82; PMID:23820013; http://dx.doi.org/10.1016/j.biomaterials.2013.06.008
   PubMed Web of Science ®Google Scholar
• Laroui H, Sitaraman SV, Merlin D. Gastrointestinal delivery of anti-inflammatory nanoparticles. Methods Enzymol 2012; 509:101-25; PMID:22568903; http://dx.doi.org/10.1016/B978-0-12-391858-1.00006-X
   PubMed Web of Science ®Google Scholar
• Xiao B, Merlin D. Oral colon-specific therapeutic approaches toward treatment of inflammatory bowel disease. Expert Opin Drug Delivery 2012; 9(11):1393-407; http://dx.doi.org/10.1517/17425247.2012.730517
   PubMed Web of Science ®Google Scholar
• Laroui H, Theiss AL, Yan Y, Dalmasso G, Nguyen HT, Sitaraman SV, Merlin D. Functional TNF-α gene silencing mediated by polyethyleneimine/TNFα siRNA nanocomplexes in inflamed colon. Biomaterials 2011; 32(4):1218-28; PMID:20970849; http://dx.doi.org/10.1016/j.biomaterials.2010.09.062
   PubMed Web of Science ®Google Scholar
• Wilson S, Dalmasso G, Wang L, Sitaraman SV, Merlin D, Murthy N. Orally delivered thioketal-nanoparticles loaded with TNFalphaB1;-siRNA target inflammation and inhibit gene expression in the intestines. Nature Materials 2011; 9(11):923-8; http://dx.doi.org/10.1038/nmat2859
   Web of Science ®Google Scholar
• Laroui H, Wilson DS, Dalmasso G, Salaita K, Murthy N, Sitaraman SV, Merlin D. Nanomedicine in GI. Am J Physiol Gastrointest Liver Physiol 2011; 300(3):G371-83; PMID:21148398; http://dx.doi.org/10.1152/ajpgi.00466.2010
   PubMed Web of Science ®Google Scholar
• Laroui H, Dalmasso G, Nguyen HT, Yan Y, Sitaraman SV, Merlin D. Drug-loaded nanoparticles targeted to the colon with polysaccharide hydrogel reduce colitis in a mouse model. Gastroenterology 2010; 138(3):843-53; PMID:19909746; http://dx.doi.org/10.1053/j.gastro.2009.11.003
   PubMed Web of Science ®Google Scholar
• Xiao B, Si X, Zhang M, Merlin D. Oral administration of pH-sensitive curcumin-loaded microparticles for ulcerative colitis therapy. Colloids Surf B Biointerfaces 2015; 135:379-85; PMID:26275840; http://dx.doi.org/10.1016/j.colsurfb.2015.07.081
   PubMed Web of Science ®Google Scholar
• Xiao B, Han MK, Viennois E, Wang L, Zhang M, Si X, Merlin D. Hyaluronic acid-functionalized polymeric nanoparticles for colon cancer-targeted combination chemotherapy. Nanoscale 2015; 7:17745-55; PMID:26455329; http://dx.doi.org/10.1039/C5NR04831A
   PubMed Web of Science ®Google Scholar
• Andre F, Schartz NE, Movassagh M, Flament C, Pautier P, Morice P, Pomel C, Lhomme C, Escudier B, Le Chevalier T, et al. Malignant effusions and immunogenic tumour-derived exosomes. Lancet 2002; 360:295-305; PMID:12147373; http://dx.doi.org/10.1016/S0140-6736(02)09552-1
   PubMed Web of Science ®Google Scholar
• Pegtel DM, Cosmopoulos K, Thorley-Lawson DA, van Eijndhoven MA, Hopmans ES, Lindenberg JL, de Gruijl TD, Wurdinger T, Middeldorp JM. Functional delivery of viral miRNAs via exosomes. Proc Natl Acad Sci U S A 2010; 107:6328-33; PMID:20304794; http://dx.doi.org/10.1073/pnas.0914843107
   PubMed Web of Science ®Google Scholar
• Fevrier B, Vilette D, Archer F, Loew D, Faigle W, Vidal M, Laude H, Raposo G. Cells release prions in association with exosomes. Proc Natl Acad Sci U S A 2004; 101:9683-8; PMID:15210972; http://dx.doi.org/10.1073/pnas.0308413101
   PubMed Web of Science ®Google Scholar
• Fevrier B, Raposo G. Exosomes: endosomal-derived vesicles shipping extracellular messages. Curr Opin Cell Biol 2004; 16:415-21; PMID:15261674; http://dx.doi.org/10.1016/j.ceb.2004.06.003
   PubMed Web of Science ®Google Scholar
• Alvarez-Erviti L, Seow Y, Yin H, Betts C, Lakhal S, Wood MJ. Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes. Nat Biotechnol 2011; 29:341-5; PMID:21423189; http://dx.doi.org/10.1038/nbt.1807
   PubMed Web of Science ®Google Scholar
• Pisitkun T, Shen RF, Knepper MA. Identification and proteomic profiling of exosomes in human urine. Proc Natl Acad Sci U S A 2004; 101:13368-73; PMID:15326289; http://dx.doi.org/10.1073/pnas.0403453101
   PubMed Web of Science ®Google Scholar
• Wolfers J, Lozier A, Raposo G, Regnault A, Thery C, Masurier C, Flament C, Pouzieux S, Faure F, Tursz T, et al. Tumor-derived exosomes are a source of shared tumor rejection antigens for CTL cross-priming. Nat Med 2001; 7:297-303; PMID:11231627; http://dx.doi.org/10.1038/85438
   PubMed Web of Science ®Google Scholar
• Taylor DD, Gercel-Taylor C. MicroRNA signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer. Gynecol Oncol 2008; 110:13-21; PMID:18589210; http://dx.doi.org/10.1016/j.ygyno.2008.04.033
   PubMed Web of Science ®Google Scholar
• Lakhal S, Wood MJA. Exosome nanotechnology: An emerging paradigm shift in drug delivery Exploitation of exosome nanovesicles for systemic in vivo delivery of RNAi heralds new horizons for drug delivery across biological barriers. Bioessays 2011; 33:737-41; PMID:21932222; http://dx.doi.org/10.1002/bies.201100076
   PubMed Web of Science ®Google Scholar
• Stenqvist AC, Nagaeva O, Baranov V, Mincheva-Nilsson L. Exosomes Secreted by Human Placenta Carry Functional Fas Ligand and TRAIL Molecules and Convey Apoptosis in Activated Immune Cells, Suggesting Exosome-Mediated Immune Privilege of the Fetus. J Immunol 2013; 191:5515-23; PMID:24184557; http://dx.doi.org/10.4049/jimmunol.1301885
   PubMed Web of Science ®Google Scholar
• van Niel G, Raposo G, Candalh C, Boussac M, Hershberg R, Cerf-Bensussan N, Heyman M. Intestinal epithelial cells secrete exosome-like vesicles. Gastroenterology 2001; 121:337-49; PMID:11487543; http://dx.doi.org/10.1053/gast.2001.26263
   PubMed Web of Science ®Google Scholar
• Robertson C, Booth SA, Beniac DR, Coulthart MB, Booth TF, McNicol A. Cellular prion protein is released on exosomes from activated platelets. Blood 2006; 107:3907-11; PMID:16434486; http://dx.doi.org/10.1182/blood-2005-02-0802
   PubMed Web of Science ®Google Scholar
• Morelli AE, Larregina AT, Shufesky WJ, Sullivan MLG, Stolz DB, Papworth GD, Zahorchak AF, Logar AJ, Wang ZL, Watkins SC, et al. Endocytosis, intracellular sorting, and processing of exosomes by dendritic cells. Blood 2004; 104:3257-66; PMID:15284116; http://dx.doi.org/10.1182/blood-2004-03-0824
   PubMed Web of Science ®Google Scholar
• Skokos D, Botros HG, Demeure C, Morin J, Peronet R, Birkenmeier G, Boudaly S, Mecheri S. Mast cell-derived exosomes induce phenotypic and functional maturation of dendritic cells and elicit specific immune responses in vivo. J Immunol 2003; 170:3037-45; PMID:12626558; http://dx.doi.org/10.4049/jimmunol.170.6.3037
   PubMed Web of Science ®Google Scholar
• Lehmann BD, Paine MS, Brooks AM, McCubrey JA, Renegar RH, Wang R, Terrian DM. Senescence-associated exosome release from human prostate cancer cells. Cancer Res 2008; 68:7864-71; PMID:18829542; http://dx.doi.org/10.1158/0008-5472.CAN-07-6538
   PubMed Web of Science ®Google Scholar
• Almqvist N, Loennqvist A, Hultkrantz S, Rask C, Telemo E. Serum-derived exosomes from antigen-fed mice prevents allergic sensitization in a model of allergic asthma. Immunology 2008; 125:21-7; PMID:18355242; http://dx.doi.org/10.1111/j.1365-2567.2008.02812.x
   PubMed Web of Science ®Google Scholar
• Tanaka Y, Kamohara H, Kinoshita K, Kurashige J, Ishimoto T, Iwatsuki M, Watanabe M, Baba H. Clinical impact of serum exosomal microRNA-21 as a clinical biomarker in human esophageal squamous cell carcinoma. Cancer-Am Cancer Soc 2013; 119:1159-67.
   PubMedGoogle Scholar
• Rupp AK, Rupp C, Keller S, Brase JC, Ehehalt R, Fogel M, Moldenhauer G, Marme F, Sultmann H, Altevogt P. Loss of EpCAM expression in breast cancer derived serum exosomes: Role of proteolytic cleavage. Gynecol Oncol 2011; 122:437-46; PMID:21601258; http://dx.doi.org/10.1016/j.ygyno.2011.04.035
   PubMed Web of Science ®Google Scholar
• Nilsson J, Skog J, Nordstrand A, Baranov V, Mincheva-Nilsson L, Breakefield XO, Widmark A. Prostate cancer-derived urine exosomes: a novel approach to biomarkers for prostate cancer. Brit J Cancer 2009; 100:1603-7; PMID:19401683; http://dx.doi.org/10.1038/sj.bjc.6605058
   PubMed Web of Science ®Google Scholar
• Wang Z, Hill S, Luther JM, Hachey DL, Schey KL. Proteomic analysis of urine exosomes by multidimensional protein identification technology (MudPIT). Proteomics 2012; 12:329-38; PMID:22106071; http://dx.doi.org/10.1002/pmic.201100477
   PubMed Web of Science ®Google Scholar
• Zhou H, Yuen PST, Pisitkun T, Gonzales PA, Yasuda H, Dear JW, Gross P, Knepper MA, Star RA. Collection, storage, preservation, and normalization of human urinary exosomes for biomarker discovery. Kidney Int 2006; 69:1471-6; PMID:16501490
   PubMed Web of Science ®Google Scholar
• Izumi H, Tsuda M, Sato Y, Kosaka N, Ochiya T, Iwamoto H, Namba K, Takeda Y. Bovine milk exosomes contain microRNA and mRNA and are taken up by human macrophages. J Dairy Sci 2015; 98:2920-33; PMID:25726110; http://dx.doi.org/10.3168/jds.2014-9076
   PubMed Web of Science ®Google Scholar
• Wolf T, Baier SR, Zempleni J. The Intestinal Transport of Bovine Milk Exosomes Is Mediated by Endocytosis in Human Colon Carcinoma Caco-2 Cells and Rat Small Intestinal IEC-6 Cells. J Nutr 2015; 145:2201-6; PMID:26269243; http://dx.doi.org/10.3945/jn.115.218586
   PubMed Web of Science ®Google Scholar
• Byun JS, Hong SH, Choi JK, Jung JK, Lee HJ. Diagnostic profiling of salivary exosomal microRNAs in oral lichen planus patients. Oral Dis 2015; 21(8):987-93; PMID:26389700
   PubMed Web of Science ®Google Scholar
• Wong DT. Salivary extracellular noncoding RNA: emerging biomarkers for molecular diagnostics. Clin Ther 2015; 37:540-51; PMID:25795433; http://dx.doi.org/10.1016/j.clinthera.2015.02.017
   PubMed Web of Science ®Google Scholar
• Zlotogorski-Hurvitz A, Dayan D, Chaushu G, Korvala J, Salo T, Sormunen R, Vered M. Human saliva-derived exosomes: comparing methods of isolation. J Histochem Cytochem 2015; 63:181-9; PMID:25473095; http://dx.doi.org/10.1369/0022155414564219
   PubMed Web of Science ®Google Scholar
• Bard MP, Hegmans JP, Hemmes A, Luider TM, Willemsen R, Severijnen LA, van Meerbeeck JP, Burgers SA, Hoogsteden HC, Lambrecht BN. Proteomic analysis of exosomes isolated from human malignant pleural effusions. Am J Respir Cell Mol Biol 2004; 31:114-21; PMID:14975938; http://dx.doi.org/10.1165/rcmb.2003-0238OC
   PubMed Web of Science ®Google Scholar
• Cappellesso R, Tinazzi A, Giurici T, Simonato F, Guzzardo V, Ventura L, Crescenzi M, Chiarelli S, Fassina A. Programmed Cell Death 4 and MicroRNA 21 Inverse Expression Is Maintained in Cells and Exosomes From Ovarian Serous Carcinoma Effusions. Cancer Cytopathol 2014; 122:685-93; PMID:24888238; http://dx.doi.org/10.1002/cncy.21442
   PubMed Web of Science ®Google Scholar
• Thery C, Zitvogel L, Amigorena S. Exosomes: Composition, biogenesis and function. Nat Rev Immunol 2002; 2:569-79; PMID:12154376
   PubMed Web of Science ®Google Scholar
• Braicu C, Tomuleasa C, Monroig P, Cucuianu A, Berindan-Neagoe I, Calin GA. Exosomes as divine messengers: are they the Hermes of modern molecular oncology? Cell Death Differ 2015; 22:34-45; PMID:25236394; http://dx.doi.org/10.1038/cdd.2014.130
   PubMed Web of Science ®Google Scholar
• Caby MP, Lankar D, Vincendeau-Scherrer C, Raposo G, Bonnerot C. Exosomal-like vesicles are present in human blood plasma. Int Immunol 2005; 17:879-87; PMID:15908444; http://dx.doi.org/10.1093/intimm/dxh267
   PubMed Web of Science ®Google Scholar
• Greening DW, Xu R, Ji H, Tauro BJ, Simpson RJ. A protocol for exosome isolation and characterization: evaluation of ultracentrifugation, density-gradient separation, and immunoaffinity capture methods. Methods Mol Biol 2015; 1295:179-209; PMID:25820723; http://dx.doi.org/10.1007/978-1-4939-2550-6_15
   PubMedGoogle Scholar
• Taylor DD, Shah S. Methods of isolating extracellular vesicles impact down-stream analyses of their cargoes. Methods. 2015; S1046–2023(15)00092-4
   Google Scholar
• He M, Crow J, Roth M, Zeng Y, Godwin AK. Integrated immunoisolation and protein analysis of circulating exosomes using microfluidic technology. Lab Chip 2014; 14(19):3773-80; PMID:25099143; http://dx.doi.org/10.1039/C4LC00662C
   PubMed Web of Science ®Google Scholar
• Vaidyanathan R, Naghibosadat M, Rauf S, Korbie D, Carrascosa LG, Shiddiky MJ, Trau M. Detecting exosomes specifically: a multiplexed device based on alternating current electrohydrodynamic induced nanoshearing. Anal Chem 2014; 86:11125-32; PMID:25324037; http://dx.doi.org/10.1021/ac502082b
   PubMed Web of Science ®Google Scholar
• Davies RT, Kim J, Jang SC, Choi EJ, Gho YS, Park J. Microfluidic filtration system to isolate extracellular vesicles from blood. Lab Chip 2012; 12:5202-10; PMID:23111789; http://dx.doi.org/10.1039/c2lc41006k
   PubMed Web of Science ®Google Scholar
• Regente M, Pinedo M, Elizalde M, de la Canal L. Apoplastic exosome-like vesicles: a new way of protein secretion in plants? Plant Signal Behav 2012; 7:544-6; PMID:22516827; http://dx.doi.org/10.4161/psb.19675
   PubMedGoogle Scholar
• Ding Y, Wang J, Wang J, Stierhof YD, Robinson DG, Jiang L. Unconventional protein secretion. Trends Plant Sci 2012; 17:606-15; PMID:22784825; http://dx.doi.org/10.1016/j.tplants.2012.06.004
   PubMed Web of Science ®Google Scholar
• Quesenberry PJ, Aliotta J, Camussi G, Abdel-Mageed AB, Wen S, Goldberg L, Zhang HG, Tetta C, Franklin J, Coffey RJ, et al. Potential functional applications of extracellular vesicles: a report by the NIH Common Fund Extracellular RNA Communication Consortium. J Extracell Vesicles 2015; 4:27575; PMID:26320942
   PubMed Web of Science ®Google Scholar
• Nielsen ME, Feechan A, Bohlenius H, Ueda T, Thordal-Christensen H. Arabidopsis ARF-GTP exchange factor, GNOM, mediates transport required for innate immunity and focal accumulation of syntaxin PEN1. Proc Natl Acad Sci U S A 2012; 109:11443-8; PMID:22733775; http://dx.doi.org/10.1073/pnas.1117596109
   PubMed Web of Science ®Google Scholar
• Wei T, Hibino H, Omura T. Release of Rice dwarf virus from insect vector cells involves secretory exosomes derived from multivesicular bodies. Commun Integr Biol 2009; 2:324-6; PMID:19721879; http://dx.doi.org/10.4161/cib.2.4.8335
   PubMedGoogle Scholar
• Ju S, Mu J, Dokland T, Zhuang X, Wang Q, Jiang H, Xiang X, Deng ZB, Wang B, Zhang L, et al. Grape exosome-like nanoparticles induce intestinal stem cells and protect mice from DSS-induced colitis. Mol Ther 2013; 21:1345-57; PMID:23752315; http://dx.doi.org/10.1038/mt.2013.64
   PubMed Web of Science ®Google Scholar
• Wiczer BM, Thomas G. Phospholipase D and mTORC1: Nutrients Are What Bring Them Together. Sci Signal 2012; 5:pe13; PMID:22457329
   PubMed Web of Science ®Google Scholar
• Blackwood RA, Smolen JE, Transue A, Hessler RJ, Harsh DM, Brower RC, French S. Phospholipase D activity facilitates Ca2+-induced aggregation and fusion of complex liposomes. Am J Physiol-Cell Ph 1997; 272:C1279-C85
   Web of Science ®Google Scholar
• Chevillet JR, Kang Q, Ruf IK, Briggs HA, Vojtech LN, Hughes SM, Cheng HH, Arroyo JD, Meredith EK, Gallichotte EN, et al. Quantitative and stoichiometric analysis of the microRNA content of exosomes. P Natl Acad Sci USA 2014; 111:14888-93; http://dx.doi.org/10.1073/pnas.1408301111
   PubMed Web of Science ®Google Scholar
• Gangalum RK, Atanasov IC, Zhou ZH, Bhat SP. α B-Crystallin Is Found in Detergent-resistant Membrane Microdomains and Is Secreted via Exosomes from Human Retinal Pigment Epithelial Cells. J Biol Chem 2011; 286:3261-9; PMID:21097504; http://dx.doi.org/10.1074/jbc.M110.160135
   PubMed Web of Science ®Google Scholar
• Van der Pol E, Hoekstra AG, Sturk A, Otto C, van Leeuwen TG, Nieuwland R. Optical and non-optical methods for detection and characterization of microparticles and exosomes. J Thromb Haemost 2010; 8:2596-607; PMID:20880256; http://dx.doi.org/10.1111/j.1538-7836.2010.04074.x
   PubMed Web of Science ®Google Scholar
• Mu JY, Zhuang XY, Wang QL, Jiang H, Deng ZB, Wang BM, Zhang LF, Kakar S, Jun Y, Miller D, et al. Interspecies communication between plant and mouse gut host cells through edible plant derived exosome-like nanoparticles. Mol Nutr Food Res 2014; 58:1561-73; PMID:24842810; http://dx.doi.org/10.1002/mnfr.201300729
   PubMed Web of Science ®Google Scholar
• Sharma S, Rasool HI, Palanisamy V, Mathisen C, Schmidt M, Wong DT, Gimzewski JK. Structural-Mechanical Characterization of Nanoparticle Exosomes in Human Saliva, Using Correlative AFM, FESEM, and Force Spectroscopy. Acs Nano 2010; 4:1921-6; PMID:20218655; http://dx.doi.org/10.1021/nn901824n
   PubMed Web of Science ®Google Scholar
• Palanisamy V, Sharma S, Deshpande A, Zhou H, Gimzewski J, Wong DT. Nanostructural and transcriptomic analyses of human saliva derived exosomes. PLoS One 2010; 5:e8577; PMID:20052414; http://dx.doi.org/10.1371/journal.pone.0008577
   PubMed Web of Science ®Google Scholar
• Thery C, Amigorena S, Raposo G, Clayton A. Isolation and characterization of exosomes from cell culture supernatants and biological fluids. Curr Protoc Cell Biol 2006; Chapter 3:Unit 3 22; 1-3.22.29; PMID:18228490
   PubMedGoogle Scholar
• Fevrier B, Raposo G. Exosomes: endosomal-derived vesicles shipping extracellular messages. Curr Opin Cell Biol 2004; 16:415-21; PMID:15261674; http://dx.doi.org/10.1016/j.ceb.2004.06.003
   PubMed Web of Science ®Google Scholar
• Zhang MZ, Yu RN, Chen J, Ma ZY, Zhao YD. Targeted quantum dots fluorescence probes functionalized with aptamer and peptide for transferrin receptor on tumor cells. Nanotechnology 2012; 23:485104; PMID:23138109; http://dx.doi.org/10.1088/0957-4484/23/48/485104
   PubMed Web of Science ®Google Scholar
• Zhang MZ, Yu Y, Yu RN, Wan M, Zhang RY, Zhao YD. Tracking the Down-Regulation of Folate Receptor-α in Cancer Cells through Target Specific Delivery of Quantum Dots Coupled with Antisense Oligonucleotide and Targeted Peptide. Small 2013; 9:4183-93; PMID:23828664; http://dx.doi.org/10.1002/smll.201300994
   PubMed Web of Science ®Google Scholar
• Yang J, Yao MH, Wen L, Song JT, Zhang MZ, Zhao YD, Liu B. Multifunctional quantum dot-polypeptide hybrid nanogel for targeted imaging and drug delivery. Nanoscale 2014; 6:11282-92; PMID:25130175; http://dx.doi.org/10.1039/C4NR03058C
   PubMed Web of Science ®Google Scholar
• Zhang MZ, Li C, Fang BY, Yao MH, Ren QQ, Zhang L, Zhao YD. High transfection efficiency of quantum dot-antisense oligonucleotide nanoparticles in cancer cells through dual-receptor synergistic targeting. Nanotechnology 2014; 25
   Google Scholar
• Song JT, Yang XQ, Zhang XS, Yan DM, Wang ZY, Zhao YD. Facile Synthesis of Gold Nanospheres Modified by Positively Charged Mesoporous Silica, Loaded with Near-Infrared Fluorescent Dye, for in Vivo X-ray Computed Tomography and Fluorescence Dual Mode Imaging. ACS Appl Mater Interfaces 2015; 7:17287-97; PMID:26189815; http://dx.doi.org/10.1021/acsami.5b04359
   PubMed Web of Science ®Google Scholar
• Wang B, Zhuang X, Deng ZB, Jiang H, Mu J, Wang Q, Xiang X, Guo H, Zhang L, Dryden G, et al. Targeted drug delivery to intestinal macrophages by bioactive nanovesicles released from grapefruit. Mol Ther 2014; 22:522-34; PMID:23939022; http://dx.doi.org/10.1038/mt.2013.190
   PubMed Web of Science ®Google Scholar
• Sancho R, Nateri AS, de Vinuesa AG, Aguilera C, Nye E, Spencer-Dene B, Behrens A. JNK signalling modulates intestinal homeostasis and tumourigenesis in mice. EMBO J 2009; 28:1843-54; PMID:19521338; http://dx.doi.org/10.1038/emboj.2009.153
   PubMed Web of Science ®Google Scholar
• Kim BM, Mao J, Taketo MM, Shivdasani RA. Phases of canonical Wnt signaling during the development of mouse intestinal epithelium. Gastroenterology 2007; 133:529-38; PMID:17681174; http://dx.doi.org/10.1053/j.gastro.2007.04.072
   PubMed Web of Science ®Google Scholar
• Raimondo S, Naselli F, Fontana S, Monteleone F, Lo Dico A, Saieva L, Zito G, Flugy A, Manno M, Di Bella MA, et al. Citrus limon-derived nanovesicles inhibit cancer cell proliferation and suppress CML xenograft growth by inducing TRAIL-mediated cell death. Oncotarget 2015; 6:19514-27; PMID:26098775; http://dx.doi.org/10.18632/oncotarget.4004
   PubMed Web of Science ®Google Scholar
• Allen TM, Cullis PR. Liposomal drug delivery systems: from concept to clinical applications. Adv Drug Deliv Rev 2013; 65:36-48; PMID:23036225; http://dx.doi.org/10.1016/j.addr.2012.09.037
   PubMed Web of Science ®Google Scholar
• Wang QL, Zhuang XY, Mu JY, Deng ZB, Jiang H, Zhang LF, Xiang XY, Wang BM, Yan J, Miller D, et al. Delivery of therapeutic agents by nanoparticles made of grapefruit-derived lipids (vol 4, 1867, 2013). Nat Commun 2013; 4:1867; PMID:23695661; http://dx.doi.org/10.1038/ncomms2886
   PubMed Web of Science ®Google Scholar
• Wang QL, Ren Y, Mu JY, Egilmez NK, Zhuang XY, Deng ZB, Zhang LF, Yan J, Miller D, Zhang HG. Grapefruit-Derived Nanovectors Use an Activated Leukocyte Trafficking Pathway to Deliver Therapeutic Agents to Inflammatory Tumor Sites. Cancer Res 2015; 75:2520-9; PMID:25883092; http://dx.doi.org/10.1158/0008-5472.CAN-14-3095
   PubMed Web of Science ®Google Scholar